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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Biocelebes KOVALEN: Jurnal Riset Kimia Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry Al-Madrasah: Jurnal Ilmiah Pendidikan Madrasah Ibtidaiyah Jurnal Ilmu Kefarmasian Indonesia Molekul: Jurnal Ilmiah Kimia Moderatio : Jurnal Moderasi Beragama Academic Journal of Islamic Principles and Philosophy
Syariful Anam
Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako, Palu, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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AKTIVITAS ANTIBAKTERI FRAKSI EKSTRAK KULIT BUAH MENTAH PISANG AMBON (MUSA PARADISIACA VAR.SAPIENTUM) TERHADAP STAPHYLOCOCCUS AUREUS Normayunita, Sri; Anam, Syariful; Khumaidi, Akhmad
Natural Science: Journal of Science and Technology Vol 4, No 3 (2015): Volume 4 Number 3 (December 2015)
Publisher : Univ. Tadulako

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Abstract

Telah diketahui Bahwa ekstrak etanol kulit buah mentah pisang ambon (Musa paradisiaca var.sapientum) mempunyai aktivitas antibakteri terhadap Staphylococcus aureus. Ekstrak kulit buah mentah pisang ambon diperoleh melalui ekstraksi secara maserasi dengan pelarut etanol 96%, dengan fraksinasi menggunakan metode kromatografi cair vakum, fraksi yang diperoleh dilakukan pengujian aktivitas antibakteri dengan metode difusi agar menggunakan paper disc. Penelitian ini bertujuan untuk menentukan fraksi yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan aktivitas tertinggi dan menentukan fraksi yang mempunyai efektivitas hampir sama dengan kontrol positif (tetrasiklin). Data yang diperoleh berupa statistik, dari hasil uji two-way ANOVA menunjukan bahwa secara keseluruhan terdapat perbedaan yang bermakna (p<0,05) terhadap semua jenis sampel. Berdasarkan uji Tukey HSD menunjukan bahwa aktivitas paling tinggi dari keempat fraksi dengan konsentrasi 30, 60, dan 90 µg/µL terdapat pada fraksi dengan konsentrasi 90 µg/µL. Pada kontrol positif untuk semua kelompok uji terdapat perbedaan bermakna (p< 0,05), artinya efektivitas kontrol positif dengan semua perlakuan menunjukan perbedaan efektivitas antara kontrol positif dengan semua fraksi uji. Dapat disimpulkan bahwa fraksi aktif dengan konsentrasi 90 µg/µL miliki aktivitas paling besar dan tidak ada efektivitas fraksi yang hampir sama dengan kontrol positif.
UJI EFEKTIFITAS EKSTRAK DAUN DAN AKAR HARRISONIA PERFORATA MERR.TERHADAP PERTUMBUHAN BAKTERI VIBRIO CHOLERAE Al Amrie, Amir Galeb; Ivan, Ivan; Anam, Syariful; Pitopang, Ramadhanil
Natural Science: Journal of Science and Technology Vol 3, No 3 (2014): Volume 3 Number 3 (December 2014)
Publisher : Univ. Tadulako

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Abstract

Penelitian tentang uji efektifitas ekstrak daun dan akarHarrisonia perforata Merr.terhadap pertumbuhan bakteri Vibrio cholerae telah dilaksanakan pada bulan Maret sampai Mei 2014. Tujuan penelitian ini yaitu untuk mengetahui keefektifan ekstrak daun dan akarH. perforata Merr.dalam menghambat pertumbuhan bakteri V. cholerae. Metode ekstraksi yang digunakan dalam penelitian yaitu metode Maserasi dan Refluks.Sedangkan pengujian daya hambat ekstrak terhadap bakteri V. Cholerae dengan menggunakan metode difusi agar (metode sumur).Penelitian ini disusun dalam Rancang Acak Lengkap (RAL) dengan 7 perlakuan dan 3 kali ulangan (untuk masing-masing daun dan akar). Perlakuan yang dicobakan yaitu pemberian konsentrasi ekstrak (daun maupun akar) 10 %, 20 %, 40 %, 60 % dan 80 % serta antibiotik doxycycline 2 % sebagai kontrol positif dan NA-CMC 1 % sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa konsentrasi ekstrak 80 % (daun maupun akar) tumbuhan H. perforata Merr.menghasilkan zona hambat yang paling besar dibanding kosentrasi lainnya dengan masing-masing sebesar (±26,53 mm dan±14,72 mm). Ekstrak daun H. perforata Merr.memiliki daya hambat yang lebih baik dibandingkan ekstrak akar.
STANDARISASI EKSTRAK ETIL ASETAT KAYU SANREGO (LUNASIA AMARA BLANCO) Anam, Syariful; Yusran, Muhammad; Trisakti, Alfred; Ibrahim, Nurlina; Khumaidi, Ahmad; Ramdanil, Ramdanil; Zubair, Muhammad Sulaiman
Natural Science: Journal of Science and Technology Vol 2, No 3 (2013): Volume 2 Number 3 (December 2013)
Publisher : Univ. Tadulako

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Abstract

Lunasia amara Blanco is a popular medicinal plant which is known as aphrodisiac in South Sulawesi Province. Biological activity as antibacterial, anticancer dan antituberculosis were also scientifically reported. This study is to ascertain the safety and quality of the plant extract by standardization procedures mentioned in literature, including specific and non-specific parameters. The result showed that ethyl acetate wood extract of L. amara Blanco, which is brown viscous extract, astringent to the taste and characteristic odor, contain water-soluble extractive matters of 23,95 ± 2,192 %, ethanol-soluble extractive matters of 67,05 ± 3,61 %, water content of 5,33 ± 0,407 %,  total ash content of 0,65 ± 0,199 %, acid-insoluble ash content of 0,58 ±0,225 %, density of 0,7734 ± 0,0016 (5%) and 0,7957 ± 0,0021 (10%), total contaminant number of bacteria and fungus of each < 1 x 104 colony/g, and Pb concentration of 10,59 ± 0,239 mg/kg. Ethyl acetate wood extract of L. amara Blanco has been qualified as standardized extract. Therefore, this study can be a reference for identification and control quality of the extract as a herb-medicine material
FORMULASI KRIM ANTIOKSIDAN EKSTRAK ETANOL BAWANG HUTAN (ELEUTHERINE PALMIFOLIA L. MERR) Sharon, Nela; Anam, Syariful; Yuliet, Yuliet
Natural Science: Journal of Science and Technology Vol 2, No 3 (2013): Volume 2 Number 3 (December 2013)
Publisher : Univ. Tadulako

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Abstract

Eleutherine palmifolia L. Merr having antioxidant activity, its because of contain flavonoid, fenolat and tanin. These compounds have effect in  preventing of free radical which cause premature aging. Research on ethanol extract of E. palmifolia L. Merr which formulated into antioxidant cream have been done by applying variation of TEA emulgator and stearic acid. That variation  were F1 (2% : 6%), F2 (3% : 12%) and F3 (4% : 18%). Determination of antioxidant activity  was done based on DPPH methode, and the Value is 98,210%. Furthermore, evaluation on  physical characteristics was done based on organoleptic test, homogenity, pH, viscosity and stability of cream preparation. Observation was done during 21 days. Obtained data were then analyze by student-t test in comparing of the value between fresh and 21 days after storage. the pH of cream F1, F2 and F3 were not showed significant decrease, while DPPH reduce percent of F1, F2 and F3 were showed significant decrease.  In contrast, viscosity of cream F3 was significant decrease. Antioxydant activity extract based on DPPH reduce percent value of F1, F2, F3 at the first day were 96,822%, 97,123% and 96,896%, respectively. Whereas that value  at 21nd days after storage  were 89,036%, 89,726% and 90,564%, respectively.  Our result showed that E. palmifolia L. Merr ethanol extract  can be formulated as a cream preparations. F2 physical properties was  fullfill standart quality, which it was used TEA emulgator and stearic acid proportion of 3% : 12%.  
Isolation of endophytic fungi from benalu batu (Begonia medicinalis) and their toxicity on Artemia Salina Syariful Anam; Armini Syamsidi; Musyahidah Musyahidah; Nurul Ambianti; Agustinus Widodo; Muhammad Sulaiman Zubair
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art3

Abstract

Abstract   Background: Endophytic fungi are microorganisms found in plant tissues that are mutually beneficial to the host plant. They are known as sources of bioactive metabolites which possess various biological activities such as antimicrobial, anticancer, antiviral, antifungal, and antioxidant.  Benalu batu (Begonia medicinalis) has been used empirically as a medicinal plant and has shown anticancer activity in breast cancer cells (T47D cells) and cervical cancer cells (HeLa cells).Objective: This study aimed to isolate the endophytic fungi from benalu batu and determine the toxicity activity and Lethal Concentration 50% (LC50) value of isolated endophytic fungi using shrimp larvae (Artemia salina). Method: Endophytic fungi were isolated from fresh parts; leaves, stems, roots of Benalu Batu. The selected parts were sterilized with ethanol 70% and sodium hypochlorite 1% subsequently placed into Potato Dextrose Agar Chloramphenicol (PDAC) then incubated at 28°C for 7 days. Isolated endophytic fungi were extracted by sonication method using ethyl acetate. The toxicity activity of isolated endophytic fungi was determined using the Brine Shrimp Lethality Test (BSLT).Results: Isolation of the endophytic fungi from benalu batu obtained 10 isolates, which the leaves part obtained 6 isolates, the stem obtained 3 isolates and the root obtained 1 isolate. The results of screening for toxicity test of 10 isolates at concentrations of 500 µg/mL shown that isolate D3, D5, and D6 gave 100% mortality. The LC50 values of isolate D3, D5, and D6 were obtained respectively in 448.03, 8.784, and 9.13 µg/mL.Conclusion: These results indicated that isolate D5 exhibits the greatest toxicity and needs to be investigated the activity for testing on cancer cells.Keywords: endophytic fungi, Begonia medicinalis, toxicity, Artemia salina Intisari  Latar belakang: Jamur endofit merupakan mikroorganisme yang terdapat dalam jaringan tumbuhan yang bersifat mutualisme terhadap tumbuhan inang. Jamur endofit telah diketahui sebagai sumber metabolit yang memiliki beberapa aktivitas biologi seperti antimikroba, antikanker, antivirus, antijamur, dan antioksidan. Tumbuhan benalu batu (B. medicinalis) telah digunakan secara empiris dan terbukti memiliki aktivitas antikanker pada sel kanker payudara (Sel T47D) dan sel kanker leher rahim (Sel HeLa). Tujuan: Studi ini bertujuan untuk melakukan isolasi jamur endofit dari benalu batu dan mengetahui toksisitas isolat jamur endofit serta menentukan nilai Lethal Concentration 50% (LC50) terhadap larva udang (Artemia salina)Metode: Jamur endofit diisolasi dari bagian segar; daun, batang, akar benalu batu. Bagian-bagian tersebut disterilisasi dengan etanol 70% dan natrium hipoklorit 1% selanjutnya diletakkan pada media Potato Dextrose Agar Chloramphenicol (PDAC) kemudian diinkubasi pada suhu 28°C selama 7 hari. Isolat jamur endofit diekstraksi dengan metode sonikasi menggunakan etil asetat. Aktivitas toksisitas isolat jamur endofit ditentukan menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil: Isolasi jamur endofit dari benalu batu diperoleh 10 isolat, bagian daun diperoleh 6 isolat, bagian batang diperoleh 3 isolat dan bagian akar diperoleh 1 isolat. Hasil penapisan uji toksisitas 10 isolat pada konsentrasi 500 µg/mL menunjukkan bahwa isolat D3, D5, dan D6 memberikan persentase mortalitas sebesar 100%. Nilai LC50 isolat D3, D5, dan D6 diperoleh masing-masing sebesar 448,03, 8,784, dan 9,13 µg/mL.Kesimpulan: Hasil ini menunjukkan isolat D5 memiliki toksisitas paling besar dan perlu dilanjutkan untuk pengujian pada sel kanker.Kata kunci : jamur endofit, Begonia medicinalis, toksisitas, Artemia salina
ANALISIS PENETAPAN KADAR NIPAGIN DALAM SEDIAAN BODY LOTION TIE (TANPA IZIN EDAR) YANG BEREDAR DI PASAR TRADISIONAL KOTA PALU Vini Mandasari; Syariful Anam; Yonelian Yuyun
KOVALEN: Jurnal Riset Kimia Vol. 2 No. 3 (2016)
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

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Abstract

This study aims to determine the levels of nipagin as preservative in body lotions which have no marketing authorization (MA). Each sample was taken from 4 traditional markets located in Palu City. The assay of nipagin in the body lotions was done by using ultraviolet (UV) at wavelength of 257 nm. From 8 different samples, 5 of them contain nipagin of which levels are as follows: A1 = 0.232%; A2 = 0.229%; B1 = 0.124%; B2 = 0.120%; C1 = 0.120%; C2 = 0.117%; and D1 = 0.267%; D2 = 0.273%; and F1 = 0.213%; and F2 = 0.215%. Based on the results obtained, those body lotions that have no marketing authorization meet the requirement of nipagin’s preservative levels according to Analitical Method of National Center for Drug and Food Testing, in which the allowed levels of nipagin for body lotion is 0.4%.Keywords: Body Lotion, Nipagin, Ultraviolet Spectrophotometer.
VARIASI WAKTU DAN CARA PENGOLAHANSEBELUM DIKONSUMSI TERHADAP PENURUNAN KANDUNGAN ASAM SIANIDA PADA VARIETAS REBUNG BAMBU AMPEL (Bambusa vulgaris Schrad. ex Wendl.) Ceria Arun Venagaya; Syariful Anam; Yonelian Yuyun
KOVALEN: Jurnal Riset Kimia Vol. 3 No. 2 (2017): Edisi Agustus
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

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Abstract

Rebung bambu ampel (Bambusa vulgaris Schrad. ex Wendl.) memiliki kandungan nutrisi, namun di samping itu juga rebung mengandung unsur anti nutrisi yang membahayakan kesehatan yaitu kandungan hidrogen sianida (HCN) sehingga dibutuhkan cara pengolahan yang benar agar kandungan sianida dapat dikurangi bahkan dapat dihilangkan sebelum dikonsumsi. Pada penelitian ini rebung diolah dengan cara perendaman dan air mengalir yang dilanjutkan dengan variasi waktu perebusan. Hasil penelitian ini menunjukan bahwa penurunan kadar sianida terendah yaitu pada perendaman dan perebusan selama 5 menit sebesar 68 ppm sedangkan penurunan kadar sianida yang paling besar terjadi pada kombinasi perlakuan rebung yang dicuci dengan air mengalir dan perebusan selama 120 menit sebesar 656,33 ppm. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa waktu perebusan mempengaruhi kadar sianida rebung, semakin lama waktu perebusan kadar sianida semakin menurun.Kata kunci : Sianida, Rebung, Bambu Ampel (Bambusa vulgaris Schrad. ex Wendl.)
ANALISIS KADAR TOTAL METABOLIT SEKUNDER EKSTRAK ETANOL DAUN TAMOENJU (Hibiscus surattensis L.) Astrid Natalia Alasa; Syariful Anam; Jamaluddin Jamaluddin
KOVALEN: Jurnal Riset Kimia Vol. 3 No. 3 (2017): Edisi Desember
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

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Tamoenju (Hibiscus surattensis L.) leaves are included in the malvaceae family which grows in the plateau and are known to have the antidiabetic activity that the standardization of the extract is needed to be conducted. The research aimed to discover the total level of secondary metabolites from ethanol extract. The extraction of Tamoenju leaves through maceration method with 96% ethanol was done to obtain the filtrate. The filtrate obtained was concentrated by using rotary evaporator at 40°C until the concentrated extract was obtained. The extract gained was then tested in a qualitative way with Alkaloid, Flavonoid, Saponin, and Tannin tests by using the suitable reagent for the test parameters. While in the quantitative test the method used was Gravimetric analysis on alkaloid and Saponin compounds, Permanganometry on Tannin compound, and UV-Visible Spectrophotometry on Flavonoid. The qualitative test results reveal that Tamoenju is positive for containing Alkaloid which was characterized by the presence of orange sediment, Flavonoid was characterized by the orange formation, Tannin was characterized by the dark blue and Saponin was characterized by the stable foam. The quantitative test results are Alkaloid by 305.181 g/g, Saponin by 371.112 g/g, Tannin by 55.417 g/g and Flavonoid by 14.999 mg/100 g.Keywords: Hibiscus surattensis L. , secondary metabolites, standardization
UJI DAYA HAMBAT EKSTRAK BATANG TUMBUHAN Harrisonia perforata Merr. TERHADAP PERTUMBUHAN BAKTERI Shigella dysentriae Dewi Permatasari; Ramadhanil Ramadhanil; Syariful Anam; Ivan Ivan
Biocelebes Vol. 9 No. 1 (2015)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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The research entitled inhibition test of stem extract of Harrisonia perforata Merr. on the growth of bacteria Shigella dysentriae has been conducted from April - May 2014. The objective of the research was to study the inhibition stem extract of H. perforate Merr. on the bactery studied. The extraction was used reflux method. The experiment was arranged in Completely Randomized Designed (CRD) by 4 treatments (concentrate extract 60%, 80%, 100% and Contrimoxazale 1% as positive control) and 3 repetitions. The result showed that the best of extract concentrate to inhibite of bacterial growth was 100%. The treatment by 60% and 80% were not significant different statistically. Keywords : Harrisonia perforata Merr.,  Shigella dysenriae, Extract concentrate, Inhibition zone.
UJI DAYA HAMBAT DAUN Harrisonia perforata Merr. TERHADAP PERTUMBUHAN BAKTERI Escherichia coli DAN Salmonella typhi Irna Olvaliani Aimang; Ramadhanil Ramadhanil; Syariful Anam; Ivan Ivan
Biocelebes Vol. 9 No. 1 (2015)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Reseacrh of inhibition test of leaves extract of Harrisonia perforata Merr. against to the growth of Eschericia coli and Salmonella thypi had been conducted during period of March to May 2014. The aim of this research was to gain the effectivity of leaves extract to inhibite the growth of E. coli dan S.thypi. Maceration method was used as the extraction method and Agar Diffusion method. The research was design by Completely Randomized Design with four(4) treatments and three(3) replications (for both bacterias). The treatments were leaves extract concentrate 15% 10%, 15%, and positive control (2 mg of Ciprofloxacin for E.coli and 2 mg Cloramfenikol for S.thypi). The result showed that leaves extract of H. perforata Merr. had inhibition effect to the growth of bacterias. The extract concentrate 15% produced the biggest inhibition zone for both E. coli and S. thypi (20,9 mm and 19,3 mm repectively) than other concentrates.   Keywords : Extract concentration, Harrisonia perforata Merr., Bacterial inhibition zone, Eschericia coli, Salmonella thypi.
Co-Authors Abd. Rahman Razak Agus Ritna Agustinus Widodo Ahmad Khumaidi Akhmad Khumaidi Alfred Trisakti Amir Galeb Al Amrie Andi Muraqmi Apriyanto S. Tapundu Arba, Muhammad Arif Prasetyo, Arif Arisca, Windhy Nur Armini Syamsidi Asriana Sultan Astrid Natalia Alasa Ceria Arun Venagaya David Pakaya Dewi Permatasari DEWI RISMAYANTI Djaleha, Helena Fransisca Fadlia Fadlia Febriyanto Rerung FIRMANITA DWIMURTI Hidayatullah Hidayatullah Ian Dianto Ibrahim Jantan Ihwam Ihwan Iklima Indriani, Meri Feki Irna Olvaliani Aimang Ivan Ivan Jamaluddin Jamaluddin Khusnul Diana Leny Maryana Maliki, Ibnu Akbar Megawati Megawati Mohamed Ali Ghandourah Muhajir Lamasai Muhamad Rinaldhi Tandah Muhammad Akhsa Muhammad Sulaiman Zubair Muhammad Yusran Musyahidah Musyahidah Nela Sharon Ni Luh Yeni Safitri Nur Khairiyah Nurlina Ibrahim Nurul Ambianti Ramadhanil Pitopang Ramadhanil pitopang Ramadhanil Ramadhanil Ramdanil Ramdanil Ritha Pratiwi Saipul Maulana Septiliana, Lilla Siti Hamdanah Siti Nuari Sri Normayunita, Sri Syaputra, Gunawan Tunreng, Muh. Fadil Usman Vini Mandasari Wa Ode Irma Indrayangingsih Walied Mohamed Alarif Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi