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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 1,040 Documents
The Efficacy of 0.5 Gram NaCl Capsule in the Treatment of Umbilical Granuloma in Neonates: A Case Report Tubagus Ferdi Fadilah; Nafisa Salma Wulandari; Nia Nurul Aziza; Dita Setiati; Firda Fairuza; Nathalia Ningrum; Meiriani Sari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 2 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i2.47649

Abstract

Background: An umbilical granuloma is a common benign condition in neonates characterized by the overgrowth of granulation tissue at the base of the umbilicus following umbilical cord detachment. While the standard treatment involves the use of silver nitrate, with its associated risks and need for clinical visits, alternative treatments such as the application of sodium chloride (NaCl) capsules have gained attention for their efficacy, safety, and cost-effectiveness in home settings. Case Presentation: Herein, we present the case of a 3-week-old female infant diagnosed with an umbilical granuloma post umbilical cord detachment. The management involved the application of a 0.5 gram NaCl capsule directly to the granuloma, covered with sterile gauze, and repeated over several days. This approach resulted in a significant reduction in granuloma size and total resolution within two days, without the complications or irritation sometimes associated with silver nitrate. Parents reported ease of administration at home and high satisfaction levels due to the treatment's effectiveness and minimal need for healthcare visits. Conclusion: The use of a 0.5-gram NaCl capsule offers a valid and effective home-based treatment alternative for umbilical granuloma. It provides a practical option, especially where access to silver nitrate is limited, with the added benefits of ease of use and reduced medical costs. With proper parental education and adherence to the treatment protocol, NaCl can serve as a first-line or alternative therapy. Further large-scale studies are recommended to verify long-term effects and potential complications. 
SONGGA WOOD (STRYCHNOS LIGUSTRINA BLUME) ASSOCIATED WITH REDUCE TUMOR NECROSIS FACTOR-ALPHA LEVELS IN ARTEMINISIN-BASED-COMBINATION THERAPY-TREATED MALARIA Kis Djamiatun
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 4 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkd (dmj).v14i4.49555

Abstract

Background: The emergence of resistance to artemisinin-based combination therapies (ACTs) complicates malaria control strategies, necessitating novel therapeutic approaches and enhanced surveillance in affected regions. Traditional herbal remedies, such as Songga wood (Strychnos ligustrina Blume), are gaining attention for their potential antimalarial and immunomodulatory properties, offering promising alternatives to combat drug-resistant malaria. Objective: This study aimed to evaluate the effect of ethanolic extracts from the stem of Songga wood (EESWS) on the modulation of TNF-α in malaria treatment with ACTs. Methods: A study used a post-test-only-control-group design with simple-random-sampling involved two treatment groups and three control groups, each with five Swiss-Webster mice. The C1 group was the healthy control, the C2 group was untreated, and the C3 group received ACT. The P1 group was given EESWS at preventive and therapeutic doses, while the P2 group received a combination of EESWS-ACT. Blood samples were collected on the day of the 8th infection to assess parasitemia percentage and plasma TNF-α levels. Results: On day 7 of PbA infection, the untreated C2 group exhibited the highest parasitemia levels (13.20 ± 4.18), while the C3, P1, and P2 groups showed significantly lower levels, with no significant differences among these treated groups (p > 0.05). Significant differences in TNF-α levels were observed, with the untreated C2 group having higher levels compared to the healthy C1 group and all treatment groups. Among the treatments, the P1 group had higher TNF-α levels than both the P2 and C3 groups, while no significant difference was observed between the C3 and P2 groups. Conclusions: All treatment regimens effectively promoted recovery from PbA infection, and the combination of EESWS with ACT appears to facilitate a more balanced modulation of inflammatory responses during the malaria recovery phase.
IRON DEFICIENCY AND GENETIC REGULATION IN TUBERCULOSIS THROUGH MOLECULAR HOST-PATHOGEN INTERACTIONS Grace Puspasari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 1 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i1.52962

Abstract

Background: Anemia is a frequent comorbidity in tuberculosis (TB), often driven by chronic inflammation and dysregulated iron metabolism. Elevated hepcidin levels limit iron availability by suppressing ferroportin, leading to functional iron deficiency and impaired erythropoiesis. Objective: This review discusses the molecular mechanisms linking iron metabolism, host immune response, and Mycobacterium tuberculosis persistence, particularly in the context of drug-resistant TB. Content:  We summarize current knowledge on the hepcidin–ferroportin axis, siderophore-mediated iron acquisition by M. tuberculosis, and the diagnostic value of biomarkers such as ferritin, transferrin saturation, and soluble transferrin receptor. Considerations for iron therapy, including its risks during active inflammation and emerging targeted treatments, are also addressed. Conclusion: Anemia in TB requires a selective, biomarker-guided approach. While iron supplementation may benefit those with true deficiency, improper use can worsen infection. Targeted modulation of iron pathways offers promising therapeutic alternatives.
SEVERE TACTILE ALLODYNIA FOLLOWING SPINAL CORD INJURY: A CHALLENGING CASE OF NEUROPATHIC PAIN MANAGEMENT Rizaldy Taslim Pinzon; Rida Ayu Cahyani; Petra Gusti Parikesit
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 6 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i6.50127

Abstract

Background: Pain management in spinal cord injury (SCI) patients remains a significant clinical challenge, particularly in cases of neuropathic pain and severe tactile allodynia. Despite adherence to standard treatment guidelines, many patients experience inadequate pain relief, leading to reduced quality of life. Tactile allodynia, an exaggerated pain response to non-painful stimuli, is a rare but debilitating manifestation of SCI-related neuropathic pain. Effective management requires a multimodal approach, integrating pharmacological and non-pharmacological interventions. Case Presentation: We present a case of a 52-year-old female with central cord syndrome following a cervical SCI caused by a road traffic accident. Despite surgical decompression and stabilization, she developed severe neuropathic pain characterized by burning sensations and profound tactile allodynia at the injury level. Initial pharmacological treatment with pregabalin and amitriptyline provided minimal relief. Due to persistent pain, the patient was hospitalized and managed with a multimodal approach, including gabapentin, tramadol, baclofen, cognitive behavioral therapy (CBT), and transcutaneous electrical nerve stimulation (TENS). This combination led to significant pain reduction, allowing discharge with an acceptable pain level. Conclusion: This case highlights the complexity of managing severe tactile allodynia in SCI patients. A tailored multimodal treatment approach combining pharmacological therapy with CBT and TENS proved effective in achieving substantial pain relief. Future studies should explore individualized treatment strategies to improve outcomes for patients with refractory SCI-related neuropathic pain.
Potential of Butterfly Pea Cream (Clitoria ternatea) in Skin Regeneration by Increasing the Number of Fibroblasts and Collagen Thickness Rizki Noval Nursyafillah; Buwono Puruhito; Liza Afriliana; Hermawan Istiadi; Galih Sari Damayanti
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 1 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i1.47269

Abstract

Background: Indonesia is a tropical country that has a high exposure to UV radiation that causes. To overcome these effects, antioxidants are needed that can inhibit the effects of UV radiation. Clitoria ternatea, which is rich in flavonoids, is able to fight free radicals and reduce the effects of photoaging. Objective: This study aims to determine the effect of Clitoria ternatea extract cream on the number of fibroblasts and collagen thickness in UVB-induced male white rats. Methods: This study was a true experimental type with a post-test only control group design with 36 male White rats divided into 4 groups. Clitoria ternatea extract cream was administered in 3 levels (2.5%, 5%, 10%) and Synchro® placebo base cream was applied on the rats' back for 30 days. Irradiation was performed 3 times a week, and the cream was applied twice a day. Statistical analysis was performed to see the mean differences between groups in UVB-induced male white rats. Results: The application of Clitoria ternatea extract cream with levels of 2.5%, 5%, and 10% can increase the number of fibroblasts significantly (p<0.05) from 7.40 ± 0.81 to 9.40 ± 1.39; 11.33 ± 1.73; 12.00 ± 1.49. At 5% and 10% levels can increase collagen thickness significantly (p<0.05) from 64.44 ± 5.64 to 70.75 ± 4.44; 77.43 ± 4.27. Conclusion: It can be concluded that Clitoria ternatea extract cream 2.5%, 5% and 10% can increase the number of fibroblasts and Clitoria ternatea extract cream 5% and 10% can increase collagen thickness. Keywords:  Clitoria ternatea; Collagen; Fibroblast; Flavonoid; Photoaging; UVB.
INHIBITORY ACTIVITY OF BIOACTIVE COMPOUNDS IN BLACK SEA CUCUMBER (HOLOTHURIA ATRA) AGAINST FALCIPAIN-2 PROTEIN IN PLASMODIUM FALCIPARUM AS ANTIMALARIA BASED ON IN SILICO STUDY Alifiah Wahyu Nur Fadilah; Prawesty Diah Utami; Nita Pranitasari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.49141

Abstract

malaria treatment, one of which is Holothuria atra. Indonesia is reported as the second-largest contributor to malaria in the Asian. Plasmodium falciparum is the most common malaria-causing parasite in Indonesia. The high incidence of resistance of the malaria parasite Plasmodium falciparum to malaria drugs makes the bioactive compounds in Holothuria atra a very advantageous discovery as a new antimalarial drug. Objective: to determine the inhibitory effects of active compounds in Holothuria atra on the development of Plasmodium falciparum based on in silico studies. Method: The research design used was a one-shot experimental study, contained several stages, including protein and ligand preparation; prediction of bioactive compound potential and target protein; molecular docking and visualization of docking results; and prediction of drug-likeness and absorption, distribution, metabolism, excretion, toxicity (ADMET) Results: Based on the test results, the active compounds are chlorogenic acid, catechin, rutin, coumaric acid, pyrogallol, and ascorbic acid, show inhibition of Falcipain-2, which is used to degrade hemoglobin and erythrocytes in the acidic digestive vacuole. Chlorogenic acid and catechin have the highest binding affinity values. The ADME analysis show that four active compounds, are catechin, coumaric acid, pyrogallol, and ascorbic acid, comply the Lipinski criteria, making them potential candidates for oral drugs. Catechin is the safest compound classified as class 6 toxicity (non-toxic). Conclusion: The research that has been carried out describes the results, that Holothuria atra has the potential to be an antimalarial drug
HEPATIC NF-kB AND CYR61 SUPPRESSION BY HOLOTHURIA SCABRA METHANOL EXTRACT IN A HIGH-FAT DIET AND DMBA-INDUCED BREAST CANCER MOUSE MODEL Demes Chornelia Martantiningtyas; Raden Ghitas Sariwidyantry
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.50957

Abstract

Background: Liver dysfunction is increasingly recognized in the context of breast cancer progression, particularly due to metastasis and systemic inflammation induced by high-fat diet (HFD)1,2 and carcinogens such as 7,12-dimethylbenz[a]anthracene (DMBA). Although some experimental studies have demonstrated the therapeutic potential of sea cucumber extract, its effect on hepatic gene expression in cancer settings remains underexplored.Objective: This study investigates the modulatory effects of methanol extract of Holothuria scabra on NF-κB and CYR61 gene expression in the liver of a breast cancer mouse model induced by HFD and DMBA.Methods: A randomized post-test only control group design was employed using C57BL/6J female mice. Animals were divided into five groups including a normal diet group (ND), a positive control group (HFD + DMBA), and three treatment groups receiving sea cucumber methanol extract (SCME) at doses of 0.33, 0.66, and 0.99 g/kg BW. Liver tissues were harvested for analysis of NF-κB and CYR61 mRNA expression via semi-quantitative RT-PCR.Results: Mice treated with SCME showed dose-dependent reductions in hepatic NF-κB and CYR61 expression. The highest dose (0.99 g/kg BW) significantly downregulated both genes compared to the HFD + DMBA group (p < 0.05).Conclusion: SCME modulates inflammatory and tumorigenic gene expression in the liver, suggesting potential anti-inflammatory and anticancer activity. Further studies are needed to explore molecular mechanisms and clinical relevance.
THE RELATIONSHIP BETWEEN STRESS LEVEL AND SITTING DURATION WITH COMPLAINTS OF LOWER BACK PAIN Dean Nur Aswitiyah Winganti; Erna Setiawati; Rahmi Isma Asmara Putri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 6 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i6.51094

Abstract

Background: Low Back Pain (LBP) is the most complained of musculoskeletal problem in the world. One of the factors causing low back pain is stress. Medical students are at high risk of experiencing LBP due to several factors such as high stress levels, study hours, and lack of physical activity. Another factor causing LBP is sitting for too long. Medical students usually spend >7 hours studying per day. Poor stress levels and long periods of sitting can cause complaints of low back pain in students. Aim: To determine the relationship between stress levels and long periods of sitting with complaints of low back pain in general medical students at Diponegoro University. Methods: This research is a cross-sectional study. Stress levels were measured using the Depression Anxiety Stress Scales 42 (DASS 42) and low back pain was measured using the Modified Oswestry Low Back Pain Disability Questionnaire. Spearman's rank correlation was used in bivariate analysis. The results were significant if the p-value <0.05. IBM SPSS Statistics software was used for statistical analysis in this study. Results: The Spearman correlation test showed significant results (p<0.001) with a moderate degree (r=0.471) between stress levels and complaints of low back pain. The Spearman correlation test showed significant results (p=0.027) with a weak degree (r=0.259) between sitting time and complaints of LBP. Conclusion: There is a relationship between stress levels and long periods of sitting with complaints of lower back pain in Medical students at Diponegoro University.Keywords: low back pain, stress level, sitting duration
Maternal and Perinatal Outcomes of Early and Late Onset Preeclampsia with Severe Features in Secondary Health Care Aryani Aziz; Uqbah Abdul Salam
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 1 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i1.46584

Abstract

Background: Preeclampsia is a condition characterized by new-onset hypertension during pregnancy, which can lead to various complications for both the mother and baby. It is categorized into early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE) based on the timing of onset, each having distinct pathophysiologies and complications. Objective: This study aims to evaluate maternal and perinatal outcomes in patients with early and late-onset severe preeclampsia. Methods: An analytic observational study with a cross-sectional design was conducted at a secondary healthcare facility. The study included 554 women with severe preeclampsia who delivered at the facility, categorized into EO-PE and LO-PE groups. Maternal characteristics and outcomes, as well as perinatal outcomes, were analyzed. Results: Out of the total cases, 40 (7.22%) were EO-PE and 514 (92.78%) were LO-PE. Maternal outcomes such as HELLP syndrome, visual impairment, placental abruption, oliguria, ICU admission, and eclampsia were significantly higher in the EO-PE group. Additionally, perinatal outcomes including birth weight and APGAR scores were notably worse in the EO-PE group. Conclusion: Adverse maternal and perinatal outcomes were significantly more prevalent in early-onset preeclampsia compared to late-onset preeclampsia.
MEIGS SYNDROME MIMICKING MALIGNANCY: A DIAGNOSIS CHALLENGE Ratri Wulandari; Yosi Tamara
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.46840

Abstract

Background: Meigs syndrome is a benign ovarian mass associated with pleural effusion and ascites. The ovarian tumor is typically a fibroma, the most common benign pure stromal tumor, with 10-15% of cases presenting with pleural effusion or ascites. Case Presentation: Here, we present a Meigs syndrome in a 57-year-old woman. This patient complained of an abdominal mass and massive pleural effusion. Multiple uterine myomas and left ovarian solid tumor were found during laparotomy. Following the removal of ovarian mass, the patient’s condition improved, and she was discharged a week after being hospitalized. Conclusion: The clinical symptoms of Meigs syndrome are similar to those of malignant disease. However, with optimal treatment, the outcome of Meigs’s syndrome is generally satisfactory. 

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