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Journal of Community and Clinical Pharmaceutical Sciences
Published by Penerbit Visi Pencerah Nusantara
ISSN : -     EISSN : 31638007     DOI : https://doi.org/10.64581/jccps.v1i1.97
Core Subject :
Journal of Community and Clinical Pharmacy is a double-blind peer-reviewed, open-access journal specializing in Pharmacy. It aims to publish articles on issues related to Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, and Alternative Medicines. Published twice a year (May and November) by Visi Pencerah Nusantara. Journal of Community and Clinical Pharmacy is an academic journal organized and operated by Visi Pencerah Nusantara which aims at publishing conceptual thought or idea and research findings that have been achieved in the field of original research.
Arjuna Subject : -
Articles 5 Documents
 1 
Garlic Plant (Allium sativum) in Ethnomedicine for the Treatment of Tinea Pedis (Athlete’s Foot): A Systematic Literature Review of Antifungal Activity Against Trichophyton mentagrophytes Muh Faisal; Dea Numayang Sari; Yulli Fitriana; Della Hazma Aulya Permata; Destira Arlita; Devana Adinda Setiawan
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.97

Abstract

Fungal skin infections such as tinea pedis are a common dermatological condition often caused by dermatophytes, particularly Trichophyton mentagrophytes. The use of medicinal plants in ethnomedicine, including garlic (Allium sativum), offers a potential alternative therapy due to its bioactive compounds that possess antimicrobial activity. This study aims to analyze the potential of garlic as an antifungal agent in the treatment of tinea pedis through a Systematic Literature Review approach. The research method employed a systematic literature review, with data sources drawn from scientific articles in the Google Scholar, PubMed, and ScienceDirect databases published between 2014 and 2024. Articles were selected based on inclusion criteria covering studies related to the antifungal activity of Allium sativum against dermatophytes, specifically Trichophyton mentagrophytes. The review results indicate that garlic contains primary bioactive compounds such as allicin and ajoene, which exhibit antifungal activity through mechanisms that inhibit fungal growth and damage the cell membranes of dermatophytes. Thus, garlic has the potential to be developed as an alternative herbal therapy for the treatment of tinea pedis. These findings provide a scientific basis for the development of natural-based antifungal products and encourage further research on their formulation and clinical efficacy.
A Systematic Analysis of the Use of Polymeric Nanoparticles to Enhance the Effectiveness of Targeted Drug Delivery in Cancer Therapy Muhammad Faisal; Dzun Haryadi Ittiqo; Yuli Fitriana; Widayatul Khairi; Wahyu Suryadi Ningrat
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.98

Abstract

Polymeric nanoparticles have emerged as a versatile platform for targeted drug delivery in cancer therapy, offering opportunities to improve therapeutic efficacy while minimizing systemic toxicity. This systematic literature review (SLR) comprehensively examines studies published over the past 10 years (2016-2025), sourced from Scopus, DOAJ, and Google Scholar, to identify key physicochemical parameters and biological mechanisms that govern nanoparticle performance. The analysis reveals that particle size critically determines tumor accumulation through the Enhanced Permeability and Retention (EPR) effect and influences systemic biodistribution, whereas surface charge modulates cellular uptake, protein corona formation, and clearance dynamics. Additionally, the implementation of surface modifications and ligand-mediated active targeting strategies further enhances selective tumor targeting and promotes apoptosis in malignant cells. Emerging trends, including dual-targeting approaches, stimuli-responsive polymers, and nanotheranostics, demonstrate the evolution of polymeric nanoparticles toward personalized and clinically translatable cancer therapies. This review underscores the necessity of integrated design strategies that combine precise physicochemical control with an understanding of biological interactions to optimize drug delivery outcomes, providing a roadmap for future research and clinical translation.
DIA-GUARD Herbal System: An Innovative Nano-Encapsulated Guava Leaf (Psidium guajava) Extract as a Natural Therapy to Inhibit Bacteria That Cause Diarrhea Doni Hardani; Dedi Arjuna Saputra; Dewi Azura; Clarifi Cahaya Al Amnora
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.99

Abstract

The high prevalence of diarrhea and increasing bacterial resistance to antibiotics have driven the development of alternative therapies based on medicinal plants. Guava leaves (Psidium guajava) are an ethnomedical plant widely used to treat diarrhea because they contain bioactive compounds such as flavonoids, tannins, alkaloids, and saponins that possess antibacterial activity. This study aims to analyze the pharmacological potential of guava leaves and to develop an innovative nanoencapsulation-based formulation as a natural therapy to inhibit bacteria causing diarrhea. The study employed an integrative review and library research approach, with literature searches conducted on Google Scholar, Scopus, DOAJ, SciSpace, Elicit, and Scite.ai covering the years 2015–2025. The results of the study indicate that guava leaf extract exhibits antibacterial activity against Escherichia coli with an average inhibition zone of 12–18 mm. The use of nanoencapsulation technology is reported to enhance the stability, bioavailability, and antibacterial efficacy of the extract compared to conventional methods. It is concluded that the integration of ethnomedical knowledge with nanoencapsulation technology has the potential to produce innovative herbal formulations that are more effective as alternative therapies for the treatment of diarrhea.
Exploration of Ethnomedicinal Plants for Skin Diseases: A Network Pharmacology Approach to Revealing the Molecular Mechanisms of Traditional Herbs R.F Yustisia; Risdayanti Risdayanti; R.A. Mauliantari
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.100

Abstract

Improvement prevalence disease skin multifactorial and limitations therapy conventional push exploration Ethnomedicine uses a systems approach to discover more effective and safe drug candidates. This study aims to analyze and synthesize scientific evidence related to the use of ethnomedicinal plants in the treatment of skin diseases and identify the relationship between ethnomedicine and drug use. between bioactive compounds with target biological through a network pharmacology approach . The method used is qualitative research with an integrative review approach , using data sources from Google Scholar, Elicit, Scite.ai, Scispace, DOAJ, and Scopus, with the inclusion criteria of articles from 2016–2026, relevant, speaking English Indonesian, And available full-text . The results of the study indicate that plants with high ethnobotanical value contain secondary metabolites such as flavonoids, alkaloids, and terpenoids that contribute to antioxidant, antimicrobial, and anti-inflammatory activities. The network pharmacology approach reveals multi-target interactions through biological pathways such as inflammation, apoptosis, and metabolism, which are strengthened by bioinformatics and molecular docking analysis . The conclusion of this study confirms that the integration of ethnomedicine and network pharmacology is able to explain comprehensive molecular mechanisms of medicinal plants. The implementation has the potential support development drug evidence-based herbal scientific and become the basis for innovation in modern dermatological therapy.
Plants Used in the Ethnomedicine of Diarrheal Diseases: A Synthesis of Scientific Evidence on the Role of Secondary Metabolites in Antidiarrheal Activity D.R Pratama; D.A Ananta; A. A. Lestari; D.N.K Maharani
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.101

Abstract

This study aims to analyze the relationship between plants used in the ethnomedicine of diarrheal diseases, their secondary metabolite contents, and the resulting antidiarrheal activities. The method used was library research with an integrative review approach, examining various scientific articles published from 2016 to 2025 obtained from several academic databases. The selection process was carried out through identification, screening, and eligibility evaluation stages to obtain relevant literature. The results showed that various plants from several families, such as Myrtaceae, Zingiberaceae, and Fabaceae, are traditionally used in the treatment of diarrhea. The most commonly used plant part was the leaves, with boiling being the primary preparation method. These plants contain major secondary metabolites such as flavonoids, tannins, alkaloids, and saponins. These compounds are known to possess pharmacological activities as antimicrobial, anti-inflammatory, antimotility, and antisecretory agents that contribute to reducing diarrhea symptoms. The conclusion of this study indicates that the use of plants in the ethnomedicine of diarrheal diseases has a strong scientific basis based on their secondary metabolite contents and pharmacological activities. These findings support the potential development of medicinal plants as an alternative natural-based antidiarrheal therapy.

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