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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 79   80   81   82   83 
Renoprotective effects of ACE inhibitors on the progression of diabetic kidney disease
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 01 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Functional and structural abnormalities in diabetic kidney disease lead to intraglomerular hypertension and albuminuria. Systemic hypertension and genetically inherited defect on autoregulation in preglomerular arterioles will enhance kidney injury in those patients. ACE inhibitors could reduce albuminuria In patients with diabetic nephropathy and animal models. Hemodynamic improvement manifested by the reduction of albuminuria by ACE inhibitors is only seen in the experimental studies. However, recent studies have shown that ACE inhibitors, especially captopril, could give protective effects on kidneys in insulin-dependent diabetics with nephropathy. Captopril also reduces the risk of death, dialysis, and kidney transplantation in those patients.Key words: diabetes mellitus -- kidney disease -- ACE inhibitors -- albuminuria -- kidney preservation
Effect of nonsteroidal antiinflammatory agent on Sprague-Dawley rats liver glutathione S-transferases activity Sudibyo Martono, Sudibyo Martono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 03 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Glutathion S-transferase (GST) is a group of multifunction isoenzymes playing a role as katalisator in releasing inflammatory mediators prostaglandin and leukotrien. Non-steroidal antiinflammatory drugs (NSAID) such as pentagamavunon-0 (Pgv-0), piroxicam, and mefenamic acid have antiinflammatory effect. Aim of study: The study was to know the effect of pentagamavunon-0 (Pgv-0), piroxicam and mefenamic acid on GST.Materials and methods: The effects of non-steroidal antiinflammatory drugs (NSAID.) piroxicam, mefenamic acid, and pentagamavunon-0 (Pgv-O) in vitro on mu and pi classes of Sprague-Dawley rats liver glutathione S-transferases (GST)-activity was studied. GST-activities was measured spectrophotometrically on the conjugation reaction between glutathione (GSH) and 1,2-dichloro-4-nitrobenzene (for representing the mu class of GST) or etachrynic acid (for representing the pi class of GST). The potency of inhibitory effect was stated as IC50 value (the concentration of inhibitor resulting in 50 % inhibition of GST-activity).Results: The result showed that piroxicam inhibited strongly the mu class of GST-activity with IC60 value of 42.66 mM and inhibited weakly the pi class of GST-activity with IC50 value of 100.79 mM. Mefenamic acid inhibited weakly the mu and pi classes of GST-activity with IC50 values of 107.09 and 275,0 mM (extrapolated), respectively. In this research, Pgv-0 was found to be the strongest inhibitor of the mu class of GST-activity with IC50 value of 3.91 mM and did not inhibit the pi class of rats liver GST-activity.Conclusions: Based on the results, it can be concluded that the three NSAIDs studied, all showed the inhibitory effects of mu class of GST-activity in decreasing order of Pgv-0, piroxicam, and mefenamic acid. Three of them did not or very weakly inhibited the pi class of rats liver GST-activity.Key words: NSAIDs - glutathione S-transferase - pentagamavunon-0 - 1,2-dikloro-4-nitrobenzene - etachrynic acid. 
Pendidikan Kedokteran dan Pelayanan Kesehatan T. Jacob, T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 8, No 04 (1976)
Publisher : Universitas Gadjah Mada

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Abstract

Pendidikan kedokteran• bertujuan • inencipta ahli-ahli kesehatan yang dapat rriernecahkan rnasaalah &darn •berbagai situasi. Yang; terutarna bertugas dalam hal ini adalah fakultas kedokteran," yang merupakan bagian dari universitas ; dengan dernikian. Keperluan akan tenaga medis yang beraneka ragam akan bertambah, misal- I nya teknisi perawatan ,intensif, jururawat epidemiologi, jururawat tugas luar, insinyur kedokteran, ahli hygiena rumah sakit dsb. Kerja sama dalam regu akan menjadi lebih penting.8. Kedudukan apotheker juga ,akan berubah; farmasi akan lebihdekat ke kedokteran. . .9. Rumah-rumah sakit yang ada sekarang. akan menjadi "kolot" dengan perubahan-perubahan tersehut di atm. • •`10. Exploii informasi akan terjadi terus, sehingga peranan pusat-pusat informasi akan sangat penting. Perkembangan ilrnu pengetahuan alarn. dan filsafat pasti akan mempengaruhi pulaunia kedokteran.Semua hal yang tersehut tadi man tak matt harus dihadapi oleh lembagaIembaga• pendidikan kesehatan. Taritangan itu menjadi lebih besar, oleh karena tenaga-tenaga clan fasilitas-fasilitas pendidikan kedokteran sangat terbatas di negeri kita. - • - • •• • •Tiga hal penting inerupakan fokus dalam pembinaan fakultas kedokteran, yaitu kedokteran korninunitas, moderniiasi klinik d.an pendewasaan ilnau-iImu kedokteran dasar, untuk menghadapi tantangan-tantangan tadi. Membangun salah satu tiang saja dariketiga tiang itu; pasti akan menimbulkan kepincangan.Fakultas Kedokteran UniVersitas Gadjah Mada telah berusaha niem- , Â·bangun jawaban terhadap tantangan tadi, tetapi karni cukup sadar bahwajalan masih sangat jauh. Distribusi alumni kami di seluruh tanah air agak .•menggembirakan, clemikian pula vertikalnya. Program kedokterankommunitas sudah beberapa Winn ditaksanakan dan terus mencoba mencari bentuknya yang tepat. Pengan fasilitas laberatoria dan rumah sakit yang terbatas, jumlah .dosen yang belum memadai dan biaya per mahasiswa per tahun yang rendah kami ter-us berusaha meningkatkan effisiensi dan. produktivitas. Pada akhirnya berhasilnya suatu .fakultas• kedokteran harus diukur pada perbandingan modal yang dituangkan Ice dalam proses pendidikan dan manfaat yang .diberikan oleh produknya-bagi kesehatan massa rakyat di seluruh tanah air meialtii . masa. - •tugas ini terletak dalain •lingkurtgan Departemen Pendidikan dan Kebudayaan. Sebagai bagiari suatu perguruan tinggi, maka Tridarma berlaku pula bagi fakultas kedokteran : Periama, mengajar para mahasiswa untuk pada suatu waktti dapat berdiri sendiri memecahkan masaalahmasaalah kesehatart.• Oleh- karena, perulidikari Mernpersiapkan mahasiswa untuk masa depan, maka perididikari haruS berorientasi ke depan, harns diSeSuaikart dengan keadaan yang diharapkan akan terdapat di masa depan. Oleh karena masa , depan yang jauh sukar dirarnalkan dengan. , tepat seluruhuya, maka mahasiswa dipersiapkan untuk dapat memecahkan soal-soal baru, menghadapi situasi baru.:„Karena pendiciikan difakultas kedokteran /amanya 6-7 tahun dan seseorang diharapkan meneapai, puncak produktivitasnya 10-15. ,tahun sesudah .tammat, maka mahasiswa -barns dipersiapkan .:untuk :16722 tahunyang, akaa datang ( Jacob,, 1. .Kedua, fakultas-kedokteran bertugas Melaltukan penelitian, Mengebbang kan ilmu-ilmu ,kedokteran jadi mencoba memecahkan Masalah masa depan yang, lebih jauh daripada mendidik. Seperti. dalam mengajar, masa depan ini juga relatif. Dalam mengajar makin tinggi tingkatsi mahasiswa, makin dekat dengan,keadaan, sekarang dia dididik. Pada tahapan koassisterisi dia dilatih merawat pasien•pasien ,,sekarang. -Dalam penelitian dalam klinik persoalan-persoalan yang lebih dekat dengan sekarang terutarna mendapat perhatian. HMO-HMO dasirkedaterari penelitian lebih mengarah ke masa depan yang jauh,. sehingga; bagi mereka yang melihat dekat, relevansinya tidak kelihatan. Bagi mahasiswa-mahasiswa tingkat, rendah kadang juga tidak kelihatan relevansi pelajaran yang diperolehnya dengan persoalan kesehatan atau praktek kedokteran sekarang. Demikian puba jika, penelitian makin dekat ke pengembangan dalam spektrum penelitian, Makin dekat pulakita dengan keadaan sekarang ; sebaliknya ke penelitian murni, makin jauh kita ke masa depan., Ketika dalam pelayanan umum (public service) fakUltas kedokteran terntaa berftinksi di tingkat klinik; meikipuri pada tingkat pre dan paraklinik pelayanan umum juga dilakukan.
Lactose Tolerance Test Pada Postg-astroenteritis akuta Teluk Sebodo, Teluk Sebodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 01 (1974)
Publisher : Universitas Gadjah Mada

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Abstract

Keyword : Lactose Tolerance
The Classical and Early methods of myringoplasty and tympanoplasty-I. Soewito, Soewito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 01 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

There is still a controversial vision about the appropriate time to carry out myringotomy or tympanoplasty-1 on chronic otitis media. Some experts agree that the most appropriate time is two or three months after dry tympanic cavity (Classical method). Other experts state that it is not necessary to wait too long, even though there is still mucoid discharge, surgery can be directly caned out (Early method).The myringoplasty and tyrnpanoplasty-I was carried out on 72 cases of active chronic otitis media, of which 43 cases using Classical method and the rest of 29 cases using Early method. The criteria of successful myringoplasty and tympanoplasty-1 surgery was a positive graft take and followed by improvement of hearing.The successful result of myringoplasty and tympanoplasty-I with Classical method was 93.02 % and with Early method was 89.65%. The statistical analysis showed that there is no significant difference in the succesful of the myringoplasty and tymphanoplasty-I surgery, between the Classical and Early method.Key Words: myringoplasty tympanoplasty-I chronic suppurative otitis media classical method early method.
Universitas Polemologi dan Perang Terakhir T. Jacob, T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 02 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This article discusses the problem of war among men which at present in the form of nuclear warfare constitutes the greatest threat against humanity and the human ecosystem. In the present state of evolution of the arms race $25 000 per second is spent for manufacturing weapons and four tons of TNT per capita arc available in the world arsenal for everybody. The cost to kill a human being has been increasing steadily, and wars have been taking more and more victims, with larger proportions of civilians. Natural scientists and engineers are more involved in the research and development of weaponry, and consequently, less funds arid manpower are allocated in the social and welfare sectors.It seems strange that the awareness of nuclear threat, which is real and immediate, is very low in the Third World; however. the International Association of University Presidents had successfully adopted the proposal for the International Day of Peace in its Congress in Costa Rica, and the first President of Gadjah Mada University since the 1950s had called attention towards studies and social innovation for the purpose of world peace.The nuclear arms race, which is more likely to precipitate a nuclear war, and which has taken victims though it has not yet become a reality, in the form of less social expenditures, its psychological influence on the young generation living continuously under a nuclear threat, and itspotential danger against the global ecosystem and human existence, altogether pales the destruction of Hiroshima by Little Boy.More important is the impotence of medical measures in case of a nuclear war, so that the one and only step to be taken is prevention. In this connection we observed the growing world movements against nuclear war which include more non-political groups without ideological affiliation.Actions that could be taken by a university in the Third World is limhed to conducting studies on human aggression and conflict resolution, teaching the etiology of war and the preservation of peace. and scientific ethics both in the hard and the soft sciences, and creating public awareness that a nuclear war is far different than a conventional one, in scale as well as in impact. In addition, Key Words: peace studies — nuclear war -- scientific ethics — arms race — Hiroshimaefforts for the prevention of nuclear war in the developed countries should be sThis article discusses the problem of war among men which at present in the form of nuclear warfare constitutes the greatest threat against humanity and the human ecosystem. In the present state of evolution of the arms race $25 000 per second is spent for manufacturing weapons and four tons of TNT per capita arc available in the world arsenal for everybody. The cost to kill a human being has been increasing steadily, and wars have been taking more and more victims, with larger proportions of civilians. Natural scientists and engineers are more involved in the research and development of weaponry, and consequently, less funds arid manpower are allocated in the social and welfare sectors.It seems strange that the awareness of nuclear threat, which is real and immediate, is very low in the Third World; however. the International Association of University Presidents had successfully adopted the proposal for the International Day of Peace in its Congress in Costa Rica, and the first President of Gadjah Mada University since the 1950s had called attention towards studies and social innovation for the purpose of world peace.The nuclear arms race, which is more likely to precipitate a nuclear war, and which has taken victims though it has not yet become a reality, in the form of less social expenditures, its psychological influence on the young generation living continuously under a nuclear threat, and itspotential danger against the global ecosystem and human existence, altogether pales the destruction of Hiroshima by Little Boy.More important is the impotence of medical measures in case of a nuclear war, so that the one and only step to be taken is prevention. In this connection we observed the growing world movements against nuclear war which include more non-political groups without ideological affiliation.Actions that could be taken by a university in the Third World is limhed to conducting studies on human aggression and conflict resolution, teaching the etiology of war and the preservation of peace. and scientific ethics both in the hard and the soft sciences, and creating public awareness that a nuclear war is far different than a conventional one, in scale as well as in impact. In addition, Key Words: peace studies — nuclear war -- scientific ethics — arms race — Hiroshimaefforts for the prevention of nuclear war in the developed countries should be supported, and solidarity among men should be intensified for further cultural emancipation.upported, and solidarity among men should be intensified for further cultural emancipation.Key Words: peace studies - nuclear war - scintific ethics - arms race - hiroshima
The Effect of Food Supplementation Program on Anthropometry, Hematology, and Parasites of Primary School Children Christin M. Santosa, Christin M. Santosa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 3 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Food supplementation is problem solving efforts during multidimensional crisis.Objectives: This research was carried to evaluate further the advantages of the food supplementation in the primary school children towards their physical development and health status.Methods: Students with completely participation on these research and their parents agreed to informed consent were taken as inclusion criteria. The subjects of this experiment were sixth grade school children and divided into 2 groups i.e 25 control and 31 treated groups. The treatment group was given food supplementation consisting of one boiled egg and one glass of green-peas porridge (220 ml) each, three times a week for 10 weeks, whereas the control group was not given any. Observations were carried out five times: at 0, 3, 7, 10, and 13 weeks. The results were analized by the Student-t test.Results: The results showed significant increases in body weights (p0.05) between control and treatment groups neither for the boys nor girls. And until the last week faeces samples, it is never detected the situation where it is free from worm investation and protozoa infection either for control or treatment group.Conclusion: The food supplementation was apparently adequate to meet the optimal caloric and proteins requirements of these children, so that could improve physical development and health status as shown by the increased anthropometric measurements, decreasing parasite infection and steady hematological picture.Key words: food supplementation - anthropometry - hematology - parasites - primary school children
Ketela Pohon dan Toksisitasnya Siti Dawiesah Ismadi, Siti Dawiesah Ismadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 02 (1975)
Publisher : Universitas Gadjah Mada

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Abstract

key words: ketela pohon
Dosen Abad XX1 Anonim, Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
Publisher : Universitas Gadjah Mada

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Abstract

Kata Kunci: Pendidikan Tinggi - Dosen
Various roles of the reticaloendothelial system Harjani, Harjani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 01 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The reticuloendothelial system is the bodys defence units, which are situated in every tissues layer and tissues folds of the body, and function as one functional unit.Its cellular components have the capacity to move to approach foreign particles by the help of the circulation function or by active amoeboid movements within the tissue, to phagocytose those foreign particles. Some of these cellular components have the capacity to make humoral antibody. Its most important function is to maintain the uniqueness of self, which includes among others:-destruction of foreign particles,-destruction of senile cells of the body, andcancer surveillance.Key Words: emperipolesis, bacterial infection - immediate and delayed hypersensitivity- Slow Reacting Substance of Anaphylaxis - blocking antibody

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