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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Keperawatan Jurnal Sains dan Teknologi Duta Pharma Journal Parapemikir Jurnal Ilmiah Farmasi International Journal of Contemporary Sciences (IJCS)
Hermawatiningsih, Oktaviarika Dewi
STIKES BHAKTI HUSADA MULIA MADIUN
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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A comparison study between single aspirin antiplatelet and single clopidogrel antiplatelet on average period of recurrent stroke dr. Sayidiman Magetan Rahmawati Raising; Oktaviarika Dewi Hermawatiningsih; Devi Mariatul Qibtiah
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.421 KB) | DOI: 10.12928/mf.v19i1.20639

Abstract

Stroke is a common neurological disease that rapidly develops clinical signs of focal and global neurological deficits, lasts 24 hours or more, and leads to death. The danger that threatens stroke sufferers is recurrent strokes which can be fatal and result in a worse quality of life than the first attack. This condition indicates that the effect of antiplatelet drugs is not strong, or called antiplatelet resistance. Antiplatelet is a blood thinner used by stroke sufferers to prevent blood clots and treat the narrowing blood vessels in the legs, namely in peripheral artery disease. This research aims to compare single aspirin antiplatelet and single clopidogrel antiplatelet on the average period of recurrent stroke. This observational research employed a cross-sectional approach by processing the medical record data of stroke patients from 2018 to 2020 at dr. Sayidiman Magetan Regional Public Hospital. The obtained data were then analyzed and concluded. The results show that the mean duration of recurrent stroke on aspirin antiplatelet use is 357.88. Meanwhile, the mean duration of recurrent stroke in the antiplatelet clopidogrel is 138.59 days. Moreover, there is a significant difference between the use of a single aspirin antiplatelet and single clopidogrel antiplatelet on the duration of recurrent stroke with a p-value of 0.000.
PENGARUH FAKTOR RESIKO KARDIOVASKULAR PADA NILAI AGREGASI PLATELET PASIEN PENYAKIT JANTUNG KORONER (PJK) Oktaviarika Dewi Hermawatiningsih; Susanti Erikania
Jurnal Keperawatan Vol. 12 No. 1 (2019): Jurnal Keperawatan, Volume XII, Nomor 1, Januari 2019
Publisher : LPPM Akper Dian Husada Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.804 KB)

Abstract

Latar Belakang : Faktor variasi individu merupakan faktor resiko kardiovaskular yang memiliki pengaruh terhadap kerja dari antiplatelet. Faktor variasi individu tersebut memiliki pengaruh terhadap mekanisme penyebab terjadinya resistensi antiplatelet. Tujuan penelitian ini untuk mengetahui pengaruh faktor resiko kardiovaskular pada nilai agregasi platelet pasien PJK. Metode : Metode penelitian yang digunakan adalah dengan menggunakan Patient Database yang dikumpulkan selama pengambilan sampel untuk mengetahui faktor resiko kardiovaskular yang dimiliki setiap pasien. Penelitian ini dilaksanakan di RS Soedono Madiun pada bulan Januari sampai Maret 2018. Pemeriksaan yang dilakukan Platelet Function Test yang digunakan untuk melihat nilai agregasi platelet pada pasien PJK. Hasil : Dari 30 sampel yang telah dilakukan analisis data diketahui bahwa faktor resiko kardiovaskular yang memiliki hubungan signifikan dengan agregasi platelet pada pasien penyakit jantung koroner (PJK) adalah jenis kelamin dengan nilai p = 0,029 sehingga dapat dikatakan bahwa antara agregasi platelet memiliki hubungan yang signifikan dengan faktor resiko kardiovaskular yaitu jenis kelamin. Kesimpulan : Faktor resiko kardiovaskular tidak memiliki hubungan yang signifikan dengan nilai agregasi platelet
Anthelmintic Test of Combination of Carrot Peels (Daucus carota L.) and Pineapple Peels (Ananas comusus) Juice Against Silkworms (Tubifex sp) Yossy Febryarti; Yetti Hariningsih; Oktaviarika Dewi H
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.535 KB)

Abstract

Background: Anthelmintics is a treatment used as an anti-worm that can eradicate worms in the human and animal bodies, one of which is against silk worms (Tubifex sp). One of the plants that may be used as anthelmintics is carrot skin (Daucus carota L.) and pineapple skin (Ananas comusus). Carrot peel contains flavonoids, quercetin, and tannins as anthelmintics and pineapple peel contains flavonoids, bromealin enzymes and tannins, so researchers are interested in making a combination of carrot peel juice and pineapple peel juice as an anthelmintic against silk worms (Tubifex sp). Objective: This study aims to determine the effectiveness of the combination of carrot peel and pineapple peel juice in eradicating silk worms (Tubifex sp). Methods: The method used is the squeeze method, specific specific standardization, lethal time test, paralysis time test. , the anthelmintic activity test of the combination of carrot peel juice and pineapple peel extract with concentrations of F1 25%: 75%, F2 50%: 50%, F3 75%: 25% using positive control Albendazole 0.06% w/v. The research data were analyzed using the Oneway Anova test. Results: The results of this study showed that the combination of carrot peel extract 75%: pineapple peel 25% had the best anthelmintic effectiveness against the lethal time. The anthelmintic effectiveness test obtained from the combination of carrot juice 25%: pineapple juice 75% showed the best results during paralysis time. The lethal time test of the combination of carrot peel and pineapple juice obtained an average time of death in F1 of 15.32 minutes. In F2, the average time of death was 18.155 minutes, while in F3 it was 20.37 minutes and the Oneway Anova result was p=0.000 (p<0.05). The paralysis time test for the combination of carrot peel and pineapple juice was found to have an average paralysis time of 13.625 minutes in F1. In F2, the average paralysis time was 13,733 minutes, while in F3 18,712 minutes and the Oneway Anova result was p=0,000 (p<0,05). Conclusion: The best combination of juice for the time of death is F1 with a concentration of 25% carrot juice: 75% pineapple juice, while the best combination for paralysis time is F1 with a 25% carrot juice concentration: 75% pineapple juice.                                                                          Keywords : Carrot Peels (Daucus carota L.), Pineapple Peels (Ananas comosus), Anthelmintics, Tubifex sp
Pengelolaan hasil tanaman obat keluarga (TOGA) jamu instan jahe merah (Zingiber officinale var. rubrum) Rahmawati Raising; Novi Ayuwardani; Oktaviarika Dewi Hermawatiningsih; Yetti Hariningsih; Vevi Maritha; Tika Indrasari
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v4i1.176

Abstract

Community participation in health development with TOGA (Family Medicinal Plants) or commonly referred to as a live pharmacy, in order to meet the family's need for medicines. Cultivation of medicinal plants for families (TOGA) can stimulate small and medium enterprises in the field of herbal medicine. Red ginger is one of the herbal plants that has been widely known as a health support product by the public because empirically it has many health benefits such as anti-inflammatory, reducing nausea and immunomodulatory with few side effects. Therefore, training is needed to improve the skills of PKK team in making Red Ginger Instant herbal products, the target of this community service activity is PKK team, using presentation methods, demonstrations on how to make red ginger instant herbal products. The results of this community service activity increase understanding of making instant herbal medicine
Polimorfisme P2Y12 Terhadap Agregasi Platelet Pada Pasien Penyakit Jantung Koroner oktaviarika dewi hermawatiningsih
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1446

Abstract

Genetic polymorphism of P2Y12 receptor is one of the factors responsible for the variation in response to antiplatelet therapy. Variations in response to P2Y12 receptors can cause Coronary Artheri Disease (CAD) in CHD patients. This research was conducted in RSUD Sidoarjo East Java  from  November  to December 2017 which aims to determine the effect of P2Y12 polymorphism on platelet aggregation in CHD patients. The research method used is Polymerase Chain Reaction (PCR) for P2Y12 genetic polymorphism and Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 30 samples, it was found that all samples had homozygot (wild type) type P2Y12 polymorphism with bp value of about 156 bp. Inferential analysis  was conducted  to determine the relationship between polymorphism of P2Y12 with platelet aggregation obtained p value = 0,130. From these results it can be said  that  between the genetic polymorphism of P2Y12 and platelet aggregation has no significant relationship.  Keywords : antiplatelet; clopidogrel; platelet aggregation; polymorphism P2Y12.
Pengaruh Polimorfisme P2Y12 Pada Penggunaan Antiplatelet Terhadap Kejadian Stroke Berulang oktaviarika dewi hermawatiningsih; Rahmawati Raising
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 1 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i1.4414

Abstract

Stroke merupakan keadaan defisit neurologik secara fokal dan global. Salah satu pengobatan yang digunakan adalah antiplatelet seperti clopidogrel yang dapat menghambat pembentukan trombus yang bisa menurunkan angka kematian. Dalam perkembangan pengobatan, terdapat variasi respon pasien terhadap terapi clopidogrel. Variasi respon tersebut seperti polimorfisme reseptor P2Y12 yang berdampak pada farmakokinetik dan farmakodinamil dari clopidogrel. Tujuan dari penelitian ini adalah untuk menyetahui pengaruh kejadian polimorfisme reseptor P2Y12 terhadap kejadian stroke berulang. Metode yang digunakan dalam peneltian ini adalah metode Polymerase Chain Reaction (PCR) yaitu dengan cara pemeriksaan polimorfisme genetik P2Y12 dan dilakukan pemantauan setiap bulan untuk mengetahui kejadian stroke berulang. Hasil yang diperoleh dari penelitian ini adalah dari 20 sampel diperoleh jenis polimorfime P2Y12 homozygot (wild type), untuk kejadian stroke berulang diperoleh 4 sampel yang mengalami kejadian stroke berulang, dan analisis pengaruh polimorfisme P2Y12 terhadap kejadian stroke berulang diperoleh nilai signifikansi 0,05, sehingga dalam penelitian ini dapat disimpulkan bahwa tidak terdapat pengaruh antara polimorfisme P2Y12 terhadap kejadian stroke berulang.
PENGARUH LAMA PENGGUNAAN NARKOTIKA DAN PSIKOTROPIKA TERHADAP NILAI RETENSI PASIEN DI RUMAH SAKIT JIWA MENUR SURABAYA Arifani Siswidiasari; Charliandri S Wahab; Oktaviarika Dewi H
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 2 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i2.4971

Abstract

Narkotika adalah zat yang dapat menyebabkan perubahan kesadaran dan pengaruh psikoaktif sementara psikotropika adalah zat yang dapat mengubah perasaan, pikiran atau tingkah laku seseorang. Narkotika dan psikotropika merupakan dua jenis zat yang dapat mengubah perasaan, pikiran atau tingkah laku seseorang. Perbedaan utama dari keduanya adalah dalam penggunaan dan potensi bahayanya. Salah satu terapi pengganti untuk mencegah intoksikasi dan gejala putus obat adalah terapi rumatan metadon untuk mengendalikan ketergantungan dan upaya pengurangan dampak buruk penularan HIV/AIDS. Penelitian ini bertujuan untuk mengetahui pengaruh lama penggunaan narkotika dan psikotropika terhadap nilai retensi pasien di Rumah Sakit Jiwa Menur Surabaya. Penelitian ini dilakukan secara retrospektif yaitu mengambil data rekam medis pasien yang mengikuti terapi rumatan metadon yang dipilih secara consecutive sampling. Data yang diperoleh sebanyak 41pasien. Hasil data demografi menunjukkan jenis kelamin terbanyak laki-laki 39 orang (95,10%), usia 26-35 tahun 25 orang (61,00%), tingkat pendidikan SMA 34 orang (82,90%), pekerjaan semua pasien bekerja 41 orang (100%), status perkawinan belum menikah 31 orang (75,60%), riwayat kriminal semua pasien tidak ada riwayat kriminal 41 orang (100%). Riwayat penggunaan narkotika terbanyak adalah opioid selama 11-15 tahun 22 orang (53,70%) dan psikotropika adalah benzodiazepin selama 11-15 tahun 12 orang (29,30%). Nilai retensi pasien terbanyak adalah ≥ 365 hari 26 orang (63,40%). Pengaruh lama penggunaan narkotika dan psikotropika terhadap nilai retensi, menunjukkan ada pengaruh yang signifikan antara penggunaan opioid dengan nilai retensi p = 0,030 odds ratios (OR) = 3,193. 
Efektivitas Penggunaan Obat Dislipidemia terhadap Kadar LDL pada Pasien Cardiovaskular Penyebab Stroke Rahmawati Raising; Oktaviarika Dewi Hermawatiningsih; Wiwi Rumaolat
INSOLOGI: Jurnal Sains dan Teknologi Vol. 3 No. 4 (2024): Agustus 2024
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v3i4.4013

Abstract

Dyslipidemia is one of the main risk factors for cardiovascular disease, and cholesterol management therapy has significant benefits in the primary and secondary prevention of coronary heart disease and stroke. Therefore, lipid-lowering therapy, especially using HMG-CoA reductase inhibitors (statins), aims to assess the effectiveness of using statin-class dyslipidemia medications, such as simvastatin and atorvastatin, in reducing LDL levels in cardiovascular patients at X Hospital. This research method uses an observational analytic study with a retrospective research design. This study employs the purposive sampling method. The results of this study show that the majority of patients are female (75%). Based on age grouping, it was found that the highest proportion of patients were aged 56-65 years, accounting for 45%. The use of dyslipidemia drugs that achieved the target LDL reduction ≥ 50% includes Simvastatin 10 mg (33.82%), Simvastatin 20 mg (11.94%), Atorvastatin 10 mg (10.45%), and Atorvastatin 20 mg (41.79%). The most effective drug in achieving the LDL reduction target was Atorvastatin 20 mg.
Factors Affecting the Retention Value of Drug Addict Patients in Methadone Maintenance Therapy Siswidiasari, Arifani; Neni Probosiwi; Nur Fahma Laili; Tsamrotul Ilmi; Prayoga Ferry Yuniarto; Anak Agung Indah Krisnadewi; Oktaviarika Dewi H
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 5 (2024): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i5.8665

Abstract

Methadone is a synthetic drug belonging to the opiate class that is given in oral dosage form to patients as a substitute therapy for opioid addiction. Methadone was chosen as the main substitution therapy because it has an effect resembling morphine and cocaine with a longer working life so that it can be given once a day which is used by drinking. This study aims to determine the factors that affect the retention value of drug addict patients in methadone maintenance therapy at Bangil Health Center. This study was conducted retrospectively, taking medical record data of patients who followed methadone maintenance therapy selected by consecutive sampling. Data obtained as many as 35 patients. The results of demographic data showed the most male sex 33 people (94.3%), aged 26-35 years 22 (62.9%), SMA 29 (82.9%), working 35 (100%), married 27 (77.1%), opium 35 (100%), amphetamines 26 (74.29%), alcohol 33 (94.29%) and tobacco 33 (94.29%). The highest initial dose was 30-50mg, 23 people (65.7%), the smallest maintenance dose <60mg, 33 people (94.3%) and the largest maintenance dose >120mg, 24 people (68.6%). The retention value of patients < 6 months is 7 people (20%) and > 6 months 28 people (80%)
Co-Authors Anak Agung Indah Krisnadewi Arifani Siswidiasari Arifani Siswidiasari Charliandri Saputra Wahab Devi Mariatul Qibtiah Hariningsih, Yetti Neni Probosiwi Novi Ayuwardani Nur Fahma Laili Prayoga Ferry Yuniarto Rahmawati Raising Rahmawati Raising Rahmawati Raising Susanti Erikania Tika Indrasari Tsamrotul Ilmi Vevi Maritha Wiwi Rumaolat Yossy Febryarti