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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 18 Documents

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Search results for , issue " Vol 8, No 1 (2018): Pharmaciana" : 18 Documents clear

Total phenol, flavonoid, and anthocyanin content and antioxidant activity of Etlingera elatior extract and nanoparticle Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Ruswanto, Ruswanto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Despite the long and wide application, traditional medicine is known for its minimum efficacy. Nanoparticle technology has reported to optimally address this weakness by enhancing the ability of the medicine to penetrate the biological membrane and, thereby, increasing the absorption. In this research, Etlingera elatior (ginger flower) extract, which has antioxiandt activity, was formulated into nanoparticles with ionotropic gelation method using chitosan (0.08, 0.09, 0.1, 0.2, and 0.3%) and 0.01% NaTPP. The nanoparticles were characterized by their particle size, polydispersity index, zeta potential, and entrapment efficiency against total phenolic compound, flavonoid, and anthocyanin. The ones with the best properties were then analyzed with Scanning Electron Microscopic (SEM) method and tested for its antioxidant activity against DPPH. The results showed that all of the formula variations produced particle size in the range of 147.0-566.2 nm with a polydispersity index of < 0.5 and zeta potential between 0.45-45.90 mV. Also, the absorption efficiencies of phenol, flavonoid, and anthocyanin were 72.62-84.24%, 55.18-92.05%, and 75.67-97.96%, respectively. Overall, the best characteristics were presented by the combination of 0.1% chitosan and 0.01% NaTPP, which produced 246.4-nm nanoparticles with a polydispersity index of 0.418, and zeta potential of 26.60 mV. These nanoparticles also contained phenol, flavonoid, and anthocyanin with good absorption efficiencies, namely 78.5186%, 92.05%, and 97.96%, respectively. SEM analysis showed that these nanoparticles were round and had a soft surface. The radical scavenging activities of the extract and the nanoparticles against DPPH, as presented by the IC50 values, were 19.614 ppm and 160 ppm.

The formulation of carvedilol transdermal patch with resin gum as rate control Yati, Kori; Pamungkas, Septiana Tri
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Carvedilol is widely prescribed for long-term hypertension treatment. It is rapidly absorbable by oral administration, but its bioavailability is merely about 20% in humans. Drug delivery is therefore imperative to overcome this weakness. One form of transdermal drug delivery system is a patch. Transdermal patch is composed of various systems, for instance, a reservoir that uses a rate control layer to manage the rate of drug release. This research aimed to observe the effect of using resin gum as the control of drug release rate on the physical characteristics and release of carvedilol in a transdermal patch. The patches were prepared in 5 formulas with different quantities of resin gum, namely 50, 100, 150, 200, and 250 mg. Afterward, they were evaluated physically, and their dissolution and diffusion rates were analyzed. The results showed that resin gum with concentrations of 150 mg and 200 mg was physically qualified for rate control. Besides, the results of dissolution and diffusion tests revealed that transdermal patches with 150 mg of resin gum exhibited the best drug release and penetration.

The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Nugrahani, Ilma; Aulia, Winni Nur
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the methodâs performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.Â Â

Formulation and physical stability test of oleanolic acid cream and gel Kartini, Kartini; Fitriani, Endang Wahyu; Tansridjata, Laurances
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. The aims of this study were to (1) formulate oleanolic acid into topical dosage forms i.e. cream and gel; and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate and cetyl alcohol as the cream base and carbomer as the gel base. Cream and gel were then subjected into accelerated (40Â±2Â°C/75Â±5% RH) and room temperature (27Â±2Â°C/73Â±5% RH) stability test for six weeks. Physical stability was determined using parameters of visual appearance, specific gravity, viscosity and flow properties, for both gel and cream, as well as the type of emulsion and particle size for the cream. Data analysis were performed using one-way ANOVA and paired t-test. It is concluded that gel and cream of oleanolic acid were able to maintain their visual appearance, specific gravity, viscosity and flow properties during six weeks of storage. In addition, oleanolic acid cream could also maintain its particle size and type of emulsion during testing.Â

Screening of Antiradical Activity From Some Central Sulawesi Mangroves Dewanto, Didit Kustantio; Tanod, Wendy Alexander; Finarti, Finarti; Renol, Renol
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antiradicals are substances with important functions for human health. Mangrove leaves are one of potential sources of natural antiradical. The objective of this research was to identify the type and fraction of mangrove leaves extract with the highest antiradical activity. The research procedure included sampling and extraction of mangrove leaves, assay of antiradical activity (DPPH), phytochemical assay and determination of IC50 for the fraction with the highest inhibition percentage. Mangrove leave samples (Rhizophora sp., Avicennia sp. and Sonneratia sp.) used in this study were collected from the Palu Bay coastal. Results showed the highest yield of extracts was from Rhizophora sp., followed by Avicennia sp. and Sonneratia sp. Inhibition percentage was higher from dried compared to fresh mangrove leaves. Additionally, the inhibition percentages of the ethanol fraction was higher than that of the ethyl acetate and n-hexane fractions, while Sonneratia sp. gave a higher inhibition percentage than Avicennia sp. and Rhizophora sp. The ethanol fraction IC50 was determined for

Chemometrics-assisted spectrophotometry for simultaneous determination of sodium benzoate and citric acid in beverage products Rahardian, Ganjar Wahyu; Monica, Sausa; Wasito, Hendri; Susilowati, Sri Sutji
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The development and validation of chemometrics-assisted spectrophotometry have been successfully performed for determination of sodium benzoate and citric acid that have overlapping of ultra violet absorption spectra. The study aimed to develop, validate, and apply spectrophotometric method with chemometrics approach for determination of both compounds in beverage products simultaneously. The analytical method was performed by making a calibration model using 16 training sets and 10 test sets of mixed solution followed by absorbance measurenment at wavelength of 190 nm up to 400 nm. In addition, the absorbance data was processed by multivariate calibration models of principal component regression (PCR) and partial least square-1 (PLS-1) and validated internally and externally to obtain optimum model. Validation of analytical methods was done by evaluating some parameters such as linearity and ranges, accuracy, precision, detection limits and quantification limits. The results showed that the optimum wavelength was 235 nm to 250 nm for sodium benzoate and 220 nm to 240 nm for citric acid with the selected optimum principal components (PCs) value were 6 (PCR) and 4 (PLS-1) for sodium benzoate and PCs 2 (PCR and PLS-1) for citric acid. The parameters of the analytical method validation developed were suitable and the analytical methods could be applied for the determination of the sodium benzoate and citric acid contents simultaneously in the beverage products.Â

Correlation of diuretic therapy toward clinicaloutcomeof patients suffering from chronic kidney disease hospitalized in RSUP DR. M. Djamil Padang Sani K., Fathnur; Nazar, Armenia; Haque, Aina Fatkhil
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTKidney is one of the most important organs of the human body. The goal of diuretic therapy is to reduce edema in patients with impaired renal function. The therapy of diuretic is very important, because the therapy is effective to control of the volume of extracellular fluid, reduce protein exretion in urine and reduce on effects of hyperceluler complications. The purpose of this research is to provide information on the effect of giving diuretics with clinical outcome of patient with cronic kidney disease. The research was conducted by using longitudinal observational study design. Longitudinal observation is a method that perform data retrieval by a prospective census method with daily follow up until patient returns. The result of research showed that the most widely used diuretic was furosemide. Then the results also showed improvement of blood pressure, pulse, respiration rate, creatinine and urea although the results were not statistically significally (p>0.05). Mortality rate of the subjects in RSUP DR. M.Djamil Padang Hospital was very small. Patient with diuretic and without diuretic have equal mortality rate (p>0.05).Keyword: Kidney, CKD, Outcome, Diuretic

Detoxification of 1,2-dihydroxy- 4-allylbenzene, a major phenolic compound in Piper betle, through glucuronidation using S9 protein of rat liver (Sprague Dawley) Martati, Erryana
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

1,2-dihydroxy- 4-allylbenzene (DHAB) is a major compound in Piper betle leaf and also a metabolite of safrole metabolism. Epidemilogic studies showed people who have betel quid chewing habit are related to the incidence of oral submucous fibrosis and/or tumor formation. The aims of this research was to study the detoxification through the glucuronidation of DHAB using S9 protein of male rat liver Â (Sprague Dawley) and a co-factor of uridin 5â²-diphosphoglucuronide acid (UDPGA). The results showed that glucuronidation of DHAB using S9 protein of rat liver resulted two isomers of glucuronide metabolites due to the availibility of two active hydroxyl groups that one of them can bind glucuronide but not two of hydroxyl at the same time.

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Muhammad Syahrir

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Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA