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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
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The Role of Midazolam on Status Epilepticus: Systematic Review Firdha, Azizah Amimathul; Puspamaniar, Vania Ayu; Machin, Abduloh
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.38806

Abstract

Background: Status epilepticus is a condition that results either in the failure of the mechanisms responsible for stopping seizures or in initiating mechanisms that cause seizures to be abnormally prolonged. Benzodiazepine is the first-line therapy for status epilepticus. The three usually used Benzodiazepines are Lorazepam, diazepam, and midazolam. Objective: This systematic review was undertaken to determine midazolam's role in managing patients with status epilepticus. Methods: A systematic search from PubMed, Science Direct, and Cochrane was conducted with predetermined keywords. Studies in randomized controlled trials assessing the impact of midazolam on epileptic status were included in the inclusion criteria. Articles are published in English, and the full text is accessible. The authors independently extracted data and assessed the risk of bias for each included study. Results: Of 6410 studies obtained from the search results, 13 studies were found that were relevant and matched the inclusion criteria. Benzodiazepines are the first line of SE therapy in an emergency. This group works by inhibiting GABA receptors and has a rapid effect in stopping seizures. Midazolam can be given intravenously, intramuscularly, or transmucosal (nasal, buccal, or rectal). Intravenous midazolam may be a good choice because of its short onset of action and, therefore, can effectively stop seizures. Conclusion: Effective and safe results have been seen with each Midazolam administration method. This suggests that Midazolam may be an excellent therapeutic option for SE. However, the type of Midazolam administration can be adjusted according to the guidelines and drug availability in each country. 
Emerging Frontiers in Cardiovascular Diagnostics: A State-of-the-Art Review Ramadhan, Roy Novri; Sari, Dewi Ratna; Akram, Muh; Nurdiansyah, Farhan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.40838

Abstract

Background: The cardiovascular diagnostic landscape is rapidly evolving, with novel and advanced techniques and technologies continually emerging. Detection, monitoring, and management of cardiovascular diseases (CVDs) are quickly changing, which are leading mortality cause globally. Objective:This review aims to provide a comprehensive and up-to-date assessment of the current cardiovascular diagnostic modalities. It seeks to elucidate novel and promising technologies, address their advantages, limitations, and potential integration into clinical practice. Methods: This literature review discusses the recent cardiovascular diagnostics which were obtained from various sources such as PubMed, EMBASE, and Web of Science for articles published in the last decade. Results: The review identified vital emerging frontiers in cardiovascular diagnosis, including advancements in multi-modal imaging (such as PET-MRI), novel biomarkers, artificial intelligence applications, and the growing utility of wearable and remote monitoring technologies. Conclusion: Emerging techniques integration inroutine clinical practice requires careful consideration of their advantages and potential for improving patient outcomes. The review highlights the pressing need for continued research and guideline to ensure these innovations realize their full potential for the future of cardiovascular medicine.
The Association Between Exclusive Breastfeeding and the Occurrence of Stunting Among Children Aged 12-60 Months in Community Health Centers in Yogyakarta City Asqy Dendy, Eureka Raihan; Putri, Rachma Greta Perdana; Yuniasih, Dewi; Kurniawan, Nurcholid Umam
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 1 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i1.40723

Abstract

Background: Stunting is a condition of chronic malnutrition caused by suboptimal nutritional intake due to prolonged inadequate food consumption. Stunting, also known as being short, indicates a growth failure that occurs both before and after birth. The categorization of stunting based on the World Health Organization's (WHO) standard growth reference is a deficit in length or height for age with a Z-score < -2. Symptoms of stunting usually appear after the golden period of growth (2 years old). One of the contributing factors to stunting in toddlers is an imbalanced food intake. Exclusive breastfeeding is a critical component of nutritional intake to support a child's good nutritional status. It may contribute to the prevalence of stunting.Methods: This is a quantitative study with a cross-sectional research design. The data collection consists of secondary data from stunting medical record records. The inclusion criteria of the study are children aged 12-60 months with complete data of anthropometric. Exclusion criteria are endocrine disorder, skeletal abnormalities, dysmorphic disorder, chronic disease, history of familial short stature, and constitutional delay of growth and puberty. Analysis of the data using Chi-square.Results: There is a relationship between exclusive breastfeeding and the occurrence of stunting in children aged 12-60 months at the Community Health Centre in Yogyakarta City with a p-value of 0.00 (p < 0.05).Conclusion: There is a correlation between exclusive breastfeeding and the occurrence of stunting among children aged 12-60 months in primary healthcare care in Yogyakarta City.
The Effect of Moringa Leaves Extract on Sperm Motility in Male Mice Exposed to Electromagnetic Radiation of Mobile Phone Sabrina, Hasnaa Alyasi; Budisulistyo, Trianggoro; Juniarto, Achmad Zulfa; Sareharto, Tun Paksi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 3 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i3.43904

Abstract

Background: Electromagnetic radiation can induce an increase in oxidative stress. The presence of oxidative stress can impact the structure of the plasma membrane of sperm cells, damage the structure of Deoxyribonucleic Acid (DNA), and accelerate the process of apoptosis, ultimately leading to a decline in sperm quality. This increase in oxidative stress can be prevented by substances that serve as antioxidants. Moringa plants, particularly the leaves, contain various substances that can act as antioxidants for the body. These include flavonoids, alkaloids, saponins, tannins, and terpenoids. The antioxidant content in Moringa leaves is believed to safeguard the process of spermatogenesisAim: To determine the impact of Moringa (Moringa oleifera) leaf extract on the motility of spermatozoa in BALB/C mice subjected to exposure to electromagnetic waves.Methods: This study utilized design featuring a post-test-only control group design, dividing participants into four randomly assigned groups, namely a negative control group, a positive control group (exposure to electromagnetic waves), and 2 treatment groups (moringa leaf extract at dose of 100 mg/kg BW and 400mg/kg BW). Each group compromised 5 experimental animals, and the treatments were administered for duration of 30 days. Spermatozoa preparations were made for each group and observed under a microscope (400x). Data were analyzed by initially testing for normality using the Shapiro-Wilk test. If the data distribution was normal, the hypothesis examination involved conducting a One Way ANOVA followed by subsequent Post Hoc testing.Results: The results of the one-way ANOVA test indicated differences between groups of mice (p<0.05). The post hoc test results further demonstrated that a dose of 400 mg/kg BW was the most effective in preventing a decrease in spermatozoa motility. This effect is believed to be atttributed to the presence of vitamin C, beta carotene, beta-sitosterol, flavonoids, and polyphenols.Conclusion: There is an improvement in spermatozoa motility in BALB/C mice exposed to electromagnetic waves after the administration of Moringa leaf extract.
Factors Related to Duration and Interaction of Doctor-Patient Communication at Diponegoro National Hospital Refertiwi, Kriesye; Nugroho, Teddy Wahyu; Bakri, Saekhol; Wulandari, Diah Rahayu
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 5 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i5.45779

Abstract

Background: Doctor-patient communication is an important foundation in the process of diagnosis, therapy, and prevention of disease. Communication has been a challenge for most doctors. The doctor's willingness to provide sufficient time is needed to establish good interaction and communication between the doctor and the patient. Aim: To determine what factors are related to the duration and interaction of communication between doctors and patients at Diponegoro National Hospital (RSND) Semarang. Methods: Research subjects using analytic survey research designs, with quantitative approaches and cross-sectional research designs. The sample of this study was 80 patients who came to internal, neurological, pediatric, and cardiovascular polyclinics RSND Semarang. The independent variables were factors related to doctor-patient communication (number of patients, type of patients, complexity of the disease, and qualifications of specialist doctors). The dependent variable was doctor-patient communication (duration and communication interaction at RSND Semarang). Results: Most of the respondents (72.5%) experienced < 8 minutes of communication. The number of patients, type of patients (old/new), and qualifications of specialist doctors (internists, neurologists, pediatricians, and cardiologists) were statistically related to the duration of communication (p < 0.005). Meanwhile, the complexity of the disease was not statistically related to the duration of doctor-patient communication (p = 0,416). There was a relationship between the number of patients, type of patients (old/new), and qualifications of specialist doctors to the communication interaction of doctor-patient (p < 0.005). On the contrary, there is no relationship between the complexity of the disease and the communication interaction between the doctor and patient (p = 0,324). Conclusion: Factors related to the duration and communication interaction between doctor and patient at RSND Semarang are the number of patients, type of patients, and qualifications of specialist doctors.
Clinicopathological Profile Of Her2 Positive (Non-Luminal) Breast Cancer Subtype At Haji Adam Malik General Hospital From 2020-2021 Natanael, Yosua; Siregar, Denny Rifsal; Siregar, Kamal Basri; Rohmawati, Lili
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 1 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i1.37533

Abstract

Background: Breast cancer is one of the cancers with the highest prevalence in Indonesia. According to GLOBOCAN data for 2020, the number of breast cancer cases reached 68,858 (16.6%) cases out of a total of 396,914 new cancer cases in Indonesia. There are many factors that can trigger cancer with different clinical manifestations and subtypes from one event to another, so researchers are interested in researching the profile of breast cancer patients with the HER2 subtype at H. Adam Malik General Hospital in 2020-2021.Objective: In the present study, we aim to determine the clinicopathological profile of Her2 positive (non-luminal) breast cancer subtype patients at Haji Adam Malik General Hospital from 2020-2021.Methods: The method used in this study is descriptive quantitative with total sampling technique. The data samples was obtained from medical records of breast cancer patient with her2 positive (non-luminal) subtype which was then sorted according to the availability of characteristic needed for this study. Results: majority of breast cancer patients with her2 positive (non-luminal) subtype at H Adam Malik General Hospital in 2020-2021 was within the age group of > 50 years, with all married status. the BMI of the majority of patients (68.6%) was normal weight, all respondent admit there was no family history diagnosed with cancer (100%), majority tumor size (52,9%) is >5 cm, with most patients having cancer metastasized to 1-3 lymph nodes (54,9%), distant metastases only in 39,2% of the total sample observed, majority (35,3%) histopathological degree is in grade 1 and grade 3 , the histopathological classification of the majority (86,3%) was IDC type. Conclusion: Overall there is diversity of frequencies within the observed clinicopathological characteristics.
Association Between Immune-Inflammation Index (SII) and Ferritin with Hepatic Function in Patients with Thalassemia Major Safitri, Titis Yoga; Setiawan L, I Edward Kurnia; Arkhaesi, Nahwa; Widyastiti, Nyoman Suci
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42811

Abstract

Background: Thalassemia major is associated with ferritin levels and SII values with impaired liver function. Furthermore, the measurement of impaired liver function is carried out using Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) levels. Increased SGPT and SGOT levels are indicators of liver necrosis. Objective: This study aimed to prove the association between SII and ferritin with SGPT and SGOT levels in thalassemia major patients. Methods: An observational analysis with a cross-sectional approach was adopted to analyze the medical records of pediatric patients at the Kasuari Clinic of Dr. Kariadi Hospital Semarang from September to October 2023. SII value and ferritin level were the independent variables, while SGOT and SGPT were dependent. Data were collected and analyzed univariately for characteristic description and bivariately using the Spearman test. Results: The median SII value, ferritin level, SGPT level, and SGOT level in thalassemia major patients were 451.73/L, 2097.30 ng/mL, 20.00 U/L, and 40.00 U/L. The results showed there was a moderately significant association between SII values and SGOT levels (p=0.010, r=-0.457) as well as ferritin and SGPT (p=007, r=0.475). There was no significant association between SII values and SGPT levels, as shown by a p-value of 0.122. Similarly, there was no association between ferritin and SGOT levels (p=0.088). Conclusion: A moderately significant association was found between SII values and SGOT levels, as well as ferritin levels and SGPT levels in thalassemia major patients. 
Support Vector Machine, Naive Bayes, and Artificial Neural Network Back Propagation Comparison in Detecting Brain Tumor Triadyaksa, Pandji; Ahmad, Harisma Zaini; Marhaendrajaya, Indras
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45462

Abstract

Brain tumors are abnormal tissue that grow uncontrolled and affect a patient's neurological function. Brain tumors come in different shapes and characteristics. Moreover, its location also differs for each patient. Brain tumors can be detected using machine learning algorithms using magnetic resonance imaging (MRI) images. However, a different machine-learning comparison is limited and needs further investigation. This study aims to compare three machine-learning methods, i.e., Support Vector Machine (SVM), Naive Bayes (NB), and Artificial Neural Network Back Propagation (ANN-BP) algorithms for detecting brain tumors. Before the comparison started, MRI image quality was enhanced by performing denoising, histogram equalization, and thresholding. After that, Gray Level Co-occurrence Matrix feature extraction was performed. MRI brain images in JPEG format were acquired from an open-access database. One thousand brain tumor and 1000 normal tumor images are used as the training data, while 100 brain tumor and 100 normal tumor images are used as testing data. Each algorithm's accuracy, precision, sensitivity, and Matthews Correlation Coefficient (MCC) are evaluated and reported. The study showed that the SVM algorithm acquired the highest performance in detecting brain tumors, followed by ANN-BP and NB. The highest accuracy, precision, sensitivity, and MCC values for testing in SVM were 98,75%, 98,22%, 99,30%, and 0,9751, respectively. Meanwhile, in testing, the highest accuracy, precision, sensitivity, and MCC values were 90.50%, 98.80%, 82.00%, and 0.8220, respectively. In conclusion, this study showed the superiority of the SVM algorithm in detecting brain tumor compared to ANN-BP and NB by performing image enhancement steps and GLCM feature extraction before its detection.
Clinical Profile of Pediatric Patients with Steroid-resistant Nephrotic Syndrome Treated by Cyclophosphamide, Cyclosporin A, Mycophenolate Mofetile and Tacrolimus in Hasan Sadikin General Hospital Widiasta, Ahmedz; Jambak, Muhammad Khalid; Sekarwana, Nanan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.41983

Abstract

Background: Steroid-resistant nephrotic syndrome is a major cause of chronic kidney disease in children and adolescents. These diseases require appropriate management, while in some developing countries; the availability of agents recommended by international guidelines is very limited. Research objectives: To determine and describe the patient profiles of pediatric Steroid Resistant Nephrotic Syndrome (SRNS) that use Cyclophosphamide (CPA), Cyclosporine(CyA), Tacrolimus, and Mycofenolat Mofetil (MMF) in Dr. Hasan Sadikin Hospital (RSHS), Bandung as a tertiary hospital in West Java, Indonesia. Methods and materials: This research used a retrospective study with crosssectional study design, total sampling method and medical record of pediatric (1-18 years old) patients from January 1st 2017–September 31st 2019 who were diagnosed as SRNS. Results : From 99 subjects that belonged to inclusion criteria, 35.4% pediatric SRNS patients were in the age group 6-10 years and 60.6% were males. Laboratorium profiles showed among all population, ureum <100 mg/dL were found as high as 97%, creatinine 0.3-1.0 mg/dL (71.7%) albumin >2,5 gr/dL (51.5%), negative hematuria (68.7%) , protein dipstick < 3 (50.5%), and LFG > 90 mL/min/1.73 m2 (79.8%).. The patients generally had use CPA (87.9%) and remission <6 month (51.5%). Conclusion: Profiles of pediatric patients are important to diagnose and prognose SRNS. By using these approaches, it is feasible to access and detect the most effective treatment for SRNS.
Recent Updates of Stem Cell Therapy in Spontaneous Intracerebral Haemorrhage Patients: A Review Article Niryana, I Wayan; Wibawa, Ida Bagus Adiguna; Kusuma, Gede Febby Pratama
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.44046

Abstract

Background: Spontaneous intracerebral haemorrhage (sICH) is a severe neurological condition with high disability and mortality rates globally. Effective therapeutic strategies to overcome the acute and long-term problems caused by sICH are still lacking. Mesenchymal stem cell (MSCs) therapy with the neuroprotective and neuroregenerative properties has the potential to overcome the complex brain injury mechanisms caused by sICH.Objective: This review highlights the recent pre-clinical and clinical findings about MSCs therapy in sICH case and their mechanisms in promoting neurological recovery.Methods: This is a literature review study. Study reports available from various accredited database such as PubMed and Google Scholar are collected using the following keywords: ((“stroke” or “intracerebral haemorrhage”)) and (“stem cell”).Results: Pre-clinical studies proved that MSCs therapy can resolved the secondary brain insult caused by sICH and improved the brain functional and clinical status. The clinical studies proved that MSCs therapy are safe and well tolerated in human bodies. There were also beneficial MSCs therapy effects in sICH patients. However, the clinical studies results were still lacking and some were inconclusive.Conclusion: The preclinical studies of stem cell therapy in spontaneous intracerebral haemorrhage showed promising evidences and the potential of stem cell therapy for clinical use. However, the clinical studies were still lacking. Further clinical studies are needed to confirm the neuroprotective and neuroregenerative benefits of MSCs therapy from the pre-clinical studies.

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