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The Journal of Pure and Applied Chemistry Research

jpacr
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Published by Universitas Brawijaya

ISSN : 23024690 EISSN : 25410733 DOI : http://dx.doi.org/10.21776/ub.jpacr

Core Subject : Health, Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 306 Documents

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A Flavonoid Glycoside Compound Isolated from Macaranga gigantifolia Merr Leaves Gian Primahana; Akhmad Darmawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Apigenin-8-C-glycoside (1), a flavonoid glycoside compound has been isolated from the leaves of Macaranga gigantifolia Merr. Isolation and purification conducted by chromatography methods and chemical structure characterization carried out by spectroscopic methods. Cytotoxicity of Apigenin-8-C-glycoside has been tested against Murine leukemia P-388 cell lines and has moderate activity with IC50 values 55.4 μg/mL.

Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell.

Absorption Activity of Cassava Peel (Manihot utilissima) as Chromium (VI) Metal Biosorbent in Electroplating Waste Iin Candrawati; Fahimah Martak; Yurike Ika Cahyo
The Journal of Pure and Applied Chemistry Research Vol 6, No 2 (2017): Edition of May-August 2017
Publisher : Chemistry Department, The University of Brawijaya

Electroplating is a process of metal veneering with another metal using the electric energy. The water waste of electroplating industry contains many kinds of heavy metal ions, especially chromium (VI) which might cause pollutions if it was not processed and it presents above the threshold allowed. The use of cellulose can be a solution, because it has the functional groups which form bonding with the metal ions. Cassava peel is one of the sources of cellulose which contains 80-85% of cellulose. This proves that cassava peel (Manihot utilissimaI) has the potential as the heavy metal biosorbent of chromium metal in electroplating waste. The methodology of the research is conducted in a series including analysis of heavy metal concentrations of chromium (VI) in electroplating waste. Biosorption treatment of cassava peel (Manihot utilissimaI) biosorbent activated by HNO3 1.5 M in electroplating waste conducted in the batch method. Analysis of heavy metal concentrations of chromium (VI) in electroplating waste was performed by Atomic Absorption Spectrophotometry (AAS) after biosorbtion process. Variation of biosorbent mass were (0.1, 0.2, 0.3, 0.4, 0.5) grams, and variation of biosorbent contact time were (10, 20, 30, 40, 50) minutes. The analysis result recorded by AAS (Atomic Absorption Spectrophotometry) showed that the level of total chromium in electroplating waste reaches 2.0777 ± 0.2785 ppm. Accordingly, the chromium test solution used in this research was 2 ppm to measure the optimum conditions of % chromium (VI) adsorbed with variation of mass and contact time. From the results of this research, the optimum mass and contact time of cassava peel biosorbent activated by HNO3 1.5 M in % chromium (VI) adsorbed were 0.1 gram and 40 minutes, respectively. Finally, the optimum mass and contact time of cassava peel biosorbent activated by HNO3 1.5 M has applied to electroplating waste. The % chromium adsorbed in electroplating waste with the addition of cassava peel biosorbent activated by HNO3 1.5 M was measured in average of 61.72%.

Profiling of The Lemongrass Oil Aroma and Their Structure-Odor Relationship: In Silico Study Udrika Lailatul Qodri; Edi Priyo Utomo; Elvina Dhiaul Iftitah
The Journal of Pure and Applied Chemistry Research Vol 6, No 2 (2017): Edition of May-August 2017
Publisher : Chemistry Department, The University of Brawijaya

Structure-odor relationship (SOR) has previously studied by semantic numerically in different Fragrance. We hypothesise that in silico method such as molecular dynamics, together with docking of the interaction between human olfactory receptor (OR1G1) and ligands, can offer extremely valuable tools of modelling SOR. Hence, the present study was carried out to express the SOR of citronellal oil fraction compare with reference smelling of floral, musk, green, wood, and fruit by employing docking and multiple discriminant analysis (MDA). Our study reveals that the number dissociation constant (Kd), bond distance, HOMO-LUMO (AE), dipole moment, kind of amino acids, Log P, surface area and hydropathy as the variable SOR from in silico anaysis. Our result has shown ligands and OR1G1 interacted with Van Der Waals and electrostatic model. MDA analysis shown molecule reference floral and fraction of lemongrass oil have similar correlation based on variable SOR with linier regression of all variable SOR to Kd value for every reference odor is R2 = 1.

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis Surya Hadi; Dina Asnawati; Baiq Mariana; Hijriati Sholehah; Andhina Rizkya Satriani; Seto Priyambodo
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

This article is a part of studies to investigate the potential of natural products from Lombok Island for antidiabetic agents. This study was directed to learn the metabolite variations of peanut hulls collected from three different locations in Lombok Island. The hull samples were extracted in methanol, followed by partition process into three fractions using three solvents with varied polarities (dichloromethane, hexane and acetone). The fractions were then separated and identified for their chemical composition by using GC-MS instrument. Metabolite variations of three extracts showed that the antidiabetic compounds stigmast-5-en-3-ol and oleic acid were found in all three locations with different percentages of abundance. Another antidiabetic compound, linoleic acid, was only identified in peanut hulls from the village of Pringga Jurang (PJ). Besides the antidiabetic compounds, there were other major compounds with known biological activities discussed to find other uses of the hulls.

Melastoma malabathricum Fruit Extract-Mediated Synthesis of Silver Nanoparticles with Sensing Ability for High Concentrations of Mercury (II) Nitrate SALPRIMA YUDHA S; Aswin Falahudin; Meka Saima Perdani; Irfan Gustian; Saiqa Ikram
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

A strategic approach was developed to synthesize silver nanoparticles from AgNO3 using Melastoma malabathricum seed extract. The reaction of silver ions with the organic compounds in the seed extract proceeded smoothly at room temperature without any additional capping agent. The appearance of an absorption peak around 427 nm provided evidence for the presence of silver nanoparticles in the reaction mixture. A diluted solution of the silver nanoparticles was treated with various concentrations of mercury (II) nitrate solutions and the resulting reaction was monitored using UV-Vis spectrophotometry

Chemical Composition of Oil Fraction Kaffir Lime (Citrus hystrix DC) as Antibacterial Activity of E.coli Rahmatika Ayu Habsari; Warsito Warsito; Noorhamdani Noorhamdani
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

The purpose of this research is to know the composition of fraction oil kaffir lime which is consist as antibacterial activity E.coli. This research uses kaffir lime oil from a branch for fractional distillation use PiloDist 104-VTU (number the stages 120), and reflux ratio 20/10 with 5 mbar pressure. Oil kaffir lime composition analysis use GC-MS (type Shimadzu QP 2010S) with a gas helium on speed 3mL/minute. Antibacterial activity assay use agar well diffusion assay which does in three concentration they are 500 µL/mL, 300 µL/mL, 100 µL/mL. The result of oil fraction kaffir lime has five fraction oil based on boiling point interval, they are A fraction oil (63,00 – 70,010 C), B fraction (71,30 – 70,800 C), C fraction (74,50 – 74,200 C), D fraction (74,20 – 74,000 C) and E fraction (72,90 – 91,100 C). The result of this research obtained five oil fraction they are monoterpene oxygenated (MO) except A oil fraction with monoterpene hydrocarbon composition (MH) 12,1%. The main component of a fraction which MO compound they are citronella, linalool and isopulegol, while in MH compound they are sabine, β-pinen, β-micren and limonene. The result of antibacterial activity assay obtained on highest concentration it is 500 µL/mL. Antibacterial activity assay also depends on fraction composition with higher composition of MO. The highest MO components of oil fraction on C oil fraction which has MO component such as citronella 74,94%; linalool 20,13%; and isopulegol 3,08%.

Biosorption of Lead(II) using Trichoderma viride in the Aqueous Solution Rensani Taloin; Anna Safitri; Sasangka Prasetyawan; Budi Kamulyan; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

Lead(II) is considered as the main cause of pollutant that is toxic, corrosive, and irritant. One method that can be applied for reducing Pb(II) in the environment is by using microorganisms. In this work, the study of biosorption of Pb(II) in the water samples was conducted using Trichoderma viride. The research is focused on determination of optimum conditions including pH, biosorption time, and initial concentration of Pb(II) used. The profiles in functional groups contained in the T. viride have been monitored using FT-IR spectrophotometry. Results showed that the maximum biosorption of Pb(II) achieved at pH 4.5, with equilibrium of contact time of 20 h, optimum concentration of 50 mg/L, and adsorption capacity of 85 mg/1x106 T. viride colonies. The FTIR results indicated that biosorption process changed the functional groups in the T. viride. These have shown in the absorption bands at ~3200 cm-1, ~2850 cm-1, ~2260 cm-1, ~1650 cm-1, ~1450 cm-1, 1180 cm-1, and in the finger printing regions. The biosorption mechanism was proposed through the adsorption process between positively charged metal ions and the negative charge on the functional groups, such as -COO-, -OPO32-, and –NH2-, on the cell surface.

Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat Muhammad Asadullah; Arie Srihardyastutie; Aulanni'am Aulanni'am
The Journal of Pure and Applied Chemistry Research Vol 7, No 2 (2018): Edition May-August 2018
Publisher : Chemistry Department, The University of Brawijaya

Diabetes mellitus type 1 (DMT1) is an insulin deficiency disorder caused by pancreatic damage characterized by chronic hyperglycemia. Animal modeling of DMT1 using inducting Multiple Low Dose Streptozotocin (MLD-STZ) elevat levels of free radicals and inflammation in pancreatic organs which then damage β cells. Ruellia tuberosa L. is a plant containing triterpenoids from the class of antioxidant and anti-inflammatory flavonoids. This study used three groups of rat: negative control group, positive control and 240 mg/kg bw therapy group. Study are based on changes MDA levels, blood glucose and histologic of pancreas. MDA level determining with TBA method, glucose levels using EasyTouch GCU and histopalogy of pancreas using Hematoxylin-Eosin staining. Statistical analysis of MDA and blood glucose (α = 0.05) showed significant decreases in MDA and blood glucose levels. Based on the results of histologic observations of pancreas descriptively showed a decreas in cell damage on Langerhans island. Thus, the provision of root extract of Ruellia tuberosa L. can inhibit the damage in rat DMT1 model so that it can be used as therapy of diabetes mellitus.

Hedyotis corymbosa L. and Sterculia quadrifida R.Br Ethanolic Extract Enhances Cisplatin’s Cytotoxicity on T47D Breast Cancer Cells Through Cell Cycle Modulation Rollando Rollando
The Journal of Pure and Applied Chemistry Research Vol 7, No 2 (2018): Edition May-August 2018
Publisher : Chemistry Department, The University of Brawijaya

Chemotherapeutic agent such as cisplatin used as cancer cure with side effects and resistance. Ursolic acid is a compound found in Hedyotis corymbosa L., (HCoL) while 8-hydroxydehydrodunnione is found in Sterculia quadrifida R.Br (SQuR) which are proven to have cytotoxic effect to cancer cells. This research aims to review the effect of cisplatin, ethanolic extract of HCoL and SQuR to sensitivity increase on breast cancer cells, which will be confirmed through apoptosis induction and cell cycle modulation. The cytotoxic effect was tested using MTT assay on T47D cell by using IC50 parameter. The combination was tested by determining their combination index (CI) and cell viability. The combination effect in apoptosis induction and cell cycle modulation were observed using flow cytometry method. The cytotoxic test result of the combination shows CI value of below 1 at the concentration of HCoL ethanolic extract as much as 0,21 µg/mL, SQuR ethanolic extract as much as 0,45 µg/mL, and cisplatin as much as 2,5 µM. The combination of HCoL ethanolic extract, SQuR ethanolic extract, and cisplatin results in phase S cell accumulation (27,73%) on breast cancer cell T47D and was able to induct apoptosis. The result proves that ethanolic extract of HCoL and SQuR can developed as a co-chemotherapeutic agent to increase the effectivity of breast cancer treatment.

Page 13 of 31 | Total Record : 306

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Editorial Address Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

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Contact Name
Masruri

Contact Email
masruri@ub.ac.id

Phone
+62341-575838

Journal Mail Official
jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA