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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 974 Documents
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Vitamin D Deficiency Linked To Depression (Systematic Review: Meta Synthesis) Talitha Salsabila; Indranila Kustarini Samsuria; Dwi Retnoningrum; Indah Saraswati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30058

Abstract

Background: Depression is a mood disorder that is marked by a persistent feeling of sadness, loss of interest; reduced energy and vitality; feelings of low self-worth or guilt; loss of appetite; disturbed sleep or insomnia; and slowness of thought or action. Vitamin D deficiency has been associated with depression. When the level of Vitamin D and serotonin is low, that leads to depression.Objective: To analyze whether vitamin D deficiency or insufficiency is associated with depression.Method: This is a Systematic Review Report. Samples were gathered from two journals – PubMed and Science Direct with specific search terms used were 'vitamin D' and 'depression', then were adjusted based on the inclusion criteria and research question. After that, the findings are combined in order to reach a conclusion so that the research question is well answered.Results: There are eleven journals that describe a link between low level of Vitamin D and symptoms of depression. The connection between the two is formed due to the neuroprotector and immunomodulatory effects of Vitamin D.Conclusion: Previous studies have shown that Vitamin D deficiency linked to depression. Keywords : Depression, level of vitamin D, vitamin D serum.
Body Mass Index and Waist Circumference are Associated with Visceral Fats Measured by Bioelectrical Impedance Analysis in Adolescents Darmawati Ayu Indraswari; Hafizhil Uzhma Al Ahmadi; Devi Wahyu Arum Sari; Timothy Jordan; Buwono Puruhito; Edwin Basyar; Saekhol Bakri; Muflihatul Muniroh
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.32040

Abstract

Background: Overweight and obesity are two health conditions that contribute to the impaired quality of life. Two parameters of obesity also indicating body composition, body mass index (BMI) and waist circumference (WC), have been used as simple tools to assess abdominal visceral fats. The correlation between both measurements and visceral fats remains unclear.Objective: The study aims at demonstrating that body mass index and waist circumference may reflect visceral fats using bioelectrical impedance analysis in adolescents.Methods: First-year students of the Faculty of Medicine Diponegoro University participated in the study. This cross-sectional study measured BMI, WC, mid-arm circumference (MAC), and visceral fat (VF) of 130 participants. BMI, WC, MAC, and VF were assessed using Omron digital scale, measuring tape, and body impedance analysis, respectively. Spearman test was used for the bivariate analysis while multiple regression was employed to perform multivariate analysis. Significant results were determined if p value <0.05 for the bivariates.Results: The correlation between body mass index and visceral fats showed a strong value with r: 0.794 and p-value=<0.001. The correlation between mid-arm circumference and visceral fats showed r= 0.713 and p value=<0.001. Meanwhile the correlation between waist circumference and visceral fats showed r= 0.655 and p value=<0.001. BMI and WC showed the greatest correlation to VF. The comparison between genders resulted in men having stronger relationships between BMI and VF, and WC and VF.Conclusion: BMI and waist circumference are strongly related to visceral fats based on BIA in medical students. 
THE EFFECT OF CORIANDER LEAF EXTRACT TOWARDS KIDNEY HISTOPATHOLOGICAL FEATURES ON WISTAR RAT INDUCED BY ORALLY ADMINISTERED MERCURY Manda Petrina; Ika Pawitra Miranti; Nani Maharani; Intan Rahmania Eka Dini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30095

Abstract

Background: Mercury’s a toxic heavy metal that damages the kidney through generation of Reactive Oxygen Species (ROS). Previous study has established that coriander leaves contained high level of antioxidants. However, there hasn’t been any experiment that examined renoprotective effect of coriander leaf extract toward the kidney of Wistar rat induced with orally administered mercury.Objective: To examine the nephroprotective activity of coriander leaf extract towards Wistar rat’s proximal tubules induced with orally administered mercuryMethods: : Experimental study with post test only control group design using 20 male Wistar rats divided randomly into 4 groups as samples. Group K0 without treatment, Group K(-) was administered 10 mg/ kgBW mercury chloride orally, Group P1 was administered 10 mg/kgBW mercury chloride and 100 mg/kgBW coriander leaf extract orally, and Group P2 was administered 10 mg/kgBW  mercury chloride and 200 mg/kgBW coriander leaf extract orally. The study was carried for 14 days after which the kidneys were examined microscopically.Results: The mean values for damaged proximal tubules were as follows: group K0 2,44±1,19; group K(-) 4,76±3,77; group P1 4,52±2,18; group P2 2,60±1,38. Mann-Whitney test showed significant differences between group K(-)>K0 (p=0,009); group P1>K0 (p=0,001); group P2<K(-) (p=0,015); group P1>P2 (p=0,001). Insignificant differences were found between group P2> K0 (p=0,936) and group P1<K(-) (p=0,579).Conclusion: Coriander leaf extract could reduce the number of damaged proximal tubules from mercury ingestion, with dose of 200 mg/kgBW showing better result than 100 mg/kgBW.Keywords: antioxidants, coriander leaf, kidney, mercury
LIQUID SMOKE SUBMERSIVE EFFECTIVENESS OF ACRYLIC PLATE TO THE GROWTH OF CANDIDA ALBICANS Mochamad Haldi Tri Hutama; Windriyatna Windriyatna; Dwi Ngestiningsih; RR Mahayu Dewi Ariani; Tyas Prihatiningsih
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30115

Abstract

Background: Acrylic denture was an alternative to replace a lost tooth, and surrounding tissues have the part of the acrylic plate, which was frequently a place of Candida albicans proliferation. The liquid smoke has a chemical compound of phenol which produced antimicrobial and could hamper or destroy Candida albicans.Objectives: To identify the acrylic plate's effectiveness, soaking into liquid smoke to the growth of Candida albicans.Methods: This research was categorized into experimental research which exerted post-test control group research design. The total sample in this research was 25 samples, four treatment groups, and one control group. This treatment covered acrylic plate soaking into liquid smoke in specific concentration level 1%, 2%, 4%, and 6% to obstruct the growth of Candida albicans. Moreover, the statistic test was conducted through Kruskal-Wallis and continued to Post-Hoc test through Mann-Whitney theory.Findings: This research showed a significant difference between the amount of Candida albicans on the control group and liquid smoke group in concentrations 1%, 2%, 4%, and p-valuable = 0,005). Further, based on the Post-Hoc test result of Mann-Whitney, it referred significant difference between concentrations 1%, 2%, 4%, and 6% within sterile aquades (p-value = 0,008).Conclusions: The liquid smoke shared effective concentration which functioned to hamper Candida albicans on the acrylic plate. The concentration level of 6% was the most effective concentration to interfere Candida albicans on the acrylic plate. Furthermore, it was not found any significant difference between resistibility of liquid smoke to Candida albicans on an acrylic plate with concentration level of 1%-6% which could be the most effective way to obstruct Candida albicans on acrylic plate.Keywords : Acrylic plate, Liquid smoke, Candida albicans 
INFECTION THAT UNDERLIES THE OCCURRENCE OF FEBRILE SEIZURES: A CASE REPORT OF A 2-YEAR-OLD BOY WITH COMPLEX FEBRILE SEIZURE Dimas Tri Anantyo; Ayu Anggraini Kusumaningrum; Nuh Gusta Ady Yolanda; Vinandra -
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.28202

Abstract

Background: Febrile seizures are seizures associated with fever during childhood that most often occurs in children ages six months-five years, with a peak incidence of 18 months Although febrile seizures generally have a good prognosis, they can signal an underlying serious acute infectious infection. This report aims to present a case of febrile seizures associated with the underlying extracranial infection in Semarang.Method: This report describes the anamnesis, physical examination, and supporting examination in patients with febrile seizures.Case: A 2-year-old boy coming to the ER with complaints of seizures that accompanied by fever, When the child seizures are unconscious, after the seizures the child cries.Discussion: The patient came with seizures accompanied by fever three times before being taken to the hospital, the duration of the seizure ± 10 seconds, with a range of ± 2 hours between the first, and the next seizures, twitching convulsions throughout the body, eyes glared upwards, when the child got the seizure, he was unconscious, and after a seizure, the child cries. Three days before, the child had a fever and a cough with yellowish phlegm. On physical examination, It was found ronchi in both lung fields. From x-ray obtained bronchopneumonia picture. Patients diagnosed with complex febrile seizures and bronchopneumonia.Conclusion: Patients were diagnosed with complex febrile seizures and bronchopneumonia, treated for six days, and sent home because the patient's clinical condition improved. Infection is associated with the incidence of febrile seizures.
THE CORRELATION BETWEEN MEAN ATERIAL PRESSURE AND BLEEDING VOLUME WITH THE NATIONAL INSTITUTE OF HEALTH STROKE SCALE (NIHSS) SCORE FOR INTRACEREBRAL HEMORRHAGE PATIENTS Shonia Syvafiftyan Rosaline; Hermina Sukmaningtyas; Arinta Puspita Wati; Sukma Imawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30061

Abstract

ABSTRACT Introduction: Intracerebral hemorrhage refers to primary, spontaneous, and non- traumatic bleeding that occurs in the brain parenchyma. Intracerebral hemorrhage accounts for approximately 10-20% of all stroke. The most common risk factor for non-traumatic hemorrhagic stroke is hypertension. The increase in Mean Arterial Pressure leads to the incidence of intracerebral hemmorhage. The NIHSS is a systematic assessment tool that quantitatively measures stroke associated with neurologic deficits. Neurological deficits that occur in intracerebral hemorrhage occur because blood enters the brain parenchyma. The incoming blood was measured by the Automatic Volume Method (software volume evaluation), namely the calculation of volume by computer software on the CT Scan tool.Aim: To determine the correlation between Mean Arterial Pressure and bleeding volume with NIHSS score in intracerebral hemorrhage patients.Methods: The research design used in this study was cross sectional. The sample of this study was 40 research subjects using purposive sampling, this study has independent variables, namely Mean Arterial Pressure and bleeding volume, while the dependent variable is the NIHSS score (National Institute of Health Stroke Scale). This study conducted an analysis using Spearman's.Results: : The results of this study indicate that there is no significant relationship between bleeding volume and NIHSS score (p = 0,157, r = 0,228) and there is no significant relationship between MAP and NIHSS score (p = 0,268, r = -0,179)Conclusion: There is no statistically significant relationship between Mean Arterial Pressure and bleeding volume with the NIHSS scoreKeywords: Mean Arterial Pressure, Bleeding Volume, National Institute of Health Stroke Scale, Intracerebral Hemorrhage
Case Report: A 10-Year-Old Girl with Systemic Lupus Erythematosus, Lupus Nephritis, Normotension On Control, Underweight, And Short Stature Khansa Pinasti Anjarsari; Gerin Orviyanti; Adhie Nur Radityo S
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30455

Abstract

Background: Systemic Lupus Erythematosus (SLE) disease is an evolutionary systemic disease affecting one or several organs of the body, such as the kidneys, skin, blood cells and blood system. In sick children, in addition to maintaining growth and development, fulfilling nutritional needs is very useful for accelerating the healing process, shortening the treatment period, reducing the occurrence of complications, reducing morbidity and mortality and preventing malnutrition due to medication or medical action. The purpose of this case is to report a case in Semarang and conduct a discussion of Systemic Lupus Erythematosus cases and the complication so that proper treatment can immediately start.Case Presentation: a 10-year-old girl came complaining of difficulty walking, patient's face was also swollen. Patients with a history of SLE, lupus nephritis, normotension on control, and had undergone 4 times CPA treatment but stopped since March 2020. The patient will continue the 2nd month of Cyclophosphamide (CPA) treatment, but the laboratory examination results show proteinuria +3, the patient also found good nutrition, short stature, and underweight, patient advised to be hospitalized.Conclusion: The patient was diagnosed with SLE, lupus nephritis, normotension on control, short stature, and underweight. Patients receive therapy in the form of methylprednisolone, CPA, anti-hypertensive supportive therapy and management of underweight and short stature children due the medication. 
THE EFFECT OF GARLIC (Allium sativum) EXTRACT ON THE HISTOPATOLOGICAL LUNG OF BALB/C MICE WITH NICOTINE EXPOSURE Ardiansyah Mahardika; Desy Armalina; Ratna Damma Purnawati; Hermawan Istiadi; Akhmad Ismail
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.32294

Abstract

Abstract Background: Nicotine is a major aspect of smoking. Nicotine cause damage to the lungs because the oxidative stress caused triggers an inflammatory response and lung damage to the alveoli. Garlic extract as an antioxidant agent so that it can against oxidative stress caused by nicotine exposure.Objective: This study is to proving the effect of multilevel dose of garlic extract on lung histopathology of BALB/c mice exposed to nicotine by inhalationMethods: The study used an experimental post test only control group design which was carried out for 24 days. Mice were given an adaptation period of 7 days followed by a treatment period of 14 days. On the last day, the lungs will be terminated and taken for histopathological tests. Mice were divided into 4 groups, namely a Healthy Control Group  that was only given standard feed, a Negative Control Group  that was given exposure to nicotine by inhalation at a dose of 10 mg/KgBW, treatment group 1 was given garlic extract 300 mg/KgBW orally and exposed to nicotine inhalation with a dose of 10 mg/KgBW, and treatment group 2 who were given garlic extract 500 mg/KgBW orally and exposed to nicotine by inhalation at a dose of 10 mg/KgBW. Histopathological preparations were made on each sample with Hematoxylin-Eosin paint which was then observed microscopically and assessed for severity of damage using scoring criteria.Results: Based on microscopic observations, the degree of lung damage is grouped into normal, mild, moderate, and severe degrees. The results in each group are in the following groups: Healthy Control Group : 73%,27%,0%,0% ; C(-) :0%,0%,33%,67% ; T1 : 0%,33%,67%,0% ; T2 : 0%,100%,0%,0%. The Kruskal Wallis test was performed to obtain significant differences, followed by the Mann Whitnney test which compared the treatment groups which showed significant results.Conclusion: By Giving garlic extract can reduce the degree of microscopic damage of mice lung due to nicotin inhalation exposure.
ASSOCIATION BETWEEN THE DEGREE OF DIABETIC RETINOPATHY AND DIABETIC MACULAR EDEMA Andhika Guna Dharma; Maharani Maharani; Riski Prihatningtias; Muhamad Taufik Mahar; Henry Setiawan; Ayu Anggraini Kusumaningrum; Arief Wildan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.30840

Abstract

INTRODUCTION: WHO estimates more than 150 million diabetes patients worldwide. One of the complications of diabetes is diabetic retinopathy which is recognized as the leading cause of blindness in the working-age population and the cause of 12% of new cases of blindness each year due to macular edema, vitreous hemorrhage, and tractional retinal detachment. Macular edema is the most common cause of decreased visual acuity. The relationship between macular edema and the degree of retinopathy is unclear, so further research is needed. This study aimed to analyze the incidence of macular edema with the degree of diabetic retinopathy.METHOD: This study used a cross-sectional method. Samples were taken from the Retina Data Register at the National Diponegoro Hospital Eye Polyclinic of all diabetic retinopathy patients who attended National Diponegoro Hospital from July to December 2020 who were recruited as participants. The variables measured included the incidence of macular edema and the degree of diabetic retinopathy. Measurements using fundoscopy, slit lamp and condensing lens + 78D according to ETDRS (Early Treatment Diabetic Retinopathy Study) criteria by an ophthalmologist. Data analysis used a bivariate difference test for 2 groups. The statistical test used was the Kruskal-Wallis test, which was significant if p ≤ 0.05.RESULTS: In this study, out of 150 eyes examined, 28 (18.7%) had macular edema. 4 (2.7%) eyes were diagnosed with Moderate NPDR, 3 (2%) eyes were diagnosed with Severe NPDR. In eyes diagnosed with PDR with or without VH or TRD, 21 (14%) eyes had macular edema. The p-value was 0.03 with the Kruskal-Wallis test, where p ≤ 0.05.CONCLUSION: There is a significant difference between the degree of diabetic retinopathy and the incidence of macular edema. The incidence of macular edema is higher in the more severe degrees of diabetic retinopathy.
EFFECT OF MOMORDICA CHARANTIA FRUIT ETHANOLIC EXTRACT ON MALONDIALDEHYDE (MDA) LEVEL IN BLOOD OF SPRAGUE-DAWLEY RATS INDUCED BY 7,12-DIMETHYLBENZ[A]ANTHRACENE Ongky Surya Wijaya Hendro; Eka Yudhanto; Ari Budi Himawan; Dea Amarilisa Adespin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.31226

Abstract

Background: Cancer is a type of disease with a high rate of diagnostic cases. The real cause of cancer remains unknown. Free radicals can cause cancer by DNA’s gen mutation. 7, 12- Dimethylbenz[a]anthracene (DMBA) is often used for researching carcinogenesis. Many types of research have used natural substances as supportive cancer therapies including Momordica charantia (bitter melon). Malondialdehyde (MDA) is one of the oxidative damage biomarkers which can significantly increase, especially on breast cancer patients. The success of therapy on a breast cancer patient is shown by decreasing MDA levels in the blood. Aim: To investigate the effect of Momordica charantia fruit ethanolic extract on malondialdehyde levels in the blood of Sprague Dawley rats induced by 7,12- Dimethylbenz [a] anthracene. Methods: This study was a true experimental randomized post-test only with control group design on rats that divided into two groups: X1 given DMBA induction only and X2 given DMBA induction with Momordica charantia fruit ethanolic extract by feeding tube with  200mg/kgbw/day for 14 days. Results: The mean of MDA level in group X1 = 0,83±0,32 and in group  X2 = 0,30±0,19. The result of the normality test of data using the Shapiro-Wilk test obtained abnormal distribution data for one of the groups. The result of independent-samples T-Test showed a significant difference with P = 0,001. Conclusion: There was an effect of Momordica charantia fruit ethanolic extract on MDA level in the blood of Sprague-Dawley induced by 7,12- Dimethylbenz[a]anthracene.

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