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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
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Articles 20 Documents
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Search results for , issue "2022: Special Issue" : 20 Documents clear
The phenolic compounds of ethanolic extract of date seed (Phoenix dactylifera L.) exert hepatoprotective activity on rat induced carragenan Warsinah Warsinah; Esti Dyah Utami; Hanif Nasiatul Baroroh
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art10

Abstract

Background: Hepatotoxic effects can occur with the use of toxic drugs or standard doses, but in the long term or chronic therapy. In addition to the drugs, carrageenan also causes hepatotoxic after 12 hours of induction intraperitoneally. The effect of liver cell repair is highly related to the antioxidant activity of phenolic compounds in date seeds.Objective: The present study determined the total phenolic levels and hepatoprotective activity of ethanol extracts of date palm seeds (EEBK) in carrageenan-induced rats.Method: Determination of total phenolics in palm ethanol extract samples was carried out with the Folin- Ciocalteu reagent. This study was the pre and post-test control group design. Examination of SGOT and SGPT levels was performed by the kinetic method based on IFCC. Data was analyzed using paired t-test and ANOVA test. Results: The total phenolic content of the ethanol extract of date seeds of Deglet Noor variety was 8.521% GAE. The ethanol extract of date seed (EEBK) with the dose of 150 mg/kg BW showed the highest reduction in SGOT levels (34.80 U / L). The highest average decrease in SGPT levels occurred at a therapeutic dose of 300 mg/kg BW was 16.20 U / L compared to doses of 150 and 600 mg/kg bb (11.60 and 15.60 U / L respectively).Conclusion: The ethanol extract of date seed (EEBK) with the doses of 150, 300, and 600 mg/kg BW   had hepatoprotective activity in carrageenan-induced rats as observed from a significant decreased in SGOT and SGPT levels (p <0.05). Key word: Date seed, phenolic total, extract, SGPT, SGOT 
Total phenolic and flavonoid contents of n-hexane fraction in binjai leaves (Mangifera caesia Jack. ex. Wall) Cahaya Rahayu Yuliani; Hafiz Ramadhan; Putri Indah Sayakti; Cast Torizellia
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art2

Abstract

AbstractBackground: Binjai leaves (Mangifera caesia Jack. ex. Wall) or M. caesia contain phenolic and flavonoid compounds important in medicinal plants development. The solvent difference and fractionation will give various active substance concentrations.Objective: To evaluate the phenolic and flavonoid content qualitatively and quantitatively from the n-hexane fraction of binjai leaves methanol extract.Methods: The soxhletation method with methanol was used to extract binjai leaves followed by fractionation. Thin Layer Chromatography (TLC) followed by spraying reagents were used to test phenols and flavonoids compounds. Folin-Ciocalteu reagents were used to analyzed total phenolics, while AlCl3 reagents were used to quantify the total flavonoid content.Result: This study gave positive results on the qualitative test of phenolics and flavonoids. Meanwhile, the fraction assay results showed total phenolic levels of 45.19 µgGAE/mg and total flavonoid levels of 165.06 µgQE/mg.Conclusion: The n-hexane fraction of M. caesia leaves methanol extracts contains phenols and flavonoid content so that it has the potential as a medicinal plant.Keywords: Binjai leaves, methanol extracts, n-hexane fraction, phenol, flavonoid. IntisariLatar belakang: Daun binjai (Mangifera caesia Jack. ex. Wall) memiliki senyawa fenolik dan flavonoid yang penting dalam pengembangan tanaman obat. Perbedaan pelarut dan fraksinasi akan memberikan kadar senyawa aktif yang berbeda.Tujuan: Penelitian ini bertujuan untuk mengetahui secara kualitatif dan kuantitatif senyawa fenolik dan flavonoid dari fraksi n-heksan ekstrak metanol daun binjai.Metode: Metode soxhletasi dengan pelarut metanol digunakan untuk mengekstraksi daun binjai yang dilanjutikan dengan fraksinasi. Kromatografi Lapis Tipis (KLT) yang dilanjutkan dengan reagen semprot digunakan untuk menguji senyawa fenolik dan flavonoid. Reagen Folin-Ciocalteu digunakan untuk menetapkan kadar total fenolik, sedangkan pereaksi AlCl3untuk menetapkan kadar total flavonoid.Hasil: Penelitian ini memberikan hasil positif pada uji kualitatif fenolik dan flavonoid, sedangkan hasil penetapan kadar fraksi memberikan hasil total fenolik sebesar 45,19 µgGAE/mg dan kadar total flavonoid 165,06 µgQE/mg.Kesimpulan: Fraksi n-heksana ekstrak metanol daun M. caesia memiliki kandungan fenolik dan flavonoid sehingga berpotensi untuk dikembangkan sebagai tanaman obat,Kata Kunci: Daun binjai, ekstrak metanol, fraksi n-heksan, fenolik, flavonoid.
The pattern of vancomycin, gentamycin, and meropenem prescriptions for the inpatients of a regional public hospital in Yogyakarta, Indonesia Mutiara Herawati; Mir-a Kemila; Putri Anggriani; Nur Mardhiyah; Siti Maulida
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art16

Abstract

Background: The mechanism of action of gentamycin is inhibiting protein synthesis inside bacteria. Meropenem and vancomycin have the same mode of action that inhibit bacterial cell wall activity. Antibiotic resistance occurs when antibiotic use does not follow the guidelines. Therefore, this study aims to determine how vancomycin, gentamycin, and meropenem are prescribed in a regional public hospital. Objective: This study aimed to evaluate the prescription of vancomycin, gentamycin, and meropenem in Yogyakarta Regional Public Hospital in 2017. Methods: This research employed a descriptive analysis with a cross-sectional design. The study was conducted to describe the profiles of vancomycin, gentamycin, and meropenem utilization. Data collection was performed retrospectively using patients’ medical record data including the diagnosis, dosage, and duration of administration.Results: The study showed that the total number of patients who received aminoglycoside: meropenem: vancomycin antibiotics in 2017 and met the research criteria was 6:8:24. According to the diagnosis, gentamycin was used for post-operation (75%), then sepsis and encephalitis. Meropenem was used for sepsis with a percentage of 67% while vancomycin was for endocarditis, intraabdominal, MRSA, cellulitis, pneumonia, and sepsis. Based on the appropriate dosage in the guidelines, the prescribing of gentamycin and meropenem resulted in 100% properness and 69.23% for vancomycin. For the duration of appropriate utilization, it was found that the most prolonged use was in patients given meropenem for 29 days, and the fastest use was a day for patients using vancomycin. Conclusion:Vancomycin, gentamycin, and meropenem had the appropriate dosage. However, discrepancies were still found in the indication and duration of the treatment using these antibiotics.Keywords: Vancomycin, gentamycin, meropenem, antibiotics
Isolation of endophytic fungi from benalu batu (Begonia medicinalis) and their toxicity on Artemia Salina Syariful Anam; Armini Syamsidi; Musyahidah Musyahidah; Nurul Ambianti; Agustinus Widodo; Muhammad Sulaiman Zubair
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art3

Abstract

Abstract   Background: Endophytic fungi are microorganisms found in plant tissues that are mutually beneficial to the host plant. They are known as sources of bioactive metabolites which possess various biological activities such as antimicrobial, anticancer, antiviral, antifungal, and antioxidant.  Benalu batu (Begonia medicinalis) has been used empirically as a medicinal plant and has shown anticancer activity in breast cancer cells (T47D cells) and cervical cancer cells (HeLa cells).Objective: This study aimed to isolate the endophytic fungi from benalu batu and determine the toxicity activity and Lethal Concentration 50% (LC50) value of isolated endophytic fungi using shrimp larvae (Artemia salina). Method: Endophytic fungi were isolated from fresh parts; leaves, stems, roots of Benalu Batu. The selected parts were sterilized with ethanol 70% and sodium hypochlorite 1% subsequently placed into Potato Dextrose Agar Chloramphenicol (PDAC) then incubated at 28°C for 7 days. Isolated endophytic fungi were extracted by sonication method using ethyl acetate. The toxicity activity of isolated endophytic fungi was determined using the Brine Shrimp Lethality Test (BSLT).Results: Isolation of the endophytic fungi from benalu batu obtained 10 isolates, which the leaves part obtained 6 isolates, the stem obtained 3 isolates and the root obtained 1 isolate. The results of screening for toxicity test of 10 isolates at concentrations of 500 µg/mL shown that isolate D3, D5, and D6 gave 100% mortality. The LC50 values of isolate D3, D5, and D6 were obtained respectively in 448.03, 8.784, and 9.13 µg/mL.Conclusion: These results indicated that isolate D5 exhibits the greatest toxicity and needs to be investigated the activity for testing on cancer cells.Keywords: endophytic fungi, Begonia medicinalis, toxicity, Artemia salina Intisari  Latar belakang: Jamur endofit merupakan mikroorganisme yang terdapat dalam jaringan tumbuhan yang bersifat mutualisme terhadap tumbuhan inang. Jamur endofit telah diketahui sebagai sumber metabolit yang memiliki beberapa aktivitas biologi seperti antimikroba, antikanker, antivirus, antijamur, dan antioksidan. Tumbuhan benalu batu (B. medicinalis) telah digunakan secara empiris dan terbukti memiliki aktivitas antikanker pada sel kanker payudara (Sel T47D) dan sel kanker leher rahim (Sel HeLa). Tujuan: Studi ini bertujuan untuk melakukan isolasi jamur endofit dari benalu batu dan mengetahui toksisitas isolat jamur endofit serta menentukan nilai Lethal Concentration 50% (LC50) terhadap larva udang (Artemia salina)Metode: Jamur endofit diisolasi dari bagian segar; daun, batang, akar benalu batu. Bagian-bagian tersebut disterilisasi dengan etanol 70% dan natrium hipoklorit 1% selanjutnya diletakkan pada media Potato Dextrose Agar Chloramphenicol (PDAC) kemudian diinkubasi pada suhu 28°C selama 7 hari. Isolat jamur endofit diekstraksi dengan metode sonikasi menggunakan etil asetat. Aktivitas toksisitas isolat jamur endofit ditentukan menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil: Isolasi jamur endofit dari benalu batu diperoleh 10 isolat, bagian daun diperoleh 6 isolat, bagian batang diperoleh 3 isolat dan bagian akar diperoleh 1 isolat. Hasil penapisan uji toksisitas 10 isolat pada konsentrasi 500 µg/mL menunjukkan bahwa isolat D3, D5, dan D6 memberikan persentase mortalitas sebesar 100%. Nilai LC50 isolat D3, D5, dan D6 diperoleh masing-masing sebesar 448,03, 8,784, dan 9,13 µg/mL.Kesimpulan: Hasil ini menunjukkan isolat D5 memiliki toksisitas paling besar dan perlu dilanjutkan untuk pengujian pada sel kanker.Kata kunci : jamur endofit, Begonia medicinalis, toksisitas, Artemia salina
Antioxidant activity of methanol extract of cassava leaves (Manihot esculenta Crantz) using CUPRAC method Putri Indah Sayakti; Norma Anisa; Hafiz Ramadhan
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art12

Abstract

Background: Antioxidants are a group of organic molecules and enzymes that work synergistically to enhance cellular defenses and combat oxidative stress. Antioxidants can come from plants because they contain many groups of phytochemical compounds and vitamins. One of the plants that has compounds with antioxidant activity is cassava.Objective: To measure the antioxidant activity of methanol extract of cassava leaves using the CUPRAC method.Methods: Cassava leaves were extracted by maceration using methanol as a solvent with the addition of 5% H2SO4. Phytochemical screening of flavonoids with Mg and HCl, while phenol with the addition of FeCl3. The antioxidant activity based on the reaction of the test solution with CUPRAC reagent. Antioxidant activity can be determined by IC50 value by using x value as concentration and y value as absorbance.Results: The results of phytochemical screening showed that the methanol extract of cassava leaves contained flavonoids and phenolic groups. The antioxidant capacity of the methanol extract of cassava leaves obtained an IC50 value of 156.03 ppm, while quercetin has a very strong capacity as an antioxidant with an IC50 of 9.83 ppm.Conclusion: The methanol extract of cassava leaves has a weak antioxidant capacity in reducing metal ions. Keywords: Cassava leaves, Manihot esculenta Crantz, methanol extract, antioxidants, CUPRAC.IntisariPendahuluan: Antioksidan adalah kelompok molekul organik dan enzim yang bekerja secara sinergis untuk meningkatkan pertahanan seluler dan memerangi stres oksidatif. Antioksidan dapat berasal dari tanaman karena banyak mengandung golongan senyawa fitokimia dan vitamin. Salah satu tanaman yang memiliki kandungan metabolit sekunder berupa flavonoid dan fenol yang berfungsi sebagai antioksidan adalah Singkong (Manihot esculenta Crantz).Tujuan: Penelitian ini bertujuan untuk mengukur kapasitas antioksidan dari ekstrak metanol daun Singkong menggunakan metode CUPRAC (Cupric Ion Reducing Antioxidant Capacity).Metode: Daun Singkong diekstraksi secara maserasi menggunakan pelarut metanol dengan penambahan H2SO4 5%. Skrining fitokimia flavonoid dengan Mg dan HCl, sedangkan fenol dengan penambahan FeCl3. Kapasitas antioksidan berdasarkan reaksi larutan uji dengan reagen CUPRAC yang diukur menggunakan spektrofotometer UV-Vis.Hasil: Hasil skrining fitokimia menunjukkan ekstrak metanol daun Singkong mengandung golongan flavonoid dan fenolik. Kapasitas antioksidan dari ekstrak metanol daun Singkong didapatkan nilai IC50 sebesar 156,03 ppm, sedangkan quersetin memiliki kapasitas yang sangat kuat sebagai antioksidan dengan IC50 sebesar 9,83 ppm.Kesimpulan: Berdasarkan hasil tersebut, dapat disimpulkan bahwa ekstrak metanol daun Singkong memiliki kapasitas antioksidan yang lemah dalam mereduksi ion logam.Kata kunci: Daun Singkong (Manihot esculenta Crantz), Ekstrak Metanol, Antioksidan, CUPRAC.
The study of drug interaction on pneumonia patients at RSUP Dr. M. Djamil Padang Lola Azyenela; Mimi Aria; Lana Aristya
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art15

Abstract

AbstractBackground: Pneumonia is one of the diseases that cause high rates of toddler deaths in the world. In Indonesia, pneumonia is the second cause of death of infants and toddlers after diarrheal diseases. Most pneumonia patients are treated with other diseases so many pneumonia patients receive more than two types of drugs in one prescription, this has the potential for drug interactions with drugs.Objective: The aim of this study was to look at potential occurrences of drug interactions in toddler patients at Dr.M. Djamil Padang Hospital hospitalized in 2019.Methods: This research was nonexperimental research design with cross-sectional descriptive methods of analysis and the data retrieved retrospectively. The patient's medical records were analyzed using the Drugs.com software and Medscape.Results: There were 62 patients who met the inclusion criteria. Among them, there were 5 pneumonia patients (8.1%) who experienced drug interactions with drugs, with the pharmacokinetic category as many as 3 cases (42.9%) affecting metabolism and drug interactions in the pharmacodynamic category by 4 cases (57.1%). Based on the severity of drug interactions, this study found 1 minor case (14.3%), 5 moderate cases (71.4%), and 1 major case (14.3%).Conclusion: From the results of the study it can be concluded that there was a potential for drug interactions in pneumonia toddler patients at Dr.M. Djamil Padang Hospital in the period 2019.Keywords: Bronchopneumonia, drug Interactions, toddlerIntisariLatar belakang: Pneumonia merupakan penyakit infeksi saluran pernapasan penyebab kematian utama pada balita di seluruh dunia. Di Indonesia, pneumonia menduduki peringkat kedua penyebab kematian bayi dan balita setelah diare. Pneumonia dapat disebabkan karena bakteri yang menyerang saluran pernapasan. Tatalaksana terapi pada pneumonia umumnya kombinasi beberapa obat. Hal ini berpotensi menimbulkan masalah pengobatan khususnya interaksi obat. Tujuan: Penelitian ini bertujuan untuk melihat kejadian interaksi obat pada pasien balita di instalasi rawat inap anak RSUP Dr. M. Djamil tahun 2019. Metode: Desain penelitian yang digunakan adalah cross-sectional deskriptif dengan pengambilan data secara retrospektif melalui rekam medis pasien. Setiap jenis obat yang tertulis rekam medis dianalisis dengan menggunakan bank data dari software Drug.com dan Medscape. Hasil: Data diambil dari 62 pasien, berdasarkan jumlah tersebut dapat diidentifikasi 5 pasien mengalami interaksi obat (8,1%), terdiri dari 71,4% moderat, 14,3% minor dan 14,3% mayor. Kesimpulan: Interaksi obat yang sering terjadi pada pasien balita dengan pneumonia adalah penggunaan kaptopril dengan furosemid. Kata kunci: Balita, interaksi obat, pneumonia
Antioxidant activity, total flavonoid, and total tannin content of ethanol extract of avocado peel (Persea americana Mill.) Rini Isromarina; Doddy Rusli; Deva Ulan Sari
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art19

Abstract

Background: Avocado is a plant that can grow in tropical climates. In general, people only consume the fruit while the skin and seeds are not used. Avocado fruit, skin and seeds contain secondary metabolites such as flavonoids and tannins which have antioxidant activity. Objective: To determine antioxidant activity, total flavonoid, and total tannin content of the ethanol extract of avocado peel. Methods: P. americana Mill. was collected from Lubuk Linggau, South Sumatra. The ethanol extract of P. americana Mill.  peel obtained by maceration with ethanol. Qualitative analysis of flavonoids using Mg and HCl while tannins using FeCl3. Determination of total flavonoid content was carried out with AlCl3 reagent and Folin-Ciocalteu reagent to determine the total tannin content and was measured by a UV-Vis Spectrophotometer. Determination of antioxidant activity using the DPPH method.Result: The results of the qualitative analysis showed that ethanol extract of avocado peel contained flavonoids and tannins. It also had antioxidant activity with IC50 of 41,93 µg/mL. The total flavonoid and tannin content of it were 125,01 mgQE/g extract and 53,82 mgTAE/g extract respectively. Conclusion: Ethanol extract of avocado peel had antioxidant activity, while the total flavonoid compounds was higher than the total tannins.Keywords: antioxidant, DPPH, total flavonoid, total tannins Intisari Latar Belakang: Buah, kulit dan biji alpukat mengandung metabolit sekunder seperti flavonoid dan tanin yang memiliki aktivitas antioksidan. Namun, penelitian terkait kulit alpukat sebagai antioksidan belum banyak dilakukan.Tujuan: Mengetahui aktivitas antioksidan total flavonoid, total tanin ekstrak etanol kulit alpukat.Metode: Buah alpukat yang diperoleh dari Lubuk Linggau, Sumatra Selatan diekstraksi dengan cara maserasi dengan pelarut etanol. Ekstrak kemudian dianalisis kualitatif untuk mengetahui kandungan flavonoid menggunakan Mg dan HCl dan tanin menggunakan FeCl3. Penentuan aktivitas antioksidan ekstrak dilakukan dengan metode DPPH, sedangkan penentuan flavonoid total menggunakan AICI3 serta tanin total menggunakan reagen folin ciocelteu yang diukur menggunakan spektrofotometer UV-VIS. Hasil:  Hasil analisis kualitatif memperlihatkan bahwa ekstrak etanol kulit alpukat mengandung flavonoid dan tanin. Esktrak etanol kulit alpukat memiliki aktivitas antioksidan kuat dengan IC50 41,93 µg/mL. Kandungan flavonoid total dan tanin total ekstrak etanol kulit alpukat masing-masing adalah 125,01 mgQE/g ekstrak dan 53,82 mgTAE/g ekstrak.Kesimpulan: Ekstrak etanol kulit alpukat memiliki aktivitas antioksidan  dengan kandungan flavonoid yang lebih tinggi dibandingkan tanin.Katakunci: antioksidan, DPPH, flavonoid total, tanin total
Evaluation of pharmaceutical services, the level of satisfaction and waiting time at Betung City Primary Health Care, Banyuasin Regency Reza Agung Sriwijaya
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art7

Abstract

Background: Pharmaceutical services play an important role in the success of patient treatment in health centers, therefore it is necessary to evaluate the management of pharmaceutical preparations and clinical pharmacy services and see the level of patient satisfaction and waiting time for prescriptions in health centers by comparing those stipulated in the regulation of the minister of health no 74 of 2016 and no 129 year 2008Objective: The purpose of this study was to evaluate the management of Consumable Medical Materials (BMHP) services, clinical pharmacy services based on Minister of Health Regulation No. 74 /2016 and Permenkes no 129/2008.Methods : This research is an observational, experimental, quantitative descriptive, cross-sectional study with prospective data collection, survey methods and interviews. Measuring instrument research, questionnaire sheet, which has been validated. Inclusion criteria are pharmacy staff who are responsible for pharmacy services at Betung Public Health Center, Banyuasin Regency. The data obtained in the form of qualitative and quantitative descriptive data.Result : The results of the study obtained services according to Permenkes No. 74 of 2016 management of pharmaceutical preparations and medical consumables of 88.26% (good) and clinical pharmacy services 26.2% (less) especially in Drug Information Services (PIO), Monitoring of Side Effects Drugs (MESO), and Drug Therapy Monitoring (PTO), the visits have not been carried out, patients are very satisfied with the services of the Betung Health Center and the average waiting time for prescription services is 4 minutes 13 seconds according to the Regulation of the Minister of Health No. 129 Year 2008.Conclusion : Pharmaceutical services that are in accordance with Permenkes No.74 of 2016 on the management of pharmaceutical preparations and BMHP are in accordance with 88.26% but clinical pharmacy services are not in accordance with Permenkes 74/2016 by 21.3% (less category), especially in clinical pharmacy services which What has not been implemented is drug information service (PIO) by 33.05% and what has not been implemented, namely monitoring of drug side effects (MESO) and monitoring of drug therapy (PTO), Visit by 0%. The level of patient satisfaction is very satisfied with the puskesmas services with a percentage of 81.3% seen from the 5 dimensions, the average value of waiting time for prescription services is 4 minutes 13 seconds according to the Ministry of Health no. 129 in 2008.Keywords: puskesmas, pharmaceutical services, Permenkes IntisariLatar belakang: Pelayanan kefarmasian memegang peranan penting dalam keberhasilan pengobatan pasien di puskesmas. Dengan demikian, perlu dilakukan evaluasi pada pengelolaan sediaan farmasi dan pelayanan farmasi klinik serta melihat tingkat kepuasan pasien dan waktu tunggu resep di Puskesmas.Tujuan: Penelitian ini bertujuan untuk mengevaluasi pengelolaan pelayanan Bahan Medis Habis Pakai (BMHP), pelayanan farmasi klinik berdasarkan Peraturan Menteri Kesehatan (Permenkes) No. 74/2016 dan Keputusan Menteri Kesehatan (Kepmenkes) nomor 129/2008.Metode: Rancangan penelitian ini adalah potong lintang dengan metode survei dan observasional. Pengumpulan data secara prospektif, dengan pembagian kuesioner yang telah valid dan wawancara. Jumlah responden adalah 80 pasien dan satu tenaga kefarmasian yang bertanggung jawab atas pelayanan kefarmasian di Puskesmas Betung Kabupaten Banyuasin. Data yang diperoleh dianalisis secara deskriptif.Hasil: Hasil penelitian menunjukkan pengelolaan sediaan farmasi dan BMHP di sebesar 88,26% (kategori baik) dan pelayanan farmasi klinik 26,2% (kategori kurang) khususnya kegiatan Pelayanan Informasi Obat (PIO), Monitoring Efek Samping Obat (MESO), dan Pemantauan Terapi Obat (PTO), visite belum dilakukan. Pasiensangat puas (81,3%) terhadap pelayanan Puskesmas Betung dan rata-rata waktu tunggu pelayanan resep adalah 4 menit 13 detik sesuai Kepmenkes No. 129/2008.Kesimpulan: Pelayanan kefarmasian yang telah sesuai dengan Permenkes No.74 Tahun 2016 yaitu tentang Pengelolaan Sediaan Farmasi dan BMHP, sedangkan pelayanan farmasi klinik belum sesuai. Sebagian besar telah merasa puas terhadap pelayanan kefarmasian di Puskemas Betung dan waktu tunggu telah sesuai dengan persyaratan.Kata kunci: puskesmas, pelayanan kefarmasian, waktu tunggu, kepuasan
Assessment of prescribing pattern based on WHO indicators at “X” Primary Health Care in Sleman Regency Kristy Tri Wardhani; Dian Medisa; Saepudin Saepudin; Ifada Ifada
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art11

Abstract

Abstract Background: Puskesmas is a primary level of health service facility that must implement rational drug use. A rational prescribing pattern will improve the quality of health services.Objective: The aim of this study was to know the prescribing pattern at the "X" Primary Health Care in Sleman Regency based on WHO indicators.Method: A retrospective observational study was conducted to assess the prescribing pattern. The sample was selected using simple random sampling and analyzed descriptively. The data was collected from prescriptions in Mei 2019.Result: The results of this study showed the average number of drugs per prescription was 2.66, drugs prescribed by generic name was 100%. The percentage of encounter in which injection and antibiotic was prescribed was 0% and 15.83% respectively. Most drugs (91.85%) were included in National Formulary.Conclusion: It can be concluded that the prescribing pattern at Puskesmas X is rational according to the target of the Ministry of Health and WHO, but it is necessary to carry out a continuous MTP (monitoring training planning) process involving related parties.Keywords: prescribing pattern, primary health care, Sleman, WHO indicatorsIntisari Latar belakang: Puskesmas adalah fasilitas pelayanan kesehatan tingkat I yang harus menerapkan penggunaan obat rasional. Pola peresepan yang rasional akan menghasilkan kualitas dalam pelayanan kesehatan masyarakat.Tujuan:  Penelitian ini bertujuan untuk mengetahui gambaran pola peresepan di Puskesmas “X” Kabupaten Sleman berdasarkan indikator peresepan WHO.Metode: Penelitian merupakan penelitian observasional secara retrospektif menggunakan resep bulan Mei 2019. Sampel resep diambil dengan metode random sampling dan data dianalisis secara deskriptif.Hasil: Hasil penelitian menunjukkan rata-rata jumlah obat per lembar resep adalah 2,66, tingkat peresepan obat dengan nama generik 100%, tingkat penggunaan antibiotik sebesar 15,83% dari total kasus, tingkat peresepan injeksi 0%, dan kesesuaian peresepan dengan Formularium Nasional 2017 sebesar 91,85%.Kesimpulan: Pola peresepan di Puskesmas X sudah rasional sesuai target Kementerian Kesehatan dan WHO, namun perlu dilakukan proses MTP (monitoring training planning) berkesinambungan melibatkan pihak terkait.Kata kunci: pola peresepan, puskesmas, Sleman, indikator WHO 
Lotion deodorant formulation of ethanolic extract of red betel leaf (Piper crocatum Ruiz & Pav) with stearic acid as base Lidia Lidia; Ensiwi Munarsih; Dini Aprilianti
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art18

Abstract

Abstract Background: Red betel leaf (P. crocatum Ruiz & Pav) possesses antibacterial properties, so the prospect is to be developed as a deodorant in lotion dosage forms.Objective: This study was conducted with the intention to prepare, evaluate, and investigate the stability of deodorant lotion preparations from the ethanolic extract of red betel leaf (P. crocatum Ruiz & Pav) based on stearic acid.Methods: The maceration method used 70% ethanol as solvent to obtain red betel leaf extract. Furthermore, the concentrated extract was formulated as a deodorant lotion formula into three formulas, FI, FII, and FIII, with varying concentrations of stearic acid 2, 4, and 6%, respectively. All the deodorant lotion formulas were evaluated, their characteristics and stability of organoleptic, pH, homogeneity, viscosity, spreadability, adhesion, and irritation properties. The physical stability test was done by cycling test. The storage stability test was evaluated for 28 days.Results: Evaluation of physical properties for 28 days showed that deodorant lotion was homogeneous and pH in the range of 5.5-6.4; viscosity, spreadability, and adhesion tests gave good results and stability.  In the irritation test, all formulas showed no irritation. Statistical test paired T-test on stability testing during storage and cycling test showed that the best and most stable formula was F3 with 6% stearic acid concentration.Conclusion: Ethanolic extract of red betel leaf (P. crocatum Ruiz & Pav) can be formulated into a deodorant lotion preparation that is stable and good during storage.Keywords: deodorant lotion, Piper crocatum Ruiz & Pav, stearic acid Intisari Latar belakang: Daun sirih merah (Dasimer) (P. crocatum Ruiz & Pav) berkhasiat sebagai antibakteri, sehingga prospek untuk dikembangkan sebagai deodorant dalam bentuk sediaan losion.Tujuan: Penelitian ini dilakukan dengan tujuan untuk membuat, mengevaluasi dan melakukan uji stabilitas sediaan losion deodoran dari ekstrak etanol Dasimer (P. crocatum Ruiz & Pav) dengan variasi basis asam sterat.Metode:  Ekstrak Dasimer diekstraksi menggunakan metode maserasi dengan etanol 70% sebagai pelarut. Ekstrak kental etanol yang diperoleh diformulasikann menjadi 3 formula losion yaitu FI, FII dan FIII dengan variasi asam stearate 2, 4 dan 6 %. Formula losion deodoran, dievaluasi karakteristik dan stabilitasnya meliputi organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat dan iritasi. Uji stabilitas fisik dilakukan dengan cycling test. Uji stabilitas dalam penyimpanan dievaluasi selama 28 hari.Hasil: Evaluasi sifat fisik selama 28 hari menunjukkan bahwa deodoran losion homogen dan pH dalam rentang yang baik yakni 5,5-6,4. Pengujian viskositas, daya sebar dan daya lekat juga memberikan hasil yang baik dan stabil. Pada pengujian iritasi, semua formula menunjukkan tidak terjadi iritasi. Uji statitistik T-test berpasangan pada pengujian stabilitas selama penyimpanan dan cycling test, menunjukkan bahwa formula yang paling baik dan stabil yaitu F3 dengan konsentrasi asam stearat 6 %.Kesimpulan:  Ekstrak etanol Dasimer (P. crocatum Ruiz & Pav) dapat dibuat menjadi sediaan deodoran losion yang stabil dan baik pada saat penyimpanan.Kata Kunci: losion deodoran, Piper crocatum Ruiz & Pav, asam stearat

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