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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 56, No. 3" : 15 Documents clear
Effect of Simvastatin in Serum Interleukin-6 Level in Patients with Acute Ischemic Stroke Meo, Maria Lettisia; Machin, Abdulloh; Hasmono, Didik
Folia Medica Indonesiana Vol. 56, No. 3
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Abstract

Acute ischemic stroke is the leading cause of death and causing permanent disability in adults worldwide. In acute ischemic stroke, IL-6 levels positively correlated to more severe neurological deficits, more extensive brain damage and worse prognoses. The use of statin was associated with milder initial stroke severity, better functional outcome and lower mortality. This clinically randomized controlled trial study was aimed to analyze the serum levels of IL 6 in acute ischemic stroke patients who treated with Simvastatin 20 mg compare to placebo. Samples were taken using consecutive sampling method from hospitalized acute ischemic stroke patients in Neurology Department of Dr. Soetomo Teaching Hospital Surabaya and Airlangga University Hospital Surabayafrom August to November 2017. Total of 44 patients met the inclusion criteria, consisting of 22 patients in treatment group and 22 patients in control group.There were no significant difference in the characteristic of the patients in both groups (p>0.05). Averages of serum IL-6 in the control and the treatment group are 38.594±74.313 and 17.760±25.253(p=0,438) while averages of serum IL-6 post in the control group and the treatment are 46.586±103.484 and 15.275±17.183 (p=0,589). There were no significant level escalation in pre and post of control group (p = 0.205) and also no significant level reduction in pre and post of treatment group (p = 0.411), while the average difference in the control group (-7.992 + 78.912 pg/ml) and in the treatment group (2.485 + 23.738 pg/ml).
In Vitro Characterization of Poly-Glycolyc Lactic-Co Acid (PLGA) –Collagen Based on Red Snapper Fish Scales (Lutjanus Sp.) Coating Chitosan as Duramater Artificial Candidate Jabbar, Hajria; Widiyanti, Prihartini; Paramadini, Adanti Wido; Putri, Dina Kartika; Isfandiary, Andini
Folia Medica Indonesiana Vol. 56, No. 3
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Head trauma was the third cause of deaths that have a high rank that can make serious head injury for 25.5%-54.9%. This study has been conducted by making a replacement layer of the brain (dura) to overcome the impact of dural defect by utilizing waste fish scales red snapper (Lutjanus sp.). Synthesis brain membranes lining processed by casting method with each various concentrations of chitosan coating of 1%, 1.5%, and 2% then dried using vacuum dry. The samples then were characterized by tensile test, FTIR, SEM and MTT Assay. FTIR test results showed that red snipperscales can produce collagen powder at amide A group with stretching of –NH functional group, amide B group has stretching of CH2 assymetry, amide I area, amide II and amide III area which show –NH bonding. Tensile test results showed that the combination between PLGA-Collagen Chitosan Coating 2% produced the highest tensile strength is 4.8 MPa which meet the standards of human duramater strength. MTT Assay results showed that the dural membrane produced no toxic seen from living cells reached 98.32%. Poly - Glycolyc Lactic - Co Acid (PLGA) - collagen coating chitosan based on red snapper fish scales (Lutjanus sp.) composites has potency as duramater artificial candidate due to the chemistry, biological and physical characteristics.
Quantity of Antibiotic Use and Resistance Pattern of Gut Normal Flora Escherichia coli at Intensive Care Unit and Tropic Infection Ward, Dr Soetomo Hospital, Surabaya, Indonesia Sholeh, Mohammad Akbaruddin; Kuntaman, Kuntaman; Hadi, Usman
Folia Medica Indonesiana Vol. 56, No. 3
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Resistance to antibiotics is increasing worldwide, including in Indonesia. The use of antibiotics is the most common cause of microorganism resistance. Individuals who received antibiotic therapy impacton changes of normal micro-flora resistance through selective pressure. This study aims to analyze the relationship of the quantity of antibiotic use with the pattern of resistance of gut normal flora Escherichia coliamong patients in Intensive Care Unit (ICU) and Tropic Infection Ward, Dr. Soetomo Hospital, Surabaya. This study was cross-sectional design with 64 samples (32 the ICU and 32 in Tropic Infection Ward). The total sample were collected for three Months. Identification of intestinal microflora was done with McConkey differential selective medium, followed by IMViC biochemical test, and sensitivity test by antibiotic disc diffusion method. Data were analyzed with Chi square test and Fisher'sExact test. There was no significant difference (p=0.441) in the quantity of antibiotic use between ICU and Tropic Infection Ward. There was no significant difference (p>0.05) in normal intestinal flora Escherichia coli resistance pattern between Tropic Infection Ward and ICU against12 types of antibiotics. Ceftriaxone was the most widely used antibiotic in the Tropic Infection Ward of 54 DDD and ICU of 100 DDD. The highest percentage of intestinal flora Escherichia coli resistance at the ICU was ceftriaxone as manyas 18 (56.3%) and at Tropic Infection Ward on ciprofloxacin and levofloxacin 20 (62.5%). The other study in Primary Health center, showed that theresistance rates of both wards were significantly different as compared to intestinal flora of patients in primary health center (p <0.001), in whichthe use of antibiotics in primary health center was also lower (1.6 DDD). There was no significant difference (p>0.05) The pattern of bacterial resistance between patient with and without antibiotic use at Tropic Infection Ward and ICU Conclusion: the quantity of antibiotic use was not significantly different against resistnt gut flora between patients in ICU and Tropic Infection ward. The pattern of bacterial resistance between patient with and without antibiotic use was also not significantly different.
Back Matter Vol. 56, No. 3 September (2020) Matter, Back
Folia Medica Indonesiana Vol. 56, No. 3
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Effectiveness of Antidiarrheal Unripe Wooden Banana (Musa paradisiaca L.) in Male Balb-C/Mice Induced with Escherichia coli Ningsih, Arista Wahyu; Rochmanti, Maftuchah; Basori, Achmad
Folia Medica Indonesiana Vol. 56, No. 3
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The survey results in Indonesia in 2017 showed that the diarrhea morbidity rate for all age groups was 6.897.463. In Indonesia, unripe wooden banana has been used empirically as an antidiarrheal by the people in Senduro village, Lumajang, East Java. The study aimed to prove the antidiarrheal effect of ethanol extract of unripe wooden banana (Musa paradisiaca L) in male Balb-C/mice induced by Escherichia coli bacteria.This study was a laboratory experimental study with post-test only control group design that used 40 micedivided into 8 groups, namely 1group without treatment (normal mice) and 7 groups induced by Escherichia coli(1negative controlgroup given CMC-Na, 3 groups positive controls were given Loperamid HCL 0,5 mg/kgBB, 1 mg/kgBB and 2 mg/kgBB and 3 treatment groups were given extracts 100 mg/kgBB, 200 mg/kgBB and 400 mg/kgBB). Observation of animals in this study was carried out for 4 hours. Data were analyzed of frequency of diarrhea, fecal weight and fecal consistency used Kruskal Wallis and the results showed significant differences between treatment groups (p <0.05). From the results of the Mann-Whitney test, the ethanol extract of unripe wooden banana with a dose of 100 mg/kgBB was notsignificantly different (p> 0.05) with the control group of Loperamid HCL dose of 0.5 mg/kgBB. Unripe wooden banana had been shown to have antidiarrheal activity at an extract dose of 100 mg/kg BB in terms of the parameters of fecal consistency, frequency of diarrhea, and fecal weight. The results showed that the higher the dose, the better antidiarrheal activity
Influence of Administering Watermelon Rind Water Extract (Citrullus vulgaris Schard) on Glucose Level of Male White Rats (Rattus norvegicus) Induced with Streptozotosin Asari, Hasyim; Sugiyanta, Sugiyanta
Folia Medica Indonesiana Vol. 56, No. 3
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Watermelon rind water extract contain of citrulline. Citrulline is a precursor of generating Nitric Oxide (NO). NO possibly reduced the level of blood glucose in streptozotosin-induced diabetic rats.This study was a laboratory experimental study completely randomized design. A number of 30 male albino Wistar rats weighting 100 – 200 gr were devided into six groups (N=5), with group 1 served as normal control group. The other groups were given streptozotosin to induced diabetes mellitus. The rats in control diabetic group were given CMC 0,5%, the others were given watermelon rind extracs for 8 days with different doses for each group. The results showed that serum glucose levels in posttest control group was significantly different, from that group of the watermelon rind extract 250 mg/kg bw/day (p = 0,000), groups of watermelon rind extract 500 mg/kgbw/day (p = 0,000) and groups of watermelon rind extract 1000 mg/kgbw/day (p = 0,000). The level of triglyceride in postest control was significantly different from that group of the watermelon rind extract 250 mg/kg bw/day (p = 0,000), groups of watermelon rind extract 500 mg/kgbw/day (p = 0,000) and groups of watermelon rind extract 1000 mg/kgbw/day (p = 0,000). The conclusion, the watermelon rind water extrac can be used to reduced glucose serum level (250, 500, 1000mg/kg bw) with the optimal dose was 500 mg /kgbw/day with the optimal dose was 1000 mg /kgbw/day.
Cochlear Dysfunction after Kanamycin Injection in Multidrug Resistant Tuberculosis Patients Brahmono, Aditya; Purnami, Nyilo; Surarso, Bakti
Folia Medica Indonesiana Vol. 56, No. 3
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Background: Longterm exposure to aminoglycoside such as kanamycin to cochlear cells is known to be associated with damage to outer hair cells in the organ Cortiand type 1 sensory hair cells in the vestibular organs which ultimately causes permanent damage to hair cells. Hair cell damage occurs from the basal cochlea (high frequency area) to the apex cochlea (low frequency area) and followed by damage from the auditory nerve. Evaluation of cochlear dysfunction on multidrug resistant tuberculosis (MDR TB) patients have been rarelyreported in the literature based on distortion product otoacoustic emission (DPOAE).Objectives: To prove cochlear dysfunction after kanamycin injection in MDR TB patient based on DPOAE examination of the overall frequencies and specific frequency. Methods: An observational longitudinal analytic with pre and post design without control group conducted in the infection division of MDR TB Outpatients Pulmonology Department and Otorhinolaryngology Community division of ORL-HNS Department Dr. Soetomo general hospital Surabaya, within 3 months in 2018, 15 ear with the best baseline examination were taken by consecutive sampling and statistical analysis for cochlear dysfunction based on overall frequency and specific frequency DPOAE examination using Mc Nemar test. Results: Based on DPOAE examination of overall frequencies there was no cochlear dysfunction (p > 0.05) but a significant difference was found at frequency of 10,000 Hertz (Hz) (p = 0.002 ). Conclusion:On ototoxicity monitoring there was no cochlear dysfunction after 4 weeks Kanamycin injection but cochlear dysfunction occurs at a specific frequency of 10,000 Hz.
Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono, Soedarsono; Semedi, Bambang Pudjo; Setiawati, Rosy; Meliana, Resti Yudhawati; Kusmiati, Tutik; Permatasari, Ariani; Bakhtiar, Arief; Syafa'ah, Irmi; Indrawanto, Dwi Wahyu
Folia Medica Indonesiana Vol. 56, No. 3
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An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.
Correlations Between Staging and Chemotheraphy Response with Testicular Carcinoma Non-Seminoma at Dr. Soetomo Hospital, Surabaya, Indonesia Nugroho, Ahmad; Renaldo, Johan; Djatisoesanto, Wahjoe
Folia Medica Indonesiana Vol. 56, No. 3
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The purpose of this study to describe patientscharacteristics, correlation between stagingnon-seminomacancer and chemotherapyresponse. Data on age, location of tumor, staging, serum levels of the tumor marker post operative, adjuvant therapy, chemotherapy side effects, and response of patient to chemotherapy were gained from medical records inSoetomo Hospital Surabaya from January 2012 to December 2015, and analyzed with SPSS. Correlation between staging and chemotherapyresponse, correlation primary tumor staging (pT) and Metastasis (M), correlation regional lymph nodes staging (N) and metastasis (M), correlation serum tumor marker and chemotherapy response was proccessed by Spearman correlation test. There were no significant correlation between pT staging and M and no significant correlation between N and M staging. Based on tumor markers (S), mostly patients were S2. There were no significant correlation between the response to chemotherapy and serum tumor marker levels. In category of staging group, the mostare 14 patientsstage III. BEP was the most adjuvant Chemotherapy.Nausea and vomiting were The most complained during chemotherapy. Anemia were the most hematologic side effects of chemotherapy.There are no significant correlation between the staging of non-seminoma and the response to chemotherapy. Conclusion: Non seminoma mostly happened in young males. Non-seminoma responses to chemotherapy. Patients in early stage would give a good response to chemotherapy compared to those with advanced stage. After chemotherapy, evaluation should be done to the patients' complaints and complete blood count to detect side effects.
Blood Type and Blood Pressure Correlations to Body Mass Index in Young Adults Suwito, Bambang Edi; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56, No. 3
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Specific ABO blood type was reported to the higher risk of having overweight and obesity. The laters had also been suggested to correlate to blood pressure. Here we studied blood type and blood pressure amongst seemingly healthy university students of IIKBW, Kediri to understand their correlations to the body mass index (BMI). The blood typing (ABO typing, Eryclone®) and blood pressure (automated digital sphygmomanometer) of 74 male and 76 female were measured in duplicate accordingly. The BMI was analysed from the student's body weight and height using a digital balance and a microtoise staturemeter, respectively. Data were analysed using SPSS 17 with p<0.05 level of significance. There were 18.7% students have A blood type, 31.3% students were B type, 44% were O and 6.0% with AB blood type. There were 30.7% students with obesity, 18% overweight, 36% normal weight and 15.3% underweight. There were 4.7% had a hypertension, 28.7% pre-hypertension, and 66.7% were normal. No significant correlations found between BMI or the blood pressure to any specific ABO blood type, except between the blood pressure and the AB blood type (r=-0.179, p=0.03). However, there was a significant correlation between BMI and blood pressure (r=0.327, p=0.000). We observed no significant associations between any specific ABO blood type with the BMI and blood pressure. However, high blood pressures amongst students with obesity were found. Males were more common to suffer from obesity and high blood pressure than females.

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