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INDONESIA
Jurnal Kesehatan Andalas
Published by Universitas Andalas
ISSN : 23017406     EISSN : 26151138     DOI : -
Core Subject : Health,
Health Professions
Jurnal Kesehatan Andalas merupakan Jurnal yang diterbitkan oleh Fakultas Kedokteran Universitas Andalas.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol. 12 No. 2 (2023): Online July 2023" : 7 Documents clear
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Putri, Nabila Priscilla; Ali, Hirowati; Tofrizal, Tofrizal; Darwin, Eryati; Susanti, Restu; Hasmiwati, Hasmiwati
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Hubungan Aktivitas Fisik dengan Ketahanan Kardiorespirasi pada Mahasiswa Program Studi Kedokteran Universitas Mulawarman Qhuzairi, Muhammad Rezwan; Magdaleni, Agustina Rahayu; Sulistiawati, Sulistiawati; Sawitri, Endang; Putra, Indra Sukmana
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2169

Abstract

Cardiorespiratory endurance is the ability of the body's circulatory and respiratory system to meet the oxygen needs of the muscles as a source of energy production during sustained physical activity. One of the factors that influenced the level of cardiorespiratory endurance of a person was physical activity. Objective: To determined the relationship between physical activity and cardiorespiratory endurance. Methods: It was an analytic observational with a cross-sectional study. Data were taken from primary data that were measured directly on 97 students of the Medical Study Program at Mulawarman University who were selected using a purposive sampling technique. The data collected included physical activity using the Global Physical Activity Questionnaire (GPAQ) and cardiorespiratory endurance using Queen's College Step Test. The statistical analysis used was Spearman's correlation test with a significance value of p <0.05. Results: The statistical test showed that the relationship between physical activity and cardiorespiratory endurance was p = 0.003 and r = 0.295. Conclusion: There was a significant positive relationship between physical activity and cardiorespiratory endurance, and the relationship's strength was weak.Keywords:  cardiorespiratory endurance, global physical activity questionnaire, physical activity, queen’s college step test
Can Purple Sweet Potato Water Extract (Ipomoea batatas L.) Induce Steatosis at Toxic Doses in Rat? Hikmatussalam, Gemila; Kharisma, Yuktiana; Romadhona, Nurul
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2172

Abstract

Purple sweet potato (Ipomoea batatas L.) has a secondary metabolite that contains a lot of antioxidants. Some of the secondary metabolites in purple sweet potato have a hepatotoxic effect. Objective: To described the toxic effects of purple sweet potato water extract on steatosis in rats. Methods: This descriptive study was conducted on 29‒30 June 2019 in the Biomedical Laboratory of the Faculty of Medicine, Islamic Bandung University, with an in-vivo experimental design with random allocation techniques and using the proposed new method on 11 rats. One of the control rats was not given extract, and ten other rats were given a dose of purple sweet potato water extract 50, 200, 400, 800, 1000, 1500, 2000, 3000, 4000, and 5000 mg/KgBW/PO. The liver organ was harvested after 24 hours, and then slides were made at the Pathology Anatomy Laboratory of Padjajaran University. Results: The histopathological view did not find any steatosis either in macrovesicular or microvesicular, but other features were found in ballooning degeneration, sinusoidal dilation, and inflammation. Conclusion: Steatosis was not found because purple sweet potato contains anthocyanins and tannins.Keywords: purple sweet potato, steatosis, tannin
Hubungan Usia dan Kadar Prostate Specific Antigen (PSA) dengan Derajat Histopatologi Adenokarsinoma Prostat di RSUD Abdoel Wahab Sjahranie Samarinda Pratiwi, Novita Eka Tyas; Riastiti, Yudanti; Irawiraman, Hadi; Danial, Danial
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2176

Abstract

Adenocarcinoma prostate generally occurs in older adults and maybe because of increase in prostate-specific antigen (PSA) levels.  It is essential to know the relationship between age and PSA levels with histopathological grade to determine the appropriate management in cases of prostate adenocarcinoma. Objective: To determined  the relationship between age and  PSA levels with the histopathological grade of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie General Hospital, Samarinda. Methods: The research design was analytic observational with a cross-sectional study approach. The data was taken from the medical records of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie Hospital Samarinda from 2018 until 2022 using the total sampling method. 52 patients met the inclusion criteria. Bivariate analysis using the Chi-square test. Results:This study showed that there was no relationship between age (p=0.433) and PSA levels (p=0.347) with the histopathological grade of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie General Hospital, Samarinda. Conclusion: There was no significant relationship between age and PSA levels with the histopathological grade of prostate adenocarcinoma at Abdoel Wahab Sjahranie Hospital, Samarinda.Keywords: adenocarcinoma prostate, age,  histopathological degree, PSA levels
Pengaruh Walking Morning Exercise Terhadap Peningkatan Kualitas Tidur pada Lansia Oktaviatama, Anisah; Mirawati, Dita; Setiawan, Cahyo
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2233

Abstract

Physiological and psychological problems can arise from sleep disorders. The majority of older people experience a decrease in sleep quality with age, so it is necessary to do morning physical activity such as walking to improve sleep quality. Objective: To determine whether walking in the morning exercise can improve older people's sleep quality. Methods: It was a quantitative research with a quasi-experimental type using a one-group pre and post-test design. The sample consisted of 28 respondents selected by purposive sampling. Measurement of sleep quality using the Pittsburgh Sleep Quality Index (PSQI) questionnaire to evaluate a person's sleep quality. The walking morning exercise intervention was carried out thrice a week for up to 4 weeks. Results: Wilcoxon test for bivariate analysis showed a significance level of 0.008 (p < 0.05). Conclusion: Walking in the morning exercise improves sleep quality in older people.Keywords:  older people, sleep quality, walking morning exercise
Mitral Stenosis Berat pada Penyakit Jantung Rematik Suwari, Cokorda Istri Padmi; Gede, Widyawati Desak
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2245

Abstract

Rheumatic Heart Disease (RHD) has high morbidity and mortality. Cardiac valve disorders after rheumatic fever are the leading cause of heart failure in children and young adults. A comprehensive understanding of RHD can help early diagnosis and provide optimal management in the future. It has been reported that a 55-year-old man came to the heart clinic of Bhayangkara Hospital Denpasar for routine control of heart disease. The patient has been diagnosed with rheumatic heart disease since 2018. The patient complains of shortness of breath when walking long distances and doing strenuous activities. The patient was diagnosed with CHF FC II ec RHD + MS moderate-severe (Wilkins score 8) + AF NVR (CHA2DS2VASc 3) and treated with heart failure and antiplatelet medication. Mitral stenosis due to RHD produces the typical pathological features seen in Transthoracic echocardiography (TTE), including fibrous thickening and calcification of the valve leaflets, fusion of the commissures, and thickening and shortening of chordae tendineae. Chronic stress overload on the LA due to MS can cause LA dilatation and trigger AF. RHD patients with AF are recommended for anticoagulation for stroke prevention. Patients with acute rheumatic fever clinical features should be evaluated further and given long-term therapy to prevent more severe heart problems.Keywords:  atrial fibrillation, mitral stenosis, rheumatic  heart  disease
Karakteristik Analisis LCS Meningoensefalitis Anak di RSUD Abdoel Wahab Sjahranie Samarinda Tahun 2019-2022 Yunita, Yunita; Riastiti, Yudanti; Muhyi, Annisa
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2287

Abstract

Meningoencephalitis is a pathological state characterized by concurrent inflammation of the meninges and the brain parenchyma. Liquor Cerebrospinal analysis (LCS) can help establish a diagnosis of diseases affecting the central nervous system, including meningoencephalitis. Objective: To identified the attributes of meningoencephalitis LCS analysis in pediatric patients at RSUD Abdoel Wahab Sjahranie Samarinda from 2019 until 2022. Methods: This study employs a descriptive research design to delineate the features of the LCS analysis. The data utilized in this study was acquired from the medical records of individuals who had experienced meningoencephalitis during their childhood and obtained as many as 39 patient data samples. Results: The findings revealed that most cases were observed in children aged 0-1 years (38.5%), with a higher incidence in males (59.0%). The LCS analysis parameters indicated that lymphocytic pleocytosis was the most common (76.9%), while clear  LCS was observed in 82.1%. The leukocyte count was within the normal range of 56.4%, and the polymorphonuclear ratio was negative (79.5%). The protein levels increased by 56.4%, while the glucose levels were within the normal range (59.0%). Conclusion: There is an increase in LCS  protein levels, which indicates inflammation.Keywords: LCS  analysis, LCS parameters, meningoencephalitis

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