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Nur Mahdi
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JPEPT
Published by DSM Publisher
ISSN : -     EISSN : 31243835     DOI : https://doi.org/10.64015/jpept.
Core Subject : Health,
Health Professions Nursing Public Health
Journal of Pharmacology Experiment and Pharmaceutical Technology - (E-ISSN: 3089-7912) is a peer-reviewed open-access journal that publishes original research and review articles in the fields of pharmacology experimental and pharmaceutical technology. This journal serves as a platform for researchers, academicians, and practitioners to share knowledge, innovations, and developments in pharmacology and pharmaceutical sciences. The journal is published four times a year (March, June, September, and December) and adheres to the highest ethical standards in scientific publishing. Each manuscript undergoes a rigorous double-blind peer-review process to ensure its quality and contribution to the field. The journal covers a wide range of topics, including but not limited to: Experimental Pharmacology (drug discovery, pharmacodynamics, pharmacokinetics, toxicology, preclinical studies) Pharmaceutical Technology (formulation, drug delivery systems, nanotechnology, biopharmaceutics, pharmaceutical analysis)
Arjuna Subject : -
Articles 11 Documents
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Formulation of Form Gel Peel Off Mask from Ethanol Extract of Hibiscus Rosa-Sinensis L. Leaves Intana Merdeka Sari; Nur Mahdi; Raisha Hamiddani Syaiful
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.4

Abstract

Cosmetics made from synthetic materials can cause side effects and damage the natural shape of the skin. One of the cosmetics that can repair, care for facial skin, cleanse and moisturize the skin is a peel-off gel face mask. Hibiscus leaves have the potential to be antibacterial containing flavonoids, saponins and polyphenols. This study aims to determine the optimal formulation of a peel-off gel mask preparation of ethanol extract of Hibiscus leaves (Hibiscus rosa-sinensis L) with concentrations of 40%, 60% and 80%. The method used is the Experimental method. The results of the evaluation test of the physical properties of the peel-off gel mask preparation showed that all formulas met the requirements for a good peel-off gel mask. Analysis of research data with one way ANOVA produced a pH test sig. 0.168> 0.05, a spread power test sig. 0.392> 0.05 showed no significant difference in each formula group while in the adhesion test sig. 0.000 < 0.05, drying time test 0.008 < 0.05, viscosity test 0.010 < 0.05 showed significant differences in each formula group. The peel-off gel mask formula of hibiscus leaf ethanol extract (Hibiscus rosa-sinensis L) which has the most optimal physical properties of the preparation is a formula with a concentration of 80%.
FORMULATION AND EFFECTIVENESS TEST OF ANTISEPTIC LIQUID HAND WASHING SOAP PREPARATION FROM TARO LEAF ETHANOL EXTRACT (Colocasia esculenta) Elvita Nurwahdini; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.5

Abstract

The use of natural ingredients as active ingredients with antibacterial activity for making hand soap is still very little. The researcher is interested in conducting research on the formulation and effectiveness test of antiseptic liquid hand soap preparations from ethanol extract of taro leaves (Colocasia esculenta). The extraction process using 70% ethanol solvent at a ratio of 1:10 for 3x24 hours. Phytochemical screening tests were carried out by testing flavonoid compounds, alkaloids, saponins, tannins, and terpenoids. We prepared a Liquid Hand Washing Soap from Taro Leaf Extract (Colocasia esculenta) using a standard formula with three concentrations. Antiseptic Effectiveness Test of Liquid Hand Washing Soap. The method used is the zigzag method. The extraction results obtained were 21.10 grams or 14.06%. The results of the phytochemical screening test were only steroids that showed negative results. Preparation of liquid handwashing soap with concentrations of ethanol extract from taro leaves at 4%, 6%, and 78% can reduce the number of colonies by 30.9%, 51.9%, and 52.5%, respectively.
EFFECTIVENESS TEST OF LARVACIDE FROM COCOR BEBEK LEAF EXTRACT (Kalanchoe pinnata L.) ON Aedes albopictus MOSQUITO LARVAE Sindi Ahmayanti; Nur Mahdi; Andi Zsazsa RM
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.7

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease transmitted by female mosquitoes of the species Aedes aegypti, but sometimes also by Aedes albopictus, which has spread worldwide recently. The goal of this study was to find out how well Kalanchoe pinnata L. (life plant) leaf extract killed Aedes albopictus mosquito larvae. This study used 600 Aedes albopictus larvae in an experimental laboratory setting with a control group that only took the post-test. There were 6 treatment groups: Manila tamarind leaf extract concentrations of 0.2 mg/ml, 0.4 mg/ml, 0.6 mg/ml, and 0.8 mg/ml; a positive control group with temephos; and a negative control group with distilled water. Observations were conducted 24 hours after treatment, with larval mortality counted every hour. The probit analysis indicated that the LC90 for Kalanchoe pinnata L. leaf extract was 12.779 mg/ml, and the LT50 at 0.8 mg/ml, which was the concentration that killed the most quickly, was 48,058 hours. The results show that an extract from Kalanchoe pinnata L. leaves can kill Aedes albopictus mosquito larvae.
ANALGESIC POWER TEST OF MAHOGANY LEAF EXTRACT (Swietenia mahagoni) ON MALE MICE (Mus musculus. L) Linda Sari; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.8

Abstract

Mahogany leaves (Swietenia mahagoni) have flavonoids in them that might help with pain by stopping the cyclooxygenase enzyme from working. The purpose of this study is to see if compounds from mahogany leaves (Swietenia mahagoni) can help relieve pain in mice that have been given acetic acid. This study used the chemical stimulation method (writhing). Twenty-five mice were divided into 5 treatment groups, namely group 1 was given Na-CMC as a negative control, group 2 was given paracetamol at a dose of 1.3 mg/20 gBW as a positive control, and groups 3, 4, and 5 were given mahogany leaf extract (Swietenia mahagoni) at a dose of 2.8 mg/20 gBW, 5.6 mg/20 gBW, and 11.2 mg/20 gBW. Each group was given treatment orally; 30 minutes later, the mice were injected with 1% acetic acid intraperitoneally. Additionally, researchers observed and counted the number of wriggles every 15 minutes for a duration of 90 minutes. This study shows that the ethanol extract of mahogany leaves (Swietenia mahagoni) at a dose of 11.2 mg/20 g BB with a 100% success rate can relieve pain.
Test of the tonic effects of dragon fruit extract (cortice hylocereus polyrhizus) on white miice Nurul Wahdah; Muhammad Riki Shindi Praristiya; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.9

Abstract

Stamina is the body's resistance to fight fatigue within a certain time limit of a person's physical ability to survive at work. Dragon fruit skin contains flavonoid compounds, which have a tonic effect on male mice. This study aims to examine the tonic effect and the dosage used in male mice. We use the Natatory Exhaustion method to determine how drugs affect the coordinates of motion, especially when they reduce central nervous control. This research is an experimental research study. This study falls under the experimental research category. They were divided into 5 treatment groups: group I received Caffeine 100 mg/KgBB as a positive control, group II received Na-CMC as a negative control, and groups III, IV, and V received extract from dragon fruit peel (Cortice Hylocereus Polyhirzus) at doses of 750 mg/KgBB, 1000 mg/KgBB, and 1250 mg/KgBB. We administered oral treatments to each group. Next, observe the length of the mice's swimming duration. The test results data were analysed by the ANOVA analysis method. The results indicated that the extract from dragon fruit peel had a tonic effect on male mice, compared to positive and negative control doses. The three groups of dragon fruit peel extract had different swimming durations of 5.32 minutes, 5.45 minutes, and 5.92 minutes, respectively.
Formulation and Evaluation of the Physical Stability of Liquid Soap Preparations with Sonneratia caseolaris Leaf Extract Muhammad Syarif Hidayatullah; Andi Zsazsa Rafiatul Muklis; Raisha Hamiddani Syaiful; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.11

Abstract

Red pidada leaf (Sonneratia caseolaris L.) is a plant that has benefits as an antioxidant with active compounds such as alkaloids, flavonoids, tannins, terpenoids, and saponins. Usually the local community uses this plant as a wet pupur. The purpose of this study was to determine whether red pidada leaves can be formulated into a liquid soap preparation that meets the requirements of physical properties and stability evaluation. This type of research is true experimental laboratory. Extraction of red pidada leaves is carried out by maceration using ethanol as a solvent. The formulation used three extract concentrations, namely F1 (2%), F2 (4%), and F3 (8%). Parameters carried out in the form of physical properties testing, including organoleptic test, pH, specific gravity, viscosity, foam resistance and stability testing with the cycling test method. The results of organoleptic physical properties testing on the three formulations showed that the F1 preparation was light brown, F2 brown, and F3 dark brown, had a distinctive aroma and had a liquid consistency in F1 and slightly thick in F2 and F3. Testing of pH, specific gravity, viscosity and foam resistance in the three formulations has met the requirements, except for the specific gravity test in the F3 preparation. Testing with the cycling test method has affected the evaluation of physical properties in the three formulations which causes a very thick consistency in the preparation. So that the tests that meet the requirements are only the pH and foam resistance tests, while the specific gravity is only in the F1 preparation.
EXPLORING THE ANTIDIABETIC POTENTIAL OF LANGSAT (Lansium Domesticum L.): A COMBINED EXTRACT APPROACH IN VIVO Juliana Handyka Rosanty Hutasoit; Andi Zsazsa Rafiatul Muklis; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.12

Abstract

Diabetes Mellitus is a chronic condition caused by increased blood glucose levels due to the body no longer being able to produce enough insulin hormone or use insulin effectively. Traditional medicine has long used Langsat, a native plant of Indonesia. Langsat is widely used by the community in treating various diseases, including as a worm medicine, fever medicine, diarrhoea medicine, and cancer medicine. This study aims to find out how well a mix of antidiabetics works with EKDL (Lansium domesticum L) in lowering blood sugar levels in male white mice (Mus musculus) and to figure out the best dose of EKDL for reducing blood sugar in the mice. Experimental research method using 35 white male mice divided into 7 groups, each group containing 5 mice, namely negative control, positive control, EK, ED, EKKDL 1:1, EKKDL 2:1, and EKKDL 1:2. The results of the ANOVA test of the EKKDL dose 1:2 (200 mg / 240 mg / kgBW) were effective in reducing blood sugar levels in mice. Analysis of blood sugar level data of mice using paired T-tests and post hoc. The results of the paired t-test showed a significant difference in blood sugar levels after treatment (p <0.005) and the results of the post hoc test showed that there was a significant difference (p < 0.005) and there was no significant difference (p > 0.005) between all EKKDL in reducing blood sugar levels in mice. The combination of langsat skin and leaf extract (Lansium domesticum L.) has effectiveness in reducing blood sugar levels in experimental animals.
Effectiveness Test Antidiarrhea of the Combination of Ziziphus Mauritiana Leaves and Curcuma Domestica Rhizome on Male Mice (Mus musculus) Rita Muliyani; Andi Zsazsa Rafiatul Muklis; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.14

Abstract

Diarrhea is a disease that experiences an increase in fecal mass and the number of bowel movements is more than 4 times per day. Synthetic drugs are often used to treat diarrhea, but they often cause dangerous side effects. Bidara leaves (Ziziphus mauritiana) and turmeric rhizomes (Curcuma domestica) are often used as alternative treatments to treat diarrhea because they contain potential diarrheal drugs. The purpose of this study is to determine the antidiarrheal effect of a combination of bidara leaf ethanol extract (BLEE) and turmeric rhizome ethanol extract (TREE) on male mice that were given PO with oleum ricini. The research method used was experimental with the induction of oleum ricini diarrhea with a combination dose of EEDB and EERK 4mg:2mg/20grBB, 2mg:4mg/20grBB and 4mg:4mg/20grBB. The results of the study with One Way ANOVA with a confidence level of 95% in this study were < 0.05 which means that there was a significant difference and continued LSD tests in all combination groups obtained a meaningful difference with the positive control group (attapulgite). The results of the study concluded that the combination of bidara leaves (Ziziphus mauritiana) and turmeric rhizomes (Curcuma domestica) had a stronger antidiarrheal effect than positive control (attapulgite).
NATURAL WEAPON AGAINST DENGUE: LARVICIDAL EFFICACY OF PAPAYA (Carica Papaya L.) FRUIT PEEL ETHANOL EXTRACT ON AEDES ALBOPICTUS Nidha Luthfiana Fawziah; Nur Mahdi; Andi Zsaza Rafiatul Muklis; Deni Setiawan
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.17

Abstract

Dengue or, as it is commonly known, dengue fever, has become a public health problem in the world, not only in Indonesia. Until now, dengue disease is still not well controlled. Dengue fever is caused by Aedes argypi and Aedes albopictus mosquitoes. The purpose of this study was to determine the effectiveness of papaya peel extract (Carica papaya L) against Aedes albopictus mosquito larvae. This study is an experimental study of post test only control group design using 600 Aedes albopictus larvae. This study used papaya peel extract with 6 concentration treatment groups of 0.4 mg/ml, 0.8 mg/ml, 0.12 mg/ml, 0.16 mg/ml, positive control group and negative control group. Observations were made 24 hours after treatment and larval mortality was calculated every 1 hour. The results showed that the average larval mortality at a concentration of 0.4 mg/ml was 6.25%, concentration of 0.8 mg/ml was 8.25%, concentration of 0.12 mg/ml was 10.75%, at a concentration of 0.16 mg/ml was 14.5%, for the positive control was 100%, and for the negative control was 0%. The results of probit analysis of LC90 of papaya peel extract amounted to 48.501 and LT50 at the fastest killing concentration of 0.16 mg/ml was 59.017 hours. Based on the results of the study, it can be concluded that papaya peel extract (Carica papaya L.) can kill Aedes albopictus mosquito larvae.
FORMULATION OF LIQUID BATH SOAP WITH PALM LEAF EXTRACT Titin Maulida; Nur Mahdi; Raisha hamiddani Syaiful
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.18

Abstract

Among the world's top producers of palm oil are Indonesia (47,000), Malaysia (19000), Thailand (3450), and Colombia (1,800). Because it contains bioactive substances like flavonoids, alkaloids, steroids, tannins, and saponification, palm oil waste—more especially, palm fronds—has antioxidant potential and can be used as a raw material to make liquid soap and other cosmetics. Through testing of Indonesian National Standard (SNI) parameters, including the organoleptic test, pH, moisture content, free fatty acids, viscosity, and specific gravity, this study seeks to ascertain if the formula of palm leaf liquid soap has a good stability concentration. In order to test the SNI parameters on the stability of the liquid soap preparation on days 1, 7, 14, 21, and 28, this study used an experimental method with variations of three concentrations of palm leaf extract, namely F1 2%, F2 4%, and F3 6%. The pH and specific gravity tests were conducted using the One Way ANOVA method because the results were normally and homogeneously distributed. Since the data for the viscosity and free fatty acid tests were not normally distributed, the Kruskal Wallis method was applied. The formulations F1 2%, F2 4%, and F3 6% were reported to have no discernible effects or differences on days 1, 7, 21, and 28. Because the liquid bath soap formulation in this investigation produced fewer than 15% free fatty acids, it was determined that it did not meet the SNI requirements for liquid bath soap. The free fatty acid test did not satisfy the SNI requirements, despite the pH, specific gravity, and viscosity tests meeting the SNI parameters for liquid bath soap.  

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