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Made Krisna Adi Jaya
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Gedung Dekanat lantai 1, Fakultas MIPA, Universitas Udayana, Jl Kampus Bukit Jimbaran No 9A, Jimbaran, Badung-Bali.
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Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2025.v01.i01
Core Subject : Health, Science, Education, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other
Journal Pharmaceutical Science and Application (JPSA) publishes high-quality original research articles, review articles, and short communications that contribute substantially to the advancement of knowledge in the field of pharmaceutical sciences and their applications. The journal welcomes interdisciplinary work that integrates basic and applied research relevant to drug discovery, development, and clinical use. Areas of interest include, but are not limited to: Pharmaceutical Technology Pharmaceutics Novel Drug Delivery Systems Biopharmaceutics and Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacognosy and Natural Product Research Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology and Molecular Pharmacology Genomics, Proteomics, and Pharmacogenomics Bioinformatics and Biotechnology The journal is committed to disseminating impactful findings that enhance pharmaceutical knowledge and promote the development of safe, effective, and accessible therapies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application" : 5 Documents clear
A SYSTEMATIC REVIEW OF DIRECT MEDICAL COSTS AND COMORBIDITIES IN HEART FAILURE Nugroho, Kana Mukti; Andayani, Trimurti; Kristina, Susi Ari
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p01

Abstract

 Background: Heart failure (HF) often coexists with multiple comorbidities, which may substantially increase healthcare resource use. However, economic evaluations often overlook the specific cost impact of comorbid conditions in HF patients. Objective: To systematically review and quantify the excess direct medical costs and markup factors associated with comorbidities in patients with heart failure. Methods: A structured literature search was conducted across four databases (PubMed, Embase, ScienceDirect, and Google Scholar) on June 28, 2025. Observational studies reporting direct medical costs of HF patients with and without comorbidities were included. All cost values were standardized to 2024 USD using the Consumer Price Index (CPI) and converted using average exchange rates. The methodological quality of included studies was assessed using criteria adapted from Huber et al. (2015). A total of six studies, all conducted in the United States, met the inclusion criteria. Narrative synthesis was performed due to heterogeneity in cost reporting. Results: Across the six studies, comorbidities significantly increased HF-related costs. Mark-up factors ranged from 0.64 to 2.15, with the highest excess costs observed in patients with hyperkalemia (USD 39,543), drug use disorder (USD 27,783), and cancer (USD 19,379). In contrast, some comorbidities, such as Alzheimer’s disease, ischemic heart disease, and type 2 diabetes mellitus, were associated with lower costs, possibly due to end-of-life care patterns or system-level cost controls. Conclusion: Comorbidities impose a substantial and variable economic burden on HF patients. Findings highlight the need for multi-country studies, standardized cost methodologies, and the inclusion of indirect costs and HF severity stratification in future research. Keywords: Comorbidities; Direct medical costs; Economic burden; Heart failure; Mark-up factor.
ANTIBACTERIAL ACTIVITY TEST OF FENNEL LEAVES AND STEMS (Foeniculum vulgare Mill.) AGAINST BACTERIA Cutibacterium acnes AND Staphylococcus epidermidis Yanti, Ni Luh Putu Kris Monika; Dasilva, Madahlena Isaura; Andreani, Putu Ririn; Suardiana, I Kadek
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p02

Abstract

Background: Acne vulgaris is a common skin problem that often affects adolescents and young adults, caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. The use of synthetic antibiotics for acne treatment can lead to resistance; therefore, it is necessary to develop alternative natural ingredients that can act as a companion or complementary therapy, such as fennel plants (Foeniculum vulgare Mill.). Objective: To identify and compare the antibacterial activity of ethanol extracts of fennel leaves and stems against C.acnes and S.epidermidis. Methods: Extraction is carried out by maceration using 96% ethanol. Antibacterial tests were carried out in vitro using disc diffusion methods with concentrations of 50%, 75%, and 100%. Tetracycline 1% is used as a positive control, and DMSO 10% as a negative control. Results: Extracts of fennel leaves and stems exhibited antibacterial activity. The diameter of the inhibition zone increased with increasing extract concentration, with the leaves extract showing greater antibacterial activity than the stems extract. Conclusion: The results of the antibacterial activity test showed that ethanol extracts of leaves and fennel stems were able to inhibit the growth of C. acnes and S. epidermidis, with an average inhibition zone of leaf extract that was more optimal than that of stems.
KNOWLEDGE AND PERCEPTIONS OF PHARMACY STUDENTS TOWARD TELEPHARMACY SERVICES IN SOUTH KALIMANTAN, INDONESIA Yatminto, Eko; Munif Yasin, Nanang; Wiedyaningsih, Chairun
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p03

Abstract

Background: Telepharmacy offers a promising solution to improve access to pharmaceutical care in remote regions such as South Kalimantan, Indonesia. However, research on pharmacy students’ knowledge and perceptions of telepharmacy remains limited, even though their perspectives are crucial for the digital transformation of pharmaceutical services. Objective: This study aimed to assess pharmacy students’ knowledge and perceptions of telepharmacy in South Kalimantan and to identify associated factors. Methods: A cross-sectional online survey was conducted among 453 pharmacy students from six universities in South Kalimantan (October–December 2024) using a validated 40-item questionnaire. Knowledge and perception scores were categorized by sample medians, and non-parametric statistical analyses were performed using SPSS version 27. Results: Overall, 58.7% of participants had high telepharmacy knowledge, indicating a moderate regional knowledge level, and 54.3% reported positive perceptions. Knowledge was significantly associated with academic year (p < 0.001), parental education (p = 0.014), and university type (p < 0.001), while perceptions were influenced by age (p < 0.001), academic year (p < 0.001), parental education (p = 0.009), and healthcare work experience (p = 0.027). No significant correlation was observed between knowledge and perception scores (ρ = 0.089, p = 0.058). Conclusion: Pharmacy students in South Kalimantan exhibited moderate knowledge and generally positive perceptions of telepharmacy, but these domains were not significantly correlated. The findings underscore the importance of standardized telepharmacy education, integration of practical training, and stronger emphasis on regulatory and data-security aspects to strengthen readiness for digital healthcare transformation.
COMPUTATIONAL DRUG DISCOVERY OF POTENT ANTIMALARIAL XANTHONES: A SYSTEMATIC REVIEW AND ADMET-GUIDED IDENTIFICATION OF A LEAD CANDIDATE Joanne Theophilia Winata; Komang Dian Aditya Putra; Yosi Bayu Murti; Akhmad Kharis Nugroho
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p04

Abstract

Background: Artemisinin resistance mediated by Kelch13 mutations threatens malaria elimination efforts. Xanthones from Garcinia mangostana present a promising alternative scaffold for antimalarial drug development. Objective: This study systematically identified potent xanthones reported in the literature and evaluated their pharmacological potential using computational methods. Methods: A comprehensive systematic review was conducted across PubMed, Scopus, and Wiley Online Library (through September 2025) following PRISMA 2020 guidelines, searching for "Xanthone" combined with "Antimalarial" or "Plasmodium". Selection criteria included original research reporting IC50 values against Plasmodium falciparum. Results: Among 165 identified compounds from 46 studies, 18 demonstrated potent activity (IC50 < 1 µM). Structure-Activity Relationship analysis revealed that synthetic xanthones with alkylamino side chains were substantially more efficacious than natural isolates. Compound 117 (3-(3- (dimethylamino)propoxy)-6,8-dihydroxy-2-methoxy-7-(3-methylbut-2-en-1-yl)-9H-xanthen-9- one) emerged as the lead candidate with IC50 of 0.1 µM. In silico ADMET profiling predicted superior intestinal absorption (>90%), compliance with Lipinski's Rule, and a favourable-toxicity profile (non-mutagenic, non-hepatotoxic) compared to the natural prototype α-mangostin. Conclusion: This integrated systematic review-cheminformatics approach, strengthened by transparent multi-criteria prioritization, identified Compound 117 as a promising pre-clinical candidate requiring further biological evaluation, including in vivo efficacy in rodent malaria models, in vitro cytotoxicity profiling, and experimental validation of predicted CYP interactions before advancing toward clinical translation.
IMPACT OF HOME PHARMACY CARE ON MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS: A QUASIEXPERIMENTAL STUDY Kesumadewi, Ayu; Dewa Ayu Putu, Satrya Dewi; Putri, Dhiancinantyan Windydaca Brata; Setiawan, Putu Yudhistira Budhi
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p05

Abstract

Background: Acne vulgaris is a common skin problem that often affects adolescents and young adults, caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. The use of synthetic antibiotics for acne treatment can lead to resistance; therefore, it is necessary to develop alternative natural ingredients that can act as a companion or complementary therapy, such as fennel plants (Foeniculum vulgare Mill.). Objective: To identify and compare the antibacterial activity of ethanol extracts of fennel leaves and stems against C.acnes and S.epidermidis. Methods: Extraction is carried out by maceration using 96% ethanol. Antibacterial tests were carried out in vitro using disc diffusion methods with concentrations of 50%, 75%, and 100%. Tetracycline 1% is used as a positive control, and DMSO 10% as a negative control. Results: Extracts of fennel leaves and stems exhibited antibacterial activity. The diameter of the inhibition zone increased with increasing extract concentration, with the leaves extract showing greater antibacterial activity than the stems extract. Conclusion: The results of the antibacterial activity test showed that ethanol extracts of leaves and fennel stems were able to inhibit the growth of C. acnes and S. epidermidis, with an average inhibition zone of leaf extract that was more optimal than that of stems.

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