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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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The Association Between Ferritin Concentration Within the Blood and Anti-Tissue Transglutaminase (tTG IgA) in Individuals with Celiac Disease Alfahad, Ahmed A. N
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.368

Abstract

Celiac disease (CD) is a major public health concern across the world. because to the related comorbidities. The purpose of this study was to research the relationship among serum ferritin and anti-tissue transglutaminase (tTG IgA) in celiac disease patients. The research was conducted in Iraq- Muthanna over the course of one year from 2022 to 2023. The study included (5o) (CD) patients and (5o) healthy peoples (control). Patients with chronic disease were excluded. Blood was drawn from (patients and healthy) and tested for ferritin and (tTG IgA). the results showed serum ferritin revealed a negatively correlation with anti-tissue transglutaminase (tTG IgA) (Pearson's regression equal to o.54) in patients with celiac disease . Finally, we can have been concluded from our study the iron storage is represented by ferritin is negatively correlated in patient with celiac disease and anti-tissue transglutaminase (tTG IgA).
Estimated Glycation End Products and Oxidative Status in Renal Failure Patients Mutlag, Salam Khalid; Mukhlif1, Mohanad Hammo
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.369

Abstract

The present study conducted to assess the Glycation end products and oxidative status of in patients with renal failure. 100 patients that have had CKD for less than 2 years have been diagnosed by a doctor. A control group of 40 stable individuals was selected. From October 2021 to February 2022, patients were confirmed to be sick with chronic renal disease at Azadi Teaching Hospital and Al-Jumhuri Hospital. ‎the results showed that the largest age group of patients was > 60 years with percent (39%). Body Mass Index (BMI) of patients was 18.5-24.9 kg with percent (52%). Residential Area of patients was urban with percent (83%). Smoking Status of patients was non-smoking with percent (68%). The current outcomes demonstrated a reduction in the concentration of total protein that is significant (P<0.05), albumin and globulin in patients compare with healthy volunteers. On the other hand, the results show a significant (P<0.05) elevated in levels of carbonyl and amino group, while decreased in thiol levels in patients compare with healthy volunteers. Otherwise, the Glycation level shows significant (P<0.05) elevated in in patients compare with healthy volunteers. Its concluded that the CKD lead to elevated Glycation level and changes in oxidative status.
Estimate of Some Immune-Biomarkers in Children with Entamoeba Histolytica Infection Shakour, Sunbul Jalal
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.370

Abstract

The current work was aimed to evaluate of some immune-biomarkers in children with Entamoeba histolytica infection. General stool examination was done to patients for detection of E. histolytica infection. A total 150 patients of less than 13 years, whom attended the parasitology section at period February to June 2023. The chosen patients were suffered from abdominal pain and diarrhea. The results showed that gender is not related to infection with E. histolytica, as there were no significant (P≤0.05) differences between the proportions of males and females. The IgG concentration of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). IgA concentration of infected children (159.42±18.62 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (38.93±7.01 ng/L). IgM concentration of infected children (4.84±0.45 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (2.17±0.35 ng/L). The IL-4 concentration of infected children (29.47±4.04 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (16.54±3.94 pg/ml). IL-6 concentration of infected children (183.25±21.37 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (26.12±4.51 pg/ml). The TLR2 levels of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). therefore, its concluded that E. histolytica lead to a high immune response that leads to an increase in levels of immune parameters in infected children
Navigating the Immune Response Landscape of Hepatitis B and Hepatitis C Virus Infections Hammood, Saja Qasim; Mahmood, Ellaf Abdulljabbar Jassim prf. Dr. Alia Essam; Kadhem, Ashwaq A.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.373

Abstract

Both the hepatitis B virus (HBV) and the hepatitis C virus (HCV) are viral pathogens that primarily target the liver and can lead to chronic liver disease. The nature of the immune response that the host mounts can vary depending on the structural differences between these two viruses. HBV is a partially double-stranded DNA virus enveloped in an outer envelope with a relatively stable genome and limited antigenic variation. It consists of an inner nucleocapsid core containing viral DNA, viral polymerase, and core antigen (HBcAg). The envelope comprises surface antigens (HBsAg) important for viral entry and immune recognition. HCV is a single-stranded RNA virus with an envelope. It has a high degree of genetic diversity due to its error-prone RNA polymerase, resulting in multiple HCV genotypes and subtypes due to its high mutation rate. Both viruses activate innate immune responses, producing type I interferons (IFNs) and pro-inflammatory cytokines. HBV can actively fight these antiviral responses in several ways, such as by making viral proteins that mess up the innate immune signalling pathways. At the same time, HCV developed strategies to evade and modulate the host's innate immune system, allowing it to establish persistent infections. The adaptive immune response against HBV and HCV involves both humoral and cellular components. Antibodies against HBsAg (anti-HBs) are critical for viral clearance and protection. CD8+ T cells are also very important for controlling HBV infection because they find and kill infected hepatocytes. During infection, HCV-specific antibodies and CD4+ and CD8+ T cells are made. However, HCV can evade immune responses by rapidly mutating its surface proteins (e.g., E2) and modulating T-cell responses. It is important to note that the immune response to HBV and HCV is a complex and dynamic process that involves various factors beyond the structural differences described above. Host factors, viral load, viral persistence, and the interplay between innate and adaptive immune responses also significantly influence the outcome of the infection
Investigating Drug Interactions And Antibacterial Activity Of Vitamin C On Pathogenic Factors Of Escherichia Coli Clinical Isolates A Tuqi, Osamah; Hussein, Aya Aziz; Hussein, Tabark abdukarim; AL-RASHIDI, REYADH R; Abbas, Mustafa Khudair
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.376

Abstract

Today, the phenomenon of multi-drug resistance has become a major cause of concern, and insufficient achievements have been made in the development of new antibiotics for the treatment of bacterial infections. Therefore, there is an unmet need for new auxiliary search. Vitamin C is one such promising supplement. The current study was conducted with the aim of explaining the antibacterial interaction effect of vitamin C in different concentrations (5-20 mg/ml) and drugs effective on Escherichia coli bacteria. In order to collect clinical samples during the months of September to November 2022, clinical samples were collected from 100 patients suspected of urinary tract infection who referred to medical centers. For identification, biochemical tests and gram staining and culture in IMViC and EMB environments were used to see metallic green polish. Then antimicrobial sensitivity test And the effect of antibiotic on biofilm formation, the effect of antibiotic and ascorbic acid on biofilm formation, biofilm inhibition rate was done for the single and combined effects of both antimicrobial substances. Finally, in order to investigate and identify the virulence gene of the isolated strains, DNA extraction was performed by PCR method. 45 samples of urinary infection culture were identified from the total of 100 samples collected, in 45 (45%) of them colonies with metallic polish were observed. 45% were men and 55% were women, and of these, a total of 45 positive E. coli cases were found in women and 17 positive cases were seen in men. Less than one year, teenagers, young and old were divided. 2 cases (2%) were in the age group of less than one year, 3 cases (3%) were teenagers, 63 cases (63%) were young and 32 cases (32%) were in the age group of middle-aged people. In a situation where the ability to form biofilm under vitamin C (ascorbic acid) treatment was not very effective and did not differ much from normal conditions, antibiotic treatment (under MBC gentamicin treatment) was somewhat successful in inhibiting biofilm formation, finally with the combination of antibiotic and Ascorbic acid was completely isolated in many resistant strains, the inability to form biofilm was evident, and this indicated the synergistic effects in the investigated composition. As the results showed, the ability to produce biofilm in the samples that had the target genes in this study was not much different from the other samples. Considering the increasing resistance to some antibiotics and wide changes in the effective spectrum of drugs and preventing the increase of drug-resistant cases, the necessity of conducting drug sensitivity tests seems very necessary. The high prevalence of E. coli antibiotic resistance and the high percentage of resistance genes in patients suffering from infections caused by this bacterium can indicate the excessive use of antibiotics. Finally, the prevalence of antibiotic resistance is a useful marker for investigating resistance genes and can be useful in ecological investigations. Also, with clear inhibitory effects, the selected antibiotic in this study along with ascorbic acid, this vitamin can be used as a supplement in some infections caused by E. coli bacteria.
DETECTION OF CRYPTOSPORIDIUM SPECIES IN CATTLE AND HANDLERS BY MOLECULAR TECHNIQUE IN WASIT PROVINCE Hasan, Murtadha Kadhim; Mohan, Zahraa Hamid; Saeed, Farah Mohammed; Mahdi, Oras Abdulsayed; Abdulhussein, Rasha Hamzah; hamzah, Sarah Hussein; Kareem, Mustafa basim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.377

Abstract

I collected 300 cow feces samples (130 males - 170 females) and used molecular analysis to detect the parasite. The results showed significant differences (p ≤ 0.05) between the infection rate using particle technology of 38% (38/100) and 41% (41/100) in cows and breeders, respectively, while traditional microscopic methods showed 21% (21/100) and 17% (17/100) in cows and breeders, respectively. DNA sequence analyzes of 10 isolates from infected cows identified four species of the Cryptosporidium parasite genus which included: C. parvum (6/10), C. andersoni (2/10), C. bovis (1/10) and C. ryanae (1/10. The species C. andersoni, C. parvum, C. bovis and C. ryanae have been genetically confirmed through DNA sequence analysis, and it is considered the first recording of these species in local cattle in Iraq. In breeders, three types of the Cryptosporidium parasite were recorded through DNA sequence analysis in 10 isolates from infected individuals, which included: C. parvum (2/10), C. andersoni (5/10) and C. hominis (3/10). It is considered the first recording of this species among breeders in Iraq.
Evaluation of different mouthwashes through their effect on their influence on the force loss of orthodontic elastic ligatures Al-Koofee, Mohammed Kadhim; Al-Saeedi, Ruaa Riyadh Abdulnabi; Moktar, Norehan; Zainuddin, Siti LA
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.379

Abstract

Background: In several orthodontic treatments, elastomeric chains are utilised to produce force, however, this force degrades over time, which may impact tooth mobility. This study aims to investigate how different mouthwashes (Chlorhexidine 0.2%, Sensodyne, and Listerine) may affect the force degradation of two different types of elastic ligatures (Ortho Matrix and 3M Unitek) through the amount of force remaining. Materials and methods: Two control groups and six experimental groups each included 600 pieces of the elastomeric chains Ortho matrix (OM) and 3M Unitek (3M). Pieces were stretched to a 25mm thickness, placed on pins set into an acrylic block, and kept at 37°C in artificial saliva. For the duration of the study, each of the test groups spent one minute immersed in one of three distinct kinds of mouthwash. Ten continuous thermocyclers with temperatures ranging from 5 to 55 degrees Celsius were performed each day, alternating between cold and hot water baths. While calculating the forces, we considered six different time intervals: the beginning, 24 hours, 1, 2, 4, and 6 weeks. The one-way analysis of variance (ANOVA) test and the t-test were used to compare the mean force of a number of different mouthwashes, elastomeric chains, and times. A value of 0.05 was chosen as the cutoff for statistical significance. Results: Over time, both types of elastomeric chains significantly lost force at 6 weeks (p<0.05). At all times, the 3M Unitek (3M) created more force than the Ortho matrix (OM) elastomeric chain. Compared to other mouthwashes, chlorhexidine mouthwash had a substantially less impact on force degradation, with discernible very simple change when compared to control groups (Artificial saliva). Conclusion: According to findings, the 3M Unitek offered a higher force level than the other sort of elastomeric chains, and there is a difference that is clinically significant between the two types of elastomeric chains. It is possible that the pH of the mouthwashes, as opposed to other substances, contributes to the gradual loss of power over time. Mouthwashes containing chlorhexidine had the third-smallest influence on the force degradation of elastomeric chains, after Sensodyne and Listerine..
ACCURACY OF CBCT IN MANDIBULAR CONDYLE VOLUMETRIC AND SURFACE MEASUREMENT: LITERATURE REVIEW Shukur, Fahad; Radhi, Sarab; Alsarav, Rusul
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.380

Abstract

The purpose of this review is to evaluate the accuracy and reliability of cone beam computed tomography (CBCT) in in the measurement and diagnosis of mandibular condyle morphology, in comparison to other diagnostic devices. The design and method In order to achieve our study, we searched several databases, including Google Scholar, PubMed, and Scopus. We only considered studies published between 2005 and 2023. Our review was focused on clinical trials, meta-analysis, article reviews, and randomized controlled trials. The exclusion criteria included patients with certain medical conditions, jaw abnormalities, jaw fractures, and animal experiments. The studies we analyzed had to address one specific question: What is the diagnostic accuracy of Cone Beam Computed Tomography (CBCT) compared to conventional tomography? conclusion: CBCT has become a cost- and dose-effective alternative to CT for examining the condyle and also TMJs. This imaging method is better than conventional radiographic methods and MRI in assessing osseous TMJ abnormalities, despite being more sensitive to motion artifacts. In addition, CBCT-MRI fused images can significantly improve the reliability of observers in determining anterior disc displacement and bone changes of the TMJ. This technology can also be utilized to improve diagnostic efficacy, especially for inexperienced residents.
ROLE OF CYTOTOXIC T LYMPHOCYTE IN ADENOVIRUS INFECTION AL-Abedi, Yasameen Waleed; Alsaeedi, Ali Abdulhussein; Halboti, Alaa Abdalhadi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.381

Abstract

The successful development of adenovirus vectors for vaccines and gene therapy will require a better understanding of the host immune response. Using the ELISPOT assay to measure IFN-g-secreting CD8þ cells, we identify immunodominant epitopes of the adenovirus hexon and DNA-binding protein in BALB/c and C57BL/6 mice. The T-cell response to the intramuscular administration of adenovirus serotype 5 peaks within a few weeks and gradually declines but is still detectable after 12 weeks. A second administration did not substantially increase the number of reactive T cells. The CD8þ T-cell response was also similar between wild type and E1-deleted adenovirus. When B-cell-deficient mice were injected with adenovirus encoding the gene for secreted alkaline phosphatase, sera phosphatase activity was reduced more quickly in mice pre-exposed to adenovirus. These results add to the evidence that cell-mediated immunity is a substantial barrier to therapeutic adenoviral vectors and provide more quantitative tools to measure cellular immune responses to adenovirus.
Exploring The Impact Of Dialysis On Neurological Conditions: Insights From Biochemical Data In Chronic Kidney Disease Thamer, Ahmed Kareem
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.382

Abstract

When an individual goes through dialysis in chronic kidney disease, the substances located in the bodies of patients undergo considerable fluctuations. Creatinine and urea are considered as kidney function indicators. In this regard, urea is an indicator of kidney change, and creatinine reflects the efficiency of glomerular filtration. The following data are markers that need to be kept on the observation under individuals on dialysis. The goal of the investigation is the biochemical parameters ratio pick up that can reflect the patients’ neurological state on dialysis. To ensure the transparency and reliability of the data sources, systematic review of scientific and methodological literature represented in the electronic databases VHL, Google scholar, SciELO, and recent publications from 2014-2023 has been carried out. Development of this subject has had given to the relationship of biochemical variables to CKD, creatinine, and urea. inclusion summary is provided. Research stakeholders included studies that were associated with patients’ biochemical variables and compared the denatured changes among bio-variable changes both before and after Dialysis. With the extracted data shown and analyzed how the dialysis treatment has impacted on patients with CKD regarding bio-variable changes. Results: the systematic review lead to a great change report in biochemical patients bio-variable among persistent kidney disease. Hemodialysis was a significant intervention since it influences metabolic values towards normalcy. Creatinine and urea were seen to be affected much since their levels of changes indicated abnormalities of kidney organs. Therefore data extracted remain valuable in that, it is required for any regular check in patients undergoing dialysis treatment. Conclusion: It is imperative that healthcare providers treating patients with CKD on dialysis be well versed with biochemical indicators such as creatinine and urea, and understand their importance in patient management. Appropriate and timely monitoring of these markers enables healthcare professionals to initiate prompt intervention and treatment adjustments to enhance patient care and quality of life. Based on these findings, the current systematic review studies demonstrate the significance of biochemical data in providing insights into the neurological state and management options for CKD patients under dialysis

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