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Munir Alinu Mulki
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PharmaCine: Journal of Pharmacy, Medical and Health Science
Published by Universitas Singaperbangsa Karawang
ISSN : 27464199     EISSN : 27464199     DOI : https://doi.org/10.35706/pc.v7i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary
PharmaCine: Journal of Pharmacy, Medical, and Health Sciences is a peer-reviewed journal dedicated to scientific publications in the fields of pharmacy, medicine, and health sciences. PharmaCine is published biannually, in March and September, by the Undergraduate Pharmacy Program, Faculty of Health Sciences, Singaperbangsa University Karawang, in collaboration with the Indonesian Pharmacists Association (IAI). This journal serves as a forum for students, pharmacists, medical personnel, and other health professionals to update their knowledge and access scientific literature. PharmaCine publishes a range of articles, including meta-analyses, original research, reviews, and case reports. Submissions are peer-reviewed to ensure scientific rigor within the relevant field. The scope of the PharmaCine Journal encompasses various pharmaceutical, medical, and health science topics, including: Pharmacology Pharmacotherapy Clinical Pharmacy Pharmaceutical Technology Herbal Pharmacy Social Pharmacy Pharmaceutical Management Clinical Biochemistry Pharmacogenetics Pharmaceutical Chemistry Pharmaceutical Biology Public Health Sciences
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 82 Documents
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Molecular Docking Study of Ageratum conyzoides-Derived Compounds Against the Human Cathepsin G–EapH1 Complex of Staphylococcus aureus: Molecular Docking Study of Ageratum conyzoides-Derived Compounds Against the Human Cathepsin G–EapH1 Complex of Staphylococcus aureus Intan Tsamrotul; Dwina Ramadhani Pomalingo; Nur Afni Syariah Nasar
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13577

Abstract

Under normal physiological conditions, neutrophils circulate throughout the bloodstream in a resting or quiescent state. However, following activation and the phagocytic uptake of opsonized bacterial pathogens, these cells experience substantial functional and physiological alterations that enhance their antimicrobial capabilities. Ageratum conyzoides is a medicinal plant reported to possess antimicrobial activity due to the presence of several bioactive phytochemicals. These compounds may serve as potential candidates for inhibiting bacterial virulence proteins. In addition to having a variety of beneficial biological activities, this compound also has some weaknesses. One of its main weaknesses is its low solubility in water, which can inhibit its bioavailability when consumed. Therefore, molecular docking of the compound Bandotan derivatives was carried out to address these weaknesses. The purpose of this study is to analyze the interaction of the Bandotan compound with the Human Cathepsin-G Inhibited by S. aureus Eaph1 receptor (6VTM); Molecular docking was performed using AutoDockTools 1.5.7, while the absorption, distribution, metabolism, and excretion properties of the compounds were predicted using the pkCSM web server, and their toxicity was evaluated using the ProTox-II web server. The ligand–receptor interactions were visualized using BIOVIA Discovery Studio Visualizer. All compounds derived from Ageratum conyzoides were able to interact with the human cathepsin G–EapH1 complex of S. aureus (PDB ID: 6VTM). Sesamin exhibited the most favorable binding energy of −6.21 kcal/mol, with an estimated inhibition constant (Ki) of 28.22 µM. The compound interacted with Arg977, Asp974, Pro975, Ile981, Asp984, Val980, Gly983, Gln976, Leu979, Glu985, and Gln982 through hydrogen bonds and other noncovalent interactions. Overall, sesamin demonstrated the best docking performance among the evaluated compounds and was identified as the most promising A. conyzoides-derived compound for interaction with the human cathepsin G–EapH1 complex.
In Vitro Antioxidant Activity of Extracts and Fractions from Common Bean (Phaseolus vulgaris L.) Pods and Leaves Using the DPPH Method: In Vitro Antioxidant Activity of Extracts and Fractions from Common Bean (Phaseolus vulgaris L.) Pods and Leaves Using the DPPH Method Dita Meidinata; Novian Liu Wion
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13183

Abstract

Phaseolus vulgaris L. is a legume rich in nutrients and containing a variety of chemical constituents. Although its seeds have been extensively studied, comparative information regarding the antioxidant potential of the pod and leaf particularly in various solvent fractions has not yet been established. The objective of this study was to determine the in vitro antioxidant activity of ethanol extracts, n-hexane fractions, ethyl acetate fractions, and aqueous fractions of the pods and leaves of common bean (Phaseolus vulgaris L.) using UV-Visible spectrophotometry with the 1,1-dipheny l-2-picrylhydrazyl (DPPH) method. Phytochemical screening results indicated that the pods and leaves simplicia of the common bean contain flavonoids, polyphenols, saponins, monoterpenoids, sesquiterpenoids, and quinones. The n-hexane fraction of common bean leaves had an EC50 value of 7.16 µg/mL, and the aqueous fraction of common bean pod had an EC50 value of 10.24 µg/mL, each exhibited the strongest free radical scavenging activity compared to the other extracts and fractions. These values were determined using quercetin as a reference substance, which had a concentration of 0.6321 µg/mL. This indicates that common bean pods and leaves have potential as natural sources of antioxidant compounds. Therefore, further research is needed to isolate the compounds that act as antioxidants in common bean pod and leaf extracts, as well as to study the in vivo antioxidant activity of common beans.

Page 9 of 9 | Total Record : 82

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