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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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The preoperative testing at laboratories in Najaf are being performed on patients at the time of the surgery in order to do this evaluation of blood-borne viruses Khzal, Alaa Mahdy obaid
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i4.406

Abstract

Al-Sadir Teaching Hospital, Najaf, Iraq was the surrounding for this study that was done during the window of time from the 1st of January to the 1st of November of the same year. A descriptive, cross-sectional, hospital-based study of hospitals is investigated. The research was conducted during January, 1st 2023 and November 1, 2023 in the course of studies. The project evlaution was launched on 21st of January and finalized on 1st of November. The purpose of this researched was to determine proportion of patients who were infected with the blood borne diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). All of these viruses are transmitted because the blood carries them. The technique was considered necessary to establish the amount of viral infection in these patients. ELISA testing was among the components, of the pre- surgical virus therapy, which was received by the patient and it was performed on the blood samples collected from the patient.Eventually we came to the conclusion that the procedures were applied as implied in the system. In our investigations, we determined that the Human Papilloma Virus (HPV) is the one virus that had been identified to be infecting the people whose cases were detected by the examination process. The second most well-known virus after Human Virus (HCV) that is also categorized as one of the human viruses is the Human and Human Immune Globaly Viruses complex (HIV). I state emphatically discrimination or age bias was non existent during data collection at any point in time of the whole process. I got the data together in a process which of a ten months' duration and took place solely in this particular educational organization. A total of 125 individuals were tested positive out of which 64 were affected by HBV, 60 (60%) got affected by HCV, and 7 (70%) were affected by HIV. The isolation of the virus was only possible when it was passed on by all male who were tested. The girls had a unique and admirable quality: not a single one of them tested positive for the infection. It was evident among the people affected that about two thirds were male. Actually, only less than 1/3 (30%) of the females getting tested HIV positive, whereas 5 (43.4%) of them had HBV and even 5 (45%) of them showed the HCV result Thus, it is evident with the result seen that the number of cases of women from prevention to men who visited the health center was much lower. We look forward to having 19,925 folks at the donation drive having filled up the collection tubes with their blood. Via the study of a total of 1,330 Hepatitis B virus cases, the test was found positive in (145) of them, and negative only in the (1205) remaining cases. By which implies gives us 19925 which is definitely it is the quantity of blood to be collected
PATHOPHYSIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AND DRUG RESISTANCE Karum, Ataa Elias; Mohammed, Soha Jassim; Hussein, Sanaa Adnan Abdul; Ahmed, Israa Saleh; Odeh, Marwa Muhammad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i4.407

Abstract

Methicillin- resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens of community and hospital acquired bacterial infections. MRSA can lead to diverse infection such as bacteremia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital- acquired infections . As well as genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. They are also becoming increasingly multi-drug resistant and have recently developed resistance to vancomycin, which has been used successfully to treat MRSA for many years . Successful treatment remains challenging and requires the evaluation of novel antimicrobials. In Conclusion the emergence of CA-MRSA and VRSA isolates is changing the management of clinical infections potentially caused by S. aureus. Rapid methods for accurate detection of MRSA are needed to promptly identify patients and implement contact precautions as well as appropriate treatment. Molecular genotyping techniques have an important role in evaluating possible outbreaks and for understanding of the emergence and evolution of MRSA strains
HEART RATE VARIABILITY BASED DRIVER DROWSINESS DETECTION: DETEKSI KANTUK PENGEMUDI BERBASIS VARIABILITAS DETAK JANTUNG Maktouf, Naba Ali; Khalaf, Sajid Saleh
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i4.408

Abstract

Driver drowsiness may cause traffic injuries and death. Various methods have been given to detect drowsiness, for instance, image-based biometric-signals-based. In this project, a new approach using heart rate and head tilt is discussed. The aim of the project is to provide a device with simple components that enables the driver to save his life by avoiding accidents caused by frequent sleepiness by giving a sound alert (alarm), which forces the driver to wake up and regain control of the car This device is not considered a treatment for the problem of sleep, but rather a preventive tool from accidents daily the project was designed with simple components, the most important of which are (ECG sensor and acceleration sensor Arduino, alarm device). ECG sensor: it used to give an ECG signal to Arduino to analysis it. ADXL335 sensor: it is placed behind the driver's head. This sensor senses the fall of the driver's head when he sleeps. It was added to sense better.
ASSOCIATION BETWEEN FEMALE HORMONES (FSH, LH, AND ESTROGEN) AS WELL AS HYPERLIPIDEMIA AND OBESITY IN AL- NAJAF HOLY CITY Jubair, Worood Muslem
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 4 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i4.409

Abstract

An excessively high level of lipids, or fat, in the blood is called hyperlipidemia. The levels of hormones in females were examined, along with their correlation with elevated body fat and impact on cardiovascular conditions. The information was gathered in Najaf City between November 1, 2023, and December 20, 2023. The results of this study showed that the concentrations for a hormone that promotes follicle development within samples had increased by 58%. LH increased in 50% of the samples that were analyzed. Better pubertal development has been associated with elevated FSH levels in the blood. Improved metabolism has been associated with an increase in blood FSH. Moreover, nonlinear correlations were found between adiposity measures and serum FSH levels.
Prevalence of Hypertension and Diabetes in Children Maktouf, Hassan Razzaq; Helal, Zainab Adnan; Kadhim, Shahad Khalid; Javat, Sattar Jabbar; Ahmed, Duha Kareem
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.410

Abstract

In 2017, the American Academy of Pediatrics issued a new clinical practice guideline for defining hypertension in children as an update to the previous Fourth Report guidelines issued in 2004. Prevalence of confirmed pediatric hypertension in children has ranged from 2% to 4% based on previous guidelines yet it is unknown what the prevalence is under the new guideline. We estimated the prevalence of elevated blood pressure, stage 1, and stage 2 hypertension by the new American Academy of Pediatrics guideline in our school-based blood pressure screening program. New prevalence estimates were compared with Fourth Report prevalence estimates in the same population by sex, age, and height factors. In 22 224 students aged 10 to 17 years screened in school as part of the Houston Pediatric and Hypertension Program at the University of Texas McGovern Medical School, the prevalence of elevated blood pressure (previously called prehypertension) increased from 14.8% by Fourth Report to 16.3% by the new American Academy of Pediatrics guideline. This increase in elevated blood pressure resulted from differential classification changes in younger and older children. Prevalence of confirmed hypertension remains at 2% to 4% in this population, however shorter children <13 years old and taller, older children 13+ years old are systematically more likely to be diagnosed with hypertension by new guidelines..
PREVALENCE AND ANTIBIOTIC RESISTANCE PROFILES OF BACTERIAL ISOLATED FROM BURN WOUND INFECTIONS Azez, Abdul Salam Abdul Sattar Abdul; abdulrazaq, luma N.abdulrazaq; Alqaisi, Mohammed Nazhan Radaan; Mohammed, Mohammed Sabah; Kenoosh, Hadeel Ahmed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.415

Abstract

Burn wound infections remain a sizeable assignment, especially because of the superiority of multidrug-resistant gram-negative organisms. The objective of this take a look at was to assess the superiority of bacterial infections in burn wounds, perceive the most not unusual bacterial species, and determine their antibiotic resistance profiles. A overall of eighty samples had been amassed from burn sufferers. Bacterial cultures were performed, and the isolated bacteria were identified using standard microbiological techniques. Antibiotic susceptibility testing was conducted using the disc diffusion method. In this study, 44 samples (73.3%) tested positive for bacterial growth. Pseudomonas sp. was the most commonly isolated bacteria (56%), followed by Staphylococcus aureus (22%) and others. Antibiotic resistance profiling revealed high resistance rates among the isolated bacteria, with Rifampicin showing the highest resistance rate (80%), followed by Cefotaxime (64%) and Amoxicillin (56%). The high prevalence of multidrug-resistant gram-negative organisms in burn wound infections underscores the urgent need for effective antibiotic management strategies. These findings highlight the importance of continuous surveillance of antibiotic resistance patterns and the development of tailored treatment protocols to mitigate the morbidity and mortality associated with burn wound infections. Additionally, there is a critical need for the development of new antimicrobial agents and infection control measures to combat the growing threat of antibiotic resistance in burn care settings.
Detection and Quantification of Human Herpes Viruses Types-6 and Cytomegaly Viruses in Sperm Samples of Patients with Fertility Disorders had, Mohammed S.; Almahbobi , Taghreed F.; Fakhrildin , Muhammad-Baqir M-R
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.419

Abstract

Background; Viral infections are common around the world and cause many health problems. Infertility in men is a widespread health problem that can affect lifestyle and psychological state. Aims of the study; Study of the effect of herpes virus type 6 and cytomegalovirus on infertility disorders in men. Methodology; A case control study was done for a 100 specimens collected from men. This study has been conducted in Al Sader Medical City / Infertility Center / Al-Najaf Al-Ashraf and privet Center Dr. Ali Al-Ibrahimi for Embryos and Infertility in najaf . During the period from 10/10/ 2023 to 10/4/2024. The current study consisted of a sample size of 100 males, which was subsequently separated into two groups. The control group comprised 40 fertile men, aged 25 to 45 years, who had experienced both primary and secondary fecundity for at least twelve months. The Patients Cases group, consisting of sixty infertile males aged between 22 and 46 years, was categorized into two subgroups based on the type of infertility. There were forty-six guys who were classified as main infertility. There were a total of fourteen men who experienced secondary infertility. Male participants who are reproductive age, normal seminal analysis which is healthy and have a child as a Control group (Fertile men). Name of patient, sample number, Age (years), Education, housing area, Type of work, height, weight, Smoking, chronic diseases, History of surgery, Primary infertility, Secondary infertility, Sperm count, Sperm motility and Sperm morphology. Detection of CMV in semen plasma by CMV ELISA kit and detection of HHV 6 in semen plasma by HHV 6 ELISA kit. Result; The results showed that there was no statistical significance in age between the two groups. They also showed that there was statistical significance in smoking, type of infertility, and duration of infertility. The results showed statistical significance in the results for herpes and cytomegalovirus. There is also no statistical significance regarding the number of cases of cytomegalovirus infection according to age. On the contrary, there was statistical significance regarding age in herpes. The results also indicated that there was statistical evidence in the sperm analysis between the two groups. Conclusions; The statistical evidence between the two groups in the number of infection cases for all groups or by age indicates the role of viral infections in causing infertility in men.
PREVENTION OF CARDIO-VASCULAR DISEASES Yo’ldosheva , S.G; Kasimova , D.A.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.420

Abstract

The human cardiovascular system, which was formed in the process of biological evolution, has not changed significantly throughout the history of mankind. But our way of life is very different from the way of life of our distant, and even not very distant, ancestors. Then movement, obtaining food, creating housing and all other types of activity required constant and large expenditures of muscle strength from a person. And the human circulatory system is initially oriented precisely towards such an intensely active lifestyle. For its normal functioning, for example, a person must walk at least 6 km a day, and this is daily! By our urban standards today, many people cannot afford to walk even one or two bus stops; there is no time for it
MINI REVIEW ABOUT RISKS OF RADIATION IN MEDICINE Sattar, Fatema; Amer, Ali Razzaq; Dhay Kazem Jabbar; Raziq, Zahraa Ayed; Mahdi, Shahad yousif
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.421

Abstract

Radiation is currently widely used and routinely applied in medicine. Diagnostic radiology, nuclear medicine, and radiation treatment have grown from their primitive beginnings 100 years ago to modern methods that are regarded as critical tools across all fields and specializations of medicine today. Ionizing radiation's inherent qualities give numerous benefits, but they can also be harmful. Its usage in medical practice requires an informed decision on the risk-benefit ratio. This choice requires knowledge of radiation in general as well as medical skill in specific. This review investigated the risks associated with radiation, their connection to medicine, and the advancements in diagnostic and therapeutic technologies. Radioactive substances and radiation are used in medicine, research, and diagnosis. The forms of radiation and their varied impacts on medicine, particularly in the treatment and diagnosis of disorders like cancer, were disclosed by our review's conclusions. It has been demonstrated that mistakes in radiation dosage can result in health issues, hence managing radiation must be done carefully both during research and in practice
The Prevalence of Bacterial Urinary Tract Infections Among School-age Children Hantoosh, Saad M.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 5 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i5.423

Abstract

Urinary tract infections (UTIs) are the most common and serious bacterial infection in children. The current study aims at identifying the most prevalent symptoms and pathogenic bacteria linked to urinary tract infections in school-aged children in Al-Muthanna Province. Between October 2023 and April 2024, a urine samples were collected from 685 (417 female and 268 male) students across three age groups: 129 (19%) (6-12 years), 240 (35%) (>12-14 years), and 316 (46%) (>14-18 years) with symptoms of urinary tract infection. Female students (345) were significantly more affected by bacterial infections compared to male students (182), χ² (df=1, N=685) = 20.2, p < .001. In cases of UTI symptom onset, the likelihood of bacterial UTIs is 1.9 times higher for children aged >12-14 and 3.2 times higher for those aged >14-18 compared to children aged 6-12. The prevalence of symptomatic UTIs among schoolchildren increases with age, from 62% to 83.9% across different age groups. Among female students aged 6-18 with UTI symptoms, 82.7% had a bacterial UTI, compared to 67.9% of male students. Over 5% of schoolchildren without bacterial UTI exhibit moderate to marked pyuria. Hematuria percentages were comparable between individuals with and without bacterial UTIs. The average pH tended to be acidic for both groups, with infected individuals having a pH less than six and uninfected individuals having a pH less than seven. Escherichia coli was the predominant infectious followed by Enterococcus faecalis, Enterobacter aerogenes, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa at rates of 74%, 41%, 33%, 36%, 29% and 19%, respectively. Staphylococcus aureus and Staphylococcus epidermidis occurred at a frequency of 12% and 8%, respectively, while Streptococcus agalactiae occurred at a frequency of 3%.

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