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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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EFFECTS OF CURCUMIN NANOPARTICLES AGAINST INDOMETHACIN INDUCED GASTRIC ULCER IN RAT Abdulkareem, Gufran; Hasan, Bushra F.; Al-Masoudi, Wasfi A.
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1332

Abstract

Objective: Gastric ulcers (GUs) are a primary disorder affecting the upper gastrointestinal tract and are caused by gastric acid. The corrosive effects of pepsin and hydrochloric acid on the gastric mucosa can lead GUs. Compare the effect of curcumin and nanocurcumin with cimetidine on serum TC, TG, LDL, and HDL total protein and albumin levels in male rats with gastric ulcer. Method: Fifty male adult albino rats, with body weights ranging between 195–205 g where all the animals were categorized into five equal groups (each group containing 10 rats). Group 1: normal group, Group 2: indomethacin group, Group 3: indomethacin with curcumin, Group 4: indomethacin with nanocurcumin, Group 5: indomethacin with cimetidine. Blood samples (4 ml) were then placed into tubes without any anticoagulant, after centrifuging serum samples were then used for determining TC, TG, LDL, HDL, total protein and albumin levels in the animals. Results: Se/NP had a spherical, smooth nanoparticles, nanometre-sized. Oral administration of nanocurcumin caused marked improvement in HDL concentration and LDL concentration compared with gastric ulcer group and there were non-significant changes compared with normal group. Oral administration of nanocurcumin and cimetidine revealed a significant increase at (p≤0.05) level in serum albumin concentration when compared with gastric ulcer group and reach to normal group. Novelty: In rats with gastric ulcers caused by Indomethacin, the prepared nanocurcumin proved to be much more effective than curcumin. These results serve as a foundation for additional pharmacological investigation that could result in the creation of novel drug formulations. 
ASSESSMENT OF HIP JOINT ENDOPROSTHESIS TREATMENT EFFECTIVENESS AND ITS IMPACT ON PATIENTS' QUALITY OF LIFE Y.U., Joynarov; N.R, Ishburiev; U.M, Shermatov; Z.Sh, Abulfayzov; M.O, Djuraev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1335

Abstract

Objective: This study investigates the effectiveness of total hip arthroplasty (THA) in restoring joint function and enhancing the overall quality of life for patients with severe hip joint disorders. Method: Conducted at the Department of Traumatology and Orthopaedics, Surkhandarya Regional Multidisciplinary Medical Centre, Uzbekistan, the study observed 82 patients who underwent THA between 2022 and 2024. The Harris Hip Score and SF-36 health survey were used to evaluate patients’ physical function, pain levels, emotional state, and social well-being before surgery and at 3 and 12 months postoperatively. Results: Findings demonstrated a significant reduction in pain and substantial improvements in mobility, independence, and physical health indicators. Patients also reported enhanced mood, sleep quality, and life satisfaction, suggesting broad psychosocial benefits beyond physical rehabilitation. Novelty: Unlike prior studies focused solely on biomechanical outcomes, this research emphasizes the holistic impact of hip endoprosthesis, highlighting THA as not merely a mechanical intervention but a transformative procedure with profound implications for psychological well-being and quality of life. The study advocates for patient-centered orthopaedic care with integrated postoperative support.
MORPHOMETRIC CHANGES IN THE TESTIS AGAINST THE BACKGROUND OF CHEMOTHERAPY-INDUCED RENAL FAILURE AND THEIR BIOCORRECTION Y.U., Joynarov; N.R, Ishburiev; U.M, Shermatov; Z.Sh, Abulfayzov; M.O, Djuraev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1336

Abstract

Objective: This study investigates the effects of chemotherapy-induced renal impairment on testicular morphology and evaluates the efficacy of a biocorrective intervention aimed at mitigating associated reproductive damage. Method: Conducted at the Department of Trauma Outcomes and Orthopaedics, Surkhandarya Multidisciplinary Medical Centre, the study utilized an animal model to simulate cytotoxic therapy-induced renal failure. Histological and morphometric analyses of testicular tissue were performed, focusing on parameters such as seminiferous tubule diameter, spermatogenic stratification, and interstitial cell function. A biocorrective agent with antioxidant properties was administered to assess restorative outcomes. Results: Chemotherapy-induced renal dysfunction resulted in significant structural alterations in the testes, including reduced spermatogenic activity and cellular degeneration. Treatment with the biocorrective compound led to partial restoration of testicular architecture and improved cellular integrity. Novelty: The study provides new insights into the systemic consequences of chemotherapy, particularly its underrecognized impact on male reproductive health, and demonstrates the therapeutic potential of targeted biocorrection in preserving gonadal function. These findings support a more integrative, organ-preserving approach in oncology care that prioritizes long-term quality of life alongside cancer eradication.
PHYSIOLOGICAL FOUNDATIONS OF PHOTOPERIODISM AND PHYTOCHROME SYSTEM IN PLANTS Muroddinova, Farida Rakhmatboy qizi
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1338

Abstract

Objective: This study aims to explore the physiological foundations of photoperiodism and the phytochrome system, detailing their mechanisms and assessing their ecological and agricultural implications. Method: The research examines the role of the phytochrome pigment system, which senses red and far-red light, and its mediation of changes in day length to regulate plant physiological processes like flowering, dormancy, and seed germination. Result: The research demonstrates that phytochrome, through its Pr and Pfr forms, governs gene expression and hormone production to regulate flowering and growth. It shows that short-day and long-day plants exhibit distinct phytochrome responses, while day-neutral plants rely on alternate factors. Novelty: By connecting molecular mechanisms of phytochrome signaling with real-world plant behavior and environmental adaptation, the paper offers a comprehensive synthesis linking basic plant science with agronomic applications. Understanding these systems allows for better crop scheduling, yield optimization in controlled environments, and adaptation of plant species to new climates through light management. This knowledge is crucial for sustainable agriculture and the development of high-yielding, climate-resilient plant varieties.
MCP-1 AND VITAMIN D PROFILES IN ESRD ON HEMODIALYSIS: A CASE-CONTROL STUDY IN AL-BASRAH CITY Fadhil , Haneen Husham; Salman , Rana Dawood; Hasan , Jubran Khaleel
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1340

Abstract

Objective: This study aimed to examine and compare serum levels of vitamin D and monocyte chemoattractant protein-1 (MCP-1) in patients with end-stage renal disease (ESRD) undergoing haemodialysis versus healthy individuals, and to evaluate their diagnostic potential as biomarkers. Method: An observational cross-sectional design was employed involving 30 ESRD patients receiving regular haemodialysis and 34 age- and sex-matched healthy controls. Serum levels of vitamin D, MCP-1, parathyroid hormone (PTH), urea, creatinine, estimated glomerular filtration rate (eGFR), and blood pressure were assessed. Results: ESRD patients showed significantly elevated levels of urea, creatinine, PTH, and MCP-1, and significantly lower eGFR and vitamin D levels compared to controls (p<0.001). ROC analysis revealed high diagnostic accuracy for PTH (AUC=0.946), with moderate-to-good performance for vitamin D (AUC=0.732) and MCP-1 (AUC=0.700). Novelty: This study contributes to the limited regional data by identifying the potential of vitamin D and MCP-1 as accessible clinical biomarkers for nutritional and inflammatory assessment in ESRD patients undergoing haemodialysis, emphasizing their role in early detection strategies and patient monitoring.
BLOOD GROUP AND ITS RELATIONSHIP WITH DIABETIC Hashim, Aswan Mahmood; Manje, Nawras Bahaa
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1344

Abstract

Objective: Diabetes is described in this article as a metabolic disease that results in hyperglycemia, or elevated blood sugar. DM pathophysiology may be divided into two primary groups. type 1 and type 2 Its connection to blood types is examined. The four basic "ABO" phenotypes—"A," "B," "O," and "AB"—make up the "ABO" system. ABO phenotypic blood types are polymorphic, genetic, antigenic substances found on the surface of red blood cells as well as other organ cells. Method: From people of both sexes (male and female), with ages ranging from 7 to 80, 97 samples were taken. People with diabetes may be anywhere from 7 to 80 years old, based on blood sugar levels. Results: In contrast to type 2 diabetes, which is more common in those over 40, type 1 diabetes may develop at any age. O+ diabetes is the most common form, and men are more likely than women to get it. The highest blood sugar level for a person aged 30 was 600. The lowest percentage is 91 for a person who is 27 years old. O+ was shown to be the kind most affected by diabetes. Blood group AB is the one least affected by diabetes. Novelty: If genes "A" and "B" are present or absent, the individual's blood class is determined by small carbohydrate epitopes. Scattered over 18 kb, the gene's seven exons are referred to as "ABO" blood types. It is located on chromosome 9q34.
THE IMPACT OF SLEEP DISORDERS ON CELLULAR IMMUNE REGULATION AMONG UNIVERSITY STUDENTS AL-Ukaily, Hussein Ali Mohammed; Al-Saadi, Zainab Nashaat Shukur
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1346

Abstract

Objective: Sleep is a fundamental biological process that contributes to regulating physiological balance within the body, particularly in maintaining the efficiency of the immune system. Recent literature indicates that sleep disturbances, especially chronic ones, may lead to impaired cellular immune function and increased general inflammatory activity. Based on this hypothesis, this study aimed to evaluate the impact of sleep disturbances on cellular immune regulation in university students by analyzing lymphocyte ratios and concentrations of certain immune cytokines in the blood. Method: The study included (60) male and female students aged (19–24) years, divided into two groups: a group with sleep disturbances (n = 30), identified based on the Pittsburgh Sleep Quality Index questionnaire (PSQI ≥ 6), and a control group (n = 30) with normal sleep patterns. Immune cell ratios (CD3+, CD4+, CD8+, and CD56+) were measured using flow cytometry, while the concentrations of the cytokines IL-6, TNF-α, and IFN-γ were determined using enzyme-linked immunosorbent assay (ELISA). Result: The results showed a significant decrease in the percentages of CD3+, CD4+, and CD56+ cells in the sleep disorder group compared to the control group (p < 0.01), while no significant differences were recorded in the percentages of CD8+ cells. Regarding cytokines, a significant increase in the concentrations of IL-6 and TNF-α was found in those with sleep disorders (p < 0.01), while there was no significant difference in the level of IFN-γ. The study also revealed a moderate positive correlation between PSQI scores and IL-6 concentrations (r = 0.58, p < 0.01), indicating that poor sleep quality is associated with increased immune inflammation. Novelty: These findings highlight the negative biological impact of sleep disturbances on cellular immune function in young university students, and suggest a potential causal relationship between poor sleep quality and the activation of inflammatory pathways.
TISSUE ORGANIZATION OF MUCOSAL IMMUNE RESPONSES: A COMPARATIVE HISTOLOGICAL ANALYSIS OF THE RESPIRATORY AND INTESTINAL BARRIERS Alrudhan, Qays Hameed Abed
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1347

Abstract

Objective: Mucosal surfaces serve as critical defensive barriers that safeguard the organism from external environmental fluctuations and persistent pathogen threats. In response to these challenges, a specialized mucosal immune system has developed, which adapts through a process known as homing, allowing it to integrate with various tissues. This integrated immune system is responsible for producing, evaluating, and executing adaptive immune responses by establishing diverse immune microenvironments at mucosal locations. The present analysis centers on the similarities between the respiratory and intestinal mucosal systems, facilitating a comparative exploration of how a seemingly analogous system has evolved to fulfill the unique demands of different environments while preserving a robust foundational architecture. Method: Each mucosal microenvironment possesses distinctive features concerning its cellular composition, structural organization, and immune processes. To elucidate this well-characterized system, an examination of the invariant structural framework of these tissues will be conducted on both micro- and macro-scales, with an emphasis on the anatomy and cellular components of Peyer's patches (PP), bronchus-associated lymphoid tissue (BALT), conjunctiva-associated lymphoid tissue (CALT), tonsils, and isolated lymphoid tissues (ILT), along with smaller clusters found within the lungs. Result: Despite these specificities that may mitigate cross-competition among them, there is a proposition that the components of mucosa-associated lymphoid tissue (MALT) share evolutionary origins. A comparative analysis of the steady state microenvironments will delve into the complexities of immune engagement, the structural plasticity that facilitates intratissular memory, and the efficacy of effector responses that enable rapid pathogen clearance without incurring detrimental effects. Dendritic cells (DCs) residing in these environments play a pivotal role by capturing antigens utilizing various internalization receptorial setups and signal transduction pathways. The cross-presenting CD103+ DCs present in both mucosal systems influence the polarization of immune responses and the selection of immune strategies employed. Novelty: Finally, a succinct overview of the enhancing environments will be provided, addressing the proactive approaches adopted by pathogens and commensals, alongside the counterstrategies implemented by the immune system to address these threats. Special attention will be afforded to the collaborative roles of epithelial and immune cells in responding to viral infections and bacterial toxins.
INVESTIGATION OF BIOLOGICAL PROPERTY FEATURES VARIABILITY OF CANDIDA FAMILY YEAST-LIKE FUNGI Zumarad, Allaberganova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1350

Abstract

Objective: Yeast-like fungi of the Candida genus are opportunistic pathogens implicated in candidiasis, yet biological variability—particularly in colony morphology and proteolytic properties—remains underexplored beyond Candida albicans, especially across strain origins, culture passages, and storage conditions. Method: This study investigated the morphological and proteolytic characteristics of Candida spp. from both hospital and collection strains, assessing variability under controlled passage conditions. Evaluations were conducted using a rice bran-based medium and a standardized scale for growth assessment. Results: The study identified distinct colony morphotypes—typical S, atypical K, and rare R forms—whose distribution varied with passage number and storage duration. Notably, collection strains exhibited a significant decline in proteolytic activity by the third passage, while hospital strains showed reduced enzymatic activity from the initial passage. Novelty: This research provides new insights into the phenotypic plasticity of Candida strains, emphasizing the diagnostic relevance of passage tracking. It also introduces a practical and accessible method for evaluating growth characteristics using rice bran-based media, contributing to improved diagnostic accuracy, treatment strategies, and epidemiological monitoring in clinical mycology.
HEMATOLOGICAL AND BIOCHEMICAL PROFILES IN RHEUMATOID ARTHRITIS PATIENTS UNDERGOING METHOTREXATE, RITUXIMAB, AND COMBINATION THERAPY Al-Shemmary, Athraa Jaleel
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1354

Abstract

Objective: Rheumatoid arthritis is one of the most prevalent chronically inflammation and systemically autoimmune illnesses. Non-steroidal anti-inflammatory medications (NSAIDs), corticosteroids, biological and synthetic disease-modifying antirheumatic pharmaceuticals (DMARDs), and immunosuppressive medications were all included in the guidelines for the treatment of rheumatoid arthritis. The aim of study Longitudinal assessment of WBC, Hb, platelets, ALT, AST, creatinine, urea, and ESR during taking Methotrexate (MTX) and Rituximab (RTX) treatment each alone and in combination for RA patients. Method: The study involved RA patient all taken treatment for 4 years divided into three subgroup: group (A) include 30 cases who were taken methotrexate only, group(B) include 20 cases were taken RTX only and group(C) include 10 cases who were taken combination of MTX and RTX for 4 year. In addition to the control group involved 60 healthy individuals. Results: Our findings reveal a significant decrease in hemoglobin (Hb) levels in RA patients undergoing these treatments (p=0.03) compared to controls(11.21,11.45, 11.21 ±SD vs. 12.56±0.96). Conversely, there was a significant increase in platelet counts (p=0.002) in treated RA patients (298.71 ,266.89,308.5±SD) compared to controls (248.96±51.54). No significant differences were observed in white blood cell (WBC) counts (p=0.26). Regarding kidney function, a significant increase in both creatinine (p=0.002) and urea (p=0.003) was noted in RA patients receiving treatment (0.69, 0.71, 0.8±SD for creatinine ; 28.5 26.88−32.34±SD for urea) when compared to controls (0.59±0.19 for creatinine; 24.63±5.51 for urea). However, liver function parameters, including ALP and AST, showed no significant differences (p=0.8 and p=0.15, respectively). Finally, a significant elevation in Erythrocyte Sedimentation Rate (ESR) (p=0.004) was observed in treated RA patients (35.63,52.81, 37.5 ±SD) versus the control group (17.7±8.47), indicating heightened inflammatory activity. Novelty: Longitudinal assessment of hematological, liver, kidney, and inflammatory biomarkers in RA patients over a four-year period under MTX, RTX, and combined treatment is rarely reported, especially with this specific comparative design including a healthy control group.

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