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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,100 Documents
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EFFECTIVENESS OF SILVER SULFADIAZINE ON WOUND HEALING AND INFECTION IN SPRAGUE DAWLEY RATS Almeric Rosali; Bernardus Parish Budiono; Neni Susilaningsih; Yora Nindita; Endang Mahati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.49093

Abstract

Background: Surgical Site Infections (SSIs) are postoperative infections categorized into superficial, deep, and organ/ space infections, mostly caused by endogenous bacteria. Silver sulfadiazine as topical antimicrobial are widely used, though its effectiveness in SSIs remains unproven. Current research focuses on its impact on lymphocyte and collagen levels in animal models to better understand its role in SSI management. Objective:  This study aimed to verify the use of silver sulfadiazine in Sprague Dawley rat models in improving healing process of SSIs. Methods: The study used a post-test only control group design to evaluate wound treatments on infected wound in rats. Thirty rats were divided into three groups: negative control (0.9% NaCl), positive control (0.9% NaCl + gentamicin), and treatment (0.9% NaCl + silver sulfadiazine). Standard wounds were treated accordingly and on day 14, tissue samples were analyzed for fibroblasts, neutrophils, macrophages, collagen, and wound diameter. Data were analyzed using One-Way ANOVA or Kruskal-Wallis for significant differences (p < 0.05). Results:  Study showed treatment group had significantly higher fibroblast (p = 0.04), neutrophil (p = 0.00), and macrophage counts (p = 0.00), as well as collagen levels (p = 0.00), compared to both positive and negative control group. Wound size in treatment group was also significantly smaller. Conclusion: Silver sulfadiazine significant reduced fibroblast, neutrophil, macrophage, and collagen counts, as well as wound size.
COMPARISON OF HIGH-FLOW NASAL CANNULA AND NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE FOR RESPIRATORY SUPPORT IN PRETERM INFANTS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Fadhilah Apriliandri; Danny Yovita Maharani; Amelina Ratih Listyaningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.53718

Abstract

Background: High-flow nasal cannula (HFNC) has gained increasing use as a non-invasive respiratory support for preterm infants, yet its relative effectiveness and safety compared with continuous positive airway pressure (CPAP) remain uncertain. Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) enrolling preterm infants (<37 weeks gestation) who received either HFNC or CPAP. Comprehensive searches were conducted in PubMed, Cochrane Library, ClinicalTrials.gov, Scopus, and EBSCOhost from 29 May, 2025 to August 17, 2025. The principal outcomes were treatment failure and the requirement for mechanical ventilation. Results: Twenty-one RCTs including 2,289 participants met eligibility criteria. Pooled analyses demonstrated no significant differences between HFNC and CPAP in preventing treatment failure (RR 1.18; 95% CI 0.91–1.52) or the need for mechanical ventilation (RR 0.97; 95% CI 0.81–1.16). HFNC was associated with lower rates of nasal trauma, abdominal distension, and pneumothorax. Other endpoints, such as duration of oxygen therapy, time to achieve full enteral feeds, and length of hospitalization, did not differ substantially between the two groups. Conclusion: HFNC appears to be as effective as CPAP in preterm infants, with additional advantages in safety and patient comfort. It may therefore represent a reasonable alternative to CPAP, provided that clinical context and individual patient factors are taken into account.
COMPARISON OF LINE DANCE AND SENAM LANSIA ON EXECUTIVE FUNCTION IN COMMUNITY-DWELLING OLDER ADULTS: A QUASI-EXPERIMENTAL STUDY Nazlah Faradila Utari; Satria Wardana; Hari Peni Julianti; Erna Setiawati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.54328

Abstract

Background: The aging population worldwide has increased interest in interventions that can preserve cognitive function, particularly executive function, among older adults. In Indonesia, senam lansia is an accessible form of aerobic exercise for the elderly, while line dance has gained popularity as a more engaging alternative that may offer long-term engagement. However, their comparative effects on executive function remain understudied. Objective: This study compares the effects of senam lansia and line dance on executive function in community-dwelling older adults. Methods: A quasi-experimental, non-randomized, pre- and post-test-controlled design was conducted involving 36 older adults. Participants were assigned to line dance or senam lansia groups, each completing 3 times 60-minute sessions for six weeks. Executive function was assessed pre- and post-intervention using the Stroop Test and Trail Making Test B (TMT-B). Baseline demographic characteristics were compared to identify group differences. Results: The line dance group was younger (64.90 ± 5.45 vs. 68.75 ± 4.99 years) and entirely female, while the senam lansia group included 25% men; adjusting for sex did not alter the cognitive outcomes. Stroop and TMT‑B scores showed no meaningful pre–post changes in either group, and intergroup comparisons were nonsignificant. Effect sizes were negligible for Stroop test, with intragroup effects were d = 0.00 (senam lansia) and d = –0.33 (line dance), with a small intergroup effect (d = –0.38). TMT‑B showed similar pattern, with intragroup effects (≈0.26–0.27) and a very small between‑group difference (pooled d ≈ 0.76). Conclusion: Short-term participation in senam lansia and line dance did not produce statistically or clinically significant improvements in executive function.
CORRELATION BETWEEN STRESS AND ANXIETY AND ACADEMIC BURNOUT AMONG FIRST-YEAR MEDICAL STUDENTS AT DIPONEGORO UNIVERSITY Salsabila Dewi Febrianti; Hang Gunawan; Widodo Sarjana; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.53413

Abstract

Background: Entering university is a critical transition for first-year students, marked by numerous academic, social, and personal adjustments. Navigating these changes requires substantial mental resilience. Failure to adapt may lead to psychological strain, particularly stress and anxiety, which can escalate into academic burnout. Medical students are at higher risk than other undergraduates. Objective: To analyze the relationship between stress, anxiety, and academic burnout among first-year medical students. Methods: This analytical cross-sectional study involved 81 first-year medical students from the Faculty of Medicine, Diponegoro University. Participants were recruited through purposive sampling. Stress levels were assessed using the Perceived Stress Scale (PSS), anxiety was measured with the Beck Anxiety Inventory (BAI), and academic burnout was evaluated using the Maslach Burnout Inventory–Student Survey (MBI-SS). Descriptive statistics were applied to present frequency distributions, while correlations were examined using Spearman’s rank and Lambda tests. Results: Most participants experienced moderate stress (55.6%), mild anxiety (60.5%), and moderate academic burnout (48.1%). Stress was very strongly correlated with academic burnout (r = 0.799, p < 0.001), while anxiety showed a strong correlation (r = 0.597, p < 0.001). Conclusion: Stress and anxiety were both significantly associated with academic burnout in first-year medical students. Stress exhibited a very strong positive relationship, whereas anxiety demonstrated a strong positive association. These findings highlight the importance of early intervention strategies to reduce stress and anxiety, while also underscoring the need for stress management and mental health support programs tailored to early-year medical students to mitigate burnout risk.
COMPLEXITIES IN MANAGING GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA: A CASE REPORT OF TOTAL GASTRECTOMY WITH DISTAL ESOPHAGECTOMY, D2 LYMPHADENECTOMY, AND ROUX-EN-Y ESOPHAGOJEJUNOSTOMY Rudi Pandapotan Napitupulu; Vincent Nathanael Parhorasan Napitupulu; Christopher Christopher; Jovan Amadeo Muliyanto; Kellyn Trycia Zenjaya
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.54108

Abstract

Background: Adenocarcinoma of the gastroesophageal junction (GEJ) poses significant diagnostic and therapeutic challenges due to its complex anatomy and variable treatment approaches between Eastern and Western guidelines. In Indonesia, where resources are limited, the Japanese Gastric Cancer Association (JGCA) guideline is often adapted for surgical management. Case Presentation: We present a 55-year-old man with progressive dysphagia, significant weight loss, and upper gastrointestinal bleeding for four months. Laboratory tests showed elevated tumor markers. Endoscopy revealed a nodular mass at the GEJ extending into the gastric corpus, confirmed by contrast-enhanced abdominal computed tomography (CT). The patient underwent total gastrectomy, distal esophagectomy, and D2 lymphadenectomy in accordance with JGCA guidelines. Reconstruction was performed using Roux-en-Y esophagojejunostomy. Histopathology confirmed a locally advanced, moderately differentiated adenocarcinoma (cT4, N3a). At one month follow-up, the patient reported symptomatic improvement. However, at two months he developed pleural effusion, ascites, and clinical deterioration, and ultimately died from multiple organ dysfunction syndrome (MODS). Conclusion: This case highlights both the technical feasibility and the limitations of radical surgery for advanced GEJ adenocarcinoma. Although total gastrectomy with distal esophagectomy and D2 lymphadenectomy was performed to optimize oncological clearance and symptom control, the outcome underscores the importance of achieving negative margins, integrating multimodal therapy, and addressing the challenges of managing complex upper gastrointestinal cancers in resource-limited settings.
TYPE 1 BRUGADA ELECTROCARDIOGRAM PATTERN IN PATIENT WITH RECURRENT HYPOKALEMIA : A CASE REPORT Melinda Veronica; Yaya Suryana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.54093

Abstract

Background: Brugada syndrome is a rare and potentially fatal arrhythmogenic disease characterized by ST-segment elevation in the right precordial lead.1–3  The Brugada electrocardiogram pattern can be triggered by different conditions, such as hypokalemia. Hypokalemia is characterized by a decreased level of potassium in the blood. The causes of hypokalemia vary, leading to different therapeutic approaches depending on the mechanism. Hypokalemia is known to potentially trigger arrhythmias. Therefore, recurrent hypokalemia with the electrocardiogram pattern of Brugada raises questions about their correlation. Case Illustration: A 22-year-old male presented to the Emergency Room at Sultan Fatah General Hospital with weakness in all four extremities. An electrocardiogram was performed, which revealed an elevation of the ST-segment in leads V1-V3. Further history-taking indicated no clinical signs or symptoms of arrhythmia, syncope, or sudden death in the patient's complaint, past medical history, or family history. Physical examination showed motor strength in the upper and lower extremities with a symmetrical value of 4 on both the right and left sides. Laboratory tests confirmed severe hypokalemia. The patient was admitted and received parenteral and oral potassium correction. Conclusion: Hypokalemia can trigger arrhythmias, one of which is the type 1 Brugada electrocardiogram pattern. Understanding the relationship between hypokalemia and Brugada syndrome can help medical professionals identify, manage, and educate patients and their families about the condition. This will ensure that the patients receive appropriate treatment for the underlying cause and enable early detection of the risk of sudden death.
COMPARISON OF SCORING SYSTEMS IN ASSESSING THE RISK OF MALIGNANCY IN OVARIAN CYSTS: A LITERATURE REVIEW AND CLINICAL IMPLICATIONS I Gde Sastra Winata; Jessica Nathalia
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.54325

Abstract

Background: Preoperative assessment of ovarian cysts with suspected malignancy requires reliable scoring systems to distinguish between benign and malignant lesions. Several scoring systems have been developed, including the Risk of Malignancy Index (RMI), IOTA Simple Rules, and IOTA ADNEX. Objective: To review the literature on the diagnostic accuracy of these scoring systems, compare their strengths and weaknesses, and discuss their clinical implications. Methods: Literature search from open-access databases until the most recent articles, including studies comparing scoring systems for ovarian/adnexal masses. Results: Several studies show that IOTA models (especially ADNEX) have higher diagnostic performance (AUC) compared to RMI. However, each system has limitations in clinical applications. Conclusion: The choice of scoring system should consider local facilities (ultrasound, tumor markers, imaging expertise) and patient risk; the use of high-performing models can improve triage and management of patients with ovarian cysts.
THE ROLE OF AUTOPHAGY AND INTERMITTENT FASTING IN METABOLIC HEALTH : A SCOPING REVIEW Nuni Ihsana; Dewi Yuniasih; Adnan Abdullah; Agus Sukaca; Ario Tejosukmono; Annisa Annisa; Bella Samapta Palupi; Wildan Fandi Farihan; Adila Putri Sholihah
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.54224

Abstract

Background: Intermittent fasting (IF) and autophagy have garnered significant attention in recent years due to their potential therapeutic effects on metabolic health and chronic diseases. Autophagy, a crucial cellular process for maintaining homeostasis, is closely linked with the metabolic changes induced by intermittent fasting. This scoping review aims to explore and summarize the existing literature on the relationship between IF and autophagy, particularly in the context of metabolic and medical research. Methods: A Scopus search identified 158 articles. After applying filters for publication year, article type, language, and medical relevance, 18 articles met the criteria for screening. Following title, abstract, and full-text assessment, 14 studies were included in this review. Results: Fourteen studies met the inclusion criteria. Most demonstrated that intermittent fasting (IF) enhances autophagy, although a few reported inconsistent effects. IF also produced several health benefits, including improved metabolic outcomes, weight reduction, anti-inflammatory and antioxidant activity, neuroprotection, and cardiovascular improvements. Some studies showed limited effectiveness of IF under specific conditions, while others compared IF with alternative interventions and reported mixed advantages. Overall, the evidence supports IF as a promising non-pharmacological strategy to modulate autophagy and improve metabolic and cellular health. Conclusion: The studies reviewed highlight the beneficial effects of IF on autophagy, particularly metabolic diseases and aging. This review emphasizes the need for more targeted studies to fully understand the role of IF in modulating autophagy and its broader health implications.
THE ROLE OF FAMILY FUNCTIONING AND TREATMENT SELF-EFFICACY IN RESILIENCE AMONG WOMEN WITH BREAST CANCER Maryati Rizka Sari; Nida Ul Hasanat; Rizki Nur Pratama
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.55523

Abstract

Background: Resilience plays a critical role in enabling women with breast cancer to adapt to diagnosis and treatment-related challenges. This study examined the roles of family functioning and treatment-related self-efficacy in predicting resilience among women with stage II–III breast cancer in Yogyakarta and Banda Aceh using a cross-sectional quantitative design (N = 81). Data were collected using the Connor–Davidson Resilience Scale (CD-RISC), the General Functioning subscale of the McMaster Family Assessment Device (FAD), and the Symptoms Management Self-Efficacy Scale for Breast Cancer (SMSES-BC) and analyzed through multiple regression. The findings indicated that although family functioning and treatment-related self-efficacy jointly contributed to resilience, only family functioning emerged as a significant independent predictor (β = 0.398, p = 0.002). In contrast, treatment-related self-efficacy did not show a significant independent effect (β = 0.133, p = 0.282). Together, the variables explained 23.8% of the variance in resilience. These findings identify family functioning as the most salient psychosocial factor in fostering resilience among women undergoing breast cancer treatment and emphasize the need to integrate family-centered approaches, such as communication training and caregiver education, into psychosocial support programs. Future longitudinal and mixed-methods research is recommended to examine additional potential mediating or moderating mechanisms through which treatment-related self-efficacy influences resilience.
PERICARDIAL EFFUSION DUE TO MYCOBACTERIUM TUBERCULOSIS AND STAPHYLOCOCCUS AUREUS COINFECTION IN IMMUNOCOMPETENT PATIENT: A CASE REPORT Limdawati Kwee; Aldrich Christiandy
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 5 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i5.53065

Abstract

Background: Pericardial effusion is a rare case, yet lethal if the treatment is not promptly given. Mycobacterium tuberculosis (MTB) is the leading cause of pericardial effusion in countries with high morbidity rate of tuberculosis, such as Indonesia. Generally, the infection happens in immunocompromised patients. Case presentation: This case report presented a 43-year-old female patient without comorbidities with worsening dyspnea exacerbated by dehydration due to acute diarrhea. The radiology imaging revealed the presence of cardiomegaly and pneumonia, meanwhile echocardiography revealed massive pericardial effusion. The pericardiocentesis result showed a negative Xpert TB result; however, elevated adenosine deaminase (ADA) and Staphylococcus aureus in the fluid culture were found. Antibiotic was given according to the culture sensitivity result as well as antituberculosis agents. Conclusion: From this case report, it is concluded that pericardial fluid culture is essential in improving diagnosis since coinfection can occur even to immunocompetent hosts. Immediate and appropriate management will reduce the fatal complication of cardiac tamponade.

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