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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,100 Documents
 106   107   108   109   110 
THE RELATIONSHIP BETWEEN SUBJECTIVE COMPLAINTS OF LOW BACK PAIN AND SLEEP QUALITY Dinanti Bintang Shahrani; Tanti Ajoe Kesoema; Erna Setiawati; Rahmi Isma Asmara Putri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.53284

Abstract

Background: Low back pain is a frequently occurring symptom closely associated with society, both in Indonesia and globally. It can be influenced by both unmodified and modified factors, such as excessive physical activity, obesity, body posture, and psychological factors. Considering these risk factors, it is known that individuals in the productive age range (<45 years) have a significant risk of experiencing low back pain. Objective: This study examines the correlation between low back pain subjective complaints and sleep quality in students at the Faculty of Medicine Diponegoro University. Methods: Analytical observational study with a cross-sectional design. Research subjects are students from the Faculty of Medicine, Diponegoro University, Semarang, which were selected using consecutive sampling. The low back pain subjective complaint is determined using the NRS and sleep quality data are determined by PSQI questionnaire. The relationship between the low back pain subjective complaint and sleep quality is analyzed using the Chi-Square correlation test and Fisher’s Exact alternative test. Results: From a total of 51 research subjects, the analysis of subjective low back pain complaint scores in relation to sleep quality yielded a p-value of 0.362. Therefore, it can be concluded that there is no significant relationship between subjective low back pain complaint scores and sleep quality. Conclusion: There is no relationship between the subjective complaints of low back pain and sleep quality among students at the Faculty of Medicine, Diponegoro University.
ASSOCIATION BETWEEN FAMILY SUPPORT AND THE SEVERITY OF FATIGUE IN PATIENTS UNDERGOING REGULAR HEMODIALYSIS Sandra Rosa Uli Siahaan; Riri Andri Muzasti; Gema Nazri Yanni; Devira Zahara
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.53499

Abstract

Introduction: Numerous studies indicate that fatigue is among the most frequently reported side effects in hemodialysis, and if left unaddressed it can negatively affect their quality of life. Conversely, family support may significantly enhance the quality of life for hemodialysis patients. This study explore the association between family support and fatigue in patients undergoing regular hemodialysis. Methods: This study used a cross-sectional survey design involving patients who regularly received hemodialysis at Haji Adam Malik Hospital. Participants were selected through consecutive sampling. Fatigue levels were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Questionnaire, which was translated into Bahasa. Family support was assessed using the Family Support Questionnaire developed by Rosyidah. The data collected from the sampling were analyzed using SPSS version 27. Results: Among the 100 hemodialysis patients, 62% reported recieving good family support, 26% reported recieving enough family support, and 12% reported recieving low family support. A survey indicated that 48% of respondents felt mild fatigue, while 36% reported moderate fatigue, and 16% felt severe fatigue. Spearman Ranks test showed a significant association between family support and fatigue (r=0,378 ; p=<0,01). Conclusion: Family support is significantly associated with fatigue in regular hemodialysis patients.
COMPARATIVE DOCKING ANALYSIS REVEALS DIVERGENT SGLT2 SELECTIVITY, FAVORING DAPAGLIFLOZIN I Dewa Agung Panji Dwipayana; Ni Luh Putu Kayika Febryanti; Made Pharmawati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.53412

Abstract

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used in type 2 diabetes therapy, but selectivity over SGLT1 is critical to minimize gastrointestinal side effects. Objectives: To evaluate and compare the selectivity of SGLT inhibitors, especially Dapagliflozin and Empagliflozin, toward SGLT1 and SGLT2 through molecular docking to inform future inhibitor design. Methods: This study used molecular docking to compare the binding profiles of five SGLT inhibitors, Dapagliflozin, Empagliflozin, Canagliflozin, Sotagliflozin, and LX2761, against SGLT1 and SGLT2 transporters Results: Dapagliflozin was the only compound to show statistically significant selectivity for SGLT2 over SGLT1 (p = 0.036), while Empagliflozin and others lacked significant differences in isoform affinity. Although Empagliflozin exhibited slightly stronger nominal binding energy to SGLT2 than Dapagliflozin, ligand efficiency (LE) analysis indicated that this was primarily due to its larger molecular size, affirming Dapagliflozin’s more efficient binding. Interaction analysis further revealed that Dapagliflozin formed a clean, stabilizing pose within the SGLT2 pocket, free of repulsive interactions, unlike Empagliflozin, which displayed an unfavorable donor-donor contact in the same site. Conclusion: These findings support the structural basis for Dapagliflozin’s higher selectivity and reinforce its profile as a SGLT2-specific agent.
ANALGESIC EFFECT OF KUMIS KUCING (ORTHOPSIPHON STAMINEUS) IN MICE (MUS MUSCULUS) WITH WRITHING METHOD Joana Anjelia Nai Da Cruz; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.51910

Abstract

Background: Pain is an unpleasant sensation that can range from mild to severe, causing discomfort and potentially disturbing daily activities. Therefore, pain management and treatment are necessary. Kumis kucing (Orthosiphon stamineus) is a traditional medicinal plant known to contain flavonoids with anti‑inflammatory and analgesic properties that can help alleviate pain. Objective: This study aimed to investigate the analgesic activity and determine the effective dose of Orthosiphon stamineus extract. Methods: The design of this study was a true experimental post‑test‑only randomized controlled group. Pain was induced using a 1% acetic acid intraperitoneal injection to evoke the writhing reflex in mice. The writhing reflex was observed every 10 minutes for 1 hour, and the data were analyzed using one‑way ANOVA followed by a post‑hoc test. Results: The results revealed significant differences in analgesic activity between the P1 and P3 groups, as well as between the P2 and P3 groups (p < 0.05), indicating that the kumis kucing extract at a dose of 0.24 mg/gBW effectively reduced pain, as demonstrated by a decreased total number of writhing reflexes. The pain protection percentage at the 0.24 mg/gBW dose was 48.75%. Conclusion: Kumis kucing extract has significant analgesic activity, with the most effective dose being 0.24 mg/gBW.
PROCIDENTIA UTERI AND RECTOCELE CONCOMITANT WITH ANEMIA OF HEMORRHOIDS GRADE IV: A CASE REPORT Gustie Nanda Riyan Pratama; Muhammad Guntur Adriadi Nugroho; Kusmardanu Setyo Sejati; Aditia Ndaru Firmansyah
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.55517

Abstract

Background: Pelvic organ prolapse in older women remains a major reproductive health issue in gynecology. Decreased pelvic floor compartment strength, which can affect multiple structures, presents new challenges beyond the scope of gynecology. Understanding the pathophysiological cascade from one compartment to another is essential to help determine appropriate initial therapy for individuals suffering from pelvic organ prolapse. Case presentation: In this case report, a patient with severe uterine prolapse for one month developed rectal prolapse and severe hemorrhoids, leading to anemia. Definitive management should be postponed to allow initial management to improve the patient's general condition. Conclusion: Asymptomatic pelvic organ prolapse should not be ignored, as it can lead to the development of other diseases and reduce the individual's quality of life. Chronic increased intra-abdominal pressure can lead to pelvic organ prolapse in more than one compartment and ultimately impair venous return. Pessary ring placement is the first option if the prolapsed mass can fully retract into the vaginal introitus. However, regular monitoring is mandatory to avoid complications after pessary ring installation.
ACUTE UPPER GASTROINTESTINAL HAEMORRHAGE CAUSED BY NON-CIRRHOTIC GASTRIC VARICES BLEEDING IN A PATIENT WITH ANTIPHOSPHOLIPID SYNDROME : A CASE REPORT Rizky Rakhmayanti; Hesti Triwahyu Hutami; Budi Setiawan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.54244

Abstract

Background: Gastric varices are intricate vascular connections linking the portosplenic venous circulation with systemic abdominal and thoracic veins. Gastric varices tend to bleed more massively and are more difficult to control endoscopically than oesophageal varices. They have a higher rebleeding and mortality risk. The management is also more complex, often requiring combined approaches such as endoscopic therapy, radiologic interventions, vasoactive agents, and sometimes shunt procedures. The hemodynamic instability in acute bleeding, coagulopathy, and portal hypertension could also complicate resuscitation and therapeutic options. In this report we describe a case of a woman, previously diagnosed with Antiphospholipid Syndrome (APS), presented with acute upper gastrointestinal haemorrhage caused by non-cirrhotic gastric varices bleeding. Case presentation: a 37-year-old female patient was admitted to the Emergency Department with the primary complaint of hematemesis. She has a history of Antiphospholipid Syndrome 3 years prior and was given anticoagulant therapy but she didn’t continue the therapy. The contrast CT of the abdomen showed that there was a thrombus within the main portal vein. She was given packed red cells transfusion and later underwent esophagogastroduodenoscopy (EGD). The EGD result showed that she had oesophagus varices grade 1 and gastric varices GOV 2. The gastric varices GOV 2 was treated with cyanoacrylate glue injection to stop the bleeding. After she was stabilized, she was given warfarin to continue the anticoagulant therapy. Conclusion: Antiphospholipid syndrome can cause a hypercoagulable state and portal vein thrombosis which later present as gastric varices bleeding and needs a careful treatment approach
VITAMIN D AND INSULIN RESPONSE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: AN IN VIVO INVESTIGATION Rendri Bayu Hansah; Kurnia Maidami Handayani; Widia Sari; Ghaniyyatul Khudri; Syandrez Prima Putra; Roland Helmizar
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.53717

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a widespread global health problem, defined by increasing insulin resistance and gradual deterioration of β-cell function. Vitamin D is posited to influence glucose metabolism, although the evidence about its impact on insulin dynamics is inconsistent. Objective: This study evaluated the effect of vitamin D supplementation on insulin levels in a streptozotocin (STZ)-induced diabetic rat model. Methods: Twenty-five Sprague Dawley rats were randomly assigned to five groups: A (healthy control), B (healthy + vitamin D 415 IU/day), C (T2DM control), D (T2DM + 415 IU/day), and E (T2DM + 1,100 IU/day). Diabetes was induced using a high-fat diet followed by STZ injection. Vitamin D supplementation was given orally for 30 days. Serum insulin and vitamin D were measured by ELISA, and group differences were analyzed using one-way ANOVA with Bonferroni post hoc testing. Results: Insulin concentrations differed significantly across groups (p = 0.022). Healthy rats receiving vitamin D (Group B) exhibited higher insulin levels compared with both diabetic controls (p = 0.004) and diabetic rats supplemented with the same dose (p = 0.005). Higher-dose supplementation in diabetic rats (Group E) showed only a nonsignificant trend toward increased insulin (p = 0.224). No significant correlation was observed between serum vitamin D and insulin levels (r = 0.171, p = 0.415). Conclusion: Vitamin D supplementation markedly enhanced insulin secretion in healthy rats but did not improve insulin output in diabetic rats. These findings suggest that vitamin D’s stimulatory effects on insulin may be more pronounced in healthy or early metabolic conditions and less effective in established diabetes.
MANAGEMENT OF ORIF IN PATIENTS WITH MAXILLOFACIAL FRACTURES Ega Iqomatul Haque; Zuyyina Maisura; Farizqa Nadila Sofiana; Muhammad Reza Pahlevi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.55833

Abstract

Introduction: A strong enough impact can cause fractures in the facial area. The most common cause of facial bone fractures is traffic accidents in two-wheeled motor vehicles. Most jaw and facial fractures occur in young men aged 16–40 years. Case Report: A 19-year-old male patient came to Dr. Kariadi Semarang Hospital, complaining of a choking bite when opening and closing the mouth after a single traffic accident. Extraoral examination showed facial asymmetry, subconjunctival bleeding dextra sinistra, palpable step off infra orbital region dextrasinistra, maxillary dextrasinistra, frontonasalis, mandibular symphysis region, and floating palpation  of the maxilla. Intraoral examination showed a 1-finger mouth opening,  an anterior bite open, vulnus laceratum anterior mandibular region of teeth 31-41 and superimposed segments  of maxillary sinistra teeth 22-23. Open Reduction and Internal Fixation (ORIF) has  been carried out with miniplates and screws as well as the installation  of Interdental Fixation (IDW) and Intermaxillary Fixation (IMF) Discussion: The main principles of fracture management are infection control, fracture fragment reduction, fixation, and immobilization. Reductions must be made to restore function and aesthetics. The occlusion should be used as a guide, so that when occlusion is achieved, the mastication function also functions properly. ORIF is the gold standard in fracture management. Conclusion: Maxillofacial fractures can be caused by various traumas, they can occur alone or at the same time as other fractures. ORIF followed by IDW and IMF insertion may be a comprehensive treatment option in maxillofacial fractures to restore good bone occlusion, aesthetics, and fixation function. 
RELATIONSHIP BETWEEN PLATELET COUNT AND BLEEDING INCIDENCE IN ACUTE LEUKIMIA Raisandra Odina Prihatono; Anugrah Riansari; Setyo Gundi Pramudo; Edward Kurnia Setiawan L
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.53249

Abstract

Background: Acute leukemia is a disease caused by abnormal maturation of hematopoietic cells in the bone marrow. Acute leukemia is classified based on the hematopoietic cells involved, which consist of Acute Myeloblastic Leukemia (AML) and Acute Lymphocytic  Leukemia (ALL). Acute leukemia condition can cause thrombocytopenia which occurs due to somatic mutations in the bone marrow  so the formation process of platelet is disrupted. A certain decrease in the number of platelets can increase the risk of bleeding in patients. Objective: To analyze the relationship between platelet count and bleeding in acute leukemia patients. Method: This study was an analytic observational study with a cross-sectional approach and analyzed the relationship between platelet count and bleeding in acute leukemia patients. Samples were taken from medical records of acute leukemia patients (AML and ALL) who fulfil inclusion and exclusion criteria from RSUD Ulin Banjarmasin. Results: Based on the analysis, there was no relationship between platelet count and bleeding in acute leukemia patients, both types of AML and ALL (p>0.05). It is also known that the highest number of platelets in acute leukemia patients types AML and ALL is found in the range of platelet counts that fall into the category of severe thrombocytopenia (>20.000 - ≤50.000/µL). The bleeding incident that occured in acute leukemia patients in this study were very diverse including petechiae, gingival bleeding, epistaxis, menometrorrhagia and gastrointestinal bleeding. Conclusion: There is no relationship between platelet count and bleeding incidence in acute leukemia patients of LMA and LLA types.
BRIEF COGNITIVE BEHAVIORAL THERAPY (CBT) FOR ADOLESCENT SOMATIC SYMPTOM DISORDER IN PRIMARY CARE : A CASE REPORT Dellma Anggini; Mualimin Mualimin
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.55276

Abstract

Background: Somatic Symptom Disorder (SSD) in adolescents is frequently associated with Adverse Childhood Experiences (ACEs), such as bullying. In primary care settings with limited access to specialist resources, structured brief interventions are urgently required. Case Presentation: A 16-year-old male presented with recurrent syncope, dyspnea, and diaphoresis over the past six months. These symptoms were triggered by traumatic memories of physical bullying experienced during elementary school. The patient underwent a Brief CBT intervention consisting of six sessions (30 minutes per session). The protocol included ABC model psychoeducation, the "Worry Time" technique, cognitive restructuring, and behavioral activation. Clinical progress was monitored through patient-reported outcomes. Significant improvement was observed. Anxiety attacks and somatic symptoms decreased from daily occurrences to once per month. The patient showed enhanced emotional regulation and successfully returned to regular school activities. While these outcomes rely on clinical observation and lack standardized psychometric scales, they indicate a positive recovery trend. Conclusion: This case suggests that Brief CBT could be a promising, effective, and safe modality in primary care for managing trauma-related somatic symptoms in adolescents, highlighting its potential as a scalable intervention in resource-limited settings.

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