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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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WRIST AND HAND STRUCTURE: HISTOLOGY AND DISEASE PERSPECTIVE Baqiyevna, Akbarova Barchinoy; Jumaramziddin Eldorbek o’g’li, No‘monjonov
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1290

Abstract

The wrist and hand are intricate anatomical structures essential for human mobility, dexterity, and performing daily tasks, comprising bones, muscles, ligaments, nerves, and blood vessels that operate as an integrated system. Diseases affecting these structures, such as tendinitis, arthritis, carpal tunnel syndrome, and osteoarthritis, compromise their function and quality of life, and their diagnosis and treatment increasingly rely on understanding histological changes at the tissue level. Despite the clinical importance of wrist and hand disorders, comprehensive analysis connecting histological features with clinical symptoms and the effectiveness of evolving treatment methods remains limited. This study aims to examine the anatomical and histological structure of the wrist and hand, analyze common diseases from a microscopic perspective, and evaluate contemporary treatment strategies based on recent scientific findings. Histological analysis reveals that inflammation, tissue degeneration, and fibrosis are common pathological features across different wrist and hand diseases, with treatments such as NSAIDs, corticosteroids, hyaluronic acid injections, and regenerative medicine showing promising outcomes. By linking clinical manifestations with underlying histological alterations, this article highlights the role of histology in early diagnosis, individualized treatment planning, and the advancement of novel therapeutic approaches. Enhancing knowledge of histological mechanisms not only improves diagnosis and treatment of wrist and hand diseases but also contributes to developing preventive strategies, ultimately advancing patient care in musculoskeletal medicine.
OUT COMES AFTER CAR T CELL THERAPY IN THE LONG RUN Faez, Samaa
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1297

Abstract

Objective: During the past several years, there has been a lot of discussion regarding the utilization of chimeric antigen receptor T-cells as an immunotherapy treatment for malignancies. Method: The scope of this study encompasses not only the negative consequences that CAR-T cells have, but also the mechanisms that are responsible for those effects, as well as potential treatments. Results: Through the utilization of this therapy strategy, both hematological malignancies and solid tumors have been successfully treated. However, it has been associated with a number of adverse reactions, such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), off-target effects, anaphylaxis, infections associated with CAR-T cell infusion (CTI), tumor lysis syndrome (TLS), B-cell dysplasia, hemophagocytic lympho histiocytosis (HLH)/macrophage activation syndrome (MAS), and coagulation disorders. Novelty: The therapeutic application of CAR-T cell therapy can be informed by this evaluation, which will furnish critical reference data.
PREVALENCE OF HYDATID DISEASE IN IRAQ: A STATISTICAL STUDY (2023) Jassim, Sura Emad; Hasoob Mohammed, Simaa
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1299

Abstract

Objective: Hydatid disease (cystic echinococcosis), caused by the larval stage of Echinococcus granulosus, remains a persistent public health concern in Iraq, particularly in areas with suboptimal livestock management and healthcare infrastructure. This study aimed to assess the national prevalence of hydatid disease across various demographic and geographic dimensions using recent official data. Method: A retrospective descriptive analysis was conducted using epidemiological data from the Iraqi Ministry of Health’s Division of Infectious Diseases, encompassing 478 confirmed cases reported in 2023. The dataset was analyzed based on age, gender, and governorate of residence using frequencies and percentages. Results: Females represented 64.9% of infections, with the 20–44 age group being most affected. The highest prevalence was found in Al-Muthanna province (1.12 per 10,000 population), indicating potential epidemiological hotspots driven by ecological and sociocultural factors. Novelty: This study provides an up-to-date national epidemiological snapshot of hydatid disease in Iraq using 2023 data, highlighting gender- and age-based vulnerability and identifying geographic clusters. The findings offer valuable insights for region-specific public health interventions and contribute new empirical evidence to the limited literature on zoonotic disease distribution in Iraq.
ASSESSMENT THE POST OPERATIVE COMPLICATION AMONG PATIENTS WITH GENERAL ANESTHESIA Kareem, Mariam Mohammed Ali; Ali Fadel Abbas; Yassien, Nada Jassem; Thuraya Ali Baseer; Layla Raheem Hakem
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1300

Abstract

Objective: Each year, increasing numbers of people are undergoing surgery. Many of these patients are older and have multiple comorbidities. General anesthesia is very common anesthetic procedure which is used in several surgical approaches. Without general anesthesia many of these surgeries are lifesaving or life-changing and would not be possible. But all medical procedures are associated with some complications, even when they are performed by experts. The severity and rate of these complications depend on patient's state of health. Method: A Descriptive quantitative design study has been used in the present study to estimate the Post operative complication among patient undergo the general anesthesia at Al-Sadder Medical City and Al-Hakeem hospital during the October,15th, 2023 to March,28th ,2024. Results: According to the current study sample researcher found the most common complication in the respiratory system was difficult breathing (50%). Regarding Gastrointestinal complications recent study showed that the highest percentage were nausea (71.0%), constipation (68.33%) and vomiting (58%). The highest percentages of complication in the cardiovascular system was hypotension (41.7%). There is low percent in urinary incontinence and dysuria with (20%) and (16.67%). Regarding to the general complications the result show that headache is the most common with (82%) from all sample. Novelty: Most of precent study sample were diabetic patient (66.7%), those with previous surgery (66.7%), those with only one previous surgery (25%), the most complication after general anesthesia were Headache, Nausea, Chills, Constipation Motor deficit. And there is no correlation between patient who had previous surgery and who had not.
NURSES’ KNOWLEDGE TOWARD MANAGEMENT OF POSTOPERATIVE PAIN AL-Hadrawy , Zainab Abidzaid Abid; Alnassar, Hawra'a Ghannam; Mohammed Baqer Hasan; Ali Takleef Noor Algburi
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1301

Abstract

Objective: Study aims to assess nurses' knowledge toward pain management post operatively and to find out the relationship between nurses' knowledge and their demographic data. Method: A descriptive cross-sectional study design was conducted at Al-Najaf city in the southern region of Iraq in Al-Zahra'a Teaching Hospital from January 28, 2025, to 6th April, 2025, in order to assess the nurses’ knowledge regarding post-operative pain management. The methodological strategies for data collection used an assessment questionnaire survey methodology. Results: In the present study, an assessment of nurses' knowledge concerning post-operative pain management revealed a good level of understanding. Furthermore, there is a significant relationship between nurses' knowledge regarding management of post-operative pain and their level of education and training courses. Novelty: Despite advancements in pain management, many patients still suffer due to a lack of nurses’ knowledge or negative attitudes toward handling.
HOST IMMUNE PROFILING IN PATIENTS WITH SEVERE COVID-19: BIOMARKERS OF IMMUNE DYSREGULATION Hasan, Husam Fadhil; Dahdoh, Mojtaba Qati; Ali, Hayder Mohsin
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1302

Abstract

Objective: Host immune profiling in severe cases of COVID-19 is an important area of focus that seeks to explain the immune dysregulation mechanisms impacting upon health. This study examines the immune landscape of patients suffering from severe COVID-19 in detail, mapping specific biomarkers of immune dysfunction. Method: By harnessing advanced technologies, including flow cytometry and transcriptomic analysis, this study captures the dynamic changes within immune cell subsets and their related pathways. Central to this exploration is understanding the interplay between innate and adaptive immunity in the context of severe COVID-19 infections. Results: Through comprehensive analysis, the study delineates the aberrant immune responses infiltrated by SARS-CoV-2, characterized by hyper inflammation, cytokine storm phenomena, and substantial variations in immunological profiles. Detailed profiling reveals notable deviations in neutrophil counts, lymphopenia, and altered cytokine levels. These disruptions are instrumental in the cascading complexities observed during disease progression. Consequently, the research identifies potential targets for modulation and future clinical application, thus aiming to enhance recovery rates and curtail mortality linked to severe COVID-19. Novelty: The identification of unique biomarkers offers profound insights into pathogenic processes, presenting opportunities for targeted therapeutic interventions and improved prognostic evaluations. The research posits that a strategic approach toward host immune profiling can profoundly impact the management and understanding of COVID-19. The findings underscore the necessity for precision medicine tailored to inherent immune irregularities, advocating for the integration of identified biomarkers in clinical practices to mitigate severe disease outcomes. The study contributes to existing literature by advocating for a paradigm shift, where immune profiling informs the design of bespoke therapeutic strategies and paves the way for innovative research trajectories in combating pandemic-related challenges.
ENHANCING ANTIFUNGAL PROPERTY AND CYTOTOXICITY PROFILE OF GOLD NANOPARTICLES BIOSYNTHESIS VIA SOME FILAMENTOUS FUNGI WITH IN SILICO STUDY Majeed, Suaded; Iman A. J. Al-Timimi; Abdullah H. Al-Saadoon
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1312

Abstract

Objective: To synthesize gold nanoparticles by fungi and testing their susceptibility as antifungals and comparing them with computerized study. Method: Synthesis of gold nanoparticles by some filamentous fungi (Aspergillus, Penicillium and Trichoderma), Au NPs characterised using (Transmission electron microscopy (TEM), Uv-vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy analyses (EDX), testing them as antifungals against pathogenic fungi (Candida albicans, C. tropicalis, Aspergillus niger, and A. flavus) and compared their results with nystatin as standard antifungal, the study was drawing a with In Silico study. Results: Aspergillus growth rate was more susceptible to nanoparticles, the percentage of growth rate was less than 70% after 48h, while Candida species were not affected by nanoparticles whether Au, and the percentage of growth rate was over 95%. The formation Au NPs confirm using UV-Vis with surface plasmon resonance at 540 nm and TEM images confirm spherical shape with average size 30 nm. The obtained data have been reported that therapeutic doses of nystatin that ranged from 8-1 μg/mL were not toxic significantly, and Au at 25% was not toxic effect significantly on cells growth. In silico study the results showed a characteristic binding affinity and conformational stability of Au-protein combination. Novelty: Synthesis of gold nanoparticles using filamentous fungi is best method and nanoparticles have a moderate antifungal activity compared to standard antifungal drug (nystatin).
THE RELATIONSHIP OF SERUM VITAMIN 25(OH)D3-LEVELS WITH WOMEN OBESITY AL- Ardhi, Ghadeer Hamid
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1316

Abstract

Objectives: This paper aims to evaluate the relationship between vitamin D3 levels and obesity in adult women compared to normal weight women. Method: Ninety-six (96) women them age around (20-50) years were collected and classified into three groups based on BMI categories. ELISA kit was used to measure vitamin D3 levels in serum of blood. Results: The results showed significantly lower vitamin D3 levels (15.28±1.13) in obese and overweight women (22.46 ±1.31) compared to normal weight group (34.40 ±2.43) at p≤ 0.05, and a negative significant correlation between vitamin25(OH) D3 levels and BMI in obese women. Novelty: This finding suggested that vitamin D3 deficiency in obese women may be due to its storage in adipose tissue which reduces its levels in the bloodstream. In addition to other different mechanism. More studies are required for detect the complex interchange between vitamin D3 and obesity to know more about the biological mechanism of action.
INCIDENCE OF SEPSIS IN CHILDREN UNDER 5 YEARS OLD WITHIN KIRKUK PROVINCE Bazzaz, Ayoub A.; Rana W. Al-Hassan; A. Yassin; Noorhan A. Chelebi
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1317

Abstract

Objectives: Medical researches on septicemia, particularly, in most susceptible age group of children i.e. newborns and young infants in Iraq are scanty. The aim of this study is to assess the incidence of blood poisoning via hematological parameters in children under 5 years old within Kirkuk Province. Methodology: Only 120 children aged 1-60 months admitted to hospital on suspicion of blood poisoning were selected and compared with other 40 healthy children of similar ages used as control. Results: Almost 42.5% of suspected cases admitted to hospital were diagnosed sepsis positive. Over 80% of affected sepsis cases were in children aged 1-18 months old but dropped down as the age advanced. The main blood parameters i.e. leucocytes (WBC), erythrocytes (RBC), hemoglobin (Hb%), Lymphocytes (L), Blood platelets (PLT) were significantly (p≤0.05-0.0001) affected up and down in sepsis patients in comparison with counterpart children. Novelty: It is concluded that the newborn and infants are more susceptible to infection than older ages due to the immaturity of the immune system in these babies, artificial rather than breast feeding, negligence and inexperience of mothers and deficiency of hygienic parameters applied. Early and regular health checkup of newborn babies under 5 years old by pediatricians deems mandatory to promote health measurements and reduce children mortality.
THE EFFECT OF BROMOCRIPTINE ON THE LEVELS OF ALKALINE PHOSPHATASE AND LIVER OF IMMATURE MALE RATS Jaber, Adhwaa Hameed
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 5 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i5.1320

Abstract

Objectives: The purpose of this investigation was to ascertain how bromocriptine (BRO) affected the livers of young male rats. Method: On the first day of experiments, the first group of five immature male rats (16 days old) weighing 25–30g was slaughtered. The remaining rats were divided into four groups, each consisting of 10 animals. The 3rd and 4th groups received BRO (IP) at 3 and 6 mg/kg BW, respectively, for two periods (9 days and 27 days), whereas the second group acted as the control and received the vehicle (IP). For the recovery trial, five rats from each group were kept for a month without receiving any therapy. Results: When compared to the control group, BRO therapy resulted in: A) a substantial loss in body the weight, B) significant rise in liver weight, and C) a significant increase in blood levels of phosphatase-alkaline in immature albino rats of both treated the groups. Novelty: The current investigation leads us to the conclusion that, even though BRO had an impact on the liver of young male rats, the effects of BRO may be recovered after a month of no treatment.

Page 32 of 38 | Total Record : 372

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