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Adam Mudinillah
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INDONESIA
Journal of Biomedical and Techno Nanomaterials
Published by Yayasan Adra Karima Hubbi
ISSN : 30481120     EISSN : 30481155     DOI : 10.70177/jbtn
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Biomedical and Techno Nanomaterials is an international forum for the publication of peer-reviewed integrative review articles, special thematic issues, reflections or comments on previous research or new research directions, interviews, replications, and intervention articles - all pertaining to the research fields of medicine, pharmaceuticals, biomaterials, biotechnology, diagnosis and prevention of diseases, biomedical devices, bioinformatics, and all other related fields of biomedical and life sciences. All publications provide breadth of coverage appropriate to a wide readership in Biomedical and Techno Nanomaterials research depth to inform specialists in that area. We feel that the rapidly growing Journal of Biomedical and Techno Nanomaterials community is looking for a journal with this profile that we can achieve together. Submitted papers must be written in English for initial review stage by editors and further review process by minimum two international reviewers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 48 Documents
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Rectilinear Motion Anomaly (Garavity Anomaly) Around Mount Kelud Nisa'i, Kamilia; Nisak, Ainun Rahmatun; Afif, Oscar; Permatasari, Indah Tian
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 3 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is a country that is prone to geological disasters due to volcanic eruptions, ground movements, earthquakes and tsunamis, due to its location at the meeting point of three active tectonic plates: the Eurasian, Pacific and Indo-Australian plates. Geophysical research is important in understanding this phenomenon by utilizing physical parameters to study the earth beneath the surface. Gravity methods show potential in providing detailed images of geological structures and rock density contrasts, especially in geothermal investigations. Mount Kelud, as one of the active volcanoes in Indonesia, is the focus of this research. By using a geophysical method approach, this research aims to analyze the gravity anomalies around Mount Kelud. It is hoped that this study will provide a deeper understanding of the gravitational anomaly phenomenon in the region, which can be useful in future disaster mitigation and management efforts.
Design of Short Peptides as Targeted Protein Inhibitors for Alzheimer’s Disease Miksusanti, Miksusanti; Razak, Faisal; Huda, Nurul; Muntasir, Muntasir
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 3 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i3.1757

Abstract

Alzheimer's disease is a neurodegenerative disorder marked by cognitive decline and memory loss, primarily caused by the aggregation of amyloid-beta and tau proteins in the brain. Conventional treatments offer limited benefits, emphasizing the need for new therapeutic strategies. To design and evaluate short peptides as targeted protein inhibitors to prevent the aggregation of amyloid-beta and tau proteins, aiming to halt or reverse the progression of Alzheimer's disease. The study employed computational modeling to design peptides, followed by in vitro assays for initial screening, and in vivo tests using transgenic mouse models to assess therapeutic efficacy and safety. Techniques included mass spectrometry, HPLC, and behavioral tests for cognitive function. Designed peptides demonstrated high binding affinity and specificity for amyloid-beta and tau proteins, reducing aggregation by 70% in vitro. In vivo studies showed significant reductions in amyloid plaques and tau tangles, with improved cognitive performance in treated mice. Peptides effectively crossed the blood-brain barrier and accumulated in target brain regions. The findings support the potential of short peptides as a novel therapeutic approach for Alzheimer's disease, warranting further research and clinical trials to validate their efficacy and safety in human subjects.
Development of Lipid Nanoparticles for Delivery of siRNA as Gene Therapy for Lung Cancer Miksusanti, Miksusanti; Amin, Rafiullah; Raza, Amir
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 3 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i3.1758

Abstract

Lung cancer remains a significant health challenge with high mortality rates, necessitating innovative treatment approaches. Lipid nanoparticles (LNP) offer a promising platform for the delivery of small interfering RNA (siRNA) as gene therapy to target specific oncogenes in lung cancer cells. To develop and optimize LNPs for efficient siRNA delivery, improving gene silencing efficiency and therapeutic outcomes in lung cancer treatment. The study involved in vitro and in vivo experiments to characterize the LNPs, evaluate gene silencing efficiency, and assess therapeutic efficacy. LNPs were formulated with specific lipid compositions and tested on lung cancer cell lines and murine models. Optimized LNP formulations demonstrated high siRNA encapsulation efficiency (>85%), stable particle size (80-120 nm), and suitable zeta potential (-30 to -50 mV). In vitro studies showed over 70% gene silencing efficiency, while in vivo experiments indicated significant tumor growth inhibition and improved survival rates in murine models. Biodistribution studies confirmed targeted delivery to lung and tumor tissues with minimal off-target effects. The study highlights the potential of LNP-siRNA therapy as an effective and specific treatment for lung cancer. Further research and clinical trials are needed to validate these findings and optimize the delivery system for clinical use.  
Synthesis and Characterization of Magnetic Nanoparticles as Contrast Agents for Tumor Imaging Kiat, Ton; Lek, Siri; Thai, Aom; Muntasir, Muntasir
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 3 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i3.1759

Abstract

Magnetic nanoparticles (MNPs) have emerged as promising materials for biomedical applications, particularly as contrast agents in tumor imaging. Early and accurate tumor detection is critical for improving treatment outcomes, yet current imaging techniques often lack sensitivity and specificity. This study aimed to synthesize and characterize magnetic nanoparticles for their potential as contrast agents in tumor imaging. The nanoparticles were synthesized using a co-precipitation method, followed by surface modification with organic compounds to enhance stability and targeting specificity. Characterization included transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and dynamic light scattering (DLS). Cytotoxicity and targeting efficiency were evaluated in vitro using cultured human tumor cells. The results demonstrated that the synthesized nanoparticles had an average size of 25 ± 5 nm, superparamagnetic properties with a saturation magnetization of 55 emu/g, and high colloidal stability due to surface modifications. Fluorescence imaging revealed significant accumulation of the nanoparticles in tumor cells, while cytotoxicity tests showed cell viability above 85% at concentrations up to 100 ?g/mL. These findings indicate the nanoparticles are safe and effective for tumor imaging. This study highlights the importance of integrating synthesis, characterization, and biological evaluation to optimize nanoparticle design for biomedical applications. While the results are promising, further in vivo studies are needed to evaluate nanoparticle distribution, accumulation, and clearance in complex biological systems. The findings provide a foundation for future research and development of advanced contrast agents for tumor imaging
Development of Composite Biomaterial Based Dental Implants to Improve Osseointegration Rith, Vicheka; Sok, Vann; Dara, Ravi
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 3 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i3.1760

Abstract

Dental implant technologies face significant challenges in achieving optimal osseointegration, critical for successful long-term patient outcomes. Traditional implant materials demonstrate limitations in biological performance, cellular interactions, and healing processes. Developing advanced biomaterial strategies capable of dynamically interacting with physiological environments represents crucial scientific innovation. Research objectives aimed to develop sophisticated composite biomaterial dental implants with enhanced osseointegration capabilities through innovative surface modifications and strategic ceramic reinforcement approaches. Experimental methodology employed comprehensive research design integrating materials science, cellular biology, and advanced computational modeling. Experimental protocols included precision biomaterial synthesis, nanoscale surface engineering, in vitro cellular response assessments, and sophisticated characterization techniques. Experimental results demonstrated statistically significant improvements in osseointegration rates, cellular attachment, and mechanical strength across developed composite biomaterial variants. Hierarchical surface modifications incorporating zirconia and hydroxyapatite reinforcements exhibited superior performance compared to traditional implant technologies. Conclusive findings validate innovative composite biomaterial approaches as transformative strategies for dental implant development, offering potential for accelerated healing, improved cellular interactions, and personalized medical interventions.
Design and Fabrication of Microfluidic Biochips for Early Detection of Sexually Transmitted Diseases Zaman, Khalil; Khan, Omar; Khan, Jamil
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i4.1761

Abstract

Sexually transmitted diseases (STDs) remain a global health problem that requires early detection and rapid treatment. This study aims to design and fabricate microfluidic biochips for the early detection of several PMS-causing pathogens, such as Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. This research method involves designing chips with microfluidic technology, fabrication using lithography techniques, and testing the sensitivity and specificity of blood, urine, and cervical fluid samples. The results show that the biochip developed has a sensitivity of up to 92% and a specificity of 95%, with a detection time of less than 10 minutes. The biochip is also capable of detecting a variety of pathogens in a single device, making it an efficient diagnostic tool. In conclusion, this microfluidic biochip has the potential to be a fast, cheap, and effective PMS detection tool for use in the field. Further research needs to be conducted to test the sustainability of chip performance under real-world conditions and for further development in the detection of various other pathogens.
Development of Nanocellulose-Based Biomaterials from Agricultural Waste for Bone Tissue Regeneration Applications Mei, Chen; Li, Zhang; Hui, Zhou
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i4.1762

Abstract

Agricultural waste has great potential to be used as biomaterial raw materials that can be used in medical applications, especially for bone tissue regeneration. Nanocellulose, which is produced from natural cellulose, offers good mechanical properties and high biocompatibility. This research aims to develop nanocellulose-based biomaterials from agricultural waste for bone regeneration applications. The purpose of this study is to explore the potential of agricultural waste, such as rice straw, peanut husks, and corn leaves, in producing high-quality nanocellulose that can be used for applications in the field of bone tissue regeneration. This study uses an experimental design with a laboratory approach. Agricultural waste is treated through nanocellulose extraction using certain chemical techniques. Material characterization was carried out using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR), as well as biocompatibility tests using osteoblast cell cultures. The results show that rice straw produces nanocellulose with the highest cellulose content (65%) and has optimal tensile strength and degradation time for bone tissue applications. Peanut husks and corn leaves also show good results, although not as good as rice straw. Agricultural waste, especially rice straw, has great potential to be used as a raw material for nanocellulose that can be used in bone tissue regeneration applications. This research opens up opportunities to develop more sustainable and affordable biomaterials for medical applications.
Optimization of Biocompatibility of Natural Polymer Hydrogels for Targeted Drug Delivery Applications Lee, Ava; Tan, Jaden; Chan, Rachel
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i4.1763

Abstract

This study aims to optimize the biocompatibility of natural polymer hydrogels for targeted drug delivery applications. Crosslinking modifications are applied to natural polymers such as alginate, agarose, and chitosan, with the aim of increasing cell viability and reducing cytotoxicity. The results showed that modified hydrogels had higher cell viability (85–90%) and lower cytotoxicity compared to unmodified hydrogels. In addition, these modifications do not trigger immunological or inflammatory reactions in the cells of the human body tested. This study suggests that the crosslinking technique can be an effective solution in developing more biocompatible natural polymer hydrogels, which can be used for targeted drug delivery applications. However, for broader clinical applications, further research is needed to explore other modification methods and test more types of polymers.
Surface Modification of Gold Nanoparticles to Improve Cancer Cell Targeting Mei, Chen; Jing, Wang; Yang, Liu
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i4.1809

Abstract

Gold nanoparticles (AuNPs) are promising agents for cancer therapy due to their unique properties, but effective targeting remains a challenge. Surface modification with specific ligands can enhance targeting efficiency. To develop and optimize surface-modified AuNPs to improve targeting of cancer cells, enhancing therapeutic outcomes while minimizing side effects. The study employed theoretical modeling, laboratory experiments, and in vivo testing. Cancer cell lines (MCF-7, A549, PC-3) and mouse models with human tumors were used to evaluate targeting efficiency. Instruments included TEM, SEM, DLS, zeta potential analysis, and HPLC. Surface-modified AuNPs showed an 80% increase in cancer cell binding compared to unmodified AuNPs. In vivo studies demonstrated a 70% reduction in tumor volume in treated mice. Stability tests indicated consistent performance under various biological conditions. Surface modification of AuNPs with specific ligands significantly enhances their targeting ability and therapeutic efficacy against cancer cells. Further clinical trials are necessary to validate these findings for clinical application.  
Development of an Aptamer-Based Electrochemical Biosensor for Early Detection of Prostate Cancer Markers Lim, Sofia; Tan, Marcus; Tan, Ethan
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i4.1811

Abstract

Prostate cancer is a leading malignancy in men, where early detection is critical for effective treatment. Current diagnostic methods, such as PSA tests, have limitations in sensitivity and specificity. To develop an aptamer-based electrochemical biosensor for the early detection of prostate cancer markers, aiming to improve diagnostic accuracy and speed. The study involved the design and optimization of aptamers through SELEX, integration with electrochemical sensors, and validation using prostate cancer cell lines and clinical samples. Instruments used include electrochemical workstations, HPLC, and mass spectrometry for characterization and evaluation. The developed biosensor demonstrated a detection limit of 0.1 ng/mL for PSA, with a response time of less than 10 minutes. High reproducibility was achieved with a coefficient of variation below 5%, and the biosensor showed significant specificity and stability in detecting PSA in various samples. The aptamer-based electrochemical biosensor offers a promising tool for the early detection of prostate cancer markers, providing higher sensitivity and specificity compared to traditional methods. Further clinical validation is necessary to confirm its efficacy and reliability in broader applications.

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