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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)

Media-Farmasi
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Published by Universitas Ahmad Dahlan

ISSN : 14127946 EISSN : 25035223 DOI : 10.12928

Core Subject : Health, Science,

Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.

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Articles 8 Documents

Search results for , issue "Vol 19, No 1: March 2022" : 8 Documents clear

Mothers levels of knowledge of self-medication of diarrhea for under-five children in Kaliwates, Jember Inasa Hazrina; Sinta Rachmawati; Ema Rachmawati
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Diarrhea is the fifth-highest cause of death in under-five children worldwide, and it is preventable. Mild diarrhea can be treated by self-medication. In this case, mothers have an important role in handling diarrhea in children. This study aims to determine the level of mothers knowledge self-medication in diarrhea to treat under-five children in Kaliwates District, Jember. This study used an observational study design with a cross-sectional approach. The data were collected in 11 integrated healthcare centers in 3 community health centers in Kaliwates District. The research respondents were 348 mothers. Before being distributed, the questionnaire was tested to explore its validity and reliability. This questionnaire was employed to assess the mothers' level of knowledge of self-medication for infants. The data were analyzed statistically using the Chi-square test and Fisher Exact. The results showed that the mothers have a sufficient of knowledge level self-treatment of diarrhea for infants. There is a significant relationship between age, recent education, employment, family income, number of children, number of adult family members, information sources, and educational experience (p < 0.05). This study suggests the importance of providing interventions to improve mothers knowledge of self-medication of diarrhea.

Antibacterial activity of ethyl acetate extracts of fungal endophytes isolated from leaf gambir leaves (Uncaria gambir (Hunter) Roxb) M. Rifqi Efendi; Mesa Sukmadani Rusdi; Anita Dinda
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Gambir (Uncaria gambir (Hunter) Roxb) is a Sumatran medicinal plant that has various bioactivities, including antibacterial. This study aims to isolate endophytic fungi from gambier leaves and test the antibacterial activity of ethyl acetate extracts of fungal endophytes from gambir leaves. The fungal endophytes were isolated by inoculating the fungus obtained from gambir leaves on potato dextrose agar (PDA) media. The fungal endophytes were identified microscopically and macroscopically. Furthermore, the fungal endophytes were cultivated using rice media : aquades (100 : 110). The cultivated fungus was macerated using ethyl acetate solvent and tested using a screening test. The antibacterial activity of the ethyl acetate extract of endophytic fungi was conducted using the agar diffusion method against Gram-positive bacteria (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923) and Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). This study has revealed five fungal isolates from gambir leaves and identified the isolates as Penicillium sp 1 (0.39 g), Penicillium sp 2 (0.26 g), Neopestalotiopsis sp (0.97 g), Colletotrichum capsici (0.46 g), and Aspergillus sp (0.25 g). The ethyl acetate extracts of each fungal endophyte show the presence of phenolic compounds and have inhibition against Gram-positive and Gram-negative bacteria. The highest antibacterial activity is shown by ethyl acetate extracts of the fungal endophytes of Neopestalotiopsis sp at a concentration of 7.5% on P. aeruginosa ATCC 27853 23±3.9 mm and S. aureus ATCC 25923 14±2.5 mm. Tests on B. subtilis ATCC 6633 and E. coli ATCC 25922 with the highest inhibition zones were indicated by the ethyl acetate extracts of the fungus Aspergillus sp of 15.3±4 mm and 14±1.9 mm, respectively.

Antioxidant activities of extracts, methanol, and n-hexane partitions of cayenne pepper (Capsicum frutescens L.) Slamet Slamet; Urmatul Waznah; Yusrilia Yusrilia
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Antioxidants are substances that can neutralize and/or stabilize free radicals. Cayenne pepper (Capsicum frutescens L.) is a natural source of antioxidants because it contains carotenoids, flavonoids, and vitamin C. This study aims to examine antioxidant activities of n-hexane, methanol, and extract of cayenne pepper (Capsicum frutescens L.) using the ferric reducing antioxidant power (FRAP) method. The extraction method was done by maceration, and the fractionation method was done by partitioning using unmixed solvents: methanol and n-hexane. The phytochemical screening test on extracts and partitions has discovered positive content of alkaloids, flavonoids, phenols, and terpenoids. Meanwhile, the TLC test used F254 silica gel as a stationary phase with chloroform: ethyl acetate as a mobile phase (6:4). The test discovered positive results containing flavonoids and phenols. Furthermore, the antioxidant activities were tested using the FRAP method with a UV-Vis spectrophotometer instrument at a maximum value of 598.05 nm and positive control of vitamin C. The results of measurement show that antioxidant activities are found in 505.67 ± 0.56 mol Fe2+/g of partition extract, 447.67 ± 16.2 mol Fe2+/g of methanol fraction, and 353± 5.29 mol Fe2+/g of n-hexane fraction.

A comparison study between single aspirin antiplatelet and single clopidogrel antiplatelet on average period of recurrent stroke dr. Sayidiman Magetan Rahmawati Raising; Oktaviarika Dewi Hermawatiningsih; Devi Mariatul Qibtiah
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Stroke is a common neurological disease that rapidly develops clinical signs of focal and global neurological deficits, lasts 24 hours or more, and leads to death. The danger that threatens stroke sufferers is recurrent strokes which can be fatal and result in a worse quality of life than the first attack. This condition indicates that the effect of antiplatelet drugs is not strong, or called antiplatelet resistance. Antiplatelet is a blood thinner used by stroke sufferers to prevent blood clots and treat the narrowing blood vessels in the legs, namely in peripheral artery disease. This research aims to compare single aspirin antiplatelet and single clopidogrel antiplatelet on the average period of recurrent stroke. This observational research employed a cross-sectional approach by processing the medical record data of stroke patients from 2018 to 2020 at dr. Sayidiman Magetan Regional Public Hospital. The obtained data were then analyzed and concluded. The results show that the mean duration of recurrent stroke on aspirin antiplatelet use is 357.88. Meanwhile, the mean duration of recurrent stroke in the antiplatelet clopidogrel is 138.59 days. Moreover, there is a significant difference between the use of a single aspirin antiplatelet and single clopidogrel antiplatelet on the duration of recurrent stroke with a p-value of 0.000.

Optimization of thin layers of coated turmeric extract (Curcuma longa L) tablets using a dipping method Adi Permadi; Sapto Yuliani; Iis Wahyuningsih; Ibdal Satar
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Turmeric extracts have many benefits, such as an anti-oxidant, anti-inflammatory, and neuro-protector for dementia. The turmeric extracts can be prepared in the form of a thin layer of coated tablets through a dipping method using the dip coating and Simplex lattice design (SLD) methods. The quality of the thin layers of coated tablets is much related to the formulation in the coating process. This research aims to formulate and optimize the coating composition of HPMC, PEG-400, and dip time. Consequently, the TSLT meets the standard requirements. The core tablets were made by using the wet granulation method with the formulation of turmeric extract, erosol, lactose, gelatin, and aquades. Before the core tablets had been produced, the eligibility of granules was initially evaluated based on the standard requirements. Subsequently, the core tablets that meet the standard requirements were printed and replicated. The coating processes on core tablets were performed by dipping into the coating solution in the various duration of dipping times: 5, 30, and 60 seconds. The coating solution consists of HPMC, PEG-400, glycerine, sunset yellow, and distillate water. Then, produced TSLTs were evaluated based on the hardness, friability, and disintegration time. The best optimization process for the mixture of HPMC and PEG-400 indicates a more positive value of R (R = 0.2024).

A study of hemodynamic medicine use in intensive cardiac care unit of dr. Soedarso regional public hospital, Pontianak Shoma Rizkifani; Intan Khairunnisa; Eka Kartika Untari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Hemodynamic medicines are important to recover patients with a critical period in the ICCU. Hemodynamic medicines have a small range of dose so that it has a large effect on the therapy. Therefore, a study on the use of hemodynamic medicines and doses is necessarily conducted. This study aims to investigate the use and doses of hemodynamic medicines administered to patients in the ICCU of dr. Soedarso Hospital Pontianak. This study is observational research with a descriptive cross-sectional design. The research sample was 49 patients who had met the inclusion criteria. The data were analyzed descriptively to describe the frequency and percentage. The results show that a single hemodynamic medicine is administered to 65% of the patients and a combination of hemodynamic medicines is administered to 35% of the patients. The single medicine refers to dobutamine administered to 84.4% of the patients. Meanwhile, the combination of hemodynamic medicines consists of dobutamine and norepinephrine that are administered to 52.9% of the patients. The doses of hemodynamic medicines frequently administered to patients are 3-5 Î¼g/kg/min dobutamine, 3-10 Î¼g/kg/min dopamine, 0.01-2-2 Î¼g/kg/min norepinephrine, and 1 mg/ml epinephrine. This study concludes that dobutamine (inotropic) is the most frequently used single hemodynamic medicine, and norepinephrine (vasopressor) is the most frequently used combined hemodynamic medicine for the ICCU patients at dr. Soedarso Regional Public Hospital, Pontianak.

The influence of service flow changes and drug consultation on quality of life of HIV/AIDS-positive patients in Sunan Kalijaga regional public hospital, Demak regency Rissa Maharani Dewi; Akrom Akrom; Ari Simbara
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Human immunodeficiency virus (HIV infection/AIDS) cannot be cured but can be controlled by antiretroviral medicines. Non-compliance with the treatment is influenced by internal and external factors. The internal factors (predisposing factors) include healthcare systems, socioeconomic conditions, and patients. Meanwhile, the external factors (enabling and reinforcing factors) include the condition of the disease and therapy. This study aims to determine the influence of service flow changes and drug consultation on the quality of life of people living with HIV/AIDS in Sunan Kalijaga Regional Public Hospital, Demak Regency.This research employed a quasi-experimental method with one group and a pre-post design. The research subject was HIV/AIDS-positive patients in Sunan Kalijaga Regional Public Hospital, Demak Regency. These subjects had met the inclusion and exclusion research criteria. The data were collected using an in-depth interview, consisting of 14 questions to determine factors in non-compliance with treatment and patients' quality of life. Patient compliance with treatment and quality of life were measured before and after the intervention. The dependent t-test was employed to determine differences in the average score of the compliance and quality of life before and after the treatment. The majority of HIV/AIDS-positive patients in Sunan Kalijaga Regional Public Hospital are in the productive age (49 people or 96.22%), female (33 people or 62.24%), employed in private jobs (16 people or 30.19%), married (34 people or 64.2%), and graduated from primary school (20 people or 37.7%). The majority of the patients have undergone the treatment for > 1 year (32 respondents or 60.4%) and received the drug regimen of ZDV + 3TC + NVP (90.57%). There is no significant difference in the patient compliance with the treatment before and after the intervention with the sig < 0.05. Moreover, the patients have a high quality of life with a compliance value of 80-100% before and after the intervention. The pre-post-interventions have influenced the physical health domain and the social relation domain with the sig < 0.05. The provision of education affects the quality of life on physical health and social relationship factors (sig < 0.005). The implementation of drug consultation could improve the HIV-positive patients' quality of life in physical health and social relationship domains. In contrast, the intervention does not affect the patients' compliance with the therapy.

Evaluation of service quality and complaint handling on outpatient satisfaction at the pharmaceutical installation of mokoyurli buol regional public hospital Chynthia Iga Saputri; RA. Oetari; Tri Wijayanti
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Pharmaceutical installations have an important role in improving and providing effective services to achieve patient satisfaction. Patients' complaints occur if they receive a service that does not meet expectations. The hospital management must investigate the causes of patients' complaints. Solving the patients' complaints indicates that the hospital can fulfill their expectations. The purpose of this study is to examine the results of servqual on service quality, customer satisfaction index, and importance-performance analysis on service quality and complaint handling. This research employed a descriptive design with qualitative and quantitative approaches. The study was conducted by distributing questionnaires to 100 outpatients. The respondents' answers were then analyzed using the Cartesian diagram to obtain quadrants A, B, C, and D. Interviews were directly conducted with the complaint management and pharmaceutical installation staff to explore the attributes included in quadrant A (top priority). The patients were selected using the purposive sampling method. Finally, the data were analyzed using the servqual analysis, importance-performance analysis, and customer satisfaction index. The result shows that the service quality dimension has a negative gap value. The reliability dimension has the smallest gap while the responsiveness dimension has the largest gap. The result of the customer satisfaction index shows that outpatient satisfaction with the service quality and complaint handling has a value of 56.53%. Thus, this dimension is categorized as quite satisfying. The result of the importance-performance analysis shows that the dimensions included in quadrant A are the tangible evidence dimension, including poor physical facilities, and the responsiveness dimension, including patients' long waiting time to manage prescriptions and complaint handling.

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widyasari putranti

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Contact Name widyasari putranti

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Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
widyasari putranti

Contact Email
widyasari@pharm.uad.ac.id

Phone
-

Journal Mail Official
mediafarmasi@pharm.uad.ac.id

Editorial Address
-

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA