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Journal of Mathematical and Fundamental Sciences
Published by Institut Teknologi Bandung
ISSN : 23375760     EISSN : 23385510     DOI : https://doi.org/10.5614/j.math.fund.sci.
Core Subject : Science, Education,
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics
Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health, Medical, Pharmacy), Mathematics, Physics, and Statistics.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 689 Documents
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Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines Bambang Tri Purwanto; Siswandono Siswandono; Suko Hardjono; Dian Triwidiandany
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 2 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.2.3

Abstract

Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N-(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N-phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N-(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N-(phenyl carbamoyl)benzamide with 0.8 mM IC80, higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N-(phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates.
Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database Muhammad Arba; Sanang Nur Safitri; Andry Nur Hidayat; Arry Yanuar; Muhammad Sulaiman Zubair; Asmiyenti Djaliasrin Djalil; Daryono Hadi Tjahjono
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.2

Abstract

The Janus tyrosine kinases (JAKs) have shown great promise as therapeutic protein targets in the treatment of cancer and inflammation diseases. This study used pharmacophore modeling to identify potential inhibitors of Janus kinase 3 (JAK3). A pharmacophore model was developed based on a known JAK3 inhibitor (1NX) and was employed to search for potential JAK3 inhibitors against Indonesian herbal compounds. Among 28 hit molecules that were identified and subjected to a molecular docking protocol against JAK3, the three compounds that had the highest affinities toward JAK3 were camelliaside B, 3-O-galloylepicatechin-(4beta-6)-epicatechin-3-O-gallate, and mesuaferrone B. These were then each subjected to a 50-ns molecular dynamics (MD) simulation. Analysis of RMSD and RMSF values indicated that the three compounds reached stability during the MD simulation. Interestingly, all three compounds had lower binding energies than 1NX against JAK3, as predicted by the MM-PBSA binding energy calculation.
Cover Vol. 51 No. 3, 2019 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Front Matter Vol. 51 No. 3, 2019 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Back Matter Vol. 51 No. 3, 2019 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy Nanan Nur'aeny; Dida Akhmad Gurnida; Oki Suwarsa; Irna Sufiawati
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.3

Abstract

One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.
Cover Vol. 52, No. 1, 2020 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 1 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Front Matter Vol. 52, No. 1, 2020 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 1 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Back Matter Vol. 52, No. 1, 2020 JMFS JMFS
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 1 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Improved Variational Iteration Solutions to the SIR Model of Dengue Fever Disease for the Case of South Sulawesi Sudi Mungkasi
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.4

Abstract

The susceptible-infected-recovered (SIR) model of the spread of dengue fever for the case of South Sulawesi is considered. Rangkuti's variational iteration method (RVIM) is recalled. This paper makes four contributions. The first one is to provide a successive approximation method (SAM) for solving the considered model. The second one is to show that SAM and RVIM are identical. Thirdly, a modification of RVIM is proposed. Fourthly, it is shown that the modification leads to an improvement of the accuracy of the method. Both RVIM and the improved version are quite accurate for short time periods. However, the improved version is more accurate and is able to provide more realistic explicit solutions to the model.

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