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Effect of Low Impact Aerobic Exercise on Functional Balance and Quality of Life in Type 2 Diabetes Mellitus Patients. Peni Hardjanti; Bayu Santoso; Nuniek Nugraheni; Agung Pranoto
Indonesian Journal of Physical Medicine & Rehabilitation Vol 2 No 01 (2013): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Objectives: To determine the effect of low impact aerobic exercise on functional balance and the quality of life in type 2 Diabetes Mellitus (DM) patientsMethods: This is an experimental study. Participants were recruited from outpatient Diabetes Clinic in Dr. Soetomo General Hospital, Surabaya, Indonesia. Subjects of this study are men and women aged 30-70 years whose diagnosed with type 2 DM, with A1c less than 10%, have been using oral anti diabetic drug or subcutaneous insulin less than 30 IU daily, blood glucose level before exercise less than 250mg%, and Berg Balance Scale between 41-56. Subjects were randomized into 2 groups with 38 subjects in the exercise group and 37 in the control group. The exercise group followed 25-30 minutes diabeticaerobic low impact exercise 3 times a week for 3months, while the control group did not. Functional balance and quality of life before and after exercise were assessed using Berg Balance Scale (BBS) andthe Sickness Impact Profile (SIP) questionnaire. Difference in BBS and quality of life improvement measured by SIP questionnaire were analyzed after 3 months of exercise.Results: Mann Whitney test showed significant difference of the total score of BBS in the exercise group (p 0.02; α < 0.05). Chi Square test revealed significant improvement in four of the twelve parameters ofthe quality of life: sleep and rest (SR) (p 0.044), body care and movement (BCM) (p 0.017), ambulation (A) (p 0.001), and work (W) (p 0.000) in the exercise group.Conclusions: Low impact aerobic exercise in type 2 Diabetes Mellitus patients may improve functional balance and the SR, BCM, A, and W parameters of the quality of life.Key words: Low impact aerobic exercise, type 2 diabetic mellitus, functional balance, quality of life.

Effect of Low Impact Aerobic Exercise on Functional Balance and Quality of Life in Type 2 Diabetes Mellitus Patients. Peni Hardjanti; Bayu Santoso; Nuniek Nugraheni; Agung Pranoto
Indonesian Journal of Physical Medicine & Rehabilitation Vol 2 No 01 (2013): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Objectives: To determine the effect of low impact aerobic exercise on functional balance and the quality of life in type 2 Diabetes Mellitus (DM) patientsMethods: This is an experimental study. Participants were recruited from outpatient Diabetes Clinic in Dr. Soetomo General Hospital, Surabaya, Indonesia. Subjects of this study are men and women aged 30-70 years whose diagnosed with type 2 DM, with A1c less than 10%, have been using oral anti diabetic drug or subcutaneous insulin less than 30 IU daily, blood glucose level before exercise less than 250mg%, and Berg Balance Scale between 41-56. Subjects were randomized into 2 groups with 38 subjects in the exercise group and 37 in the control group. The exercise group followed 25-30 minutes diabeticaerobic low impact exercise 3 times a week for 3months, while the control group did not. Functional balance and quality of life before and after exercise were assessed using Berg Balance Scale (BBS) andthe Sickness Impact Profile (SIP) questionnaire. Difference in BBS and quality of life improvement measured by SIP questionnaire were analyzed after 3 months of exercise.Results: Mann Whitney test showed significant difference of the total score of BBS in the exercise group (p 0.02; α < 0.05). Chi Square test revealed significant improvement in four of the twelve parameters ofthe quality of life: sleep and rest (SR) (p 0.044), body care and movement (BCM) (p 0.017), ambulation (A) (p 0.001), and work (W) (p 0.000) in the exercise group.Conclusions: Low impact aerobic exercise in type 2 Diabetes Mellitus patients may improve functional balance and the SR, BCM, A, and W parameters of the quality of life.Key words: Low impact aerobic exercise, type 2 diabetic mellitus, functional balance, quality of life.

Serum Level Changes of Neurotrophin-3 after Performing Diabetic Foot Exercise in Diabetic Neuropathy Tri Wahyuliati; Agung Pranoto; Samekto Wibowo
International Journal of Public Health Science (IJPHS) Vol 4, No 4: December 2015
Publisher : Intelektual Pustaka Media Utama

The research aimed to determine the pattern of changes in serum levels of NT-3 in the improvement of diabetic neuropathy, after doing diabetic foot exercise. A true experimental study with randomaized pre – post test control trial. A total of 36 subjects meeting the inclusion and exclusion criteria were included in the exercise group or the control one with age matched systematic random sampling method. Exercise group had a significant improvement on the score of ABI (p.0.002), systolic blood pressure (p.0.014), diastolic blood pressure (p.0.055), DNS (p.0.01), DNE (p.0.001) and increased of serum level of NT-3 (p.0.049). Control group had result respectively on ABI (p.0.131), systolic blood pressure (p.0.668), diastolic blood pressure (p.0.216), DNS (p.1.00), DNE (p.0.543), and increase of NT-3 (p.0.264). The comparation results of the two groups had a significant different on the score of ABI (p.0.01), systolic blood pressure (p.0.01), diastolic blood pressure (p.0.01), DNS (p.0.01), DNE (p.0.01), and increased of NT-3 (p.0.01). Diabetic foot exercise had a peripheral affect on a clinically significant improvement based on ABI scores, systolic and diastolic blood pressure, DNS and DNE, and increase of serum level of NT-3.

In-Vitro Differentiation Adipose-Derived Mesenchymal Stem Cells into Pancreatic Progenitor Cells Hermina Novida; Agung Pranoto; Askandar Tjokroprawiro; Sony Wibisono; Purwati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14752

Background: Adult stem cells are currently reliable sources of mesenchymal stem cells for regenerativetherapy, include diabetes mellitus. The aim of this study is to develop endocrine pancreatic progenitor cellscharacterized by Pdx1 and insulin expression from rat adipose-derived mesenchymal stem cells using twosteps in-vitro differentiation.Methods: In this experimental study, ADMSCs were isolated from rat adipose tissue and exposed toinsulinogenic differentiation medium containing nicotinamide, activin A and glucagon-like peptide-1 (GLP1). After induction, the existence of pancreatic progenitor cells (PPCs) was confirmed by immune-stainingassay of Pdx1 and insulin.Results: After three weeks of in-vitro differentiation, expression of Pdx1 and insulin proteins showed upas green in the immunofluorescence assay. Immunofluorescence intensity of Pdx1 was higher in PPCs thanin ADMSCs control (p<0.05). Immunofluorescence intensity of insulin was also higher in PPCs than inADMSCs control (p<0.05). Therefore, in-vitro differentiation was successful to develop PPCs from ratADMSCsConclusion: This study has demonstrated the in-vitro differentiation of ADMSCs into PPCs that expressedPdx1 and insulin

Kendali Glikemik pada Pasien Diabetes Melitus Tipe 2 dengan dan tanpa Tuberkulosis Paru Wahiduddin Wahiduddin; Agung Pranoto; Sudjarwo Sudjarwo
Media Kesehatan Masyarakat Indonesia Vol. 15 No. 1: MARET 2019
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

Glycemic control is important for people with diabetes mellitus (DM) because it has implications for effortsto manage DM. Pulmonary tuberculosis (PTB) is one of the many complications in DM patients associatedwith the process and results of treatment of the disease. The study aimed to determine glycemic control based onparameters of fasting blood glucose level (FBG), 2 hours post prandial blood glucose (2hPBG) and HbA1c in patientswith type 2 diabetes mellitus (T2DM) who had pulmonary TB. A cross-sectional study was conducted on 45T2DM subjects with PTB and 45 T2DM subjects without PTB who were outpatient in two hospitals in Surabaya.The results of the examination of FBG, 2hPBG, and HbA1c were analyzed descriptively, displayed in the form ofmean values and standard deviations (SD). The mean and SD were FBG (202.11 ± 78.68 mg/dl), 2hPBG (283.20± 107.20 mg/dl), and HbA1c (11.20 ± 2.61%) in T2DM subjects with pulmonary TB while subjects without pulmonaryTB were obtained FBG (175.29 ± 61.38 mg/dl), 2hPBG (208.22 ± 75.60 mg/dl), and HbA1c (9.34 ± 2.22%).The mean of FBG, 2hPBG and HbA1c of T2DM patients with pulmonary TB were higher than T2DM withoutpulmonary TB. This shows that the control criteria for DM that have not yet reached the target need to be done inan effort to better monitor glycemic control.

The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Agung Pranoto; Satiti Retno Pudjiati; Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.814 KB)

Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.

Risk Factors of Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus (DM) Patients at Dr. Soetomo General Academic Hospital, Surabaya Joshua Teofilus Sutadji; Agung Pranoto; Risky Vitria Prasetyo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 1 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I12023.12-16

Highlights:1. The highest risk was a history of hypertension, followed by a history of low HDL levels.2. Patients with type 2 DM at Dr. Soetomo General Academic Hospital, Surabaya, had a greater risk of developing CKD for patients with a history of hypertension (3.801 times higher) and patients with a history of low HDL (3.356 times higher). AbstractIntroduction: Type 2 diabetes mellitus (DM), categorized as a non-communicable disease, has become a global health concern. This study aimed to identify the risk factors for chronic kidney disease (CKD) in type 2 DM patients at Dr. Soetomo General Academic Hospital, Surabaya.Methods: This was a case-control study. The samples were collected using consecutive sampling methods from the medical records Dr. Soetomo General Academic Hospital, Surabaya. The total samples were 158 patients consisting of 79 cases and 79 controls. Independent variables were a history of uncontrolled HbA1c levels; hypertension; high triglyceride (TG) levels; low high-density lipoprotein (HDL) levels, high low-density lipoprotein (LDL) levels, and being overweight. The dependent variable was CKD. Samples were analyzed using the Chi-Square test and logistic regression.Results: From six independent variables that were analyzed, two variables had significant results based on the Chi-Square test. Logistic regression was performed and showed the significant results between risk factors of CKD and type 2 DM patients at Dr. Soetomo General Academic Hospital, Surabaya, were a history of hypertension (OR = 3.801, 95% CI = 1.875-7.706) and a history of low HDL levels (OR = 3.356, 95% CI = 1.650-6.827). The highest risks were a history of hypertension followed by a history of low HDL levels.Conclusion: Type 2 DM patients at Dr. Soetomo General Academic Hospital, Surabaya, with a history of hypertension and a history of low HDL had a greater risk of developing CKD.

CLINICAL PROFILE OF TYPE-1 DIABETES PEDIATRIC PATIENTS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL SURABAYA: CORRELATION OF GROWTH STATUS AND METABOLIC CONTROL Grawira Drana Putra Respati; Muhammad Faizi; Agung Pranoto; Mia Ratwita Andarsini
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.7-13

Highlights1. Diabetes mellitus type 1 (DM) is a chronic autoimmune illness characterized by insulin insufficiency and hyperglycemia as a consequence.2. Stable HbA1c levels may be indicative of improved growth rates. AbstractBackground: Type-1 diabetes mellitus (DM) is a chronic auto-immune disease characterized by insulin insufficiency and resultant hyperglycemia caused by the destruction of insulin-producing beta cells in the pancreas. Metabolic control in type-1 DM affects the metabolism of patients, one of which is growth status, which is influenced by growth hormone. Improved growth rates can indicate stable HbA1c levels. However, whether growth is affected by the degree of diabetic control is still debatable. Objective: This study was conducted to determine whether the metabolic control correlates with growth status of children with type-1 diabetes in the Endocrine Polyclinic at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Material and Method: Retrospective observational analysis with a cross-sectional method was conducted on 96 type-1 DM patients at Dr. Soetomo General Academic Hospital Surabaya, Indonesia. The analysis was carried out using Chi-Square test to determine whether there was a correlation. Result: From a total of 96 pediatric patients, the majority was male (54.1%), patients with high-risk metabolic control were 79.2%, and those with z-score normal category were 62.5%. The results indicated no significant correlation between growth status and metabolic control of pediatric patients, with Chi-Square test results showed p=0.421 (p>0.05). Conclusion: There was no significant correlation between growth status and metabolic control of type-1 diabetes pediatric patients at the Endocrine Polyclinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

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