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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,055 Documents
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PROFILE OF VISUAL FUNCTION AFTER PHACOEMULSIFICATION AT A SECONDARY HOSPITAL Christina Aritonang; Sarah Nia Amru
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.55460

Abstract

  Background: Cataract is the leading cause of preventable blindness worldwide, with the highest burden in developing countries. In Indonesia, East Java has the highest incidence of cataract. Objective: To evaluate the visual function outcomes after phacoemulsification through a social service program at a secondary hospital in Gresik Regency, East Java, Indonesia. Methods This retrospective observational study included 40 patients undergoing phacoemulsification surgery (April 22 to May 15, 2025). Eligible patients were those with mature or immature cataracts, with preoperative vision ranging from mild impairment to blindness, according to WHO criteria. Postoperative evaluations were conducted on days 1 and 14. Data were obtained from medical records and analyzed with the Wilcoxon and Friedman tests using SPSS version 27. Results: Among 40 patients, 37.5% were severely visually impaired and 32.5% were blind preoperatively. Postoperatively, blindness declined to 11.5% on day 1 and 2.5% on day 14, with 45% achieving good vision. Visual acuity and contrast sensitivity showed significant improvement postoperatively (both p < 0.001). Surgical complications included iritis, Descemet’s membrane detachment, elevated intraocular pressure, and one patient did not receive an implant due to a posterior capsular rupture during the surgery. Conclusion: Visual function demonstrates significant early improvements phacoemulsification through this social service program, highlighting the value of assessing multiple visual function parameters in routine postoperative evaluation. 
PREVALENCE OF ALK (D5F3) EXPRESSION IN NON-SMALL CELL LUNG CANCER IN MRCCC SILOAM HOSPITALS Keitaro Joy Suryajaya; Sony Sugiharto
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.52880

Abstract

  Background: Lung cancer is the primary cause of cancer-related illness and death worldwide. GLOBOCAN 2022 reports 2,480,675 lung cancer cases (12.4% of all cancers), with the highest mortality rate (1,817,469 deaths). ALK rearrangement plays a significant role in tumor progression, survival, and metastasis, but the prevalence of ALK-positive tumors varies across populations. Data on ALK rearrangement in multi-ethnic populations like Indonesia remains limited. Objective: To describe the prevalence and distribution of ALK rearrangement in Indonesian NSCLC patients by gender, age, and histological subtype. Methods: This descriptive study uses a cross-sectional design with a retrospective approach based on the results of immunohistochemistry of ALK (D5F3) expression in NSCLC patients. This study included all patients diagnosed with NSCLC who were examined for ALK (D5F3) expression. The exclusion criteria of this study were patients with incomplete data, patients diagnosed with anaplastic large cell lymphoma, and lung metastasis. Results: The prevalence of ALK-positive NSCLC patients at MRCCC Siloam Hospitals Semanggi from 2020 to 2024 was 24 cases (7.8%) out of a total sample of 306. Most cases were male patients, accounting for 14 cases (58.3%). ALK-positive cases were predominantly found in patients aged 60 years and under, accounting for 14 cases (58.3%). Lung adenocarcinoma is the NSCLC subtype that has the highest number of ALK-positive cases, with 21 cases (87.5%). Conclusion: This study reveals a higher prevalence of ALK-positive NSCLC in the Indonesian population. This result provides a treatment option for NSCLC patients who have negative expressions of EGFR and PD-L1, offering them new hope for targeted therapy.
TRANSFORMING MDR-TB TREATMENT: EVIDENCE FOR SHORTER, SAFER, AND COST-SAVING REGIMENS WITH BPAL Rivaldo Heru Setiawan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.52974

Abstract

Background: Tuberculosis (TB) remains a major global public health challenge, with multidrug-resistant TB (MDR-TB) contributing substantially to poor outcomes. Conventional regimens span 18–24 months, leading to limited adherence and treatment success. Shorter treatment regimens (STRs), such as the BPaL regimen (bedaquiline, pretomanid, and linezolid), have emerged as promising alternatives. This systematic review assessed the efficacy, safety, and economic impact of 6-month STRs for drug-resistant TB. Methods: A systematic literature review was conducted in accordance with PRISMA 2020 guidelines. PubMed and ScienceDirect were searched for studies published between 2021 and 2025. Eligible studies included clinical trials, cohort studies, and economic evaluations of regimens lasting ≤6 months. Study quality was appraised using the Joanna Briggs Institute (JBI) Critical Appraisal Tools. Results: Five studies met the inclusion criteria. BPaL regimens consistently achieved high treatment success rates (>80%), with faster sputum conversion and lower mortality compared with conventional injectable-based regimens. For example, one study in Thailand reported 82.1% favorable outcomes with BPaL versus 61–65% with standard long regimens. The all-oral BPaL regimen was generally well tolerated, with substantially fewer serious adverse events such as ototoxicity and nephrotoxicity. Economic evaluations demonstrated significant cost savings for both health systems and patients, alongside gains in disability-adjusted life years (DALYs) averted.   Conclusion: Six-month, all-oral BPaL regimens are effective, safer, and more cost-efficient than conventional MDR-TB therapies. Despite challenges related to drug availability and the infrastructure needed to monitor adverse events, the evidence strongly supports their accelerated global implementation to improve MDR-TB outcomes.
THE ASSOCIATION BETWEEN SERUM VITAMIN D LEVELS AND LIPID PROFILES AMONG PEOPLE WITH EPILEPSY Santoso Jaeri; Elisabeth Shanti Regita Putri; Caraka Adhika Rahardjo; Alivia Azka Fadhilah; Arinta Puspita Wati; Lusiana Batubara; Hardian Hardian
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.54625

Abstract

  Background and Purpose: Epilepsy, a neurological condition, is defined by the occurrence of unprovoked seizures on at least two occasions, with a minimum interval of 24 hours separating the initial and subsequent events. Individuals diagnosed with epilepsy frequently exhibit vitamin D deficiency, which influences various metabolic processes, including modifications to lipid profiles. Despite this, the precise relationship between serum vitamin D levels and lipid profiles continues to be a subject of ongoing investigation. This study aimed to examine the correlation between serum vitamin D concentration and lipid profiles. Methods: A cross-sectional study design was employed, encompassing 29 patients with epilepsy who were treated at the outpatient clinic of the Department of Neurology, Diponegoro National Hospital, Semarang. Participants were divided into two groups based on their serum vitamin D levels: the vitamin D deficiency group (n=9) and the vitamin D insufficiency group (n=20). Demographic and clinical information was gathered, vitamin D levels were measured using ELISA, and lipid profiles were assessed using spectrophotometry. A chi-square analysis was conducted to explore the relationship between serum vitamin D levels and lipid profiles in patients with epilepsy. Results: The average vitamin D concentration was 13.45 ± 5.74 ng/mL, with all participants showing deficient vitamin D. Examination of lipid profiles indicated mean values for total cholesterol at 183.76 ± 38.34 mg/dL, LDL cholesterol at 103.55 ± 34.92 mg/dL, HDL cholesterol at 48.72 ± 15.98 mg/dL, and triglycerides at 158.14 ± 104.48 mg/dL. Statistical analysis revealed that LDL levels were significantly elevated in the group with insufficient vitamin D (p = 0.029), while there were no significant differences in triglyceride, total cholesterol, or HDL levels. Statistical analysis revealed that LDL levels were significantly elevated in the group with insufficient vitamin D (p = 0.029), while there were no significant differences in triglyceride, total cholesterol, or HDL levels. Conclusion: There may be a link between low vitamin D levels and adverse LDL cholesterol levels; however, further research is required to confirm this.
IMPACT OF CHEMOTHERAPY, SURGERY, AND RADIOTHERAPY ON COLORECTAL CANCER PATIENTS: A MULTIFACETED PERSPECTIVE Vito Mahendra Ekasaputra; Abdullah Rizky; Linailil &#039;Ulya; Ragita Shabrina; Chodidjah Chodidjah; Eko Setiawan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.53103

Abstract

Background: Colorectal cancer is a major contributor to cancer-related morbidity and mortality. Multimodal treatment approaches, such as surgery, chemotherapy, and radiotherapy, aim to improve survival and quality of life, yet their impact on various clinical outcomes in Indonesian patients remains underexplored. Objective: This study examines the impact of different treatment modalities on carcinoembryonic antigen (CEA) levels, nutritional status, pain, functional status, and survival in advanced-stage colorectal cancer patients. Methods: This retrospective cross-sectional study reviewed medical records of stage III patients aged 19–64 years treated between 2018 and 2024 at two Central Java hospitals. CEA was measured from serum via ELISA, nutritional status by body mass index (BMI), pain by Numerical Rating Scale (0–10), and functional status by Karnofsky Performance Index (0–100%). Mann–Whitney U and Fisher’s Exact tests were applied (p < 0.05). Results: BMI was lower in the surgery + chemotherapy + radiotherapy group compared with surgery + chemotherapy alone (median 18.6 vs. 20.5 kg/m², p = 0.04). Neoadjuvant + adjuvant chemotherapy was associated with lower postoperative CEA levels (2.6 vs. 7.5 ng/mL, p = 0.02) and higher one-year survival (96% vs. 88%) and higher one-year survival (96% vs. 88%), although this difference was not statistically significant. Pain was lower in the neoadjuvant-only group than in the neoadjuvant + adjuvant group (median NRS 2 vs. 4, p = 0.03), while functional status remained high (>70%) across groups. Conclusion: Neoadjuvant chemotherapy showed favorable trends in CEA reduction, survival, and pain control, while chemoradiotherapy was linked to poorer nutritional status. Despite limitations, these findings provide context-specific evidence to inform multimodal treatment strategies in Indonesia.

Page 106 of 106 | Total Record : 1055

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