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Academia Open
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 27147444     DOI : 10.21070/acopen.11.2026.12985
Core Subject : Health,
Medicine & Pharmacology Public Health
Academia Open is published by Universitas Muhammadiyah Sidoarjo published 2 (two) issues per year (June and December). This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal aims is to provide a place for academics and practitioners to publish original research and review articles. The articles basically contains any topics research or review. Academia Open is available in online version. Language used in this journal is Indonesia or English.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 2,389 Documents
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Green Synthesis of Ag2O/Ag NPs via Ginkgo Biloba and Their Anticancer Effects: Sintesis Hijau Ag2O/Ag NPs melalui Ginkgo Biloba dan Efek Antikankernya Ola Abedallah Manatee; Nadia Naeema; Ahmed A. Thamer
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10459

Abstract

This study focuses on establishing a green, inexpensive, non-toxic alternative for treating cancers. This aim explores the synthesis and use of silver oxide nanoparticles (Ag2O/Ag NPs) using a green synthesis technique. Considering that there is a high death rate in cancer, breast cancer in particular, which is highlighted by a breast cancer cell line MCF-7, we have decided to use nanotechnology as a therapeutic tool. Conventional ways of coping with cancer symptoms, including radiotherapy, chemotherapy, and immunotherapy, even though they are the most effective, have the drawback of high costs and side effects. Instead of toxic chemicals, nanoparticles are gaining more interest due to their peculiarity of chemical and physical specifications, with Ag2O/Ag NPs pointing to a wide range of actions from anticancer effectiveness. Using the extract from the Ginkgo biloba plant, we achieved the green synthesis of Ag2O/AgNP via the new method widely adopted for environmental and health safety reasons. The nanoparticles were synthesized and characterized with SEM, HRTEM, EDX Spectroscopy, SEAD pattern, and DLS, and it was evident that the particles were spherical, homogeneously distributed in size, and compositively pure. Moreover, the Ag2O/Ag NPs were tested for their cytotoxic efficacy towards MCF-7 breast cancer cells, employing the MTT assay and the Hochst blue-fluorescent staining method, which demonstrated an effective dose-dependent toxicity that highlighted the possibility of such NPs as a candidate cancer therapeutic. Moreover, these nanoparticles were found to show antimicrobial activity, which helped to broaden their biomedical potential. The present research emphasizes the necessity of friendly-to-environment nanoparticle synthesis and provides an additional clue toward developing cancer treatments. Highlights: Develop green, cost-effective, non-toxic cancer treatment using Ag2O nanoparticles. Synthesized Ag2O/AgNPs via Ginkgo biloba extract; tested anticancer efficacy. Ag2O/AgNPs show dose-dependent cytotoxicity and antimicrobial potential. Keywords: AgO ;Ag ; Capping agent; Cancer; Ginkgo biloba
Hemorrhagic Fever and Desertification Phenomenon: Demam Berdarah dan Fenomena Desertifikasi Dhuha Adnan Neamah; Arwa Alaa Hussein; Enas Saad Sobeih
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10460

Abstract

A collection of viral disorders known as hemorrhagic fever are brought on by various virus families and impact many bodily systems and organs, harming the cardiovascular system overall. The symptoms can include circulatory instability, coagulation problems, altered mental state, and, in extreme cases, death. Desertification is the process by which land in arid, semi-arid, and dry regions deteriorates due to a lack of water sources, causing a decline in biodiversity and plant life, which in turn causes the topsoil layer to disappear and, ultimately, the land's capacity to sustain human, animal, and agricultural life. Highlights: Hemorrhagic fever: viral disorders harming organs, cardiovascular system, causing death. Symptoms: circulatory instability, coagulation issues, altered mental state, fatal outcomes. Desertification: land degradation reduces biodiversity, plant life, and agricultural capacity. Keywords: Hemorrhagic fever , Desertification, Viral Hemorrhagic Fever (VHF)
Assessment of Possible Road Injuries Caused by an Earthquake: Penilaian Kemungkinan Cedera di Jalan yang Disebabkan oleh Gempa Bumi Hasanboy Nurmatov; Mavludahon Umarovа
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10461

Abstract

The article provides data on the extent to which the forecast of the state of roads in a region with a strong earthquake, the level of damage of vehicles during an earthquake depends on their physical state of absorption due to atmospheric, hydrosphere, lithospheric effects and man-made impacts and to what extent special requirements for the construction and control of transport facilities in seismic areas are met, as well. The assessment of the destruction of roads that may occur as a result of an earthquake provides for such aspects as the conclusions of the control of transport facilities carried out earlier in seismic areas, the identified causes of road damage, the effectiveness of antiseismic protection methods when carrying out new construction work and the overhaul (reconstruction) of transport infrastructure to increase seismic stability. The degree of damage to vehicles due to an earthquake is divided into five parts according to the set "rules of transport facilities in seismic areas" (d1–d5), the characteristic of damage situations in each and, accordingly, the degree of damage to structures is shown in the table. From the cited data, on the example of the Angren-Pop railway line, certain levels of damage are observed at high scores of earthquake intensity, even in seismically stable structures, and measures to eliminate damage according to construction standards are covered. Highlights: Road and vehicle damage linked to seismic and environmental factors. Assessment of antiseismic methods and transport facility standards. Angren-Pop railway damage highlights intensity and reconstruction measures. Keywords: earthquake, transport, artificial structures, road infrastructure, tectonic displacement, seismic area, seismic stability, tectonic wave, seismogravitational impact, economic damage, secondary consequence, accident-rescue
Strategies for Digital Transformation in Madrasah Education for Institutional Excellence: Strategi Transformasi Digital dalam Pendidikan Madrasah untuk Keunggulan Institusi Fitrotul Choiriyah; Gunarti Dwi Lestari
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10463

Abstract

General Background: Digital transformation is essential in modern education, including madrasahs. Specific Background: Indonesian madrasahs face challenges in integrating technology while preserving Islamic values. Knowledge Gap: Limited strategies exist for sustainable digital transformation in madrasahs. Aims: This study analyzes innovation diffusion strategies to enhance madrasahs' digital adaptation. Results: Key strategies include infrastructure development, educator training, stakeholder collaboration, and data-driven evaluations, with challenges like budget constraints and resistance to change. Novelty: It bridges innovation theory with practical applications in madrasahs. Implications: Findings guide policymakers and educators to drive effective, culturally aligned digital transformation. Highlights: Digital transformation in madrasahs requires robust infrastructure, skilled educators, and cultural adaptation. Innovation diffusion strategies provide a structured approach to overcoming resistance and implementing technology. Collaboration among stakeholders and continuous training are critical for sustainable educational advancements. Keywords: Digital Transformation, Madrasah Education, Educational Technology, Institutional Excellence, Innovation Diffusion
Pedagogical Conditions of Realisation of Educational Functions in The Process of Educational Activity in Universities: Kondisi Pedagogis Realisasi Fungsi Pendidikan dalam Proses Kegiatan Pendidikan di Perguruan Tinggi Fayzieva Maftuna Ilkhomovna
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10464

Abstract

The article is devoted to the pedagogical conditions for the realisation of educational functions in the process of academic activity in higher education institutions. The article considers key aspects such as the creation of an educational environment, integration of educational tasks into the educational process, the role of the teacher as a mentor and moral authority, and the use of modern teaching methods and technologies. Special attention is paid to extracurricular activities that contribute to the development of social activity and responsibility of students. The article emphasizes the importance of an integrated approach, including organizational, methodological, psychological, pedagogical and social conditions for effective education. The expected result is the formation of comprehensively developed specialists ready for active participation in society. Highlights: Pedagogical conditions for educational functions in higher education Teacher roles, modern methods, and extracurricular activities Integrated approach for developing responsible, socially active specialists Keywords: pedagogical conditions, educational functions, educational activity, students' education, educational process, extracurricular activity, teacher's role, innovative methods, social responsibility, self-development
Methods For Assessing The Environmental Impact of Large Industrial Enterprises on The Regional Economy: Metode Untuk Menilai Dampak Lingkungan dari Perusahaan Industri Besar Terhadap Perekonomian Daerah Savrieva Madina Khakimovna; Dilmurodov Abbas Anvar oglu
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10466

Abstract

The article presents an analysis of the methods that can be used to assess the impact of large industrial monopolies on the ecological state of the region, their sizes and indicators. The analysis of the methods of determining the coefficient indices of large enterprises in ensuring the ecological safety of the region while achieving economic well-being, environmental impact and efficient use of natural resources, reflecting environmental criteria and environmental quality indicators in financial statements in standard market assessments, which evaluate the activities of the enterprise from the point of view of balanced ecological and economically sustainable development, is presented. Highlights: Impact Analysis: Assess industrial monopolies’ ecological effects and regional safety. Methods: Evaluate coefficient indices linking environmental impact with economic well-being. Sustainability: Balance ecological criteria in financial reports for sustainable development. Keywords: ecological state, assessment of the ecological state, environment, ecological safety, ecological impact in stabilizing the regional economy, environmental objects, ecological impact coefficient index
Evaluation of IL-18 and TNF-α in patients with Plasmodium vivax Malaria infection in Diyala Province/Iraq: Evaluasi IL-18 dan TNF-α pada pasien dengan infeksi Malaria Plasmodium vivax di Provinsi Diyala/Irak Amal kamil Abdulsada; Khawla Hussein Sabbar; Hwaida Sh. Al-Mahdawy
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10470

Abstract

Malaria, caused by Plasmodium vivax, remains a significant health issue in northeastern Iraq. This study collected 5 ml of blood samples from 50 malaria patients and 50 healthy controls at Jalawlaa Hospital in Diyala Province. The infection rates were 13% in the 10-24 age group, 22% in the 25-39 group, and 15% in the 40-64 group, with no significant differences in gender or residency. Patients showed elevated levels of P. vivax IgG antibodies (2.14±0.17) compared to the control group (0.09±0.02), with significant increases in IL-18 (16.97±1.04 vs. 1.73±1.73) and TNF-α (18.45±0.81 vs. 1.31±0.31) levels (P≤0.0001). A strong correlation was found between P. vivax IgG antibodies and IL-18 and TNF-α levels (r=0.666, 0.730). ROC analysis showed excellent diagnostic accuracy for P. vivax IgG antibodies, with 98% sensitivity and 100% specificity at a cutoff value of >1.02. Additionally, a mutation in the TNF gene (SNP rs12934561) was identified, with wild TT and CC variations changing to CC, TT, and TC in patients compared to controls. These findings suggest that P. vivax IgG, IL-18, and TNF-α are valuable biomarkers for malaria diagnosis and highlight genetic variations linked to immune responses. Highlights: Malaria caused by Plasmodium vivax identified in northeastern Iraq, affecting various ages. Patients showed high P. vivax IgG, IL-18, and TNF-α levels (P≤0.0001). TNF gene mutation (SNP rs12934561) found, indicating genetic variation in immune response. Keywords: IL-18, TNF-α, Plasmodium vivax, Malaria, Diyala Province/Iraq.
Cultural Dynamics Shaping the Adoption of Modern Management, Green Innovation, and Digitization in Uzbekistan's Business Landscape: Dinamika Budaya Membentuk Adopsi Manajemen Modern, Inovasi Hijau, dan Digitalisasi di Lanskap Bisnis Uzbekistan Gabriel Ayodeji Ogunmola
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.10407

Abstract

Since the gain of independence in 1991, Uzbekistan has worked through diverse economic transformations with a transition from a central economy to a Market economy. These have sought to develop entrepreneurship and encourage FDI inflows, at the same time business is still shaped by history, culture and institutions. For this investigation, the affect of the cultural dimensions including collectivism, power distance, and long term orientation towards the adoption of modern management practices, green innovation and digitization in Uzbekistan is examined. Hofstede’s Cultural Dimensions Theory, Theory of Planned Behavior, and the Technology-Organization-Environment are used to analyze these influences in the present research. The study shows that collectivism positively influences the implementation of the modern management practices while high power distance negatively influence it. Long-term orientation to a very large extent influences green innovation and appropriate attitude toward technology is essential for digitalization. Subjective norms which are highly endorsed scale and perceived behavioral control further enhance green innovation and digitization respectively. Furthermore, other adoption conditions such as the technological and environmental support for the adoptions are important while size and centralization of organizations present adoption challenges. Thus, this work enriches the scientific literature by revealing the dependencies of business activities in a transitional economy with respect to cultural values. The conclusions for business and authorities stress the importance of cultural contingency approach to improve organization performance and improvement in Uzbekistan. The future research should incorporate longitudinal studies and pay attention to such other cultural dimensions and characteristics of organizations. Highlights: Uzbekistan transitions from central to market economy, shaping business by culture. Collectivism aids modern management; power distance hinders; long-term orientation boosts innovation. Cultural values, technology, and environment critical for green innovation, digitization success. Keywords: Cultural dimensions, Hofstede's Cultural Dimensions Theory, Theory of Planned Behavior, Technology-Organization-Environment framework, sustainability
Sustainable Approaches to Synthesis SnO2/MWCNT Nanocomposite Using Eggplant Extract: Study Structural Optical and Morphological Properties: Pendekatan Berkelanjutan untuk Sintesis Nanokomposit SnO2/MWCNT Menggunakan Ekstrak Terong: Mempelajari Sifat Optik dan Morfologi Struktural Oday Jawad Kadhim; Ahmed A. Thamer
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10472

Abstract

To develop eco-friendly methods in nanotechnology, an innovative approach to the fabrication of SnO₂/MWCNT nanocomposites using an easily used yet effective green method was achieved. This study shows a sustainable route to highly reducing chemical synthesis, using the natural reducing properties of the eggplant extract. Working successfully, the research was able to create a hybrid nanomaterial comprised of tin oxide (SnO₂) and multi walled carbon nanotubes (MWCNTs) using a simple co-precipitation technique. Combining SnO₂ and MWCNT resulted in a nanocomposite with an intriguing transformation from nanotubular to flower-like structures and uniform distribution of the particles. Detailed analysis showed a crystallite size of ~ 21.75 nm for pure SnO₂ up to 38.98 nm in the hybrid form and retained good uniformity ~ 45.84 nm. Most importantly, the integration of MWCNTs yielded an optimized bandgap reduction from 3.5 to 3.1 eV, improving the material’s light absorption ability. Such improvement opens up exciting applications in photocatalysis, gas sensing and energy storage devices. This eco friendly synthesis method is proven to be viable for creating green advanced nanomaterials, which not only provides proof of concept for green approach in creating advanced nanomaterials but allows for more sustainable practices in nanotechnology development while keeping the high performance standards needed for practical applications. Highlights: Eco-friendly SnO₂/MWCNT synthesis using eggplant extract Green nanotechnology: improved bandgap, structure, and uniformity Applications in photocatalysis, gas sensing, and energy storage Keywords: SnO­­­2 NPs, SnO2/MWCNT, Eggplant Extract, green synthesis
Isolation and Diagnosis of Microorganism from Sandwiches (Street-Food and Fast Food): Isolasi dan Diagnosis Mikroorganisme dari Sandwich (Makanan Jajanan dan Makanan Cepat Saji) Ali Y. Khudhair; Saif al deen M. Khatlan; Suaad W. Kadium
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10475

Abstract

Fifty food samples were collected from 60 randomly chosen fast food and traditional restaurants in Al-Najaf, Iraq. These samples were incubated to encourage bacterial growth at 37°C for 24 to 48 hours, while fungi were cultured at 25°C for seven days. The analysis showed that out of the 17 samples isolated from the food, nine different bacterial genera and ten fungal genera were identified, the bacterial and fungal species isolated in this study included Staphylococcus aureus, Shigella sp., Escherichia coli, Streptococcus sp., Salmonella sp., Bacillus subtilis, Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus, Penicillium expansum, Penicillium sp., Rhizopus sp., Cladosporium sp., Alternaria sp., and Fusarium sp. The findings revealed that Aspergillus niger was the most predominant species, followed by Penicillium sp., and then Aspergillus flavus and Alternaria sp., with their respective frequencies being 52%, 45%, 50%, and 31.3%. The occurrence rates in falafel were 80%, 75%, 73%, and 45% respectively. In the case of beef burgers, Aspergillus flavus was predominant, with a frequency and visible percentage of 36%, 53%, and 35% respectively. Cladosporium sp. showed the lowest frequency and appearance percentage in beef pizza, with values of 26% and 6.6% respectively. Highlights: Food samples tested: 9 bacterial, 10 fungal species identified. Aspergillus niger predominant in falafel, beef burgers, and beef pizza. Cladosporium sp. showed lowest frequency and appearance in beef pizza. Keywords: Street-Food , Fast Food, Staphylococcus aureus, Sandwiches

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