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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 51, No. 4" : 13 Documents clear
Effect of hydroxyethyl starch 200/0.5 on von willebrand factor serum level and activated partial thromboplastin time (aptt) Atmaja, Sarah Puspita; Khotib, Junaidi; Rahardjo, Eddy; Shinta, Dewi Wara; Rahmadi, Mahardian; Suprapti, Budi
Folia Medica Indonesiana Vol. 51, No. 4
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Abstract

Hydroxyethyl starch (HES) is a colloid administered frequently for intravascular volume expansion during perioperative period. Impairment of haemostasis have been reported during HES administration, but the volume of solution administered was usually higher than 20 ml.kg-1. The objective of this study was to evaluate the effect of Hydroxyethyl starch 200/0.5 dose less than 20 ml.kg-1 on von Willebrand factor serum level and activated partial thromboplastin time. A prospective, observational study was conducted to evaluate von Willebrand factor and activated partial thromboplastin time of patients receiving Hydroxyethyl starch 200/0.5. Inclusion criteria were patients undergoing elective surgery who were going to receive Hydroxyethyl starch 200/0.5 intraoperatively. Fourty six patients were divided into patients receiving crystalloid only group (n=23 patients) and hydroxyethyl starch (n=23 patients). Coagulation variables were assesed 30 minute after insicion and 60 minute after infusion of crystalloid or colloid. Measurement of von Willebrand within each group after crystalloid or HES 200 infusion showed significant decrease, from (mean±SE) 97.688±15.219 ng/ml to 31.611±10.058 ng/ml (p< 0.001) in crystalloid group and 92.884±15.208 ng/ml to 27.378±6.399 ng/ml (p<0.001) in HES 200 group. Activated partial thromboplastin time change was statistically significant (mean±SE) 31.27±1.39 to 35.61±1.62 in HES group only (p=0.007), but this change was not clinically significant. In conclusion, there was neither significant difference in von Willebrand serum level nor in activated partial thromboplastin time between the two groups. There was no coagulation influence with clinically significant effect in the use of HES 20 ml/kg BW in patients undergoing elective surgery.
Ethanol extract of mangosteen peel reduces histological count of alveolar macrophage and pulmonary alveolar space size in male white rats (rattus norvegicus) exposed to cigarette smoke Santoso, Anna Lewi
Folia Medica Indonesiana Vol. 51, No. 4
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This study aims to analyze histological alveolar macrophage cell number and width of pulmonary alveolar space white male rats given ethanol extract of mangosteen peel and then exposed to cigarette smoke. Smoking can reduce antioxidant and increases free radicals, so it is recommended increasing the antioxidants found in many mangosteen rind. This research was an experimental laboratory using the randomized post test-only control group design. White rats male were chosen randomly into 5 groups (K1, K2, P1, P2, P3). K1 (control-), only the Na-CMC 0.5%, K2 (control+) given Na-CMC 0.5% solution and smoke, P1, P2, P3 given the ethanol extract of mangosteen rind (50, 100, and 200mg/kg wt) and smoke. The data were tested normality and homogenity. Then they were analyzed with one-way Anova, LSD. Data that are not normally tested with Robust tests – (Brown-Forsythe) and Tamhane's. Correlation test with Pearson and Spearman. Robust test results, the number of alveolar macrophages, value p=0.000 (p
Barthel index score in stroke patients increases after undergoing medical rehabilitation Ganing, Sirly Nabireta Maharani; Subadi, Imam; Sugianto, Paulus
Folia Medica Indonesiana Vol. 51, No. 4
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Abstract

Stroke is the leading cause of death among Indonesian people over the age of five years, comprising 15.4% of all deaths, with a mortality rate of 99/100 000, and the number of disability is 685/100 000. Medical rehabilitation has an effect in improving functional status of patients with stroke, especially if it is done intensively in the first 6 months after stroke attack. Measurement of functional status is commonly used in clinic, including in Dr. Soetomo Hospital. However, no study had been conducted in measuring functional status using Barthel Index in Surabaya. Therefore, this study identified the difference of the functional status of stroke patients before and after undergoing medical rehabilitation. The study used an experimental method with pre and post design with total sampling. The samples were 47 stroke patients in Dr. Soetomo Hospital, Surabaya. Data were obtained from March - April 2014 using Barthel Index. Data analysis used Wilcoxon Sign Rank test, including the distribution of each variable, which showed signification value of <0.05. This study concluded that Barthel Index score increases after undergoing medical rehabilitation.
Correlation of hearing impairment and communication disorder among geriatric in geriatric clinic, dr. Soetomo hospital surabaya M, A Ratna Kartika; Purnami, Nyilo; Liben, Paulus
Folia Medica Indonesiana Vol. 51, No. 4
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The objective of this study was to analyze correlation between hearing impairment and communication disorder among geriatrics in Geriatric Clinic, Dr. Soetomo Hospital. A randomized cross-sectional study design has been used in this study. Analysis was done by filling in some questionnaire and interview to some patients who were randomly selected according to predetermined condition. The data were collected and reviewed for the factors, which were assumed as risk factors of hearing disorder and life's quality deterioration. Statistical analysis was performed using Fisher's Exact Test using SPSS program version 17. Results showed correlation between hearing impairment and the quality of life and social communication (p=0.033, OR=6.11). However, there was no correlation between hearing impairment with diabetes mellitus (p=0.255), with hypertension (p=0.565), and noisy environment (p=0.689). In conclusion, the study showed that there is correlation between hearing impairment and communication disorder.
Biofilm bacteria plays a role in csom pathogenesis and has significant correlation with unsafe type csom Artono, Artono; Purnami, Nyilo; Rahmawati, Rosydiah
Folia Medica Indonesiana Vol. 51, No. 4
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Chronic suppurative otitis media (CSOM) may cause severe morbidity and mortality and remains a major health problem worldwide. The incidence of CSOM in Indonesia (1994-1996) is estimated at about 8.36 million people and CSOM general prevalence is 3.8% (Helmi 2005). This study aims to prove the existence of bacterial biofilm in patients with safe type and hazard type CSOM from mastoidectomy. The design was observational analytic with cross sectional approach. This study was conducted at the Teratai Wards, IBP Dr. Soetomo Hospital, and Electron Microscopy Unit, Faculty of Medicine, Airlangga University Surabaya, from November 2013 to June 2014. Samples of pathological tissues were taken by consecutive sampling and bacterial biofilms examination was done by SEM. SEM results categorized the biofilm bacteria as positive or negative. Biofilm bacteria tested positive when it shows three-dimensional representation of bacteria with clear shapes and sizes and clusters, the formation of amorphous material consisting of glycocalyx material surrounding the bacteria, and surface attachment. Biofilm bacteria was regarded as negative when there is no bacterial cluster, glycocalyx and surface attachment. This study was performed on 33 CSOM patients. Samples were divided into unsafe type CSOM (17 patients) and safe type CSOM (16 patients). Positive biofilm bacteria was found in 12 patients with unsafe type (75%) and 6 patients with safe type (35.35%). Negative biofilm bacteria was found in 4 patients with the unsafe type (25%) and 11 patients with safe type (67.9%). Logistic regression analysis revealed p value = 0.027, indicating the biofilm bacteria have a significant correlation with unsafe type CSOM (p <0.05). In conclusion, biofilm bacteria plays a role in CSOM pathogenesis of biofilm bacteria has significant correlation with unsafe type CSOM.
Sub-acute stent thrombosis and in-stent restenosis associated with antiplatelets clopidogrel resistance and protein s deficiency Kurniawan, M Zakky; Pratanu, Iswanto
Folia Medica Indonesiana Vol. 51, No. 4
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Protein S deficiency and antiplatelets clopidogrel resistance may uncommonly be responsible for coronary artery thrombosis. Hereby we report a patient presented with coronary disease, who had undergone PCI. However, two days later the patient was found in-stent thrombosis. Primary PCI was performed later with good result, but after 4 months evaluation with treadmill test we found significant ST depression in related region. It was suspected the patient had in-stent re-stenosis incidence. Further hematologic investigation showed that this patient had antiplatelets clopidogrel resistance and protein S deficiency. Double antiplatelet with another kind of antiplatelets and anticoagulant had given in this case. However, the remaining consideration is the choice for reperfusion strategy.
Injected citicoline improves impairment and disability during acute phase treatment in ischemic stroke patients Wahyudi, Rino; Hasmono, Didik; Fitrina, Ruhaya; Armal, Khairil
Folia Medica Indonesiana Vol. 51, No. 4
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Treatment strategy of ischemic stroke is to reduce the extent of the damage and rescue neurons from death in the early days of ischemic events. Recombinant Tissue-Plasminogen Activator (r-TPA) is the only recommended therapy, but their use is very limited. Citicoline is a neuroprotectant with a therapeutic effect on several stages of the ischemic cascade. However, its use is still being debated. The purpose of this study was to analyze the use of supplementation citicoline injection in patients with acute ischemic stroke in relations to differences in changes in the level of interference (impairment), rate limitation (disability) and the level of obstruction (handicap) between the group receiving supplementation of citicoline injection 2x500 mg iv and the group without supplementation during acute phase treatment. This study was a prospective cohort study using experimental design in patients with acute ischemic stroke who met the inclusion and exclusion criteria with or without supplementation citicoline between January - April 2015 in the National Stroke Hospital, Bukittinggi. Rate of interference was assessed with NIHSS, level of limitations with Barthel Index, and level of obstruction with modified Rankin Scale. Assessment was done 2 times, before and after the treatment. Statistical methods used in this study were Wilcoxon signed rank test, paired T-test and Mann-Whitney test. This study was conducted on 50 subjects divided into 2 groups, a control group without supplementation and group treated with injected citicoline of 2x500 mg iv. Demographic and baseline characteristics did not differ between groups. There were differences in level of interference changes. Mean decrease in control group was 0.96 ± 1.74 NIHSS, while that in treatment group was 2.84 ± 1.46 NIHSS (p <0.05). There were differences in changes in the level of limitations. Mean increase of Barthel Index in control group 9.60 ± 11.17 and in treatment group 20.40 ± 13.99 (p <0.05). However, changes in the level obstacle showed no difference. In conclusion, citicoline injection supplementation in patients with ischemic stroke during acute phase treatment showed improvement differences in changes in the level of distraction (impairment) and the rate limitations (disability), but showed no difference in changes in the level of obstruction (handycaps).
Nutritional status affects incidence of pneumonia in underfives Wicaksono, Henry
Folia Medica Indonesiana Vol. 51, No. 4
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Pneumonia is an acute infection disease which remains the main killer of children under 5 years old worldwide. Based on Unicef's report, 17% of all children death is caused by pneumonia. Indonesia was in 10th position of the highest incidence of pneumonia and diarrhea which caused the death of children under 5 years old in 2013. In Gane Luar Public Health Center, there were at least 3 patients with pneumonia every month during 2014. The risk factors are less exclusive breastfeeding, malnutrition, low birth weight, less coverage of measles vaccine, indoor air pollution, and the high level of occupation density. The purpose of this research was to determine the relationship between exclusive breastfeeding, nutrition status, the type of house flooring, and pneumonia incidence in children under 5 in working area of Gane Luar Public Health Center, South Halmahera. A case control study was conducted to each 25 samples of case and control which were collected by simple random sampling technique during July-December 2014. Data were collected through a questionnaire using interview method, observation, and physical examination, and then it's analyzed by Regression Logistic, Chi Square, and Odds ratio to check for strength of association between variables at 95% confidence level. The results indicated that nutrition status was significantly related to Pneumonia incidence (p = 0.019 ; OR 3.795), however exclusive breastfeeding (p = 0.29) and type of house flooring (p = 0.086) weren't. In conclusion, the nutrition status was significantly related to the incidence of Pneumonia in working area of Gane Luar Public Health Center.
Pci in patient with heavy calcified lesion. Management and balloon rupture complication Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 51, No. 4
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Balloon angioplasty in calcified coronary lesions may have a decreased success rate and an increased incidence of complications. This lesion remain a technical challenge in interventional cardiology despite novel approaches and devices. We describe a case with heavy calcified coronary lesion in LAD that was not only resistant to high-pressure inflation of conventional, non-compliant balloons and cutting balloon but the inflations also results in balloon rupture. Even, the first balloon became fracture and entrapment in LAD. The fractured balloon could be removed using second baloon inflation in LCX. The angioplasty balloon was successfully performed after rotational atherectomy by rotablator and succesfully continued by implantation stent DES.
The use of hydroxyethyl starch 200/0,5 as plasma subtitutes is safe in hypovolemic patients as indicated in changes of n-acetyl--glucosaminidase and creatinin serum parameters Shinta, Dewi Wara; Khotib, Junaidi; Rahardjo, Eddy; Rahmadi, Mahardian; Suprapti, Budi
Folia Medica Indonesiana Vol. 51, No. 4
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Hydroxyethyl Starch (HES) is a compound that improves intravascular volume effectively and rapidly without causing tissue edema. However, HES also has renal safety profile which is still being debated. Based on clinical experience in Dr. Soetomo Hospital, the frequency of acute renal failure following HES 200/0.5 administration at a dose of less than 20 ml/kg (maximum dose) is very rare. The purpose of this study was to evaluate the effect of HES 200/0.5 at a dose of less than 20 ml/kg in patients undergoing surgery. N-acetyl-b-D-Glucosaminidase (NAG) per urine creatinine ratio and creatinine serum were used as main parameter to assess renal injury. This research was observational and prospective design in patients undergoing elective surgery at Gedung Bedah Pusat Terpadu, Dr. Soetomo Hospital, who requiring resuscitation therapy with HES 200/0.5 and met the inclusion and exclusion criteria. NAG was measured prior to surgery and 12 hours after administration of fluid therapy, while creatinine serum was observed before surgery and 48 hours after resuscitation. This study was conducted for three months, and obtained 50 subjects divided into 2 groups, crystalloid group and HES 200/0.5 group. Demographic and baseline characteristics did not differ between groups, except the total bleeding volume. Total bleeding in HES 200/0.5group was higher than crystalloid group (p <0.0001). The mean volume of fluid received in HES 200/0.5 group was 2042.0 ± 673.9 mL, higher when compared with that of crystalloid group (910.0 ± 592.0 ml). Doses of HES 200/0.5 received was 8.31 ± 4.86 ml/kg. Measurement of the of NAG/creatinine ratio and creatinine serum showed significant increase in both groups, but still within the normal range. In addition, the value of these two parameters did not differ between groups. In conclusion, HES 200/0.5 in a dose of less than 20 ml/kg is safe to use in patients who suffered from hypovolemic hemorrhage, without prior history of renal impairment.

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