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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,085 Documents
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CORRELATION OF WIDAL TITER WITH THE NUMBER OF LEUKOCYTES, LYMPHOCYTES AND NEUTROPHILS IN TYPHOID FEVER PATIENTS Fitriani, Desi; Aliviameita, Andika
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53482

Abstract

Background: Typhoid fever is an acute infection caused by the bacteria Salmonella typhi. In typhoid fever patients, abnormal leukocyte, lymphocyte, and neutrophil counts are often found. Typhoid fever is prevalent in tropical regions, including Indonesia, where it ranks fifth among infectious diseases, affecting 1.6% of the general population. Objective: The aim of this study is to determine the correlation between Widal titer and the number of leukocytes, lymphocytes, and neutrophils in typhoid fever patients. Methods: The research design used quantitative analysis with a cross-sectional method. The study utilized secondary data from 30 respondents patients with typhoid fever at ‘Aisyiyah Siti Fatimah Tulangan Hospital, conducted in April 2024. Results: The research data were analyzed using Spearman's correlation test in SPSS, and the results showed a significant correlation (p=0.014; r=-0.444) between the Widal titer for S. typhi O and S. typhi H with the leukocyte count, no significant correlation (p=0.855; r=0.035) between Widal titers for S. typhi O and S. typhi H with lymphocyte counts, and a significant correlation (p=0.023; r=-0.413) between Widal titers for S. typhi O and S. typhi H with neutrophil counts. Conclusion: Based on the research results, here is a significant correlation between Widal titer and leukocyte count and between Widal titer and neutrophils.   There is no significant relationship between Widal titer and lymphocyte count in patients with typhoid fever.
RECURRENT MALIGNANT PERIPHERAL NERVE SHEATH TUMOR OF THE LEFT FEMUR POST MULTIMODAL THERAPY IN 61 YEARS OLD MALE: A CASE REPORT Zuvarcan, Diaz Alifarizki; Bryan, Christopher; Marwanta, Sri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53468

Abstract

Background: Malignant peripheral nerve sheath tumors (MPNST) are rare, aggressive soft tissue sarcomas with a high rate of recurrence and metastasis. Sporadic MPNSTs, especially in older adults without neurofibromatosis type 1, present additional diagnostic and therapeutic challenges. Case Presentation: We report a 61-year-old male with a recurrent sporadic MPNST of the left femur. Over six years, he underwent three surgical excisions, radiotherapy, and two lines of chemotherapy. Despite initial partial response, the disease progressed with pulmonary metastases. Histopathology revealed spindle cell sarcoma with lymphovascular and skeletal muscle invasion. Conclusion: This case highlights the difficulty of achieving durable control in recurrent MPNST despite multimodal therapy. It underscores the importance of vigilant follow-up, individualized treatment plans, and supportive care in advanced disease settings.
THE PREVALENCE OF SLEEP DISORDERS IN THE DEVELOPMENT OF ACADEMIC AND MENTAL VALUES IN MEDICAL STUDENTS: A QUALITATIVE META-SYNTHESIS Puteri Derajat, Mawar Labbaika
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54877

Abstract

Background: Recent studies indicate that sleep disturbances are highly prevalent among medical students worldwide, and although clinical and educational research has established that inadequate sleep negatively affects cognitive and psychological functioning, the integrated role of sleep disturbances in shaping both academic performance and mental health outcomes is not yet fully understood. Objective: This study examines the prevalence of sleep disturbances among medical students and seeks to identify and understand their associations with academic achievement and mental health conditions. Methods: A systematic literature review was conducted using peer-reviewed journals published between 2020 and 2025, synthesizing qualitative and quantitative findings through narrative and thematic analysis to evaluate patterns across studies. Results: The findings demonstrate that poor sleep quality and insufficient sleep duration were consistently observed to be associated with lower academic performance, increased stress levels, anxiety, depressive symptoms, and burnout, with stronger negative outcomes reported among students in clinical years; sleep quality showed a statistically significant negative correlation with psychological distress and academic decline. Conclusion: The results confirm that sleep disturbances play a significant role in both academic and mental development among medical students, indicating that the study successfully identified the expected relationships; future research should focus on longitudinal designs and intervention-based studies to evaluate causal mechanisms and effective sleep improvement strategies within medical education systems.
COMPARISON OF NORDIC WALKING AND SENAM LANSIA ON FUNCTIONAL CAPACITY IN POSTMENOPAUSAL WOMEN Hakim, Hernanda Haudzan; Julianti, Hari Peni; Dewi, Novita Sari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53238

Abstract

Background: Functional capacity is the ability to perform physical activities without pain or fatigue. In postmenopausal women, there are significant changes in cardiovascular, musculoskeletal, and pulmonary functions, which can lead to a decrease in functional capacity. Regular and controlled physical activity can enhance muscle metabolism and cardiopulmonary fitness, thereby increasing functional capacity. Nordic walking and senam lansia are examples of popular physical activities in the Indonesian community, particularly among postmenopausal women. Objective: To compare the effect of Nordic walking and senam lansia on functional capacity of postmenopausal women. Methods: This study was a quasi experimental pretest-posttest control group design. There were 26 participants divided into two groups: group A (n=13) received Nordic walking training 3 times a week for 12 weeks, and group B (n = 13) received senam lansia 3 times a week for 12 weeks.  Functional capacity is obtained through the measurement of METs scores, converted from the result of 6-minute walking test (6MWT) using the Nury formula. Results: After twelve weeks, there was a significant improvement in METs scores in both the Nordic walking group (p=0.001) and the senam lansia group (p<0.001). There was a statistically significant difference in delta METs score between the Nordic walking group (0.98±0.12) and the senam lansia group (0.40±0.24) (p<0.001). Conclusion: Both Nordic walking and senam lansia improved functional capacity in postmenopausal women after 12 weeks, with Nordic walking producing a greater effect.
PROBIOTIC SUPPLEMENTATION IN INFANTILE COLIC: A COMPARATIVE LITERATURE REVIEW BETWEEN BREASTFED AND FORMULA-FED INFANTS Sais, Vira Cendana; Putri, Erika Aini; Yustisiani, Aliffa Neta; Falakhi, Qoniatunnisa Nuzulul; Penadi, Hafidhania; Amalia, Nurlinah
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53313

Abstract

Background: Infantile colic is a functional gastrointestinal disorder in infants under five months, marked by excessive, unexplained crying, and is increasingly linked to gut dysbiosis and intestinal inflammation. Probiotics may help relieve colic by modulating gut microbiota, with effects differing by feeding type. Objective: This study aims to evaluate the effectiveness of probiotics in managing infantile colic, with a focus on differences in outcomes between exclusively breastfed and formula-fed infants. Methods: This literature review identifies randomized controlled trials and cohort studies involving infants aged 0–12 months that are diagnosed with colic and receiving probiotics. The outcomes are crying frequency and duration, or symptom improvement, and compared effects between exclusively breastfed and formula-fed infants. Seven databases were searched using combinations of relevant keywords, limited to publications from the past five years. Data were synthesized using narrative qualitative analysis. Results: From 1,886 initially identified records, 29 studies met the eligibility criteria after screening and full-text assessment. Among the included studies, 13 investigated probiotics alone, 10 focused on breastfed infants, 4 on formula-fed infants, and 2 involved both feeding types. Most studies supported the efficacy of Lactobacillus reuteri DSM 17938 in reducing crying duration and frequency, particularly in breastfed infants. Formula-fed infants showed variable outcomes, potentially influenced by probiotic strain, feeding composition, and study design. Conclusion: Probiotics, especially Lactobacillus reuteri, demonstrate promising effects in alleviating colic symptoms, predominantly among breastfed infants. Feeding type may act as a modifier of probiotic efficacy, highlighting the need for tailored interventions based on nutritional context.
THE EFFECT OF MUNTINGIA CALABURA ETHANOLIC LEAVES EXTRACT FOR ASPIRIN-INDUCED GASTRIC MUCOSAL DAMAGE Rizky, Almaarif Faiq; Annisaa', Eva; Maharani, Nani; Utomo, Astika Widy
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54192

Abstract

Background: Muntingia calabura leaves have been claimed to relieve pain, fever, inflammation, and many others. Many studies has already prove the potential of these leaves as anti-inflammation, anti-nociceptive, and anti-proliferative. It might have capability to protect gaster from ulcer. Objective: This study aimed to know the effect of Muntingia calabura ethanolic leaves extract (MCELE) for aspirin-induced gastric mucosal damage on wistar rats. Methods: Twenty-five wistar rats is divided into 5 groups. K2 group (aspirin 300 mg/kg. K1, P1, P2, and P3 group received misoprostol 100 mcg/kg, MCELE 100 mg/kg, MCELE 250 mg/kg, and MCELE 500 mg/kg respectively 1 hour before the administration of aspirin 300 mg/kg. All treatments were administered orally once daily for 7 consecutives days. On day 8, all rats were sacrificed, and gastric tissues were collected for histopathological examination. The tissues were stained with hematoxylin and eosin (H&E) and evaluated under light microscopy to assess mucosal damage, including desqumasion, epithelial erosion, and ulceration. Statistical analysis was performed using the Kruskal-Wallis test, followed by the Mann-Whitney test for pairwise comparisons. Differences were considered statictically siginificant at p<0.05. Results: Histopathology test result showed a significant difference between K1 group and K2 group (p=0.003). Each treatment group also showed a significant difference when compared to K2 group (p<0.05). P3 group and K1 group showed a similar effect on rat’s gastric mucosa (p=1.000). Conclusion: Administration of MCELE may lower gastric mucosal damage on wistar rats induced by aspirin, with 500 mg/kg dose is almost as effective as standard drugs (Misoprostol).
RELATIONSHIP BETWEEN KNOWLEDGE LEVELS AND ATTITUDES WITH ADHERENCE TO ANTIRETROVIRAL (ARV) THERAPY OF HIV/AIDS PATIENTS IN RSUP Dr. KARIADI, SEMARANG Ginitri, Arumdipta; Annisaa', Eva; Wulandari, Fitri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.52589

Abstract

Background: Antiretrovirals (ARV) are drugs that People Living with HIV/AIDS (PLWHA) take to enhance quality of life. Therapy adherence (>95%) is required to attain virologic suppression, prevent resistance, therapy failure, and death. Factors affecting adherence are the level of knowledge and attitude. Objective: This study aims to identify the relationship between knowledge level and attitude with adherence to ARV therapy of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang. Methods: Analytical observational research with cross-sectional design using questionnaires, sampling method using purposive sampling. Adherence questionnaire using MARS-5, knowledge and attitude questionnaires were developed by the researcher, and validity and reliability tests were carried out. Univariate analysis using frequency distribution table, and bivariate analysis using Chi-Square test. Results: The level of knowledge of respondents was good at 88.30%, and poor at 11.70%. The attitude was good at 96.81%, and poor at 3.19%. The compliance was high at 65.96%, and low at 34.04%. A significant association was observed between the level of knowledge (p = 0.028) and attitude (p = 0.014) with adherence to ARV therapy. Conclusion: The majority of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang, who received ARVs, the knowledge level was good, the attitude was good, and the adherence was high. There is a relationship between the level of knowledge and attitude with adherence to ARV therapy of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang.
METTL25 EXPRESSION PROFILING ACROSS HUMAN TISSUES AND CANCERS Aziz, Nur; Rahmawati, Laily; Qomaladewi, Nurinanda Prisky
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53300

Abstract

Background: Although recent studies have established the critical roles of methyltransferases in epigenetic regulation and cellular homeostasis, the biological function of METTL25, a member of this enzyme family, is not well known. Current clinical research has identified various methyltransferases as key regulators of gene expression, yet METTL25 remains functionally uncharacterized, representing a significant knowledge gap in our understanding of methyltransferase biology. Objective: This study examines the expression patterns of METTL25 across normal human tissues and cancer contexts to identify its potential physiological and pathological roles and to understand its regulatory mechanisms in health and disease. Methods: We conducted a systematic computational analysis using large-scale publicly available transcriptomic and proteomic datasets. Expression patterns were analyzed across normal human tissues and cancer cell lines. Correlation analysis between mRNA and protein levels was performed, followed by differential gene expression analysis comparing thyroid carcinoma to normal thyroid tissue. Functional enrichment analysis was applied to identify biological pathways associated with METTL25 expression. Results: METTL25 exhibited tissue-specific expression patterns with highest expression observed in endocrine organs (thyroid, adrenal glands) and immune compartments (lymphoid tissues). Moderate correlation between mRNA and protein levels was identified (r=0.404 ; p=0.001), indicating transcriptional control of protein abundance. METTL25 expression was significantly downregulated in thyroid carcinoma compared to normal thyroid tissue (p<0.01). Higher METTL25 expression in tumors was statistically significant and positively correlated with gene signatures related to wound healing, coagulation, and hemostasis pathways. Conclusion: METTL25 functions as a tissue-restricted methyltransferase with tumor suppressor characteristics in thyroid cancer. The positive correlation between METTL25 expression and wound healing pathways was statistically significant, suggesting its involvement in tissue repair mechanisms. These findings provide the foundation for future mechanistic studies investigating METTL25's role in cancer biology and its potential as a therapeutic target.
SCHOOLS BEYOND ACADEMICS: A SYSTEMATIC REVIEW OF PREVENTION STRATEGIES FOR YOUTH ANXIETY AND DEPRESSION Nakia Kalioriza Gurky; Natalie Audrey Susanto; Sarah Novelina Napitupulu
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54326

Abstract

Background: Schools are increasingly recognized as settings that extend beyond academic learning, providing opportunities to promote students’ mental health and well-being. However, depression, anxiety, and behavioral disorders remain the leading causes of illness and disability among adolescents. More than 7% of adolescents aged 13–17 and over 36% of children with behavioral issues are diagnosed with anxiety disorders. Depression is estimated to occur 3.4% of 15–19-year-olds. Given these circumstances, school-based prevention programs have been implemented as a potential strategy to address these concerns. Nonetheless, the effectiveness of such interventions in preventing anxiety and depression remains uncertain. Method: Research was conducted by systematically review searching online literature using Medical Subject Headings (MeSH) terms: “school-based program,” “school,” “adolescents,” “prevention,” “anxiety,” and “depression.” Inclusion criteria comprised open-access studies published between 2020 and 2025, involving children and adolescents aged 5–19 years, and employing experimental or quasi-experimental designs, including randomized controlled trials, with full-text availability. A total of 15 studies were included. Results: 10 studies demonstrated school-based prevention programs promoted positive outcomes in anxiety and depression, while 5 studies reported no significant effects. The prevention programs included CBT-based, physical activity-based, and electronic-based interventions. Conclusion: The findings indicate that Cognitive Behavioral Therapy (CBT)–based, mindfulness, and physical activity–related interventions show the greatest promise in preventing anxiety and depressive symptoms in children.
ASSOCIATION BETWEEN HbA1C AND TRIGLYCERIDE LEVELS IN DIABETES MELLITUS PATIENTS WITH OBESITY Fernanda, Nicky Rayi; Hendrianingtyas, Meita; Setiawan L, Edward Kurnia
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53245

Abstract

Background: The prevalence of type 2 diabetes mellitus (T2DM) continues to increase, while the obese group has a risk of T2DM seven times greater than the non-obese group. Obesity can also increase triglyceride levels with a significant impact on HbA1c. The relationship between increased HbA1c values and triglyceride levels in T2DM with obese patients needs further discussion. While previous studies have shown correlation between HbA1c and triglycerides, evidence remains scarce in obese with type 2 DM patients in Indonesia. Aim: To analyze the association between HbA1c and triglyceride levels in diabetes mellitus patients with obesity. Methods: This study was an observational analytical with a cross-sectional design conducted on 38 subjects from February – October 2022. The data obtained for this research was secondary data from the medical records of T2DM with obese patients at the Diponegoro National Hospital. The independent variable in this research was HbA1c and the dependent variable was triglyceride levels. The correlation analysis was done using Spearman Rank test. Results: The Spearman Rank’s correlation test results between HbA1c and triglyceride levels in T2DM with obese patients were p<0.001 and coefficient correlation = 0.57. Conclusion: There was a significant positive relationship with a strong correlation between HbA1c and triglyceride levels in T2DM with obese patients. This finding supports the importance of HbA1c and triglyceride monitoring in clinical practice, especially in obese T2DM patients, to manage and reduce long-term cardiovascular risk.

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