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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
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Articles 8 Documents
 1 
Search results for , issue "Vol 6, No 2 (2018)" : 8 Documents clear
Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung Andri Rezano; Chen En Pan; Afrida Aizzatun Istiqomah; Almira Zada
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1663.038 KB) | DOI: 10.15850/1374

Abstract

Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer.   Methods: A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre- and post-neoadjuvant chemotherapy were obtained in cm3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis. Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14–20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14–20% but less effective in patients with Ki-67 expression of >20%. Conclusions: Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer. DOI: 10.15850/ijihs.v6n2.1374
Infused Oyster Mushroom (Pleurotus ostreatus) Inhibits Glucose Absorption through Intestinal Mucosal Membrane in Wistar Rats Eko Fuji Ariyanto; Muhammad Nurhalim Shahib; Abdullah Firmansah Wargahadibrata
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.482 KB) | DOI: 10.15850/1354

Abstract

Objective: To observe the effects of infused oyster mushroom (latin name: Pleurotus ostreatus) on glucose absorption through the intestinal mucosal membrane in Wistar rats.Methods: This study used experimental design. Subjects of this study were six Wistar rats which were randomly divided into two groups; three rats were used for the analysis of the most effective time for glucose absorption and the other three were used to evaluate the effect of infused oyster mushroom on glucose absorption. The intestine of subjects was connected to in situ perfusion machine. Control glucose solution (Ctr) or glucose solution containing 5% (Oys 5%), 10% (Oys 10%), and 20% (Oys 20%) infused oyster mushroom was added into the perfusion machine and flowed back and forth in the lumen of intestine subsequently, accompanied by washing procedures using 0.9% NaCl between treatments. The glucose concentration was determined using deproteinization method followed by absorbance measurement. Student’s t test was performed to analyze the difference between groups.Results: The level of glucose absorbed through intestinal mucosal membrane in control glucose solution and glucose solution with different concentrations of infused oyster mushroom, i.e. 5%, 10% or 20%, was 25.19+3.4 mg/dL, 16.27+0.86 mg/dL, 13.22+1.58 mg/dL and 10.03+1.25 mg/dL, respectively. Student’s t test showed significant differences between groups; Ctr and Oys 5% (p=0.03), Ctr and Oys 10% (p=0.02), and Ctr and Oys 20% (p=0.007).Conclusion: Infused oyster mushroom inhibits glucose absorption through intestinal mucosal membrane in Wistar rats.Keywords: Oyster mushroom (Pleurotus ostreatus), glucose absorption, intestine DOI: 10.15850/ijihs.v6n2.1354
Effect of 3-Day Storage and Temperature on ADP-induced Platelet Aggregation Puspita, Nanda Ayu; Suryawati, Suryawati
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/1375

Abstract

Objective: To observe platelet functions during the 3 days of platelet storage and to evaluate the effect of storage temperature towards platelet aggregation response. Methods: Two conditions of platelet storage were used in this study: at room temperature and in a cold condition at 4 °C to observe the temperature effect on platelet aggregation. The aggregation test was performed using a 96-wells plate platelet aggregation method. Results: At room temperature on day 1, the response of platelet aggregation reduced to 34.9±10.6%, which was less than half of the aggregation of fresh platelet (100%). The aggregation on day 2 reduced modestly (26.8±4.2%), in comparison with that seen on the first day. On day 3, platelet aggregation deteriorated significantly (6±1.2%), which was comparable to the control group without the presence of platelet agonist (6.1±1.4%). When platelets are stored at 4 °C, the aggregation response to ADP stimulation was slightly different to that shown by platelets stored at room temperature (22 °C). At the 4 °C, the aggregation response was 68.11±34.2%, 57.1±21.4%, and 5.9±2.6% at day 1, day 2, and day 3, respectively. The result showed that storing the blood at 4 ˚C or room temperature was not able to preserve platelet function, as the deterioration of platelet aggregation response over time was still taking place. Although was not statistically significant, our result indicated that cold storage reduced platelet responsiveness toward ADP activation. Conclusions: This current study provides evidence of the deterioration of platelet function during first 3 days of platelet storage. Moreover, we found that storing platelets in 4 °C showed no significant benefit in preserving the ADP-induced platelet aggregation capacity compared to that stored in 22 °C. Keywords: Adenosine diphosphate, platelet, platelet aggregation, platelet storage DOI: 10.15850/ijihs.v6n2.1375
Ethanol Extract of Stylissa carteri Induces Cell Death in Parental and Paclitaxel-Resistant Cervical Cancer Cells Isna Nisrina Hardani; Fachreza Aryo Damara; Annisa Dewi Nugrahani; Muhammad Hasan Bashari
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.808 KB) | DOI: 10.15850/1378

Abstract

Objective: To evaluate the cytotoxic effects of ethanol extract from marine sponge Stylissa carteri in both parental and paclitaxel-resistant HeLa cervical cancer cells. Methods: This was an experimental in-vitro study subjected ethanol extract from Stylissa carteri obtained from Pramuka Island, Kepulauan Seribu National Park, Jakarta. Both parental and paclitaxel-resistant HeLa cells were treated with ethanol extract followed by microscopic observation and MTT assay. The IC50 and drug curves were analyzed using four-parametric logistic regression by SigmaPlot for Windows version 12.0 from Systat Software Inc., USA.Results: Ethanol extract from Stylissa carteri triggered cell death-associated morphological changes in parental Hela cells. It demonstrated cytotoxic activities with an IC50 value of 1 ppm. Importantly, this extract also triggered cell death in paclitaxel-resistant HeLa cells. The IC50 of ethanol extract of Stylissa carteri was 4 ppm in paclitaxel-resistant HeLa cells.Conclusions: There is a potential cytotoxic activity of Stylissa carteri that is not only confirmed in parental HeLa cells but also in paclitaxel-resistant HeLa cells.Keywords: Cervical cancer, paclitaxel resistance, HeLa cells, cytotoxicity assay, Stylissa carteri DOI: 10.15850/ijihs.v6n2.1378
Characteristics of Cerebrospinal Fluid in Tuberculous Meningitis Patients with Hydrocephalus Astrid Tamara Maajid Budiman; Nida Suryana; Ahmad Faried; Ida Parwati
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.931 KB)

Abstract

Objective: To describe cerebrospinal fluid (CSF) characteristics in tuberculous meningitis (TBM) with hydrocephalus patients as diagnostic criteria of TBM.Methods: A cross-sectional using retrospective method was applied in this study by obtaining medical records of TBM with hydrocephalus patients that were treated at Department of Neurosurgery Dr. Hasan Sadikin General Hospital, Bandung from January 2014–September 2016. Results: Sixty one records were included in the study. Patient characteristics such as age, gender, and CSF laboratory features such as color and clarity, cells and differential count, protein, and glucose were recorded and descriptively analyzed. The majority of CSF macroscopic appearance was seen to be clear (88%) and colorless (88%). Median for CSF cell count was 25 cells/mm3 with lymphocyte predominance (median: 76%). Increased protein from normal value range was seen in CSF (median: 50 mg/dL) while the mean for CSF glucose in this study remained in its normal value range (mean: 58.9±26.68 mg/dL) with lower CSF to blood glucose ratio (mean: 0.41±0.27).Conclusions: Clear CSF with colorless appearance, lymphocyte pleocytosis, high protein level, and low CSF glucose as well as blood glucose ratio remain typical CSF characteristics of TBM patients found at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital, Bandung. Keywords: Cerebrospinal fluid, hydrocephalus, tuberculous meningitis DOI: 10.15850/ijihs.v6n2.1129
Pregnancy Rate after Intrauterine Insemination with the Presence or Absence of Leukocytospermia in Sperms Prepared using Density Gradient Method Rini Widyastuti; Julius Pangayoman; Aida Riyanti; Alkaustariyah Lubis; Mas Rizky Anggun Adipurna Syamsunarno
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6963.431 KB) | DOI: 10.15850/1318

Abstract

Objective: To examine the association between different concentrations of leukocyte and sperm recovery rate after sperms are prepared using density gradient method and pregnancy rate after intrauterine insemination (IUI). Increased leukocytes in semen have been associated with increased reactive oxygen species (ROS) that reduces sperm quality.Methods: Semen samples that were collected from 31 male partners of couples undergoing infertility investigation were analyzed for sperm concentration, motility, and leucocytes concentration. Semen samples were then divided in two groups based on their leucocytes concentrations (category A: >0 to <1 × 106/mL; category B: >1 x 106/mL. Semen samples were processed using density-gradient centrifugation technique. Results: There was a significant difference in the number of sperms harvested and sperm motility after preparation. Interestingly, pregnancy rate after IUI was higher (p<0.05) in non-leukocytospermia semen (39%) when compared to leukocytospermia semen (30%).Conclusions: Seminal leukocytes (PMNL) concentration affects pregnancy rate after intrauterine insemination. Keywords: Density gradient method, sperm recovery rate, intrauterine insemination, pregnancy rate DOI: 10.15850/ijihs.v6n2.1318
Cervical Stump Fibroidpost Supra-cervical Hysterectomy Sherman David Mathew; Betsy Abraham
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.478 KB) | DOI: 10.15850/1257

Abstract

Objective: To describe of a rare case of cervical stump fibroid presenting as a late complication of supra-cervical hysterectomy.Methods: A 68-year old-female with a history of lower abdominal pain and distention for six months with increasing intensity was referred from a local clinic to the department of radio-diagnosis for evaluation. She had a history of subtotal hysterectomy previously. On ultrasonography and computerized tomography imaging studies, a large adnexal lesion was noted suggesting the possibility of a cervical stump leiomyoma. The patient underwent an elective surgery and the diagnosis was confirmed in the context of histological findings.Results: Patient was operated for the radiologically diagnosed large cervical stump leiomyoma which was laterhistologically confirmed with an uneventful recovery.Conclusions: Imaging investigations like computerized tomography and magnetic resonance imaging are valuable in the diagnosis of rare adnexal masses from cervical stump arising as late delayed complications of supra-cervical hysterectomy. Keywords: Cervical stump leiomyoma, computerized tomography, magnetic resonance imaging, supra-cervical hysterectomy DOI: 10.15850/ijihs.v6n2.1257
Osteoporosis Prevention Exercise Effects to Bone Density in Children with Thalassemia Andreas Arie Widiadiaksa Waluyojati; Marietta Shanti Prananta; Marina Annette Moeliono
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.406 KB) | DOI: 10.15850/1349

Abstract

Objective: To discover recommendation of osteoporosis prevention exercise (OPE) for children with thalassemia.Methods: This study was conducted in the period of April–June 2017 by using quasi experimental and pretest-posttest designs. Eleven thalassemia patients who were the members of a thalassemia patient foundation and an association of parents of thalassemia patients, Yayasan Thalassaemia Indonesia and Perhimpunan Orangtua Penderita Thalassemia Indonesia, were enrolled in the study as the subjects. Sample calculation was carried out by using consecutive sampling method. The subjects were given OPE intervention 2 times per week during 12 weeks with 35 minutes of each session. BMD of spinal lumbar examination was performed before and after practicing OPE. Collected data were analyzed statistically by using paired t and Wilcoxon tests with p value <0.05.Results: After the intervention, BMD value of L1, L2, and L3 segments did not improve significantly while BMD value of L4 segment and average Z-score showed significant improvement (p<0.05).Conclusions: Osteoporosis prevention exercise can improve BMD in children with thalassemia. Continuous OPE program can be recommended for children with osteoporosis-induced thalassemia.Keywords: Bone mineral density, osteoporosis, osteoporosis prevention exercise, thalassemia, Z-score DOI: 10.15850/ijihs.v6n2.1349

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