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The Journal of Pure and Applied Chemistry Research

jpacr
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Published by Universitas Brawijaya

ISSN : 23024690 EISSN : 25410733 DOI : http://dx.doi.org/10.21776/ub.jpacr

Core Subject : Health, Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 306 Documents

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Liquid Chromatography for Analysis of Metformin in Myrmeleon sp. Afidatul Muadifah; Hermin Sulistyarti; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Myrmeleon sp is a typical of insect larva which has been used in Indonesia for diabetes treatment. However, there is no sufficient scientific report explaining the bioactive compounds in this insect. Based on our preliminary research, this insect contained metformin, i.e. one of bioactive compounds for the treatment of type-2 diabetes. Therefore, this study is focused on the development of separation technique using high performance liquid chromatography (HPLC) on a reverse phase C-18 column with UV detection to identify and quantify metformin in methanol extract of Myrmeleon sp. Several parameters of HPLC method were optimized with respect to high resolution of separation and accurate determination of metformin. Satisfied separation was obtained under gradient elution mode using aqueous methanol mobile phase varied from 50-90 % of methanol with flow rate of 0.5 mL/min and detection wavelength of 233 nm. The method performed total separation for all compounds in less than 11 minutes. Spiking technique was chosen for metformin identification and quantitation. Metformin in extract Myrmeleon sp was eluted at retention time (tR) of 4.095 minutes, similarly with retention time of standard metformin of 4.092 minutes. The quantity of metformin in Myrmeleon sp can be simply determined by comparing the additional area of standard metformin with area of metformin from extract Myrmeleon sp. The results confirmed that methanol extract of Myrmeleon sp contained anti-diabetes compound of metformin of 0.58 mg/g Myrmeleon sp larvae with acceptable coefficient variation of 5.56 %.

Green Tea Extract (Camellia sinensis L.) Effects on Uric Acid Levels on Hyperuricemia Rats (Rattus norvegicus) Putranty Widha Nugraheni; Fitria Rahmawati; Chanif Mahdi; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Uric acid is the end product of purine degradation. When uric acid levels exceed normal limits, it will build up and cause hyperuricemia. Allopurinol is one of the most effective and common medicine for hyperuricemia, but it brings serious side effects, therefore it is needed alternative therapy for hyperuricemia. One plant that may be expected to low uric acid levels is green tea (Camellia sinensis L.), that contains many antioxidants polyphenols, especially flavonoids. Flavonoid has strong antioxidant properties, act as free radical and metal scavengers, and also xanthine oxidase (XOD) inhibitors. This study investigates the potential of green tea using various doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg of body weight in 24 white male rats (Rattus norvegicus) Wistar strain that has been received high purine diet in 60 consecutive days. This study used DHBSA methods to measure uric acid levels in blood serum and urine that excreted 8 hours before surgery. Green tea extract that contains polyphenol can inhibit XOD activities, therefore, it leads to decrease uric acid level in blood and increase the excretion through urine by modulating urate gene transporter. A therapy with 600 mg/kg body weight of GTE is the most effective dose to decrease uric acid levels in serum and to increase excretion of exceeding uric acid significantly (p < 0.01), from One Way ANOVA and Tukey analysis.

Optimization Of Elevating Blood Uric Acid Levels With High Purine Diet Fitria Rahmawati; Putranty Widha Nugraheni; Chanif Mahdi; Arie Srihardyastutie; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

Exploration of the use of medicinal plants to lower uric acid levels has been widely practiced. Stages of new drug development research is a preclinical test using experimental animals, therefore the manufacture of an animal model of hyperuricemia is necessary. This study aims to determine the optimal induction of uric acid to increase blood uric acid levels by administering high purine foods such as cow’s liver, cow’s spleen, Gnetum gnemon, emping and fried peanuts. Eighty male white rats were used individuals to be divided into 4 groups, they were: (I) cow’s liver, (II) cow’s liver and cow’s spleen, (III) cow’s liver, cow’s spleen and boiled gnetum gnemon beans, and (IV) cow’s liver, cow’s spleen, emping and fried peanuts. This study using easy touch GCU to measure blood uric acid level. The result of statistical analysis of uric acid level means with 5 times repetition using One Way ANOVA showed that there was a very significant difference between treatments (p <0,01). The results concluded that high purine diet in group I, II and III had not been able to increase uric acid levels significantly. High purine diet group IV was able to increase blood uric acid levels significantly to make the rats experiencing hyperuricemia with the level of 6.54 mg/dL on day 7 and 13.79 mg/dL on day 14.

Effect of Tin Electrode (Sn), Electrode Distance and Thin Layer Size of Zinc Phthalocyanine (ZnPc) to Resistance Changes With Ozone Exposure Agustina Mogi; Masruroh Masruroh; Rachmat Triandi Tjahjanto
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

This study was aimed to determine the effect of tin electrode distances and the thickness of a thin layer of ZnPc (Zinc phtyalocyanine) toward changes in resistance with ozone exposure. Tin deposition on the glass surface was conducted using spraying method. The reaction between ozone and ZnPc produces electrical properties that can be read through the resistance value of the multimeter. Based on this study, it was investigated that the smaller a distance between the electrode and the thicker deposition of ZnPc lead to the less resistance. This showed that a thin layer of the conductivity increases along with the longer exposure to ozone gas. The movement of electrons with the hole was free.

Metabolite Profiling of Tabat Barito (Ficus deltoidea) Using UPLC-QTOF-MS/MS Nurmaida Nurmaida; Latifah K Darusman; Mohamad Rafi; Rudi Heryanto
The Journal of Pure and Applied Chemistry Research Vol 7, No 2 (2018): Edition May-August 2018
Publisher : Chemistry Department, The University of Brawijaya

Tabat Barito (Ficus deltoidea) is known as a plant that has potency as an antioxidant because of containing a significant phenolic compound. In this study, we performed metabolite profiling on F. deltoidea leaves by UPLC-QTOF-MS/MS to identify its phenolic compounds. Extraction by maceration and ultrasonication techniques with methanol (MM and UM) and ethanol (ME and UE) were used to extract the F. deltoidea metabolites. About 70 metabolites were identified by using UPLC-QTOF-MS/MS in negative ion mode. The amounts of metabolites found in each extract were different, i.e., 45 metabolites in MM, 64 metabolites in UM, 42 metabolites in UE and 41 metabolites in ME. MS/MS could further tentatively identify 16 metabolites. The identified compounds belonged to the class of flavonoids and phenolic acid. Also, we conducted an antioxidant activity by using DPPH method on each extract to determine its potency as an antioxidant. The highest antioxidant activity was exhibited by UM extract (IC50 71.93 ppm) may be due to the number of metabolites in UM extract which was higher than the other extract based on the detected metabolites.

Preparation and Characterization of Highly Water Soluble Curcumin – Dextrose Cocrystal Katherine Kho; Denny Nugroho; Asaf Kleopas Sugih
The Journal of Pure and Applied Chemistry Research Vol 7, No 2 (2018): Edition May-August 2018
Publisher : Chemistry Department, The University of Brawijaya

Curcumin is a natural food colorant isolated from rhizomes of turmeric (Curcuma longa). Despite its many favorable properties, curcumin is practically insoluble in water and relatively unstable, thus limiting its application. In this research, a potential method to improve curcumin solubility and stability, i.e. cocrystallisation of curcumin with dextrose was investigated.. The effect of curcumin content in the cocrystals on solubility and yield of the product was studied. The morphology of the cocrystals was observed using SEM. In addition, stability in different pH range was investigated. Crystal structure and curcumin – dextrose interaction were analyzed using FT-IR spectra and DSC thermograms. The result shows that curcumin – dextrose cocrystal is a potential food colorant that could be applied to water – based food at various pH range.

Application of Modified Clay Catalysts in Oligomerization of Light Olefins Raila Toktassyn; B.T. Utelbayev
The Journal of Pure and Applied Chemistry Research Vol 7, No 2 (2018): Edition May-August 2018
Publisher : Chemistry Department, The University of Brawijaya

The oligomerization of light olefins to high-octane clean engine fuels is one possible way to solve increased requirements for motor fuels. This paper presents a study of catalytic oligomerization of C2-C4 olefins on Ru-Fe supported pillared clay catalyst with different metallic quantity. The prepared catalysts were characterized by X-ray diffraction, N2 adsorption-desorption at 77K, BET and BJH methods. The BET and BJH methods showed the pillared clay had significantly increased surface area and when an appropriate amount of Ru and Fe were added, the bimetallic alloys were uniformly dispersed on the modified clay surfaces and had an average mesopore size of 4.1 nm. It is indicated that excess metal oxides blocked the surface of bimetallic RuFe/MMC system, resulted in decreased catalytic activity. The low metal content catalysts showed higher oligomerization activity and increasing the Fe content gave selectivity to isomerization reactions.

Characteristic of Cellulose Isolated From Papyrus Fibers (Borrasus flabelifer L) And Its Citrate Ester Anna Apriani Maniuk Solo; Masruri MASRURI; Barlah Rumhayati
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

The chemical modification using esterification method to modification the papyrus fiber cellulose with citric acid was studied. Parameters investigated included the citrate acid concentration (between 0.3 to 0.6 M), and reaction temperature (from 110 to 140o C). The ester cellulose, which was a new product reaction between citric acid and cellulose, had Substitution Degree (SD) from 0.088 to 1.147 and yield from 73.75% to 97.73%. The esterification product was analyzed with FTIR spectrophotometer and Scanning Electron Microscopy (SEM) to identify the functional groups and the morphology of ester cellulose. Based on this research, modified cellulose have the peak of ester carbonyl functional group (C=O) at 1740.43 cm-1 and O-H alcohol functional group (O-H) at band 3406.82cm-1. Modification with citric acid 0.6 M at 120o C is the best condition to get the high DS value 1.147 in 97.73 yield as a brown powder.

Temperature Effect of Crystalinity in Cellulose Nanocrystal from Oil Palm Empty Fruit Bunch (OPEFB) using Sonication-Hydrothermal Methods Zulnazri Zulnazri; Fika Anjana; Achmad Roesyadi
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Production of cellulose nanocrystals (CNCs) from cellulose of oil palm empty fruit bunches (OPEFB) have been done. The delignification of OPEFB was mixed with 17,5% NaOH and carried out in the three-neck flask with refluxed for 2 hour at 80oC. Further the suspension was bleached with NaOCl 2% for 1 hour at 70oC. Then, to produce CNCs, Cellulose was firstly sonicated for 30 minutes at 40oC. After that cellulose was hydrolized at hydrothermal reactor for 0,1,2,3,4,5, hours at 110 and 120oC respectively. After filtration and washing, CNCs was analyzed by X-Ray Diffraction and the result shows that the grade of the highest CNCs crystalinity at consentration of HCL 2 M at a temperature of 110oC with reaction time of 2 hours is equal to 75.87%. It can be concluded that sonication-hydrothermal can increase the grade of crystalinity of cellulose nanocrystal.

Effect of Radioactivity of Technetium-99m on the Autosterilization Process of non-sterile Tetrofosmin Kits Widyastuti Widyastuti; Enny Lestari; Darma Sangaji
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Technetium-99m labeled radiopharmaceutical is commonly used in nuclear medicines as a diagnostic agent, by mixing the sterile kit with Tc-99m. Manufacturing of kits requires an aseptic facility which need to be well designed and maintained according to cGMP, since mostly kits can not be terminally sterilized. Radiopharmaceuticals as pharmaceuticals containing radionuclide is assumed to have an autosterilization property, but correlation between radioactivity and capability of killing microorganisms has to be studied so far. The aim of this study is to investigate the effect of radioactivity on the autosterilization process of radiopharmaceuticals. The study was carried out by adding Tc-99m of various radioactivity into non-sterile tetrofosmin kits, then the samples were tested for sterility. Sterile tetrofosmin kit and non-sterile kit with no Tc-99m added will be used as a negative control and positive control respectively. The sterility was tested using standard direct inoculation method, by inoculating samples in culture media for both bacteria and fungi and observing qualitatively within 14 days. The results showed that the samples with radioactivity of 1, 3 and 5 mCi changed the clarity of the media to turbid, conformed with the performance of positive controls but samples with radioactivity of 10 mCi and 20 mCi did not change the clarity of the media, conformed with the performance of negative control, indicating neither growth of bacteria nor fungi. It is concluded that Tc-99m behaves as an autosterilizing agent at certain radioactivity. Therefore the preparation of Tc-99m radiopharmaceutical can be considered as terminal sterilization rather than aseptic preparation.

Page 11 of 31 | Total Record : 306

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Masruri

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jpacr@ub.ac.id

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Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

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Kota malang,

Jawa timur

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Masruri

Contact Email masruri@ub.ac.id

Phone +62341-575838

Journal Mail Official jpacr@ub.ac.id

Editorial Address Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location Kota malang, Jawa timur INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Masruri

Contact Email
masruri@ub.ac.id

Phone
+62341-575838

Journal Mail Official
jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA