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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 651 Documents
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Risk Factors for Stroke in Lacunar Ischemic Stroke Patients Irwanda, Thalita Permata Padhantya; Narwanto, Muhammad Ihwan; Putri, Komang Yunita Wiryaning
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4138

Abstract

The shift in global epidemiology has significantly increased the prevalence of non-communicable diseases, positioning stroke as one of the primary contributors to both disability and vascular-related mortality worldwide, with a notable impact observed in Asia. This research endeavours to explore the correlation between various stroke risk factors and the occurrence of lacunar stroke at Dr Soebandi Regional Hospital,  Jember, Indonesia. Employing a cross-sectional correlational design, the study drew upon data extracted from medical records of 41 patients who had experienced a first-time ischemic stroke between 2022 and 2023. The primary variables under investigation were gender, age, hypertension, diabetes mellitus, dyslipidaemia, and heart disease. Statistical analysis conducted with Chi-square test indicated a significant association between hypertension and diabetes mellitus, with both conditions linked to an 11-fold increased risk of lacunar stroke compared to having only one condition. In contrast, factors such as age, gender, dyslipidaemia, and heart disease did not exhibit significant associations. These results emphasize the imperative for rigorous management of hypertension and diabetes to reduce the risk of lacunar stroke.
Effect of Striped Catfish (Pangasianodon Hypophthalmus) Supplementation on Mice (Mus Musculus) Colon Wibowo, Agung Ary; Hosea, Nathania; Triawanti, Triawanti; Lahdimawan, Ardik; Priyono, Sasongko Hadi; Siagian, Andreas Marojohan Haratua; Sikumbang, Kenanga Marwan
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4395

Abstract

Diet affects the microbial structure of the gut and human metabolic functions. Disruption of nutrient sources that produce short-chain fatty acids (SCFA) will cause atrophy and inflammation of the colonic mucous. Striped catfish (Pangasianodon hypophthalmus) increases SCFA production because of its high levels of carbohydrates, protein, and fat content. This experimental study used 50 male mice (Mus musculus) aged 3 months old, weighing 20-30 grams, divided into control group (given standard feed) and treatment group (given mixture of standard feed and striped catfish meat). The mice were given treatment for eight (8) weeks at the Faculty of Medicine and Health Sciences, Lambung Mangkurat University, Indonesia, from May to July 2024 and then sacrificed. Colon biopsies were examined using hematoxylin-eosin staining to determine crypt morphology, number of goblet cells, and number of inflammatory cells at Ulin Hospital Banjarmasin, Indonesia, from July until October 2024. The crypt morphology in the treatment group showed fewer abnormalities (5 out of 25 samples) compared to the control group (11 out of 23 samples) (p=0.041) with a moderate correlation (p=0.295). The number of goblet cells was higher in the treatment group (200.4±54.1) than in the control group (134.5±34.3) (p=0.001) with a strong correlation (p = 0.616). The number of inflammatory cells was lower in the treatment group (9.9±4.4) than in the control group (27.6±7.8) (p=0.001) with a very strong correlation (p=0.838). Thus, striped catfish supplementation reduces morphological abnormalities of the crypts and the number of inflammatory cells, as well as increases the number of goblet cells in the colon of mice.
Rare Eccrine Porocarcinoma of The Eyelid in A Non-Caucasian Patient Boesoirie, Shanti F.; Mardianty, Friska; Wahyu, Tri; Dewi, Niluh Putu Ayu; Nursalamah, Mia; Dahlan, Mohamad Rinaldi; Kartiwa, Raden Angga
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4193

Abstract

Eccrine porocarcinoma of the eyelid is a rare and locally aggressive tumor with a significant risk of metastasis and recurrence after surgical excision. There are only eight cases of eyelid porocarcinoma reported in the literature, most involve Caucasian patients. A 58-year-old non-Caucasian male had a recurrent mass of the left upper eyelid for a year. He underwent two prior mass removal procedures in the same location of the upper eyelid. At the time of this study, the patient underwent full-thickness excision, and a lateral canthal defect with superior palpebral involvement was sacrificed. The periosteal flap from the lateral orbital rim was attached to the edge of the intact tarsal plate of the upper eyelid as a part of the defect reconstruction. Good outcomes in terms of tumor recurrences, cosmesis, and upper eyelid functionality were observed one month following surgery. According to the histopathology, the tumor was identified as eccrine porocarcinoma, and the patient was recommended for chemotherapy. The 4-month follow-up showed no recurrence or metastasis. Eccrine porocarcinoma is a rare condition that should be taken into account when making a differential diagnosis for patient with malignant eyelid tumors. Wide excision is still a treatment of choice. 
Heat Stress Exposure and Chronic Kidney Disease in Indonesian Rayon Factory Workers Suraya, Anna; Ningsih, Sri Utami; Lelitasari, Lelitasari; Sulandari, Uci; Shanmugam, Rekha; Venugopal, Vidhya
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4169

Abstract

Chronic kidney disease (CKD) has become an emerging occupational health concern, particularly among workers exposed to high temperatures. This study aimed to determine the prevalence of CKD among workers in a rayon factory in West Java, Indonesia, and evaluate its association with occupational heat exposure. A retrospective cohort study was conducted using secondary data from the company’s annual medical check-up records (2022–2023) and workplace heat stress measurements obtained in 2017 using the Quest Temp Wet-Bulb Globe Temperature monitor. Workers who completed medical examinations in both years and gave written informed consent to participate in the study were included. CKD was defined as a serum creatinine level >1.2 mg/dL and an estimated glomerular filtration rate <60 mL/min/1.73 m² in two consecutive years. Chi-square tests were used for bivariate analysis, and multivariate logistic regression was performed to obtain adjusted odds ratios (ORs). Of 675 eligible workers, male constituted the majority (99.7%) and 49% were older than 40 years. Most workers (96.1%) were exposed to workplace temperatures above 28°C, and obesity (47%), hypertension (16.7%), and diabetes mellitus (5.5%) were common comorbidities. The prevalence of reduced kidney function was 5.5%, with heat exposure of 28.2–30°C associated with an OR of 4.5 (95% CI: 1.372–14.792). The prevalence of CKD was 0.9%, and heat exposure in the same temperature range demonstrated an OR of 8.958 (95% CI: 1.207–66.515). However, the association was not statistically significant after adjusting for age, obesity, and hypertension. These findings suggest that occupational heat exposure may contribute to early kidney impairment, highlighting the need for heat mitigation strategies and routine worker health monitoring in industries where workers are at risk of heat exposure.
Changes in Astigmatism After Phacoemulsification with a Superior Incision Pritasari, Alteriana Mydriati Sita; Giza, Putri Arifkha; Fatmawati, Dina; Suparmi, Suparmi
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4364

Abstract

Surgically induced astigmatism (SIA) is a common phacoemulsification procedure for senile cataracts. The size, location, and incision type significantly influence the SIA degree. This study aimed to evaluate the effect of a superior incision on astigmatism levels in patients both before and after phacoemulsification for senile cataracts. This retrospective analytical observational study utilized a cohort at Sultan Agung Islamic Hospital, Semarang, Indonesia, between November 2023 and May 2024. The accessible population consisted of patients treated during the study period. A total of 65 eyes from patients who underwent phacoemulsification with a superior incision were included in the study. Twenty-five patients (38.5%) exhibited against-the-rule (ATR) astigmatism before the surgical procedure, which decreased to 16 patients (24.6%) following surgery. In contrast, after phacoemulsification with a superior incision, the number of patients with with-the-rule (WTR) astigmatism increased from 61.5% to 75.4%. The astigmatism value before phacoemulsification with a superior incision was 1.274±1.02, while the value was 0.945±1,02 afterwards. The Wilcoxon Test revealed a significant difference (p<0.05) in the mean of astigmatism values before and after the procedure with a superior incision, indicating the surgical effect on reducing astigmatism. This study confirms that phacoemulsification using a superior incision significantly reduces postoperative astigmatism, particularly in patients with WTR astigmatism. Combining small incisions and sutureless techniques enhances corneal stability, accelerates healing, and improves surgical outcomes.
Effects of Propofol and Thiopental on Brain Relaxation and Hemodynamic Response to Craniotomy Supratentorial Tumors Removal Valentino, Andrea; Wijaya, Wan Novriza; Anggraeni, Novita; Sony, Sony
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4283

Abstract

Surgical procedures for brain tumors, particularly supratentorial tumor removal via craniotomy, present challenges related to brain relaxation and maintaining hemodynamic stability. The choice of intravenous anesthetics, such as Propofol and Thiopental, is crucial due to their distinct effects on intracranial pressure (ICP), cerebral blood flow (CBF), and hemodynamic parameters. This study aimed to compare the effects of Propofol and Thiopental on brain relaxation and hemodynamic responses during supratentorial tumor removal. A randomized experimental study was conducted at Arifin Achmad General Hospital, Riau, Indonesia, from May to September 2024 involving patients undergoing elective craniotomy for supratentorial tumors. Patients were divided into two groups: the Propofol group (1-3 mg/kg body weight, with maintenance of 50-100 µg/kg/min) and the Thiopental group (4-6 mg/kg body weight, with maintenance of 100-200 µg/kg/min), both receiving continuous infusion until a bispectral index of 40-60 was achieved. Hemodynamic parameters, including systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and heart rate, were measured at various stages: before induction, during surgery, and at multiple intervals. Brain relaxation was subjectively assessed by a neurosurgeon using a four-point scale. Results showed that 90% of subjects receiving Thiopental experienced good brain relaxation during duramater opening, compared to 70% in the Propofol group, though this difference was not statistically significant (p=0.118). Hemodynamically, the Thiopental group exhibited higher diastolic blood pressure and MAP at induction (p<0.05). In conclusion, Thiopental demonstrated superior hemodynamic stability, albeit both agents provided equally effective brain relaxation.
Avicenna Perpective of Learning-Difficulties, Screen-Time, and Emotional-Behavioral Issues in Children with Tuberculosis Nisaa', Defa Rahmatun; Dz, Abdus Salam; Karim, Abdul; Sambas, Dedi Rachmadi; Ramadhan, Muhammad Fachdi
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4299

Abstract

Pediatric tuberculosis has become a significant issue in Indonesia, affecting physical, mental, social, and educational aspects of the child. This correlational quantitative study aimed to analyze the correlation between learning-difficulties, screen-time, and emotional-behavioral issues of children with tuberculosis from the perspective of Avicenna. Data collection was performed on 68 children aged 5–12 years in Cirebon, Indonesia, during December 2024. Learning-difficulties were assessed using the Collorado Learning Difficulties Questionnaire in mathematics and language proficiency tests, while emotional-behavioral issues were measured using the Pediatric Symptom Checklist-17. Data analysis was then performed using the Spearman-Rank correlation test. Results showed that there was no significant relationship between learning-difficulties and children's emotional-behavioral issues in either language (r=0.56, p>0.05) or mathematics (r=0.212, p>0.05). However, excessive screen-time was significantly associated with emotional-behavioral issues (r=0.63, p<0.05). Avicenna's perspective shows the importance of balancing physical, mental, and spiritual health to support children's development. This study recommends reducing screen-time, providing family support, and integrating spiritual values into health interventions for children with tuberculosis to mitigate the psychosocial impacts of the disease. Thus, a holistic approach grounded in cultural and spiritual values for managing the condition is crucial.
Left Ventricular Function in Steroid-Resistant Nephrotic Syndrome At Dr. Hasan Sadikin Hospital Kusumaputri, Aghnia Ghassani; Rahayuningsih, Sri Endah; Rossanti, Rini; Apandi, Putria Rayani; Widiasta, Ahmedz
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4406

Abstract

Steroid-resistant nephrotic syndrome (SRNS) is a nephrotic syndrome (NS) which does not respond to high-dose corticosteroid therapy after 4 to 8 weeks. SRNS occurs in approximately 10–20% of childhood idiopathic nephrotic syndrome. SRNS patients are at risk of developing cardiovascular complications due to the long duration of the disease. This retrospective descriptive study investigated left ventricular function in pediatric patients with steroid-resistant nephrotic syndrome (SRNS) at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from 2018 to 2022. A total of 42 patients aged 1 month to 18 years who underwent transthoracic echocardiography (TTE) were included. Left ventricular function was assessed using ejection fraction (EF) and fractional shortening (FS). Most patients (61.9%) had normal EF and FS values, while 38.1% showed decreased systolic function. The mean EF and FS were 55.8% and 30.2%, respectively, with median values of 59.3% and 31.2%. An important finding in this study is that some children with SRNS exhibited decreased EF and FS values despite having no other identifiable risk factors for ventricular dysfunction, such as congenital heart disease (CHD), rheumatic heart disease (RHD), chronic kidney disease (CKD), or hypertension. This finding sugest that ventricular dysfunction may still occur independently in some cases of SRNS.
Effectiveness of Red Ginger (Zingiber Officinale Var. Rubrum) Hydrogel Extract as a Fever Reducer in Mice (Mus Musculus) Panna, Syafril S.; Kartika, Irna Diyana; Irwan, Andi Alamanda; Ardiansar, Abdul Mubdi; Anshary, Suci Noviyanah
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Fever is a common physiological response to infection, and its management is crucial to prevent complications such as dehydration and organ damage. While pharmacological treatments like antipyretics are commonly used, there is a growing interest in exploring natural alternatives. Red ginger (Zingiber officinale var. rubrum) has shown potentials as a natural antipyretic due to its active compound, gingerol, which inhibits prostaglandin synthesis and reduces inflammation. This study aimed to evaluate the efficacy of red ginger-based hydrogel formulations in managing fever. Male albino mice were used as test subjects, with fever induced via subcutaneous injection of peptone solution. Three concentrations of red ginger extract (3%, 5%, and 10%) in hydrogel form were tested. Temperature changes were recorded at 15-minute intervals for 60 minutes post-treatment. Results showed that the 5% red ginger hydrogel formulation demonstrated the most significant temperature reduction, with an average decrease of 8.2°C when compared to 4.65°C in the 3% formulation and 4.45°C in the 10% formulation. The 5% formulation also displayed optimal physical properties, including viscosity and pH stability, ensuring efficient absorption of the active compounds. The 10% formulation showed reduced effectiveness due to its high viscosity, which impaired absorption. In conclusion, the 5% red ginger hydrogel formulation is the most effective concentration to reduce fever, highlighting its potential as a natural, affordable, and accessible alternative to conventional antipyretic treatments. Future studies should further explore its clinical applications and scalability in diverse healthcare settings
Correlation of Leukocytes, Neutrophil-To-Lymphocyte Ratio, C-Reactive Protein, and Serum Lactate with Amputation Incidence in Diabetic Foot Ulcer Patients Primadian, Krisandi; Hapsari, Putie; Yarman, Indra Prasetya; Soedjana, Hardisiswo; Djajakusumah, Teguh Marfen
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4161

Abstract

Diabetic foot ulcers are a major cause of approximately 85% of amputations in non-trauma patients. One of the contributing factors is the presence of extensive gangrenous infections. Effective management of diabetic foot infections to prevent amputation requires knowledge of various factors such as ulcer location, depth, neuropathy, vasculopathy, infection, and the presence of infection, which can be identified through inflammatory markers. This retrospective cohort study aimed to evaluate the correlation between leukocyte count, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and serum lactate levels with the incidence of amputation in DFU patients. All DFU patients admitted to Dr. Hasan Sadikin General Hospital, Bandung, from January 1 to December 31, 2023, who met the inclusion criteria were included using purposive sampling. A total of 47 patients with diabetic foot ulcers were included in this study. The mean, median, and range of leukocytes were 18,532, 16,015, and 55,184, respectively, with higher values observed in amputation cases. NLR values were also higher in amputation cases, with a mean of 9.54, median of 6.00, and range of 47.32. Similarly, CRP levels were elevated in amputation cases, with a mean of 9.56, median of 6.75, and range of 26.16. There is a significant correlation between leukocytes, NLR, CRP, and serum lactate with the incidence of amputation in diabetic foot ulcer patients.

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