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Adam Mudinillah
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Journal of Biomedical and Techno Nanomaterials
Published by Yayasan Adra Karima Hubbi
ISSN : 30481120     EISSN : 30481155     DOI : 10.70177/jbtn
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Biomedical and Techno Nanomaterials is an international forum for the publication of peer-reviewed integrative review articles, special thematic issues, reflections or comments on previous research or new research directions, interviews, replications, and intervention articles - all pertaining to the research fields of medicine, pharmaceuticals, biomaterials, biotechnology, diagnosis and prevention of diseases, biomedical devices, bioinformatics, and all other related fields of biomedical and life sciences. All publications provide breadth of coverage appropriate to a wide readership in Biomedical and Techno Nanomaterials research depth to inform specialists in that area. We feel that the rapidly growing Journal of Biomedical and Techno Nanomaterials community is looking for a journal with this profile that we can achieve together. Submitted papers must be written in English for initial review stage by editors and further review process by minimum two international reviewers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 48 Documents
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A REVIEW OF NANOPARTICLE-BASED STRATEGIES FOR OVERCOMING THE BLOOD-BRAIN BARRIER IN NEURODEGENERATIVE DISEASE THERAPY Marliana, Thika; Magar, Bina; Denis, Samuel
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2975

Abstract

Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and related disorders, remain difficult to treat effectively due to the restrictive nature of the blood–brain barrier, which severely limits drug delivery to the central nervous system. Many therapeutic agents with proven molecular efficacy fail to achieve clinical success because they cannot reach target sites in the brain at sufficient concentrations. This review aims to critically analyze nanoparticle-based strategies developed to overcome the blood–brain barrier and to evaluate their potential in neurodegenerative disease therapy. A narrative-integrative review method was employed, drawing on peer-reviewed articles indexed in major scientific databases, including studies on lipid-based, polymeric, inorganic, and biomimetic nanoparticles. The reviewed evidence indicates that nanoparticle systems significantly enhance brain delivery through mechanisms such as receptor-mediated transcytosis, adsorption-mediated transport, and biomimicry, leading to improved pharmacokinetics and therapeutic efficacy in preclinical models. Lipid-based and biomimetic nanoparticles demonstrate the greatest translational promise due to favorable safety and biological compatibility, while polymeric systems offer high design flexibility. Despite these advances, challenges related to long-term safety, reproducibility, and clinical translation persist. In conclusion, nanoparticle-based delivery represents a pivotal strategy for overcoming the blood–brain barrier, and continued interdisciplinary research is essential to translate these technologies into effective therapies for neurodegenerative diseases. Keywords: blood–brain barrier; nanoparticles; neurodegenerative diseases; nanomedicine; targeted drug delivery
BIO-FABRICATION OF A PRE-VASCULARIZED SKIN GRAFT USING A CO-AXIAL ELECTROSPINNING TECHNIQUE AND ENDOTHELIAL PROGENITOR CELLS Rahman, Shahinur; Ahmed, Shakib; Islam, Zahidul
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2976

Abstract

Severe skin injuries caused by burns, chronic wounds, and trauma remain a major clinical challenge due to limited graft survival and delayed vascular integration following transplantation. Insufficient early vascularization frequently leads to ischemia and graft failure, restricting the effectiveness of conventional tissue-engineered skin substitutes. This study aims to develop a pre-vascularized skin graft using a co-axial electrospinning technique integrated with endothelial progenitor cells to enhance early vascular functionality and graft viability. An experimental biofabrication approach was employed, involving the fabrication of core–shell electrospun fibrous scaffolds, encapsulation of endothelial progenitor cells, and comprehensive structural and biological evaluation in vitro. Scaffold morphology, porosity, and integrity were characterized, followed by assessment of cell viability, proliferation, endothelial marker expression, and formation of vascular-like networks. The results demonstrated that co-axial electrospinning produced uniform, highly porous fibrous scaffolds capable of maintaining endothelial progenitor cell viability and supporting their angiogenic behavior. Encapsulated cells exhibited sustained proliferation and organized into capillary-like structures within the scaffold matrix, while scaffold architecture remained structurally stable. These findings indicate that the proposed biofabrication strategy enables intrinsic pre-vascularization of engineered skin grafts prior to implantation. In conclusion, co-axial electrospinning combined with endothelial progenitor cells represents a promising and scalable approach for generating pre-vascularized skin grafts, with significant potential to improve graft integration and clinical outcomes in regenerative skin therapy.
BIOMIMETIC MINERALIZATION OF HYDROXYAPATITE ON A COLLAGEN-NANOFIBER COMPOSITE SCAFFOLD FOR BONE TISSUE ENGINEERING APPLICATIONS Murat Arslan; Erdo?an, Aylin; Akbulut, Baran
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2977

Abstract

Bone tissue engineering seeks to develop biomaterial scaffolds that can replicate the complex hierarchical structure and biological functionality of native bone extracellular matrix. Conventional bone substitutes often fail to simultaneously achieve sufficient mechanical strength, osteoconductivity, and biological integration, limiting their effectiveness in repairing critical-sized bone defects. This study aims to develop a collagen–nanofiber composite scaffold functionalized through biomimetic mineralization of hydroxyapatite to enhance its suitability for bone tissue engineering applications. An experimental biomaterials approach was employed, involving fabrication of collagen nanofiber scaffolds followed by controlled biomimetic mineralization in simulated physiological conditions. The resulting scaffolds were characterized for morphology, mineral composition, crystallinity, and mechanical properties, and subsequently evaluated in vitro using osteogenic cell models to assess cell adhesion, proliferation, differentiation, and matrix mineralization. The mineralized scaffolds exhibited uniform nanoscale hydroxyapatite deposition, physiologically relevant Ca/P ratios, and significantly enhanced mechanical stiffness compared to non-mineralized controls. Biological assays demonstrated improved osteogenic cell attachment, elevated alkaline phosphatase activity, and increased calcium deposition on mineralized scaffolds. These findings indicate that biomimetic mineralization effectively integrates inorganic and organic phases to produce a scaffold that closely mimics native bone structure and function. In conclusion, collagen–nanofiber scaffolds mineralized with hydroxyapatite using a biomimetic approach represent a promising platform for bone tissue engineering and warrant further in vivo investigation.
QUANTUM DOTS AS NEAR-INFRARED FLUORESCENT PROBES FOR REAL-TIME IN VIVO BIOIMAGING OF CANCER CELL METASTASIS Traore, Oumar; Konate, Binta; Diarra, Fatiata
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2978

Abstract

Cancer metastasis is the primary cause of cancer-related mortality, yet its dynamic progression in living systems remains difficult to visualize due to limitations of existing imaging probes. Conventional fluorescent dyes used for in vivo bioimaging often suffer from poor photostability, limited brightness, and insufficient tissue penetration, restricting their ability to capture metastatic events in real time. This study aims to develop and evaluate near-infrared-emitting quantum dots as fluorescent probes for real-time in vivo bioimaging of cancer cell metastasis. An experimental nanobiotechnology approach was employed, involving the synthesis of near-infrared quantum dots, surface functionalization to enhance biocompatibility, physicochemical and optical characterization, and biological evaluation using metastatic cancer cell lines and small animal models. Optical analysis demonstrated high quantum yield, narrow emission bandwidth, and excellent photostability within the near-infrared window. In vitro assays confirmed high cell-labeling efficiency with minimal cytotoxicity, while in vivo imaging revealed sustained and high-contrast fluorescence signals that enabled continuous tracking of cancer cell migration and organ colonization. Ex vivo validation corroborated in vivo imaging findings. These results indicate that near-infrared quantum dots provide superior performance compared to conventional fluorescent probes for dynamic metastasis imaging. In conclusion, quantum dot–based near-infrared probes represent a powerful and versatile platform for real-time in vivo visualization of cancer metastasis, offering significant potential for advancing cancer research and diagnostic imaging.
DEVELOPMENT OF A BIO-MEMS CANTILEVER-BASED BIOSENSOR FOR THE RAPID, LABEL-FREE DETECTION OF THE AVIAN INFLUENZA VIRUS Rocha, Thiago; Mendes, Clara; Lima, Rafaela
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2979

Abstract

Avian influenza virus remains a significant threat to global public health, poultry industries, and food security due to its high transmissibility and zoonotic potential. Rapid and reliable detection is essential for early outbreak control, yet conventional diagnostic methods are often time-consuming, laboratory-dependent, and rely on labeled reagents, limiting their applicability in field and point-of-care settings. This study aims to develop a Bio-MEMS cantilever-based biosensor capable of rapid, label-free detection of the avian influenza virus with high sensitivity and specificity. An experimental Bio-MEMS approach was employed, involving microfabrication of silicon cantilevers, surface biofunctionalization with virus-specific recognition elements, and real-time mechanical sensing of virus–receptor interactions. The biosensor’s performance was evaluated by measuring cantilever deflection responses under controlled exposure to varying viral concentrations. The results demonstrate stable baseline behavior, low noise levels, and clear concentration-dependent deflection signals, achieving rapid detection within minutes and a low limit of detection without signal amplification. Non-target analytes produced negligible responses, confirming high specificity. In conclusion, the developed Bio-MEMS cantilever-based biosensor provides an effective platform for rapid, label-free detection of avian influenza virus. This technology shows strong potential for integration into portable diagnostic systems and could be adapted for surveillance of other viral pathogens.
SURFACE-ENHANCED RAMAN SPECTROSCOPY (SERS) USING SILVER NANOSTARS FOR THE MULTIPLEXED DETECTION OF DISEASE BIOMARKERS IN SERUM Tchuente, Nadine; Ngassa, Michel; Ewane, Elvis
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2980

Abstract

Early and accurate detection of disease biomarkers in serum is essential for clinical diagnosis, prognosis, and precision medicine, yet conventional immunoassays often rely on labeled reagents, multiple processing steps, and limited multiplexing capability. Surface-Enhanced Raman Spectroscopy (SERS) offers label-free molecular specificity, but its clinical application has been constrained by reproducibility and sensitivity challenges in complex biological matrices. This study aims to develop a silver nanostar–based SERS platform for the multiplexed detection of disease biomarkers directly in serum. An experimental nanobiosensing approach was employed, involving the synthesis of shape-controlled silver nanostars, surface functionalization with biomolecular recognition elements, physicochemical characterization, and SERS-based analytical evaluation in serum samples. The results demonstrate that silver nanostars generate strong and stable Raman enhancement, enabling clear discrimination of multiple biomarker signatures at low nanomolar concentrations. High linearity, acceptable reproducibility, and minimal matrix interference were achieved under multiplexed conditions. Comparative analysis confirmed superior performance of nanostars relative to conventional spherical nanoparticles. In conclusion, silver nanostar–based SERS provides a robust, label-free, and highly sensitive platform for multiplexed serum biomarker detection. This approach holds significant potential for advancing clinical diagnostics and translational bioanalytical applications.
PHOTOTHERMAL THERAPY OF TRIPLE-NEGATIVE BREAST CANCER USING FOLIC ACID-TARGETED GOLD NANORODS Mayers, David; Reid, Jemima; Thompson, Shannon
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2981

Abstract

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by the absence of hormone receptors and HER2 expression, resulting in limited therapeutic options and poor clinical prognosis. Conventional treatments such as chemotherapy often lack selectivity and are associated with significant systemic toxicity, highlighting the urgent need for more precise and effective therapeutic strategies. This study aims to develop and evaluate folic acid–targeted gold nanorods as a photothermal therapy platform for selective treatment of TNBC. An experimental nanomedicine approach was employed, involving the synthesis of gold nanorods, surface functionalization with folic acid to enable folate receptor–mediated targeting, physicochemical characterization, and biological evaluation in TNBC models. Photothermal performance was assessed under near-infrared laser irradiation, while cellular uptake, cytotoxicity, and therapeutic selectivity were systematically analyzed. The results demonstrate that folic acid functionalization significantly enhanced nanoparticle uptake by TNBC cells, leading to higher localized temperature elevation and pronounced cancer cell ablation compared to non-targeted nanorods. Minimal cytotoxic effects were observed in normal breast cells, indicating favorable selectivity. In conclusion, folic acid–targeted gold nanorods provide an effective and selective photothermal therapy strategy for TNBC. This approach shows strong potential for advancing targeted nanomedicine and offers a promising alternative for treating aggressive breast cancer subtypes.
TARGETING THE TUMOR MICRO-ENVIRONMENT: NANOPARTICLE-MEDIATED DELIVERY OF IMMUNOMODULATORY DRUGS TO ENHANCE CANCER IMMUNOTHERAPY Ali, Omar; Mohamed, Ahmed; Hassan, Mariam
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2982

Abstract

The tumor micro-environment plays a central role in regulating antitumor immune responses and represents a major barrier to the effectiveness of cancer immunotherapy. Immunosuppressive cellular components, abnormal vasculature, and inhibitory cytokine networks often limit immune cell infiltration and reduce the efficacy of systemically administered immunomodulatory drugs. This study aims to investigate nanoparticle-mediated delivery strategies to selectively target the tumor micro-environment and enhance cancer immunotherapy outcomes. An experimental nanomedicine approach was employed, involving the design and characterization of drug-loaded nanoparticles, evaluation of biodistribution and tumor localization, and assessment of immunological responses in tumor models. Nanoparticle performance was compared with free drug administration to determine delivery efficiency and therapeutic impact. The results demonstrate that nanoparticle-mediated delivery significantly improved accumulation of immunomodulatory drugs within tumor tissues, leading to enhanced cytotoxic T cell infiltration, reduced immunosuppressive cell populations, and improved antitumor efficacy. Targeted delivery also reduced off-target immune activation and systemic toxicity compared to conventional administration. In conclusion, nanoparticle-based targeting of the tumor micro-environment offers an effective strategy to overcome immunosuppressive barriers and amplify the therapeutic potential of cancer immunotherapy. This approach provides a promising framework for the development of next-generation precision immuno-oncology treatments.

Page 5 of 5 | Total Record : 48

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