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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
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Insilico Analysis of Codon 131 Polymorphism in FcγRIIA Gene and it is Association with Clinical Symptoms Persistence of Dengue Patients Enny Nugraheni; Dwi Ramadhani; Mardhatillah Sariyanti; Ety Febrianti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31010

Abstract

Background. Dengue Hemorrhagic Fever (DHF) is infection caused by Dengue Virus. Failure of vascularization is a main symptom of Dengue Hemorrhagic Fever inducing mediator secretion by an immune cell. FcgRIIA  and CCL2 have a significant role in dengue pathogenesis and possibility in having a chance to cause dengue with a worse manifestation. Objective. Analysis of bio-informatic structure, function and expression of FcgRIIA  gene. Methods. Insilico analysis used NCBI database to find position and sequences. Analysis mutant use SNO and OMIM. Protein prediction withUniprot.  Result. FcgRIIA   human with access number of NM_001136219 by a length of 2429 bp has its full name as Fc Fragment of IgG receptor IIa, located in 1q23.3 chromosom. analyzed mutation was rs1801274 with type of missense protein residue function experiencing a change from Histidin (H) turning into Arginin (R) with allele of wild-type A and becoming G amino acid position of 166. there was structural difference of FcgRIIA   gene in wild type and mutant. Conclusion. Gene FcγRIIA  is a play a role of pathogenesis of dengue infection. Mutation in FcγRIIA  have polymorfisme at Dengue Hemorrage Fever
Relationship of Myopia Degree with Retinal Detachment Incidence at Diponegoro National Hospital Pradya Rahmawati Subagyo; Trilaksana Nugroho; Arnila Novitasari Saubig
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32528

Abstract

Background: Myopia is one of the visual disorders that has a high prevalence in the world. Based on the severity degree, myopia is divided into three criteria, namely mild, moderate and severe. Severe-degree myopia patients are more likely to suffer from certain eye diseases, especially those associated with the retina, such as retinal detachment.Objective: To analyze the relationship between the degree of myopia and the incidence of retinal detachment.Methods: This research is an observational analytical with cross-sectional approach. The research data was obtained using consecutive sampling from the medical records of myopia patients in Diponegoro National Hospital during 2015-2020. Research subjects used in this research were 70 patients who fulfill the inclusion and not the exclusion criteria. The data were analyzed using Chi Square test.  Results: The prevalence of retinal detachment is dominated by the age group of 51-60 years old (18.6%), male (35.7%) and a severe degree of myopia (34.3%). The results of the Chi Square test show that there is a significant relationship between the severity degree of myopia and the incidence of retinal detachment.Conclusion: There is a significant relationship between the degree of myopia and the incidence of retinal detachment.
The Effect of Radiotherapy on Blood Components of Cervical Cancer Patients Afina Yuliani Putri; Yan Wisnu Prajoko; Julian Dewantiningrum; Ch Nawangsih Prihharsanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30411

Abstract

Background: Radiotherapy exposure is known to have a lethal effect on blood cells because hematopoietic cells are very sensitive to radiation exposure even at low doses. Cervical cancer with radiotherapy can have the effect of reducing blood cells. Blood cells that may experience the effects of radiotherapy include haemoglobin, leukocytes and platelets.Objective: Knowing the effects of radiotherapy towards blood components of cervical cancer patients.Methods: This study was an observational study with the type of study before and after design. Data collected from medical records as secondary data in the Radiotherapy Unit of Dr. Kariadi Semarang in 2019-2020 with a total of 128 cervical cancer patients undergoing 3D radiotherapy. The statistical test used the Saphiro Wilk data normality test and the result data analysis used the Paired T Test and the Wilcoxon test.Results: Hypothesis testing for Hb levels using the Paired T Test showed an insignificant value of p=0.749 and p=0.141. Hypothesis test for the number of leukocytes and platelets using the Wilcoxon test. Leukocytes received a significant value of p=0.000 and insignificant p=0.957. Platelets received a significant value of p=0.000 and p=0.000. Hb value decreased by -0.44, leukocytes by -3.5, and platelets by -84.34.Conclusion: There was an insignificant decrease in haemoglobin levels yet significant decrease in leukocyte and platelet counts in cervical cancer patients undergoing radiotherapy where the platelets experienced the most decrease compared to haemoglobin and leukocytes.
THE EFFECT OF BEETROOT JUICE (Beta vulgaris L.) ON THE CONCENTRATION OF SPERMATOZOA IN WISTAR RATS EXPOSED TO MOSQUITO COIL SMOKE Dean Pandu Eko Sapto; Donna Hermawati; RR. Mahayu Dewi Ariani; Farmaditya Eka Putra
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31222

Abstract

Background: Mosquito coil smoke contains Allethrin that can increase the free radical effect. This process  may result in the damage of the cell membranes that triggered by oxidative stress. Oxidative stress can affect spermatogenesis and decreasing the quality of spermatozoa, including the spermatozoa concentration. Beetroot contain flavonoid as an antioxidant which can counteract the free radicals in the body.Purpose: To identify the effect of beetroot juice in the spermatozoa concentration of Wistar rats that exposed by mosquito coil smoke.Method: This study used Post Test Only control group design. The samples were 28 male Wistar rats that divided into 4 groups. The Control Group(-) was a group without treatment. The Control Group(+) was only exposed by mosquito coil smoke. Group P1 was exposed by mosquito coil smoke and given 8 ml of beetroot juice. P2 group was exposed by mosquito coil smoke and given 16 ml of beetroot juice. For 56 days, on the 57th day all rats were terminated and spermatozoa concentrations were examined.Results: The average concentration of spermatozoa was: Group K(-)=20,00; Group K(+)=8,00; P1 group=12,40; P2 group=17,20. One Way ANOVA test found there were significant differences among the five treatment groups. Post-Hoc test found there were significant differences among K(-) with K(+), K(-) with P1, K(-) with P2, K(+) with P1, K(+) with P2 and P1 with P2.Conclusion: Beetroot juice administration increasing the spermatozoa concentration of male wistar rats that exposed by cigarette smoke.Keywords: Mosquito coil smoke, beetroot juice, spermatozoa concentration
Relationship Between Frequency Of Tension Type Headache (TTH) In Epilepsy With Cognitive Function Diah Patlika; Herlina Suryawati; M.I. Widiastuti; Endang Kustiowati; Hexanto Muhartomo; Arinta Puspita Wati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32620

Abstract

Background : Epilepsy is a chronic disease that increases the risk of interictal headaches, one of which is tension type headache (TTH). TTH in epilepsy is triggered by recurrent neurogenic inflammation and central sensitization leading to pericranial tenderness. Recurrent neurogenic inflammation can affect cognitive function. The frequency of TTH in epilepsy is thought to be related to cognitive function score.Objective : Analyzing the relationship between the category of TTH frequency, onset of epilepsy, seizure frequency, age and education with cognitive score.Methods : Our study is an analytic observational study with a cross sectional design that took place from April to September 2021. The subjects of the study were epilepsy patients suffering from TTH at Dr. Kariadi Hospital, Semarang who met the inclusion and exclusion criteria. Patients’s data was obtained by filling out a questionnaire form. Assessment of the category of TTH frequency used ICHD-3 beta 2013 criteria. Assessment of cognitive function used the MoCA-Ina score. Data was analyze with Spearman correlation test, the results were significant if the p value <0.05.Results : Forty one epilepsy patients consist of 14 infrequent episodic TTH, 14 frequent episodic TTH and 13 chronic TTH. There was significant relationship between the MoCA-Ina score and the TTH frequency category (r=0,362; p=0,02), and education level (r=0,493; p=0,001). There was a weak relationship between the MoCA-Ina score and the onset of epilepsy or seizure frequency, while there was no relationship with age.Conclusion : There was a moderate relationship between the TTH frequency in epilepsy with cognitive function. Keywords : epilepsy, tension type headache (TTH), Montreal Cognitive Assesment -  Indonesian version (MoCA-Ina)
FACTORS ASSOCIATED WITH MEDICATION ADHERENCE IN HYPERTENSION IN THE NGLUWAR PUBLIC HEALTH CENTER IN MAGELANG REGENCY Taufan Agung Wicaksono; Arwinda Nugraheni; Firdaus Wahyudi; Pipin Ardhianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31477

Abstract

Background: Adherence is an important matter in the succession of hypertension medication. Despite the fact, it was found that many with hypertension had not used antihypertension medications as prescribed.Objective: To acknowledge the factors correlated to antihypertension medication adherence.Method: We used an observational, cross-sectional study model with a quantitative analytical approach. Some 131 qualified hypertensive patients of Ngluwar Public Health Center were recruited in February and March of 2021. A sampling method of purposive sampling was used. The data obtained were statistically analyzed using the chi-square test. Results: Eighty-two respondents (62.6%) had high medication adherence and 49 respondents (37.4%) were low at medication adherence. The statistical analysis results are as follows. Level of education (p = 0.374, PR = 1.264, CI 95% = 0.765-2.090), job status (p = 0.025, PR = 0.591, CI 95% = 0.367-0.953), comorbidity (p = 0.366, PR = 1.239, CI 95% = 0.772-1.988), duration of hypertension (p = 0.604, PR = 1.124, CI 95% = 0.722-1.751), family support (p = 0.142, PR = 1.396, CI 95% = 0.890-2.190), health worker support (p = 0.002, PR = 1.994, CI 95% = 1.313-3.028), affordability (p = 0.329, PR = 1.246, CI 95% = 0.802-1.937) and accessibility (p = 0.564, PR = 1.240, CI 95% = 0.623-2.468), and polypharmacy (p = 0.573, PR = 0.848, CI 95% = 0.488-1.474).Conclusion: Job status and health worker support were significantly correlated to antihypertensive medication adherence.
IDENTIFICATION OF SECONDARY METABOLITE COMPOUNDS IN TUNICATE (Polycarpa aurata) ASSOCIATED BACTERIA Sheila Raisa; Astika Widy Utomo; Rebriarina Hapsari; Endang Mahati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30103

Abstract

Background: Marine biodiversity in the last few decades has been explored and utilized as marine natural products. The secondary metabolites produced by marine organisms are utilized by humans in various aspects of life. One of the main source of secondary metabolites is marine invertebrates, such as tunicate. Several previous studies have shown that many metabolites have been identified in the last 40 years.Objective: This study aimed to identify the metabolite compounds produced by tunicate-associated bacteria.Methods: The two isolates of bacteria associated with tunicate Polycarpa aurata, Bacillus wiedmannii and Virgibacillus salarius, obtained from the culture collection of Tropical Marine Biotechnology laboratory, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang were used as material in this study. This study was carried out in Integrated Laboratory Diponegoro University from July to September 2020. Laboratory experiment was conducted by culturing these bacteria in Zobell Marine Broth 2216 at room temperature. The incubated culture was then added with ethyl acetate in a ratio of 1: 2 and then the supernatant was separated and evaporated. Analysis of the tunicate-associated bacteria methanol extract was carried out using Gas Chromatography-Mass Spectrophotometry (GC-MS).Results: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound (100%) was discovered by GC-MS analysis from the tunicate-associated bacteria B. wiedmannii and V. salarius extract.Conclusion: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound is an isomer compound of Delta-9-Tetrahydrocannabinol (Δ9-THC) which needs further research on its application in medical and non-medical aspects.
The Association between Face Mask Use and Headache: A Challenge in the New Normal Era Wira Dharma Utama; Erlina Purnamayani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.32104

Abstract

Abstract Background: Indonesia has entered a new normal in the Covid-19 era and implemented strict health protocols in day-to-day activities. Transportation sectors, including air transportation, have been allowed to continue their services as long as they follow the health protocols, such as the mandatory use of face masks. Unfortunately, face masks now deal with several negative health issues, e.g., headache.Objective: To observe the association between face mask use and headache among airport officers and the average degree of the headache experience.Methods: The study was conducted at the Sultan Mahmud Badaruddin II (SMB II) International Airport in Palembang. The data were collected by a questionnaire gathered from December 2020 to January 2021. The data were processed using a quantitative approach with analytical methods.Results: From 207 airport officers, the major characteristics were female (57.9%), indoor workplaces (78.3%), face masks use ≤ 4 (four) hours per day (58.9%), and no headaches while using face masks (70.1%). There was a significant relationship between headache and face masks used > 4 hours per day (p < 0.001; 95% CI = 6.201 {3.215-11.958}). The mean of headaches degree using the VAS score was 2.3 (scale 0 - 10).Conclusion: Headaches could result from wearing facemasks for more than 4 hours per day. The mean degree of headaches due to facemasks used was relatively mild. The present research suggests that face masks must not cause other health problems. Improvement in face masks is the key to facing the Covid-19 pandemic and as important as washing hands and physical distancing.Keywords: Face mask; Headache; VAS Score
Correlation between Interleukin 10 Serum Levels and Severity of Peripheral Neuropathy in Multibacillary Leprosy Patients a Research Article Fajar Sekti Reliyana; Hexanto Muhartomo; Endang Kustiowati; Yosep Ferdinand Rahmat Sugiyanto; Retnaningsih Retnaningsih; Arinta Puspita Wati; Rahmi Ardhini; Aditya Kurnianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32648

Abstract

ABSTRACT  Background of the ResearchLeprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. Clinical presentations of leprosy neuropathy are obtained when the nerve damage is more than 30% of peripheral nerve fibers. The anti-inflammatory property of interleukin 10 is supposed to protect tissue from the damage caused by proinflammatory cytokines. Instead, it causes extensive nerve damage due to suppression of the cellular immune system, failure of forming granuloma to limit the growth of Mycobacterium leprae. As a result, it multiplies and spreads. Purpose of the ResearchThe purpose of the research is to analyze the correlation between interleukin levels 10 serum and the severity of peripheral neuropathy. Methods of the ResearchThe method used is cross-sectional research on 30 subjects with multibacillary leprosy aged 18-65 at the Neurology Department of Kelet Hospital Jepara from September to October 2021. The questionnaire was used to collect data of the patients. Interleukin level 10 serum evaluation is assessed by examining blood serum. Data analysis used Spearman Correlation Test. The significant result occurs if it is p<0.05. Research resultPatients with multibacillary leprosy are mostly men (73.3%). There is also a strong significant correlation between interleukin 10 levels and the severity of peripheral neuropathy (p<0.001) with rho (0.7) ConclusionThere is a strong and significant correlation between serum interleukin 10 levels and the severity of peripheral neuropathy in multibacillary leprosy Keywords: multibacillary leprosy, interleukin 10, peripheral neuropathy
Correlation between Body Mass Index, Muscle Mass, and Muscle Explosive Power in First-Year Medical Students of Diponegoro University Devi wahyu arum sari; Hafizhil Uzhma Al Ahmadi; Timothy Jordan; Buwono Puruhito; Edwin Basyar; Darmawati Ayu Indraswari
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31687

Abstract

Abstract Background: Muscle explosive power as a component of physical fitness is an important factor that supports athletic performance in most sports. jump height and vertical jump performance in assessing explosive muscle power are influenced by various factors, including physiological, biomechanical, and anthropometric factors. Body mass index, muscle mass, and fat mass are important anthropometric factors in supporting jumping performance.Objective: To analyze the relationship between body mass index and muscle mass with legs muscle explosive power in first-year medical students of Diponegoro University.Methods: This study is an observational analytic study with a cross-sectional design. The subjects consist of 60 males and 108 females in first-year medical students of Diponegoro University who met the criteria. Body mass index and muscle mass were measured by Omron bioelectrical impedance analyzer, and muscle explosive power was measured by vertical jump test. Data were analyzed with the Kolmogorov Smirnov normality test and Spearman correlation test.Results: The average value of body mass index was 21.760±2.7734, muscle mass was 29.468±4.3283, and muscle explosive power was 29.468±4.3283. Muscle mass was positively correlated with legs muscle explosive power (p=0.00, R= 0.583) and negatively correlated between body mass index and legs muscle explosive power but it was not statistically significant (p=0.823 dan R=- 0.017) in first-year medical students of Diponegoro University.Conclusion: Muscle mass was positively correlated with legs muscle explosive power and body mass index showed no significant correlation with muscle explosive power. Keywords: body mass index, muscle explosive power, muscle mass, vertical jump test

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