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PharmaCine: Journal of Pharmacy, Medical and Health Science
Published by Universitas Singaperbangsa Karawang
ISSN : 27464199     EISSN : 27464199     DOI : https://doi.org/10.35706/pc.v7i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary
PharmaCine: Journal of Pharmacy, Medical, and Health Sciences is a peer-reviewed journal dedicated to scientific publications in the fields of pharmacy, medicine, and health sciences. PharmaCine is published biannually, in March and September, by the Undergraduate Pharmacy Program, Faculty of Health Sciences, Singaperbangsa University Karawang, in collaboration with the Indonesian Pharmacists Association (IAI). This journal serves as a forum for students, pharmacists, medical personnel, and other health professionals to update their knowledge and access scientific literature. PharmaCine publishes a range of articles, including meta-analyses, original research, reviews, and case reports. Submissions are peer-reviewed to ensure scientific rigor within the relevant field. The scope of the PharmaCine Journal encompasses various pharmaceutical, medical, and health science topics, including: Pharmacology Pharmacotherapy Clinical Pharmacy Pharmaceutical Technology Herbal Pharmacy Social Pharmacy Pharmaceutical Management Clinical Biochemistry Pharmacogenetics Pharmaceutical Chemistry Pharmaceutical Biology Public Health Sciences
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 79 Documents
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Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Kharina Septi Lestari; Aulia Nurfazri Istiqomah; Reza Pratama; Boy Ignatius Simamora; Anissa Nadya Oktriyani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Analisis Keamanan Produk Saus Sambal Non-BPOM Berdasarkan Uji Cemaran Kimia dan Mikrobiologi yang Ditemukan di Pasar Kranji, Kota Bekasi: Analysis of Bacterial and Chemical Contamination in Non-BPOM Licenced Packaged Chili Sauce Found in Kranji Market, Bekasi City Michael Dayln Silalahi; Ahsanal Kasasiah; Aliya Azkia Zahra
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 1 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i1.13181

Abstract

Several studies have shown that sauces circulating on the market still contain microbial contamination exceeding the threshold and dangerous dyes such as Rhodamine B. This study highlights the importance of education for producers to take care of BPOM licensing in order to increase consumer confidence and product safety. This study aims to evaluate the safety of non-BPOM packaged chili sauce products sold in the Kranji market. Bekasi City, with a focus on microbial contamination and the content of dangerous dye Rhodamine B. Microbial tests were carried out using the Total Plate Count (TPC) method based on BPOM standard No. 13 of 2019, while the Rhodamine B content was analyzed using Thin Layer Chromatography (TLC). The results showed that all samples tested met BPOM microbiological safety standards with the number of colonies not exceeding 10⁴ colonies/g and no Rhodamine B was found in the samples tested for stain observations on TLC. With these results, the products tested can be said to be safe for consumption even though they do not yet have a BPOM licensing. Keywords: sauce; chili; rhodamin B; contamination; TPC.
Pemanfaatan Umbi-Umbian sebagai Bahan Pengisi dalam Pengembangan Pakan Ikan Berbasis Nutrisi Alami: Utilization of Tubers as Filler Ingredients in the Development of Natural Nutrition-Based Fish Feed Haetami, Kiki; Budiana, Yoga Nugraha; Abun, Abun
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13186

Abstract

Freshwater fish feeds are typically high in protein (>25%), creating a need for cost-effective carbohydrate fillers that do not compromise growth performance. Tuber crops (cassava, taro, sweet potato, potato) are promising carbohydrate sources; however, antinutritional factors and processing methods largely determine their success. This review searched literature on Google Scholar. Inclusion criteria were studies on aquaculture fish species that reported at least one performance outcome (growth/SGR, FCR, PER) or digestibility, and that specified the tuber organ/material and the applied processing. Exclusion criteria were non-aquatic studies, studies without performance/digestibility data, and non-scholarly secondary sources. Two reviewers screened independently, with disagreements resolved by consensus. A narrative/thematic synthesis was conducted. Fermentation and/or heat processing consistently reduced antinutritional factors and improved starch digestibility. In tilapia and catfish, carbohydrate substitution from tubers was generally safe at ~20–30% of diet carbohydrates without significant deterioration in SGR/FCR when adequate processing was applied; higher inclusion levels depend on species, life stage, and detoxification intensity. Tuber crops are therefore promising filler ingredients, particularly when preceded by fermentation. Practically, a 20–30% substitution can serve as a starting point for formulation, followed by optimization by species and production stage. Keywords: Tuber crops; Filler materials; Spare protein; Processing; Aquaculture.
Optimasi Formula Granul Effervescent Ekstrak Rimpang Temu Putih (Curcuma zedoaria) dengan Variasi Pemanis Alami sebagai Antioksidan: Optimization and Antioxidant Evaluation of Effervescent Granules Containing White Turmeric (Curcuma zedoaria) Rhizome Extract with Natural Sweeteners Diki Zaelani; Ratu Siti Robiatul Awaliyah; Rahmat Santoso; Emma Emawati; Reza Pratama
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13193

Abstract

White turmeric (Curcuma zedoaria), a member of the Zingiberaceae family, contains bioactive compounds with antioxidant potential, but its utilization remains limited due to its bitter taste and less practical traditional preparations. This study aimed to optimize the formulation of effervescent granules containing white turmeric rhizome extract using different natural sweeteners and to evaluate their physical properties and antioxidant activity. The effervescent granules were prepared by the wet granulation method using stevia (F1, 17.5%), palm sugar (F2, 10%), and corn sugar (F3, 14.5%) as sweeteners. The granules were evaluated for physical characteristics (organoleptic properties, moisture content, flow rate, angle of repose, dissolution time, pH, foam height, and hedonic test) and antioxidant activity using the DPPH method both qualitatively and quantitatively. The results showed that all formulas met the standard physical requirements of effervescent granules. The best formulation was obtained from F3 (corn sugar) with the highest acceptance score in the hedonic test. The antioxidant activity of white turmeric extract exhibited an IC₅₀ value of 53.53 ppm, while the effervescent granules showed strong antioxidant activity with IC₅₀ values of 62.53 ppm (F1), 62.62 ppm (F2), and 62.79 ppm (F3). These findings indicate that variations in natural sweeteners influence the sensory characteristics without significantly reducing the antioxidant potency of the formulation. Keywords: Effervescent granules; Curcuma zedoaria; Natural sweeteners; Antioxidant, Formulation optimization.
Evaluasi Pasca Pelatihan Pada Pelatihan Penugasan Khusus Tenaga Kesehatan Berbasis Tim (Tugsus) di Puskesmas Tahun 2024: Post-Training Evaluation of Team-Based Special Assignment (Tugsus) at Primary Health Centers in 2024 Rahman, Fauzi; Anisah, Ani; Prameswari, Kania
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13250

Abstract

Indonesia faces significant challenges with the uneven distribution of human resources for health (HRH), especially in Disadvantaged, Border, and Outermost Areas (DTPK). To address this, the Ministry of Health launched the Team-Based Special Assignment (Tugsus) program, supported by targeted training for health workers. This study aimed to evaluate the implementation of this training after its completion, focusing on the relevance of the training materials, their application in the field, and the impact of Tugsus teams on the performance of Primary Health Centers (PuskesmasThis study employed a cross-sectional evaluation design conducted in a single data collection phase. The approach used was a mixed method, combining qualitative and quantitative approaches, the study was conducted from April 28 to May 07, 2025. Data were gathered via online questionnaires 188 of 240 program alumni (Batches 27-29), 33 supervisors, and 59 colleagues. Results indicate that the training materials are highly suitable (average 91. 31%) for practical needs and are widely applied (average 94. 33%). The highest application rates are seen in soft skills, such as Coaching (98. 40%), and routine activities, like Posyandu (99. 47%). In contrast, application of systemic topics, such as Accreditation (85.64%), is somewhat lower. The presence of Tugsus teams shows a significant positive effect, mainly by filling critical HRH gaps. However, a gap remains between the ideal concepts taught during training and the realities faced in the field, primarily due to structural barriers like limited local HR and facilities. The evaluation results show that this training provides participants with relevant competencies, but to enhance the program's future impact, there should be a focus on strengthening the capacity of the Puskesmas system to adopt innovations, rather than solely emphasizing individual competencies. Keywords: Post-Training evaluation; Team-Based special assignment; Primary health center.
Identification of Potential Anti-Blood Cancer Compounds from Centella asiatica via In Silico Approaches: Molecular Docking, ADMET Prediction, and Drug-Likeness Evaluation: Identification of Potential Anti-Blood Cancer Compounds from Centella asiatica via In Silico Approaches: Molecular Docking, ADMET Prediction, and Drug-Likeness Evaluation Syarifah Nazila Fitriani Al-Hasany; Nily Sua’ida; Rizki Rahmadi Pratama; Halimah Halimah; Nor Syipa Hayati; Muhammad Fauzi
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13545

Abstract

Blood cancer is a hematological malignancy characterized by abnormal proliferation of blood cells due to genetic mutations. Conventional therapies such as chemotherapy and radiotherapy often cause significant side effects, highlighting the need for safer alternatives. Natural products, including Centella asiatica, have been widely explored as potential anticancer agents. This study aimed to evaluate the binding affinity, pharmacokinetic properties, and drug-likeness of bioactive compounds from Centella asiatica using an in silico approach. Molecular docking was performed using AutoDock 1.5.6 to determine binding free energy (ΔG), followed by ADMET prediction and Lipinski’s Rule of Five evaluation. The results showed that quercetin, centellin, labiatenic acid, kaempferol, and asiatic acid exhibited binding affinities of -6.51, -4.92, -5.07, -6.16, and -6.97 kcal/mol, respectively, with asiatic acid demonstrating the strongest interaction. ADMET analysis indicated generally favorable absorption and low toxicity profiles, although variability in permeability and metabolic interactions was observed. Drug-likeness evaluation revealed that most compounds met key Lipinski parameters, with minor deviations related to lipophilicity and molecular weight. In conclusion, Centella asiatica contains promising bioactive compounds with potential anti-blood cancer activity supported by favorable pharmacokinetic and drug-likeness profiles. Further in vitro and in vivo studies are required to validate these findings.
Relationship Between Demographic Characteristics, Knowledge of Antihypertensive Drug Use, and Health-Seeking Behavior Among the Elderly with Hypertension in Karawang Regency: Relationship Between Demographic Characteristics, Knowledge of Antihypertensive Drug Use, and Health-Seeking Behavior Among the Elderly with Hypertension in Karawang Regency Salman Salman; Kurniati Nawangwulan; Yosi Meidiawati
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13538

Abstract

Hypertension in the elderly can reduce physical ability, daily activities, and psychological well-being, impacting quality of life. Factors related to the quality of life among the elderly with hypertension, such as demographic characteristics, knowledge of antihypertensive drug use, and health-seeking behavior, have been studied only to a limited extent at the primary healthcare level. This study aims to analyze the relationship between demographic characteristics, knowledge of antihypertensive medication use, and health-seeking behavior (HSB) with the quality of life among the elderly with hypertension in the service area of the Telukjambe Timur Community Health Centre in Karawang Regency. This study uses a quantitative approach with a cross-sectional design implemented in August-October 2025, with 68 respondents selected through purposive sampling. Data were collected using a structured questionnaire. Quality of life was measured using the WHOQOL-BREF, and HSB was assessed using a structured questionnaire developed based on the Andersen Behavioral Model. The analysis was descriptive and bivariate, using the chi-square test. The results showed that the majority of respondents had a good quality of life (76.5%). Knowledge of antihypertensive drug use (OR = 23.333; p = 0.001) and health-seeking behavior (OR = 12.600; p = 0.001) showed the strongest associations with quality of life among elderly with hypertension. These findings indicate that the quality of life of elderly with hypertension is related to their knowledge of drug use and active engagement in healthcare services. Education about antihypertensive therapy and the promotion of health check-ups at health facilities are strategies for supporting the quality of life among the elderly with hypertension.
Xanthine Oxidase Inhibitory Potential of Ficus nekbudu Warb.: A Phytochemical and Bioactivity Study: Xanthine Oxidase Inhibitory Potential of Ficus nekbudu Warb.: A Phytochemical and Bioactivity Study Santoso, Feronia Reni Cyrena; Siregar, Tagor M.; Zendrato, Harti Fornita
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13552

Abstract

Hyperuricemia resulting from excessive xanthine oxidase (XO) activity can lead to gout arthritis. Synthetic compounds such as allopurinol are effective but associated with adverse effects, driving interest in plant-derived alternatives. Ficus nekbudu Warb. (Moraceae) is an underexplored species in a genus with documented pharmacological potential; however, its XO inhibitory activity has not previously been investigated. This research aimed to evaluate the XO inhibitory activity of Ficus nekbudu Warb. leaf extracts. Methods: Leaves were extracted sequentially by reflux using n-hexane, ethyl acetate, and 96% ethanol. Total phenolic content (TPC) and total flavonoid content (TFC) were determined then XO inhibitory activity was measured spectrophotometrically at 290 nm using allopurinol as a positive control, and Pearson correlation analyses were performed. The 96% ethanol extract yields the highest TPC (89.20 ± 3.49 mg GAE/g), while the ethyl acetate extract contains the greatest TFC (137.04 ± 7.19 mg QE/g). All three extracts exhibit XO inhibition, with the n-hexane extract showing the strongest activity (IC₅₀ = 20.58 ± 6.51 µg/mL), followed by ethyl acetate (24.05 ± 5.38 µg/mL) and ethanol (26.30 ± 0.70 µg/mL), compared with allopurinol (3.57 ± 0.06 µg/mL). Ficus nekbudu Warb. leaf extracts demonstrated xanthine oxidase inhibitory activity across different polarity fractions. These findings suggest that phenolic and flavonoid compounds may contribute to the observed inhibitory activity, although further studies are required to clarify the specific active compounds and inhibition mechanism. Overall, Ficus nekbudu Warb. shows potential as a natural candidate for hyperuricemia management.
Uji Aktivitas Antioksidan & Inhibitor α-Glukosidase Bakteri Endofit Daun Jagung (Zea mays L.): Antioxidant and α-Glukosidase Inhibitory Activities of Corn Leaf Endophytic Bacteria (Zea mays L.) Putri Nadia Utami; Muhammad Yunus; Edy Fachrial
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13536

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and closely associated with oxidative stress. The development of natural agents with antioxidant properties and α-glucosidase inhibitory activity is considered a promising approach for controlling blood glucose levels. This study aimed to evaluate the antioxidant activity and α-glucosidase inhibitory potential of endophytic bacteria isolated from corn leaves (Zea mays L.). This study was conducted in vitro through the isolation of endophytic bacteria, followed by macroscopic and microscopic characterization using Gram staining, catalase testing, antioxidant activity evaluation using the DPPH method, and α-glucosidase inhibition assays employing p-nitrophenyl- α-D-glucopyranosidase as the substrate. The results showed that ten endophytic bacterial isolates had diverse morphological characteristics, with Gram staining and catalase test results indicating variations in physiological properties between isolates. All isolates showed antioxidant activity with inhibition percentages ranging from 57.4%–76.8%. Isolate P7 showed the highest antioxidant activity and α-glucosidase enzyme inhibition activity of 97.67%, higher than the positive control acarbose.These findings indicate that corn leaf endophytic bacteria, particularly isolate P7, have potential as a natural source of bioactive with antioxidant and antidiabetic properties through the inhibition of α-glucosidase.

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