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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 116   117   118   119   120 
Human papillomavirus (HPV) as the causal factor of tympanal cholesteatoma in malignant-type chronic suppurative otitis media Bambang Udji Djoko Rianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Tympanal cholesteatoma is an uncoordinated, uncontrolled hyperproliferative epidermic epithelial cells keratinized with aggressive, erosive and destructive development to the mucous membrane and the bone of external auditory canal and tympanic cavity. This process is invasive and may migrate to the surrounding tissue. Ethiopathogenesis of tympanic cholesteatoma is unknown. Histological examination shows that there are hyperproliferative development, papillomatous, koilocyte clusters and destruction of the bone. These abnormalities are characteristics of papillomavirus.Objective: To know the whether HPV-18 is the risk factor in the occurrence of tympanic cholesteatoma ini malignant-type chronic suupurative otitis media.Methods: A case-control study was conducted on 31 tympanal cholesteatoma specimens from malignanttype chronic suppurative otitis media as the case group, and 31 mucosal tympanic cavity specimens from benign-type chronic suppurative otitis media as the control group. For detecting Polymerase chain reaction (PCR) examination was used to detect DNA HPV-18, that performed in Parasitology laboratorium Faculty of Medicine, Gadjah Mada University.Results: Polymerase chain reaction (PCR) examination showed that there were 21 (67.7%) DNA HPV-18 positive specimens in the case group, while in the control group there were 5 (16.1 %) DNA HPV-18 positive specimens. This difference was statistically significant (p = 0.0001; Odds ratio: 1 0.92; 95 % confidence interval = 2.83-45.29). Immunohistochemistry examination was used to identify host immune response to HPV, by observing the interleukin-1 IIl-1) and interferon g IIFN g) expressions. Both Il-1 and IFN g cytokines were highly expressed in tympanic cholesteatoma samples, compared to both in the control group. The difference was statistically significant (p < 0.05, Odds ratio 14.29; 95% confidence interval: 3.64-60.5 and p< 0.05, Odds ratio:10.2; 95% confidence interval: 2.74-40.35, respectively). Conclusion: It can be concluded that HPV-18 DNA was iidentified, and was one of the multiple risk factors in the occurence of tympanic cholesteatoma in malignant-type chronic suppurative otitis media..Key words: tympanal cholesteatoma - human papillomavirus - malignant-type chronic suppurative otitis media
Uji Lapangan Skala Kecil Tentang Pengaruh Kahut Panas Chlorpyrifos Terhadap Nyamuk Aedes aegypti dan Anopheles aconitus Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 01 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Sugeng Juwono Mardihusodo, Kasumbogo Dengue Haemorrhagic Fever (DI-IF) and malaria are two major diseases of public health importance in Java, and other areas of Indonesia. Chemical insecticides are still the main weapon in the control of the disease vectors particularly in epidemic situations. In case of malaria vector control, mainly in Java, one of the problems encountered in the field is the development of highly resistant strain of Anopheles aconitus to DDT. Efforts should be taken, therefore, to find a better and more effective insecticide for controlling the vector.Clorpyrifos (Lorsban *180 EC) at doses of 100 ml/ha, 200 ml/ha. and 300 ml/ha applied as thermal fog was proved to be highly effective for controlling Aedes aegypti and An. aconitus mosquitoes, equal to that of malathion at the dose of 438 ml/ha..Considering the effectiveness and efficiency of the control, the recommended dose of chlorpyri - fos for two species of mosquitoes is 100 ml/ha.Key Words: thermal fog — chlorpyrifos — malathion — Aedes aegypti — Anopheles
Soal-soal ujian objektif dalam ilmu kedokteran: macam ragamnya dan untung ruginya. T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 9, No 03 (1977)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keywords: macam soal-soal ujian-kedokteran
Sexual dimorphism of pelvimetry in children at the circum puberal age: A study of children in lmogiri District Bantu! Regency Yogyakarta Special Provinc Janatin Hastuti Janatin Hastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 3 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Age of circum puberal is important because during this period primary and secondary sexual characteristics are developing. Morphological sexual differentiations of boys and girls during this period cause sexual dimorphism, i.e. anatomical differences especially in the body measurements. One of the important variations is the measurements of pelvic (pelvimetry).Objective: The aims of this studi were to know the pelvimetric sexual dimorphism of boys and girls at the circum puberal age.Methods: Investigation was conducted on 172 children of 12 up to 15 years old which consisted of 72 boys and 100 girls who were born and lived in Imogiri District, Bantu! Regency, Yogyakarta Special Province.The samples were divided into 4 groups and were measured on height, weight, bicristal breadth, biiliospinal anterior breadth, bitrochanteric breadth, distance of lumbale-symphysion and pelvic girdle. The indices calculated are Livi's index, bicristal index, bitrochanteric index, and the sexual dimorphism index of all measurements. The datas were analysed using two-ways anova, student-t analysis, and Kolmogorov-Smirnov test.Results: The result showed that bicristal breadth, biiliospinal anterior breadth and distance of lumbalesymphysion did not indicate sexual dimorphism significantly in children in the circum puberal age, although girls at 12 and 13 years old have greater measurements than boys. Bitrochanteric breadth and pelvic girdle showed sexual dimorphism since the age of 13 years, girls had greater measurements than boys. Sexual dimorphism of pelvic shape showed by bicristal index was happened at 15 years old, girls had greater index than boys. Sexual dimorphism of hip shape showed by bitrochanteric breadth index was happened since 13 years old, girls had greater index than boys.Conclusions: It was concluded that pelvic measurements showed sexual dimorphism in children at the circum puberal age by different time and pattern.Key words: sexual dimorphism - pelvimetry - children - circum puberal
Expression of CD5, CD1 0, Bcl-2 and Bcl-6 in diffuse large B cell lymphoma based on International Prognostic Index Indrawati Tody Guntersah
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 03 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Diffuse large B cell lymphoma is the most common type of non-Hodgkin lymphoma. This tumor has heterogeneous clinical feature, morphology, genetic and molecular alterations. Diffuse large B cell lymphoma with a germinal centre ( GC ) pattern of gene expression including CD10 and Bcl-6 has a more favorable outcome. CD5 and Bcl-2 expression has been shown to have an adverse effect on the outcome in diffuse large B cell lymphomaObjective: To investigate the difference of CD5, CDlO, Bcl-2 and Bcl-6 expression based on International Prognostic Index IIPI) in diffuse large B cell lymphomaMethods: Fourty five cases of B cell diffuse large B cell lymphoma from embedding parafin tissue were constituted the basis of the study. Immunohistochemical examination using CD20, CD5, CD10, Bcl-2 and Bcl-6 monoclonal antibody was done. The difference of CD5, CD10, Bcl-2 and Bcl-6 expression between high and low IPI of diffuse large B cell lymphoma were analized by chi square testResult: There Vlias significant difference between the number of cases with positivity of CD5 and CD10 expression in high and low IPI of diffuse large B cell lymphoma. The result supported that immunophenotyping related B cell differentiation can help to predict clinical behavior and prognosis in diffuse large B cell lymphoma.Conclusion: Conclusion: There was significant difference between the number of cases with positivity of CD5 and CD10 expression in high and low IPI of diffuse large B cell lymphoma. The result supported that immunophenotyping related B cell differentiation can help to predict clinical behavior and prognosis in diffuse large B cell lymphoma.Key words : diffuse large B cell lymphoma, CD5, CD 10, IPI
Cerebrotendinous xanthomatosis Soedarmadji Soedarmadji
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 03 (1983)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A case of cerebrotendinous xanthomatosis in an Indonesian male, 25 years of age, is reported. The diagnosis was based on clinical features, laboratory and histopathologic examinations, without measurement of cholestanal concentration either in the plasma or in the xanthoma.Key Words: xanthoma - normolipidemia lipoidosis - cataracta juvenilis - neurologic disturb 
Observations on The Life Cycle of An Eimeria SP.Of Chikens In Peninsular Malaysia Budihardjo Budihardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 04 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The life cycle of an unidentified Eimeria sp. from domestic chickens in Malaysia was studied. Sporulation of oocysts was completed in 34 hours at room temperature (30° C). Oocysts are ellipsoidal to ovoid averaging 21 by 18 millimicron with a yellowish double waIl. There is a polar granule. Sporocystsare elongated and ovoid averaging 11 by 6 millimicron in size with a Stieda .body and containing a sporocysts residuum.First generation schizonts develop throughout the intestine, mainly in the crypt of Lieberktihn but also in the muscularis muscosae, lamina propria and epithelial cells above the host nucleus. About 1.4 morozoites are produced.Second generations also develop throughout the' intestine, mainly in the 'lamina propria, below the host nucleus. About 12 morozoites are produced.Gametoytes are most numerous in the mid-intestine, large intestine and cecum and are mainly in the lamina propria.Pathogenicity was mild. Diarrhea and mucoid edema were the only clinical signs observed and the infection was self-limiting, ending after about 20 days.
The combined treatment of vitamin A eye drops, oral vitamin A , and oral doxycycline in meibomian gland dysfunction. Suhardjo Suhardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 04 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The frequency of meibomian gland dysfunction (MGD) patients is increasing in elderly and especially in female. Meanwhile the relationship of dry eye with meibomian gland dysfunction is close. Dry condition of eye will result in epitheliopathy, susceptibility to superinfection, scarring sequelae, and neovascularization in ocular surface. Vitamin A can prevent epitheliopathy and disturbance of tear film stability. Oral doxycycline inhibits lipase activity of any attendant microorganism.Objective: To evaluate the effect of systemic combined therapy vitamin A and doxycycline with vitamin A eye drops versus vitamin A eye drop and oral doxycycline in the management of meibomian gland dysfunction.Methods: The design of study was double blind randomized clinical trial. Setting was at Dr Sardjito Eye Clinics. The subjects were 60 MGD patients aged 50-79 years old, male and female were enrolled in this study and divided into two groups. The group I received vitamin A eye drops and oral doxycycline of 100 mg for 4 weeks. The group II was treated with oral vitamin Aof 6000 IU two times per day for 3 weeks, vitamin A eye drops, and oral doxycycline of 100 mg for 12th weeks. Both groups were followed at 4, 8, and 12 weeks for clinical signs, tear production (Schirmer test), quality of mucine (ferning test), and quality of ocular surface (rose bengal test).Results: Improvement was obtained in both group, in clinical signs of MGD as well as in tear production, quality of mucine, and ocular surface condition. There was no significant difference between both groups (p=0.58, RR =0.86, 95%, CI 0.21-3.50). The combined treatment of oral vitamin A, vitamin A eye drops and oral doxycycline of 100 mg in 12 weeks results in similar improvement with treatment by vitamin A eye drops and oral doxycycline in 4 weeks in MGD patients. The side effect of doxycycline was gastrointestinal problem in 2 patients.Conclusion: The result of this study supports that four weeks treatment is sufficient in achieving improvement of meibomian gland dysfunction patients.Key words: Vitamin A - doxycycline - meibomian gland dysfunction - four weeks
The association of acety/ation status with the occurrence of autonomic neuropathy: Diabetic neuropathy cases study Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Acetylation is a type of drug metabolism pathway. People can be divided into two groups: rapid acetylators, i.e. those who will acetylate drugs (chemical substances) rapidly, and slow acetylators, i.e. those who will acetylate drugs (chemical substances) slowly. Many studies reported that slow acetylator become more succeptable to certain diseases compared to rapid acetylators. Neuropathy might occur in diabetes mellitus, with the following symtoms mononeuropathy, symmetrical peripheral polyneuropathy and/or autonomic neuropathy.Objective: To study the association between acetylation status with the occurrence of autonomic neuropathy on diabetic neuropathy cases.Methods: An analytical descriptive study involving 140 patients of diabetic neuropathy was conducted at Sardjito Central General Hospital, Yogyakarta, Indonesia.Results: Schellong Test confirmed a definite sympatic neuropathy in 11 (7,9%) patients. The examination of acetylation status revealed that 68%' of patients were rapid acetylators, and 32% patients were slow acetylators. Among the patients with autonomic neuropathy, it was found that 64% were slowly acetylators, whereas only 36% were rapid acetylators. Among the patients without autonomic neuropathy, 30,5% were slowly acetylators, whrereas 69,5% were rapid acetylators: this distribution frequency was similar to the normal population.Conclusion: Slow acetylation status had significant association (p<0,05) with the occurrence of autonomic neuropathy. Key words: acetylation status - autonomic neuropathy - diabetic neuropathy - sympatic neuropathy - Schellong Test 
Ureterovaginalfistel, a distal portion complication of the ureter injury - Case report Prawito Singodimedjo Prawito Singodimedjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 01 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In the female complication of the distal portion of the ureter injury is the ureterovaginal fistula, seen most often after the Wertheim hysterectomy. The true incidence of the disease is difficult to ascertain in the literature. Incontinence isthe first symptom of the ureterovaginal fistula patient. An IVP, RPG, cystography, cystoscopy and double dye test investigations are to be advocated for diagnosis of the disease.Ureterovaginal fistula is repaired by standard ureteroneocystostomy, incorporating an antirefluxing submucosal tunnel.Key Words: Wertheim hysterectomy - ureterovaginal fistula - incontinence - ureteroneocystostomy - ureter injury

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