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Isolation of endophytic fungi from benalu batu (Begonia medicinalis) and their toxicity on Artemia Salina Syariful Anam; Armini Syamsidi; Musyahidah Musyahidah; Nurul Ambianti; Agustinus Widodo; Muhammad Sulaiman Zubair
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art3

Abstract Background: Endophytic fungi are microorganisms found in plant tissues that are mutually beneficial to the host plant. They are known as sources of bioactive metabolites which possess various biological activities such as antimicrobial, anticancer, antiviral, antifungal, and antioxidant. Benalu batu (Begonia medicinalis) has been used empirically as a medicinal plant and has shown anticancer activity in breast cancer cells (T47D cells) and cervical cancer cells (HeLa cells).Objective: This study aimed to isolate the endophytic fungi from benalu batu and determine the toxicity activity and Lethal Concentration 50% (LC50) value of isolated endophytic fungi using shrimp larvae (Artemia salina). Method: Endophytic fungi were isolated from fresh parts; leaves, stems, roots of Benalu Batu. The selected parts were sterilized with ethanol 70% and sodium hypochlorite 1% subsequently placed into Potato Dextrose Agar Chloramphenicol (PDAC) then incubated at 28°C for 7 days. Isolated endophytic fungi were extracted by sonication method using ethyl acetate. The toxicity activity of isolated endophytic fungi was determined using the Brine Shrimp Lethality Test (BSLT).Results: Isolation of the endophytic fungi from benalu batu obtained 10 isolates, which the leaves part obtained 6 isolates, the stem obtained 3 isolates and the root obtained 1 isolate. The results of screening for toxicity test of 10 isolates at concentrations of 500 µg/mL shown that isolate D3, D5, and D6 gave 100% mortality. The LC50 values of isolate D3, D5, and D6 were obtained respectively in 448.03, 8.784, and 9.13 µg/mL.Conclusion: These results indicated that isolate D5 exhibits the greatest toxicity and needs to be investigated the activity for testing on cancer cells.Keywords: endophytic fungi, Begonia medicinalis, toxicity, Artemia salina Intisari Latar belakang: Jamur endofit merupakan mikroorganisme yang terdapat dalam jaringan tumbuhan yang bersifat mutualisme terhadap tumbuhan inang. Jamur endofit telah diketahui sebagai sumber metabolit yang memiliki beberapa aktivitas biologi seperti antimikroba, antikanker, antivirus, antijamur, dan antioksidan. Tumbuhan benalu batu (B. medicinalis) telah digunakan secara empiris dan terbukti memiliki aktivitas antikanker pada sel kanker payudara (Sel T47D) dan sel kanker leher rahim (Sel HeLa). Tujuan: Studi ini bertujuan untuk melakukan isolasi jamur endofit dari benalu batu dan mengetahui toksisitas isolat jamur endofit serta menentukan nilai Lethal Concentration 50% (LC50) terhadap larva udang (Artemia salina)Metode: Jamur endofit diisolasi dari bagian segar; daun, batang, akar benalu batu. Bagian-bagian tersebut disterilisasi dengan etanol 70% dan natrium hipoklorit 1% selanjutnya diletakkan pada media Potato Dextrose Agar Chloramphenicol (PDAC) kemudian diinkubasi pada suhu 28°C selama 7 hari. Isolat jamur endofit diekstraksi dengan metode sonikasi menggunakan etil asetat. Aktivitas toksisitas isolat jamur endofit ditentukan menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil: Isolasi jamur endofit dari benalu batu diperoleh 10 isolat, bagian daun diperoleh 6 isolat, bagian batang diperoleh 3 isolat dan bagian akar diperoleh 1 isolat. Hasil penapisan uji toksisitas 10 isolat pada konsentrasi 500 µg/mL menunjukkan bahwa isolat D3, D5, dan D6 memberikan persentase mortalitas sebesar 100%. Nilai LC50 isolat D3, D5, dan D6 diperoleh masing-masing sebesar 448,03, 8,784, dan 9,13 µg/mL.Kesimpulan: Hasil ini menunjukkan isolat D5 memiliki toksisitas paling besar dan perlu dilanjutkan untuk pengujian pada sel kanker.Kata kunci : jamur endofit, Begonia medicinalis, toksisitas, Artemia salina

ANALISIS BIAYA PENGOBATAN PENYAKIT GINJAL KRONIK RAWAT INAP DENGAN HEMODIALISIS DI RUMAH SAKIT UMUM DAERAH UNDATA PALU Muhamad Rinaldhi Tandah; Ihwan Ihwan; Khusnul Diana; Zulfiah Zulfiah; Nurul Ambianti
Jurnal LINK Vol 15, No 2 (2019): NOVEMBER 2019
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Poltekkes Kemenkes Semarang

Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan global. Pembiayaan penyakit ginjal merupakan peringkat kedua terbesar dari BPJS kesehatan setelah penyakit jantung. Indonesia memasuki era Jaminan Kesehatan Nasional (JKN) sejak 01 Januari 2014. Pola pembayaran JKN adalah dengan sistem Indonesia Case Base Group (INA-CBGs). Penelitian ini bertujuan untuk mengetahui rata-rata biaya pengobatan, komponen biaya yang paling besar, serta selisih antara biaya pengobatan pasien PGK dengan JKN rawat inap terapi hemodialisis dengan standar tarif INA-CBGs. Penelitian ini merupakan penelitian deskriptif dengan pengumpulan data sekunder berupa biaya medik langsung dari perspektif rumah sakit pada pasien PGK rawat inap dengan JKN terapi hemodialisis di RSUD Undata Palu periode Januari - Desember 2017. Hasil penelitian menunjukan rata-rata biaya medik langsung pasien PGK rawat inap dengan hemodialisis sebesar Rp 11.074.834. Komponen biaya terbesar adalah biaya hemodialisis sebesar Rp 155.122.000 (37,86%) dari total pembayaran, dan selisih antara biaya medik langsung pasien PGK JKN rawat inap hemodialisis dengan standar tarif INA-CBGs sebesar Rp 191.920.841 (46,84 %) dari total biaya rumah sakit.

ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO Nurul Ambianti; Muhamad Rinaldhi Tandah; Khusnul Diana; Ratu Balqis
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5135

Abstract The defective and expired drugs are one of the problems that can reflect the inaccuracy and poor of drug management in a Hospital Pharmacy Unit (HPU). This research was conducted to determine the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs at the Regional General Hospital (RGH) Tora Belo. This type of researched is a non-experimental study with cross sectional data collection. The data used are primary data obtained from the results of questionnaires that have been filled out by pharmacist at Tora Belo Hospital. The analysis used in this study is correlation analysis using the Spearman-Rho test, to determine the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs. The number of samples is 33 people taken by total sampling. Time to collect research data during May-October 2020. From the results of the study, it is known that the level of knowledge of the respondents is dominated by the sufficient category, namely 17 respondents (71.1%), it is known that the attitude of the respondents was included in the very strong category of 18 respondents (85.78%), and the results of the correlation analysis the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs obtained a significance value of 0.021. So it can be concluded there is a relation between the level of knowledge and attitude of pharmaceutical workers in preventing defective and expired drugs at Tora Belo Hospital.

PATTERNS OF MEDICINE USE FOR COVID-19 PATIENTS AT UNDATA HOSPITAL PALU Amelia Rumi; Nurul Ambianti; Desti Sulistiani Arbi
Indonesian Journal of Health Administration Vol. 10 No. 1 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jaki.v10i1.2022.99-110

Background: Covid-19 cases had drastically increased. Little therapy has been formulated to respond to the situation. Covid-19 symptoms in Indonesia are divided into four classes: asymptomatic, mild, moderate, and severe. Aims: This study aims to illustrate the pattern of drug use in Covid-19 patients at Undata Palu Hospital. Methods: This study is a type of cross-sectional descriptive study using a cross-sectional design and collecting data retrospectively from medical records at Undata Hospital Palu in 2020. Results: In 2020, 186 patients were confirmed positive for Covid-19. There were 95 female patients (51.9%) and 50 patients at the age of 46-55 years (27.3%). The severe symptoms happened to 109 patients (59.6%). The most common clinical manifestation was cough in 127 patients (23.3%). The most common comorbidity was pneumonia (30.8%). The most widely used primary therapy was the antibiotic azithromycin applied to 155 patients (30.0%), and the most widely used supportive therapy was vitamin C among 141 patients (20.1%). Oseltamivir antiviral therapy was administered to 132 patients (25.6%) and remdesivir to 34 patients (6.6%). Conclusion: Covid-19 patients were mostly treated with antibiotic therapy (41.5%), antiviral therapy (32.2%), antimalarial therapy (15.7%), and corticosteroid therapy (10.7%). As many as 132 patients took oseltamivir, and 34 patients took remdesivir. However, for now, oseltamivir is no longer used.

GAMBARAN PEMBUANGAN OBAT YANG TIDAK DIGUNAKAN DI KALANGAN MASYARAKAT KOTA PALU Nurul Ambianti; Ririen Hardani; Muhamad Rinaldhi Tandah; Handoko Putro
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 6 No. 1 (2022): April 2022
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v6i1.3700

Disposal of drugs that are not used in the community has a very negative impact on the environment. Many drugs are not used and become a big problem, some of which can cause contamination to the environment and disrupt the ecosystem. This study aimed to describe the description of the procurement, use, storage, disposal of drugs as well as public attitudes and information about drugs that are not used, namely damaged and expired among the people of Palu City. This study was a cross-sectional with a population of 84,374 households and a sample of 100 households in Palu City from February to April 2021. This study conducted using the convenience sampling. The independent variable in this study was drug disposal and the dependent variable was drugs that were not used. The data obtained from the questionnaire then analyzed descriptively. The result obtained that many of people bought drugs at pharmacies (78%) with reasons of wanting to buy of their own volition (38%), storing drugs in medicine boxes (56%), throwing drugs in public trash (78%) and respondents think that the improper disposal of unused and expired drugs can have an impact on the environment (70%) because many respondents have never received education related to drug disposal (65%). The majority of people throw away unused or expired drugs that they get from pharmacies in public trash and because of the lack of information regarding the disposal of drugs they get which can have a bad impact on the surrounding environment. Â KeywordsÂ Â Â Â Â Â Â Â : expired drug, drug disposal, unused drug

ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO Ambianti, Nurul; Tandah, Muhamad Rinaldhi; Diana, Khusnul; Balqis, Ratu
Acta Pharmaciae Indonesia Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5135

Abstract The defective and expired drugs are one of the problems that can reflect the inaccuracy and poor of drug management in a Hospital Pharmacy Unit (HPU). This research was conducted to determine the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs at the Regional General Hospital (RGH) Tora Belo. This type of researched is a non-experimental study with cross sectional data collection. The data used are primary data obtained from the results of questionnaires that have been filled out by pharmacist at Tora Belo Hospital. The analysis used in this study is correlation analysis using the Spearman-Rho test, to determine the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs. The number of samples is 33 people taken by total sampling. Time to collect research data during May-October 2020. From the results of the study, it is known that the level of knowledge of the respondents is dominated by the sufficient category, namely 17 respondents (71.1%), it is known that the attitude of the respondents was included in the very strong category of 18 respondents (85.78%), and the results of the correlation analysis the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs obtained a significance value of 0.021. So it can be concluded there is a relation between the level of knowledge and attitude of pharmaceutical workers in preventing defective and expired drugs at Tora Belo Hospital.

Analysis of Therapy Satisfaction on the Quality-of-Life of Type 2 Diabetes Mellitus Patients at Anutapura Hospital Palu: Analisis Kepuasan Terapi Terhadap Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di RSUD Anutapura Palu Zainal, Setiawati Fadhilah; Rumi, Amelia; Tamrin, M.; Rosita, Habiba; Hasymi, Abdurrahman; Alydrus, Rugayyah; Ambianti, Nurul
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16887

Background: Type 2 Diabetes Mellitus (Type 2 DM) is a chronic disease characterized by increased blood glucose levels caused by impaired insulin function. In Palu City, Type 2 DM is the 2nd most common in Central Sulawesi with a total of 26,204 people. Objective: This study aims to determine the relationship between therapy satisfaction and the quality of life of Type 2 DM patients who perform outpatient treatment at Anutapura General Hospital, Palu. Methods: With a random sample approach, 100 respondents were used in this cross-sectional study that employed an observational method. Data collection used instruments in the form of a DMSAT (Diabetes Medication Satisfaction Tool) therapy satisfaction questionnaire and a DQOL (Diabetes Quality Of Life) quality of life questionnaire. Results: The results of the study were obtained on therapy satisfaction from Type 2 DM patients with the number of respondents in the very satisfied (1.0%), satisfied (90.0%), and quite satisfied (9.0%) categories while the results of the study of the quality of life of Type 2 DM patients 2 fall into the good category (38.0%), and the bad category (62.0%). The statistical analysis test used was the Spearman Rank Correlation test. The results of the Spearman Rank Correlation test value p = 0.037 or p <Î± (0.05), then H0 is rejected, which means that there is a relationship between satisfaction with therapy and quality of life in patients with Type 2 DM which is very weak. Conclusion: The conclusion in this study is that there is a very weak relationship between therapy satisfaction and quality of life of patients.

Edukasi Bahaya Penyalahgunaan Obat Pada Siswa Sekolah Dasar Inpres Inti Tondo Muhamad Rinaldhi Tandah; Khusnul Diana; Nurul Ambianti; Setiawati Fadillah Zainal
Jurnal Dedikatif Kesehatan Masyarakat Vol 4 No 1 (2023): Oktober
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/dedikatifkesmas.v4i1.733

Penyalahgunaan obat terutama dikalangan remaja dan anak-anak menjadi salah satu hal yang perlu diantisipasi bersama. Adanya penyalahgunaan obat menjadi salah satu pelanggaran kemanusiaan yang dapat berdampak pada hancurnya generasi bangsa. Kurangnya pengetahuan terkait penggunaan obat dan mudahnya mendapatkan obat-obatan di pasaran memberikan ruang kepada masyarakat khususnya pelajar sekolah untuk memperoleh obat-obatan secara bebas tanpa pengawasan, arahan dan resep dari dokter dan apoteker. Sehingga, penting dilakukan pengenalan produk obat-obatan dan bahayanya apabila disalahgunakan pada pelajar. Tenaga kesehatan khususnya tenaga kefarmasian berperan penting dalam memberikan informasi dan edukasi yang terkait penyalahgunaan obat-obatan. SD Inti Tondo adalah salah satu sekolah yang berada di Kecamatan Mantikulore Kota Palu. Lingkungan sekolah menjadi tempat yang rawan bagi penyalahgunaan obat yang mengandung narkotika, psikotropika, obat keras tertentu dan obat yang mengandung prekursor farmasi. Penyalahgunaan obat dapat merusak perkembangan jiwa generasi muda baik si pengguna maupun orang sekitarnya. Tujuan kegiatan pengabdian kepada masyarakat ini untuk mengedukasi siswa dan guru SD Inpres Inti Tondo terhadap bahaya pengalahgunaan obat-obatan. Kegiatan dilakukan dengan metode ceramah dan diskusi menggunakan alat bantu LCD dalam memaparkan materi edukasi. Tahapan kegiatan yang dilakukan adalah koordinasi ke lokasi, pemaparan materi edukasi dan diskusi tanya jawab kepada peserta. Kegiatan pengabdian kepada masyarakat yang telah dilakukan berlangsung baik dan lancer. Pada sesi diskusi dan tanya jawab, didapatkan bahwa siswa SD Inpres Inti Tondo mendapat peningkatan pengetahuan tentang jenis-jenis obat yang berbahaya dan bahaya serta dampak dari penyalahgunaan obat. Kata Kunci: bahaya, penyalahgunaan, obat, siswa

Analisis Biaya Penyakit Diabetes Melitus Sebagai Pertimbangan Perencanaan Pembiayaan Kesehatan: Cost Analysis of Diabetes Mellitus Disease as Considerations In Health Funding Planning Abror, Nurul Ambianti; Andayani, Tri Murti; Sulistiawaty, Endang
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Disease cost analysis is an important element in the decision making process of chronic disease, because it can evaluate the cost of illness and illustrate diseases that require an increase in resources for the prevention or therapy. This study aims to determine the total cost of diabetes mellitus (DM), so it can be used as a health fund planning considerations related to the effectiveness and efficiency of medication costs for patients in Yogyakarta Regional Public Hospital. The method used is observational prevalence. The data were obtained retrospectively with patients primary diagnosed and secondary diagnosed of diabetes mellitus with or without complications in the period January to June 2014 in Yogyakarta Regional Public Hospital. The Financial perspective used is the hospitals perspective as health care providers to take into account the direct medical costs by using a bottom-up approach. Data analysis was performed using Kruskal-Wallis and Mann-Whitney Whitney to determine differences in the direct medical costs of outpatient diabetic patients in terms of age, the number and type of diabetes complications, as well as to determine the direct medical cost differences hospitalized diabetic patients in terms of age, the number of complications, type of diabetes, duration of hospitalization and inpatient classes.The results of the research showed that the patients who entered the inclusion criteria as much as 1.689 episodes of visits, which consisted of 1.531 episodes of outpatients visits and 158 episodes of inpatients visits. The total cost of DM based on hospital perspective Rp1.203.799.389,00 IDR within six months. There is a significant difference in direct medical costs in outpatients in terms of the number of factors of complications (p=0.004) and a significant differences direct medical costs inpatients in terms of the number of factors of complications, length of stay and inpatient class in hospitalization (p=0.000).

Development of Drug Plan and Control App Using ABC, VEN, and Combined Methods for Inventory Control Tandah, Muhamad Rinaldhi; Ambianti, Nurul; Putri, Yenita Kartika; Diana, Khusnul
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.451

Drug Plan and Control (Drug PC) application is a web-based digital tool designed to support pharmaceutical management in healthcare facilities by assisting in the planning, monitoring, and control of drug inventories. This study aimed to enhance the Drug PC (Plan and Control) application by integrating a drug categorization feature to improve pharmaceutical inventory control. Efficient inventory management is critical in healthcare, as poor control can lead to shortages, overstocking, and financial inefficiencies. The application was developed using PHP as the programming language and MySQL as the database management system. Drug categorization was performed using the ABC method, the VEN method, and a combination of both (ABC-VEN matrix). To evaluate the application's performance, Blackbox testing was conducted to assess the functionality of the user interface. In addition, manual calculations using Microsoft Excel were performed to validate and compare the application results with drug inventory data from two hospitals. Ethical approval was obtained from the Health Research Ethics Committee of the Faculty of Medicine, Tadulako University. The results demonstrated successful integration and 100% functionality accuracy of the new features. Categorization outputs aligned fully with manual data. Hospital 1 followed a typical ABC distribution (70:20:10%), while Hospital 2 showed deviations. VEN classification revealed a significantly higher proportion of Vital (V) drugs in Hospital 1 compared to Hospital 2 (p < 0.05). Combined ABC-VEN results showed CE (C + Essential) as the most common group. High-cost drugs (Category I) represented the majority of investment in both hospitals. In conclusion, the study shows that integrating categorization methods into digital tools like Drug PC can enhance drug inventory control, improve procurement planning, and optimize healthcare resource allocation.

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