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JPEPT
Published by DSM Publisher
ISSN : -     EISSN : 30897912     DOI : https://doi.org/10.64015/jpept.
Core Subject : Health,
Health Professions Nursing Public Health
Journal of Pharmacology Experiment and Pharmaceutical Technology - (E-ISSN: 3089-7912) is a peer-reviewed open-access journal that publishes original research and review articles in the fields of pharmacology experimental and pharmaceutical technology. This journal serves as a platform for researchers, academicians, and practitioners to share knowledge, innovations, and developments in pharmacology and pharmaceutical sciences. The journal is published four times a year (March, June, September, and December) and adheres to the highest ethical standards in scientific publishing. Each manuscript undergoes a rigorous double-blind peer-review process to ensure its quality and contribution to the field. The journal covers a wide range of topics, including but not limited to: Experimental Pharmacology (drug discovery, pharmacodynamics, pharmacokinetics, toxicology, preclinical studies) Pharmaceutical Technology (formulation, drug delivery systems, nanotechnology, biopharmaceutics, pharmaceutical analysis)
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Articles 21 Documents
 1   2   3 
Formulation and Evaluation of the Physical Properties of Clay Mask Containing Ethanol Extract of Kenikir (Cosmos caudatus) Leaves Puspawan Hariadi; Rina Sri Apriani; Baiq Maylinda Gemantari; Tri Puspita Yuliana; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.19

Abstract

The demand for natural-based cosmetic products continues to increase due to their perceived safety and minimal side effects. Kenikir leaves (Cosmos caudatus Kunth) are known to contain active compounds such as flavonoids, tannins, and phenols, which have antioxidant potential and can be utilized in facial mask preparations. This study aims to formulate a clay mask preparation from the ethanol extract of kenikir leaves and evaluate its physical properties. The extract was obtained through maceration using 96% ethanol, and then formulated into three concentrations: F1 (0.5%), F2 (1%), and F3 (2%). The evaluation of the preparation included organoleptic tests, adhesion test, spreadability test, and pH measurement. The results showed that F1 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.3 cm. F2 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.2 cm. F3 had a pH of 6, adhesion time of 4.6 seconds, and spreadability of 5 cm. The evaluation results indicated that all clay mask formulations met the physical quality criteria for clay masks.
POTENSI FRAKSI ETIL ASETAT KULIT BUAH RENGGAK (AMOMUN DEALBATUM ROXB) SEBAGAI AGEN ANTIBAKTERI Puspawan Hariadi; Widia Hidayati; Tri Puspita Yuliana; Baiq Maylinda Gemantari; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i2.1

Abstract

Tanaman renggak (Amomun dealbatum Roxb) merupakan tanaman yang tergolong  dalam jenis tumbuhan aromatik yang termasuk dalam suku jahe – jahean, tanaman ini mengandung senyawa metabolit sekunder berupa flavonoid, Tanin, Alkoloid, Saponin, Steroid yang memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk mengkaji potensi fraksi kulit buah dari tanaman renggak sebagai antibakteri dengan variasi konsentrasi 10%, 20%, 30%, 40% terhadap bakteri staphylococcus aureus dan pseudomonas aeruginosa. Fraksinasi dilakukan menggunakan metode fraksi cair – cair, dan pengujian aktivitas antibakteri dilakukan menggunakan difusi sumuran. Hasil pengujian fraksi pada bakteri staphyloccoccus aureus pada konsentrasi 10%, 20%, 30% dan 40 % masing masing memilik daya hambat sebesar 11,45 mm, 12,19 mm, 13,62 mm, 15,38 mm dan pada bakteri peudomonas aeruginosa masing masing sebersar 8,24 mm, 9,23 mm, 11,16 mm, 12,63 mm, hal ini menunjukan bahwa tanaman renggak memiliki potensi sebagai antibakteri.
Qualitative Analysis of Secondary Metabolites in Beetroot Extract (Beta vulgaris L.) through Phytochemical Screening Teguh Adiyas Putra; Silvia Ainnur Rahmah; Dita Maharani; Dini Rizkiyatul Auliyah; Ade Irawan
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.2

Abstract

Beetroot (Beta vulgaris L.) is a plant rich in bioactive compounds and has significant potential for development in the pharmaceutical field as a natural antioxidant source and raw material for health related products. Secondary metabolites such as flavonoids, tannins, saponins, and alkaloids play an important role in providing biological activities; therefore, their identification is necessary to determine their pharmacological potential. However, scientific information regarding the profile of secondary metabolites in beetroot extract through phytochemical screening remains limited and requires further investigation. This study aimed to analyze the presence of secondary metabolites in beetroot (Beta vulgaris L.) extract through qualitative phytochemical screening. The research employed a laboratory experimental method, with extraction carried out using the maceration technique for three days with 96% ethanol as the solvent. A total of 200 grams of beetroot simplicia were extracted to obtain a concentrated extract, which was subsequently subjected to phytochemical analysis. The screening included the identification of flavonoids, tannins, saponins, alkaloids, steroids-terpenoids, and betacyanin, conducted in triplicate with one blank sample. The results indicated that the beetroot extract positively contained all identified secondary metabolites, suggesting that beetroot has strong potential as a natural source of bioactive compounds and promising applications in the pharmaceutical field.
Identification of Secondary Metabolite Compounds in Black Mangrove Leaves (Rhizophora mucronata Lamk.) Teguh Adiyas Putra; Mariam Ulfah; Nanda Satria Nugraha; Putri Nur Fauziyah; Zahrotun Nisa; Like Efriani
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i2.3

Abstract

Indonesia has a very large mangrove forest area, reaching nearly 3.5 million hectares or about 25% of the world’s total mangrove forests, with one of the dominant species being Rhizophora apiculata which grows in muddy tropical coastal areas. Plant extracts are a potential source of natural antimicrobial compounds because they contain various active substances with bacteriostatic properties that can be utilized as alternative therapies. This study aimed to identify the phytochemical metabolite compounds contained in mangrove leaf extract. The research design used in this study was a laboratory experimental design with a qualitative approach including the identification of flavonoids, tannins, saponins, and alkaloids. The results of the study showed that the phytochemical screening carried out on the mangrove leaf extract indicated the presence of several secondary metabolites, namely flavonoids, tannins, and saponins, which showed positive results in each test. These results conclude that mangrove leaf extract contains phytochemical metabolites including flavonoids, tannins, and saponins. 
FORMULASI DAN UJI EFEKTIVITAS SEDIAAN LOTION ANTIOKSIDAN DARI EKSTRAK ETANOL DAUN SUNGKAI (Peronema Canescens Jack.) Nur Syamsiah; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.4

Abstract

Perawatan kulit penting untuk melindungi kulit dari sinar ultraviolet, oleh karena itu kulit harus selalu dijaga kebersihan, kesehatan, dan perawatannya. Salah satu perawatan kulit yang umum digunakan untuk tubuh adalah lotion yang baik untuk kulit dan dapat melindungi kulit dari sinar ultraviolet dan radikal bebas. Tujuan penelitian ini adalah untuk menentukan aktivitas antioksidan ekstrak etanol daun sungkai (Peronema Canescens jack) menggunakan metode DPPH dengan konsentrasi 15 ppm, 30 ppm, 45 ppm, 60 ppm, dan 75 ppm. Nilai IC50 yang diperoleh adalah 13,661 ppm. Penelitian dimulai dengan pembuatan simplisia kemudian ekstrak yang diperoleh diuji untuk skrining fitokimia dan uji aktivitas antioksidan dan dilanjutkan dengan pembuatan formulasi lotion yang dibuat dengan empat konsentrasi, yaitu F0 (Basis), F1 (0,0015%), F2 (0,003%), dan F3 (0,0045%). Lotion tersebut kemudian diuji untuk evaluasi stabilitas fisik melalui uji organoleptik, homogenitas, pH, dan dispersibilitas. Hasil pengujian antioksidan menggunakan metode DPPH dengan konsentrasi 15 ppm, 30 ppm, 45 ppm, 60 ppm dan 75 ppm memperoleh hasil IC50 dari ekstrak etanol daun sungkai sebesar 13,661 ppm (sangat kuat). Sedangkan hasil uji evaluasi penambahan ekstrak etanol daun sungkai pada preparat tersebut terdapat perbedaan pada uji adhesi. Berdasarkan hasil uji stabilitas fisik, dapat dilihat bahwa formula F1 adalah formula terbaik, dilihat dari hasil uji adhesi yang menunjukkan bahwa formula F1 lebih baik daripada preparat lainnya, sedangkan hasil uji lainnya tidak signifikan
FORMULASI DAN EVALUASI STABILITAS FISIK SEDIAAN KRIM PELEMBAB WAJAH MENGANDUNG EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis. Jacq.) Halimatus Sa'diah; Ani Agustina; Nur Mahdi; Deni Setiawan
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i2.5

Abstract

Ethanol extract of oil palm leaves (Elaeis guineensis Jacq.) is known to have antioxidant activity that has the potential to be developed as an active ingredient in facial moisturizing cosmetics. This study aims to formulate ethanol extract of oil palm leaves into a facial moisturizing cream preparation and evaluate the physical characteristics and stability of the preparation. The study was conducted experimentally in a laboratory with four formulas, namely F0 (0%), FI (0.0133%), F2 (0.0266%), F3 (0.0399%) of oil palm leaf extract. Evaluation of the preparation included organoleptic tests, homogeneity, pH, spreadability and viscosity during 28 days of storage at room temperature. The results showed that all formulas were semi-solid, homogeneous, and organoleptically stable without changes in color, odor, or phase separation during storage. The pH value of all formulas was in the range of 6-7 cm and the viscosity met the requirements of a cream preparation. Statistical analysis showed no significant differences in spreadability and viscosity between the formulas (p>0.05). Based on the research results, the ethanol extract of oil palm leaves can be formulated into a facial moisturizing cream with good characteristics and stability.
FORMULASI SABUN CAIR PEMBERSIH TANGAN EKSTRAK ETANOL 96% DAUN BINTARO (Cerbera odollam): LIQUID HAND CLEANING SOAP FORMULATION WITH 96% ETHANOL EXTRACT OF BINTARO LEAVES (Cerbera odollam) Muhammad Hadiannoor; Andi Zsazsa Rafiatul Mukhlis; Raisha Hamiddani Syaiful
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 1 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.10

Abstract

Daun Bintaro (Cerbera odollam) adalah tanaman yang mampu menghambat Salmonella typhi, Staphylococcus aureus, Streptococcus mutans, dan Escherichia coli dengan kandungan flavanoid, alkaloid, saponin, fenol, tanin dan terpenoid. Dalam penggunaan secara tradisonal, daun Bintaro berfungsi sebagai obat demam kejang. Tujuan penelitian yaitu untuk mengetahui uji sifat fisik secara optimal dan pengaruh konsentrasi ekstrak daun Bintaro (Cerbera odollam). Jenis penelitian menggunakan true eksperimental laboratory. Ekstraksi daun Bintaro menggunakan metode maserasi dengan pelarut etanol 96%. Formulasi menggunakan tiga konsentrasi, yaitu 4%, 5%, dan 6%. Parameter uji sifat fisik yaitu uji pH, penyimpanan suhu ruang, viskositas, ketinggian busa, dan alkali bebas atau asam lemak bebas, lalu dilanjutkan dengan analisis data menggunakan uji Anova dan Kruskal-Wallis. Hasil sifat fisik menunjukkan uji organoleptis mengalami perubahan pada warna dan tekstur yang awalnya hijau kehitaman dan cair menjadi coklat kehitaman dan kental. pada uji ketinggian busa sediaan 4% dan 6% ada dua dari empat penyimpanan suhu ruang yang tidak memenuhi syarat, namun jika dihitung dengan rata-rata tetap memenuhi syarat. Semua konsentrasi pada uji sifat fisik telah memenuhi syarat SNI dan tidak ada perbedaan yang signifikan berdasarkan software spss (> 0.05). Kata kunci: Daun Bintaro, sabun cair, formulasi, sifat fisik, Cerbera odollam
NARRATIVE REVIEW : KAJIAN KANDUNGAN SENYAWA FLAVONOID DAN FENOLIK PADA TANAMAN MANGGA KASTURI (Mangifera Casturi Kosterm.): NARRATIVE REVIEW: STUDY OF FLAVONOID AND PHENOLIC COMPOUND CONTENT IN MANGIFERA CASTURI MANGO PLANTS (Mangifera Casturi Kosterm.) Eka Purnama Sari; Indah Taufiqoh; Reski Tiku Sarampang; Yasmin Shopiah; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 1 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.9

Abstract

Kasturi mango, also known as Mangifera casturi Kosterm. is a plant endemic to Kalimantan that has great potential as a source of bioactive compounds, especially flavonoids and phenolics. These two compounds are known to perform various biological functions, including antioxidants, antibacterials, and anti-inflammatory. The aim of this study was to study and summarize scientific evidence on the content of flavonoids and phenolics in various parts of the kasturi mango plant. The method used included understanding scientific literature from 2013–2025 from bold databases such as PubMed and Google Scholar. Inclusion and exclusion criteria were used to select the collected articles; the result was 30 articles that were evaluated descriptively. The results showed that flavonoids and phenolics were found in the leaves, bark, fruit peel, seeds, and fruit of kasturi mango through qualitative and quantitative analyses. The leaves are the part of the plant with the highest flavonoid and phenolic content. Thus, kasturi mango has great potential to be developed as a source of natural antioxidants and raw materials for natural-based health products.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BATANG BROTOWALI (Tinospora crispa L.) TERHADAP BAKTERI Staphylococcus epidemidis: ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF BROTOWALI STEM (Tinospora crispa L.) AGAINST Staphylococcus epidemicis BACTERIA Sulistiyani Rahmawati; Andi Andi Zsazsa Rafiatul Mukhlis; Raisha Hamiddani Syaiful; Rahmayani Maghfirah
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 1 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.8

Abstract

Skin disease is a fairly common and serious health problem in Indonesia. This problem can occur due to a lack of public awareness of health, resulting in the transmission of diseases, including skin health disorders, such as Staphylococcus epidermidis bacteria. This bacteria causes swelling like acne. One of the plants commonly used is the Brotowali plant. This study aims to determine the antibacterial effectiveness of the ethanol extract of Brotowali stems (Tinospora crisa L.) in inhibiting the growth of Staphyloccocus epidermidis. The method used is an experimental method with a disc diffusion test method. The bacteria used are Staphyloccocus epidermidis bacteria. The test is divided into 5 treatment groups, namely a negative control of sterile distilled water, a positive control of tetracycline, dose I, dose II and dose III. The results of the inhibition zone diameter are indicated by the appearance of a clear area on the disk and data analysis using the ANOVA test followed by the LSD test. The results of the antibacterial inhibition zone diameter in each group were, positive control 19.28 mm, dose I 5.52 mm, dose II 7.88 mm, and dose III 15.32 mm. The results of the Anova test data analysis obtained an antibacterial p-value of 0.015 (α <0.05) there was a significant difference, while the results of the LSD test in the test obtained positive control results with all doses I, II, and III significantly different in inhibiting the growth of the bacteria.
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK KOMBINASI DAUN KASTURI (Mangifera casturi) DAN DAUN KELAPA SAWIT (Elaeis guineensis) TERHADAP BAKTERI Propionibacterium acnes: ANTIBACTERIAL ACTIVITY TEST OF COMBINATION EXTRACT OF MUSHROOMS (Mangifera casturi) AND OIL PALM (Elaeis guineensis) LEAVES AGAINST Propionibacterium acnes Mardhatillah Mardhatillah; Nur Mahdi; Anita Ratna Dilla
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 1 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.7

Abstract

Acne is a common skin disorder worldwide, with a prevalence of 9.4%, mainly affecting adolescents. A key factor is Propionibacterium acnes, which has developed resistance to several antibiotics. This highlights the need for safe, natural alternatives. Kasturi mango leaves (Mangifera casturi) and oil palm leaves (Elaeis guineensis) leaves contain flavonoids and saponins with antibacterial potential. This study aimed to evaluate the antibacterial activity of their combined extracts against P. acnes. The research used an experimental design with the disc diffusion method. Seven groups were tested: single extract of kasturi mango leaves, single extract of oil palm leaves, combinations I (1:2), II (2:4), III (4:4), positive control (erythromycin), and negative control (sterile distilled water). Data were analyzed using SPSS to assess statistical differences. Results showed weak antibacterial activity from the combined extracts. The highest effect, combination III (4:4; 80 mg EDK : 80 mg EDKS), produced a 4.5 mm inhibition zone, still lower than the positive control. This suggests the tested concentrations were insufficient to suppress P. acnes. The Kruskal–Wallis test produced a p-value of 0.014 (p < 0.05), confirming significant differences among groups. Further studies should test higher single-extract concentrations before combining, to optimize antibacterial effects against P. acnes.

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