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Isolation of endophytic fungi from benalu batu (Begonia medicinalis) and their toxicity on Artemia Salina Syariful Anam; Armini Syamsidi; Musyahidah Musyahidah; Nurul Ambianti; Agustinus Widodo; Muhammad Sulaiman Zubair
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art3

Abstract Background: Endophytic fungi are microorganisms found in plant tissues that are mutually beneficial to the host plant. They are known as sources of bioactive metabolites which possess various biological activities such as antimicrobial, anticancer, antiviral, antifungal, and antioxidant. Benalu batu (Begonia medicinalis) has been used empirically as a medicinal plant and has shown anticancer activity in breast cancer cells (T47D cells) and cervical cancer cells (HeLa cells).Objective: This study aimed to isolate the endophytic fungi from benalu batu and determine the toxicity activity and Lethal Concentration 50% (LC50) value of isolated endophytic fungi using shrimp larvae (Artemia salina). Method: Endophytic fungi were isolated from fresh parts; leaves, stems, roots of Benalu Batu. The selected parts were sterilized with ethanol 70% and sodium hypochlorite 1% subsequently placed into Potato Dextrose Agar Chloramphenicol (PDAC) then incubated at 28°C for 7 days. Isolated endophytic fungi were extracted by sonication method using ethyl acetate. The toxicity activity of isolated endophytic fungi was determined using the Brine Shrimp Lethality Test (BSLT).Results: Isolation of the endophytic fungi from benalu batu obtained 10 isolates, which the leaves part obtained 6 isolates, the stem obtained 3 isolates and the root obtained 1 isolate. The results of screening for toxicity test of 10 isolates at concentrations of 500 µg/mL shown that isolate D3, D5, and D6 gave 100% mortality. The LC50 values of isolate D3, D5, and D6 were obtained respectively in 448.03, 8.784, and 9.13 µg/mL.Conclusion: These results indicated that isolate D5 exhibits the greatest toxicity and needs to be investigated the activity for testing on cancer cells.Keywords: endophytic fungi, Begonia medicinalis, toxicity, Artemia salina Intisari Latar belakang: Jamur endofit merupakan mikroorganisme yang terdapat dalam jaringan tumbuhan yang bersifat mutualisme terhadap tumbuhan inang. Jamur endofit telah diketahui sebagai sumber metabolit yang memiliki beberapa aktivitas biologi seperti antimikroba, antikanker, antivirus, antijamur, dan antioksidan. Tumbuhan benalu batu (B. medicinalis) telah digunakan secara empiris dan terbukti memiliki aktivitas antikanker pada sel kanker payudara (Sel T47D) dan sel kanker leher rahim (Sel HeLa). Tujuan: Studi ini bertujuan untuk melakukan isolasi jamur endofit dari benalu batu dan mengetahui toksisitas isolat jamur endofit serta menentukan nilai Lethal Concentration 50% (LC50) terhadap larva udang (Artemia salina)Metode: Jamur endofit diisolasi dari bagian segar; daun, batang, akar benalu batu. Bagian-bagian tersebut disterilisasi dengan etanol 70% dan natrium hipoklorit 1% selanjutnya diletakkan pada media Potato Dextrose Agar Chloramphenicol (PDAC) kemudian diinkubasi pada suhu 28°C selama 7 hari. Isolat jamur endofit diekstraksi dengan metode sonikasi menggunakan etil asetat. Aktivitas toksisitas isolat jamur endofit ditentukan menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil: Isolasi jamur endofit dari benalu batu diperoleh 10 isolat, bagian daun diperoleh 6 isolat, bagian batang diperoleh 3 isolat dan bagian akar diperoleh 1 isolat. Hasil penapisan uji toksisitas 10 isolat pada konsentrasi 500 µg/mL menunjukkan bahwa isolat D3, D5, dan D6 memberikan persentase mortalitas sebesar 100%. Nilai LC50 isolat D3, D5, dan D6 diperoleh masing-masing sebesar 448,03, 8,784, dan 9,13 µg/mL.Kesimpulan: Hasil ini menunjukkan isolat D5 memiliki toksisitas paling besar dan perlu dilanjutkan untuk pengujian pada sel kanker.Kata kunci : jamur endofit, Begonia medicinalis, toksisitas, Artemia salina

ANALISIS BIAYA PENGOBATAN PENYAKIT GINJAL KRONIK RAWAT INAP DENGAN HEMODIALISIS DI RUMAH SAKIT UMUM DAERAH UNDATA PALU Muhamad Rinaldhi Tandah; Ihwan Ihwan; Khusnul Diana; Zulfiah Zulfiah; Nurul Ambianti
Jurnal LINK Vol 15, No 2 (2019): NOVEMBER 2019
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Poltekkes Kemenkes Semarang

Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan global. Pembiayaan penyakit ginjal merupakan peringkat kedua terbesar dari BPJS kesehatan setelah penyakit jantung. Indonesia memasuki era Jaminan Kesehatan Nasional (JKN) sejak 01 Januari 2014. Pola pembayaran JKN adalah dengan sistem Indonesia Case Base Group (INA-CBGs). Penelitian ini bertujuan untuk mengetahui rata-rata biaya pengobatan, komponen biaya yang paling besar, serta selisih antara biaya pengobatan pasien PGK dengan JKN rawat inap terapi hemodialisis dengan standar tarif INA-CBGs. Penelitian ini merupakan penelitian deskriptif dengan pengumpulan data sekunder berupa biaya medik langsung dari perspektif rumah sakit pada pasien PGK rawat inap dengan JKN terapi hemodialisis di RSUD Undata Palu periode Januari - Desember 2017. Hasil penelitian menunjukan rata-rata biaya medik langsung pasien PGK rawat inap dengan hemodialisis sebesar Rp 11.074.834. Komponen biaya terbesar adalah biaya hemodialisis sebesar Rp 155.122.000 (37,86%) dari total pembayaran, dan selisih antara biaya medik langsung pasien PGK JKN rawat inap hemodialisis dengan standar tarif INA-CBGs sebesar Rp 191.920.841 (46,84 %) dari total biaya rumah sakit.

ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO Nurul Ambianti; Muhamad Rinaldhi Tandah; Khusnul Diana; Ratu Balqis
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5135

Abstract The defective and expired drugs are one of the problems that can reflect the inaccuracy and poor of drug management in a Hospital Pharmacy Unit (HPU). This research was conducted to determine the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs at the Regional General Hospital (RGH) Tora Belo. This type of researched is a non-experimental study with cross sectional data collection. The data used are primary data obtained from the results of questionnaires that have been filled out by pharmacist at Tora Belo Hospital. The analysis used in this study is correlation analysis using the Spearman-Rho test, to determine the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs. The number of samples is 33 people taken by total sampling. Time to collect research data during May-October 2020. From the results of the study, it is known that the level of knowledge of the respondents is dominated by the sufficient category, namely 17 respondents (71.1%), it is known that the attitude of the respondents was included in the very strong category of 18 respondents (85.78%), and the results of the correlation analysis the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs obtained a significance value of 0.021. So it can be concluded there is a relation between the level of knowledge and attitude of pharmaceutical workers in preventing defective and expired drugs at Tora Belo Hospital.

PATTERNS OF MEDICINE USE FOR COVID-19 PATIENTS AT UNDATA HOSPITAL PALU Amelia Rumi; Nurul Ambianti; Desti Sulistiani Arbi
Indonesian Journal of Health Administration Vol. 10 No. 1 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jaki.v10i1.2022.99-110

Background: Covid-19 cases had drastically increased. Little therapy has been formulated to respond to the situation. Covid-19 symptoms in Indonesia are divided into four classes: asymptomatic, mild, moderate, and severe. Aims: This study aims to illustrate the pattern of drug use in Covid-19 patients at Undata Palu Hospital. Methods: This study is a type of cross-sectional descriptive study using a cross-sectional design and collecting data retrospectively from medical records at Undata Hospital Palu in 2020. Results: In 2020, 186 patients were confirmed positive for Covid-19. There were 95 female patients (51.9%) and 50 patients at the age of 46-55 years (27.3%). The severe symptoms happened to 109 patients (59.6%). The most common clinical manifestation was cough in 127 patients (23.3%). The most common comorbidity was pneumonia (30.8%). The most widely used primary therapy was the antibiotic azithromycin applied to 155 patients (30.0%), and the most widely used supportive therapy was vitamin C among 141 patients (20.1%). Oseltamivir antiviral therapy was administered to 132 patients (25.6%) and remdesivir to 34 patients (6.6%). Conclusion: Covid-19 patients were mostly treated with antibiotic therapy (41.5%), antiviral therapy (32.2%), antimalarial therapy (15.7%), and corticosteroid therapy (10.7%). As many as 132 patients took oseltamivir, and 34 patients took remdesivir. However, for now, oseltamivir is no longer used.

GAMBARAN PEMBUANGAN OBAT YANG TIDAK DIGUNAKAN DI KALANGAN MASYARAKAT KOTA PALU Nurul Ambianti; Ririen Hardani; Muhamad Rinaldhi Tandah; Handoko Putro
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 6 No. 1 (2022): April 2022
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v6i1.3700

Disposal of drugs that are not used in the community has a very negative impact on the environment. Many drugs are not used and become a big problem, some of which can cause contamination to the environment and disrupt the ecosystem. This study aimed to describe the description of the procurement, use, storage, disposal of drugs as well as public attitudes and information about drugs that are not used, namely damaged and expired among the people of Palu City. This study was a cross-sectional with a population of 84,374 households and a sample of 100 households in Palu City from February to April 2021. This study conducted using the convenience sampling. The independent variable in this study was drug disposal and the dependent variable was drugs that were not used. The data obtained from the questionnaire then analyzed descriptively. The result obtained that many of people bought drugs at pharmacies (78%) with reasons of wanting to buy of their own volition (38%), storing drugs in medicine boxes (56%), throwing drugs in public trash (78%) and respondents think that the improper disposal of unused and expired drugs can have an impact on the environment (70%) because many respondents have never received education related to drug disposal (65%). The majority of people throw away unused or expired drugs that they get from pharmacies in public trash and because of the lack of information regarding the disposal of drugs they get which can have a bad impact on the surrounding environment. Â KeywordsÂ Â Â Â Â Â Â Â : expired drug, drug disposal, unused drug

Analisis Faktor yang Mempengaruhi Kepatuhan Pengobatan Antiretroviral pada Pasien HIV/AIDS Ririen Hardani; Amelia Rumi; Afriani Kusumawati; Adelisa Putri; Nurul Ambianti
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.14610

Terwujudnya terapi pengobatan yang efektif tergantung dari kepatuhan seseorang meminum obat. Tujuan penelitian ini adalah untuk menetapkan pengaruh faktor pengetahuan, pemberian konseling dan ketersediaan sarana dan fasilitas kesehatan terhadap kepatuhan pengobatan antiretroviral pada pasien HIV/AIDS. Metode pada penelitian ini menggunakan penelitian analitik yang dikerjakan secara cross-sectional dengan menggunakan kuisioner faktor yang mempengaruhi kepatuhan dan kuisioner kepatuhan MARS (Medication Adherence Rating Scale) pada pasien HIV/AIDS yang mengonsumsi obat antiretroviral dengan analisis data menggunakan uji Chi-square dengan nilai signifikan p<0,05. Dari hasil penelitian jumlah sampel yang diperoleh sebanyak 92 pasien, 20 pasien memiliki kepatuhan rendah, 15 pasien memiliki kepatuhan sedang dan 57 pasien memiliki kepatuhan tinggi. Hasil penelitian menunjukkan bahwa pada faktor yang mempengaruhi kepatuhan yaitu pengetahuan dengan nilai signifikan (p=0,001), pemberian konseling dengan nilai signifikan (p=0,000) dan ketersediaan sarana dan fasilitas kesehatan dengan nilai signifikan (p=0,002) memiliki hubungan yang signifikan terhadap kepatuhan. Sehingga dapat disimpulkan bahwa faktor pengetahuan, pemberian konseling dan ketersediaan sarana dan fasilitas kesehatan memiliki pengaruh terhadap kepatuhan pengobatan pasien HIV/AIDS. Kata Kunci: HIV/AIDS, Antiretroviral, Kepatuhan, MARS, Pengobatan The realization of effective treatment theraphy depends on a person’s adherence to taking medication. The purpose of this study was to determine the effect of knowledge, counseling and availability of health facilities and facilities on antiretroviral treatment adherence in HIV/AIDS patients. The method in this study used an analytic study that was carried out in a cross-sectional manner using a questionnaire on factors that affect adherence and the MARS (Medication Adherence Rating Scale) adherence questionnaire in HIV/AIDS patients taking antiretroviral drugs with data analysis using the Chi-squere test with a significant value. p<0.05. From the results of the study with a total sample of 92 patients, 20 patients had low adherence, 15 patients had moderate adherence and 57 patients had high adherence. The results showed that the factors that influenced adherence, namely knowledge with a significant value (p=0.001), counseling with a significant value (p=0.000) and the availability of health facilities and facilities with a significant value (p=0.002) had a significant relationship. to compliance. So it can be concluded that the factors of knowledge, counseling and availability of health facilities and facilities have an influence on adherence to treatment of HIV/AIDS patients.

Analisis Efektivitas Biaya Penggunaan Antibiotik Levofloksasin dan Azitromisin pada Pasien Penderita Corona Virus Disease-19 pada Tahun 2021 di RSUD Madani Palu: Cost-Effectiveness Analysis of Levofloxacin and Azithromycin Antibiotics Usage in Patients with Corona Virus Disease-19 in 2021 at Madani Hospital in Palu Muhamad Rinaldhi Tandah; Ririen Hardani; Nurhafifah Wulandari Kassa; Nurul Ambianti
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 6 No. 7: JULY 2023 -Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v6i7.3262

Latar belakang: Corona Virus Disease 2019 (Covid-19) merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 yang dapat menyebabkan gejala gangguan pernapasan akut seperti demam, batuk dan sesak napas. Dalam penatalaksanaannya, Covid-19 membutuhkan biaya yang besar. Tujuan: Penelitian ini bertujuan untuk mengetahui antibiotik manakah yang paling cost-effective antara azitromisin dan levofloksasin dalam pengobatan Corona Virus Disease-2019 periode 2021 di RSUD Madani Palu. Metode: Desain penelitian ini adalah observasional cross-sectional dengan pengambilan data pasien secara retrospektif (Januari-Desember 2021). Metode penelitian pada penelitian ini adalah purposive sampling. Analisis efektivitas biaya dilakukan dengan menghitung Average Cost Effectiveness Ratio (ACER) dan Incremental Cost Effectiveness Ratio (ICER). Hasil: Jenis kelamin laki-laki sebesar 51% dengan usia 26-45 tahun dibandingkan perempuan sebesar 49%, dan lama rawat inap terbanyak 14 hari. Biaya medis langsung pasien pengguna azitromisin lebih rendah sebesar Rp1.659.698,66 dibandingkan pasien pengguna levofloksasin sebesar Rp1.711.361,17. Nilai ACER antibiotik azitromisin sebesar Rp92.205 dan nilai ACER antibiotik levofloksasin sebesar Rp136.939. Kesimpulan: Dapat disimpulkan bahwa kelompok terapi antibiotik azitromisin lebih cost-effective dibandingkan dengan kelompok terapi antibiotik levofloksasin.

EDUKASI OBAT RUSAK DAN KEDALUARSA PADA MASYARAKAT DESA TOSALE, KECAMATAN BANAWA SELATAN, KABUPATEN DONGGALA khusnul diana; Muhamad Rinaldhi Tandah; Nurul Ambianti; Setiawati Fadhilah Zainal
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 1 No. 1 (2022): Oktober 2022
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2022.v1.i1.16099

Using damaged and expired drugs in the community can be a problem for health. Using medicines that have been damaged or drugs that have expired can be fatal, ranging from poisoning, and disability, to causing death. Many factors can cause damaged and expired drugs, both occurring in health facilities (such as pharmacies, hospitals, health centers, and distributors) or the storage of drug users in this case in the community. People as users of medicinal products sometimes do not know how the physical characteristics and signs of drugs are damaged and medicines that have expired. This community service activity was carried out in the Tosale Village area of Donggala to assist the local community in knowing and recognizing drugs that were damaged or expired. This activity is carried out using lecture and discussion methods around recognizing the characteristics and signs of damaged and expired drugs, how to prevent the occurrence of damaged and expired drugs and how to store medicines to avoid damage. Evaluation of activities by giving short questions to participants about the material that has been given to identifying damaged and expired drugs. Active participants who answered correctly were given the appreciation in the form of mementos from the service team. This activity was completed by the target number of participants and the time given by the Tosale Village Head.

EDUKASI PENGELOLAAN OBAT RUSAK DAN KEDALUWARSA MENGGUNAKAN MEDIA LEAFLET DI DESA UENUNI, KECAMATAN PALOLO, KABUPATEN SIGI: Education on Management of Damaged and Expired Medicines Using Leaflet Media Khusnul Diana; Nurul Ambianti; Muhamad Rinaldhi Tandah; Setiawati Fadhilah Zainal
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 2 No. 1 (2023): Oktober 2023
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2023.v2.i1.16660

Masyarakat memperoleh obat dari apotek atau fasilitas kesehatan akan menyimpan obat-obatannya di rumah untuk berbagai keperluan termasuk penggunaan darurat dan penyakit akut atau kronis. Kebanyakan obat-obatan yang di simpan di rumah akhirnya tidak digunakan dan menjadi kedaluwarsa. Kurangnya pengetahuan dan informasi terkait cara mengelola obat rusak dan obat kedaluwarsa mengakibatkan masyarakat melakukan praktik pembuangan obat yang tidak digunakan langsung ke tempat sampah umum. Hal ini akan menyebabkan permasalahan yang cukup besar dilingkungan masyarakat. Kegiatan pengabdian kepada masyarakat dilakukan di Desa Unenui Kecamatan Palolo Kabupaten Sigi. Secara tipologi dan geologi desa ini terletak di pegunungan, sehingga akses sarana fasilitas kesehatan dan tenaga kesehatan masih terbatas. Pengabdian ini bertujuan untuk membantu masyarakat dalam memahami dan meningkatkan pengetahuan terkait pengelolaan obat rusak dan kedaluwarsa. Kegiatan ini dilakukan dengan metode edukasi melalui upaya pemberian informasi dan pembagian leaflet tentang definisi obat rusak dan kedaluwarsa, penyebab dan ciri-ciri obat rusak, cara pengecekkan obat kedaluwarsa, serta cara memusnahkan obat rusak dan kedaluwarsa. Evaluasi kegiatan dengan memberikan pertanyaan singkat kepada peserta tentang isi materi pada leaflet. Kegiatan ini selesai dilaksanakan sesuai dengan target jumlah peserta dan waktu yang diberikan oleh Kepala Desa Uenuni.

ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO Ambianti, Nurul; Tandah, Muhamad Rinaldhi; Diana, Khusnul; Balqis, Ratu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5135

Abstract The defective and expired drugs are one of the problems that can reflect the inaccuracy and poor of drug management in a Hospital Pharmacy Unit (HPU). This research was conducted to determine the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs at the Regional General Hospital (RGH) Tora Belo. This type of researched is a non-experimental study with cross sectional data collection. The data used are primary data obtained from the results of questionnaires that have been filled out by pharmacist at Tora Belo Hospital. The analysis used in this study is correlation analysis using the Spearman-Rho test, to determine the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs. The number of samples is 33 people taken by total sampling. Time to collect research data during May-October 2020. From the results of the study, it is known that the level of knowledge of the respondents is dominated by the sufficient category, namely 17 respondents (71.1%), it is known that the attitude of the respondents was included in the very strong category of 18 respondents (85.78%), and the results of the correlation analysis the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs obtained a significance value of 0.021. So it can be concluded there is a relation between the level of knowledge and attitude of pharmaceutical workers in preventing defective and expired drugs at Tora Belo Hospital.

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