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African Journal of Sciences and Traditional Medicine
Published by Lembaga Yasin Alsys
ISSN : -     EISSN : 15957942     DOI : https://doi.org/10.58578/AJSTM
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Nursing Public Health
African Journal of Sciences and Traditional Medicine aims to publish rigorous, peer-reviewed research that advances scientific knowledge in natural and life sciences while promoting analytically grounded and evidence-informed scholarship in traditional medicine and related biological fields. • Scientific Advancement: disseminate high-quality studies that deepen understanding in biological, biochemical, environmental, and health-related sciences. • Traditional Medicine Research: encourage scientifically grounded research on plant medicine, phytomedicine, bioactive compounds, and traditional therapeutic knowledge. • Life-Science Integration: promote interdisciplinary links among biochemistry, molecular biology, microbiology, toxicology, biotechnology, parasitology, and health sciences. • Application and Relevance: support studies with meaningful implications for public health, medicinal resource development, environmental health, and agricultural or biomedical applications.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 73 Documents
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Extraction, Application and Characterization of Dyed Fabric from Ptericarpus erinaceous Joshua Yakubu; Bifam Mathias; Andema Aaron Kanadi; Sunday Akuewanhor Osemeahon
African Journal of Sciences and Traditional Medicine Vol 3 No 3 (2026): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v3i3.11827

Abstract

Growing environmental and health concerns regarding synthetic dyes have renewed interest in natural colorants for textile applications. This study aimed to extract dye from the stem of Pterocarpus erinaceus, apply it to cotton fabric, and characterize the resulting dyed material. The dye was extracted through maceration, producing a yield of 16%. The extract was initially applied without a mordant and subsequently using pre-mordanting, simultaneous mordanting, and post-mordanting techniques with CuSO₄, KAl(SO₄)₂·12H₂O, and FeSO₄·7H₂O. Post-mordanting produced the most attractive shades, including dark brown, brown, and gray, with dye-absorption values of 0.07, 0.07, and 0.05 for CuSO₄, KAl(SO₄)₂·12H₂O, and FeSO₄·7H₂O, respectively. The dyed fabrics exhibited moderate-to-good color fastness to washing, rubbing, and light, with ratings ranging from 3.0 to 5.0; mordanted samples generally demonstrated superior performance. Scanning electron microscopy and thermogravimetric analysis further indicated a strong relationship between the surface morphology and thermal behavior of the dyed cotton fabrics. These findings demonstrate the potential of P. erinaceus stem extract as a natural dye for cotton textiles and provide a basis for further research evaluating natural mordants as alternatives in sustainable textile coloration.
GC–MS Phytochemical Characterization and Comparative Antidiabetic Activities of Methanolic Extracts of Calotropis gigantea Leaves, Stem Bark, and Roots in Streptozotocin-Induced Diabetic Rats Mercy iliya Tumba; Isaac John Umaru; Chinedu Imo
African Journal of Sciences and Traditional Medicine Vol 3 No 3 (2026): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v3i3.11828

Abstract

Calotropis gigantea is widely used in traditional medicine for treating various health conditions. This study evaluated the phytochemical composition and comparative therapeutic effects of methanolic extracts from its leaves, stem bark, and roots in streptozotocin (STZ)-induced diabetic albino rats. Plant materials were air-dried, pulverized, and extracted through cold maceration in methanol for 72 hours, after which the extracts were concentrated using a rotary evaporator and characterized by gas chromatography–mass spectrometry (GC–MS). Thirty-six male albino rats were randomly assigned to six groups: normal control, diabetic control, metformin-treated (100 mg/kg), and leaf-, stem-bark-, and root-extract-treated groups (100 mg/kg each). Treatments were administered for 14 days. Fasting blood glucose, liver and kidney function indices, and lipid profiles were assessed, alongside histopathological examination of liver and kidney tissues. GC–MS identified several bioactive compounds, including the oxygenated monoterpenes 7-octen-2-ol, α-terpineol, and D-limonene, indicating potential antioxidant relevance. Diabetes induction increased fasting blood glucose from 4.93 ± 0.25 to 16.14 ± 0.98 mmol/L, and concentrations remained elevated in untreated diabetic rats. All extracts significantly reduced blood glucose, with the root extract producing the greatest reduction, from 15.37 ± 1.10 to 8.93 ± 1.94 mmol/L, comparable to the response observed with metformin. The root and leaf extracts demonstrated the strongest improvements in renal function indices, whereas the leaf extract produced the most pronounced reductions in alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities. The leaf extract also reduced serum triglyceride and cholesterol concentrations while increasing high-density lipoprotein levels. Histopathological findings corroborated the biochemical results by demonstrating reduced liver and kidney tissue damage in treated animals. These findings indicate that C. gigantea, particularly its root and leaf extracts, possesses antidiabetic, hepatoprotective, nephroprotective, and lipid-modulating potential, supporting its further investigation as a candidate for managing diabetes mellitus and its associated complications.
Phytochemistry, Antibacterial Properties, and FT-IR Spectra of Khaya senegalensis Stem Bark Extracts against Escherichia coli 0157:H7 and Salmonella typhimurium Jude Marvin; Ewansiha Joel Uyi; Joseph Fashe; Usaku Reuben
African Journal of Sciences and Traditional Medicine Vol 3 No 3 (2026): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v3i3.12028

Abstract

The increasing prevalence of multidrug-resistant bacterial pathogens has intensified the search for alternative antimicrobial agents derived from medicinal plants. This study investigated the phytochemical composition, antibacterial activity, and Fourier-transform infrared (FTIR) spectra of methanolic and n-hexane extracts of Khaya senegalensis stem bark against Escherichia coli O157:H7 and Salmonella typhimurium. The extracts were obtained by reflux extraction, and their phytochemical constituents were quantified. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations were determined using broth microdilution and subculture methods, respectively, while functional groups were characterized using a PerkinElmer 100-series FTIR spectrometer. The methanolic extract contained higher concentrations of phenols, flavonoids, alkaloids, and tannins, whereas the n-hexane extract contained higher concentrations of saponins and steroids. The methanolic extract exhibited greater antibacterial activity, with E. coli O157:H7 showing the highest susceptibility (MIC = 3.12 mg/mL), followed by S. typhimurium (MIC = 12.5 mg/mL). By comparison, the n-hexane extract produced an MIC of 25 mg/mL against both bacterial isolates. The FTIR spectrum of the methanolic extract displayed five absorption peaks, including bands at 3271.86 and 1604.91 cm⁻¹ associated with terminal alkyne C–H and aromatic C=C stretching, respectively, and bands at 1031.28, 562.00, and 552.94 cm⁻¹ within the fingerprint region. The n-hexane extract exhibited bands corresponding to O–H stretching, aromatic C=C stretching, N–O stretching, alkane C–H bending, C–O–C stretching, and C–O stretching. These findings demonstrate that the antibacterial activity of K. senegalensis stem bark varies according to solvent polarity and phytochemical composition, with the methanolic extract showing superior efficacy against the tested organisms. The study provides preliminary scientific support for the traditional use of K. senegalensis stem bark in managing diarrhoea, dysentery, and other gastrointestinal ailments, while further toxicological and in vivo investigations are required to establish its therapeutic applicability.

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