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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
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Articles 39 Documents
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Search results for , issue " PKM-P 2014" : 39 Documents clear
Penentuan Tanggapan Amplitudo dan Sensitivitas Hasil Ekstrak Daun Sirsak Untuk Tujuan Radiografimedis Dety Lestari, Anastasia Kadek; Patti, Yoseph Nikolaus; Salu, Viktorinus Sesarius; Wabang, Keszya
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

It has been investigated about Electron Spin Resonance spectra of Sour-sop Leaves (Annona muricata L) extract compound from Kupang distric. The aim of this research is to determine the amplitude response and sensitivity of sour-sop leaves extract compound to X-ray radiation. In this research, sour-sop leaves extract compound is obtained by maceration extraction method using n-Hexane and ethanol pro analysis solvent, then its extract is evaporated. Furthermore, it is conducted annealing process to obtain its powder. Samples of sour-sop leaves extract compound were weighed 0.2 grams then be irradiated with X-rays voltage of 70 kV - 85 kV at RSU Prof. W.Z. Yohanes Kupang. The dose rate were obtained in this research is from 8,69 x 10-8 Gy/hour to 9,91 x 10-8 Gy/hour. Subsequently, these samples was calibrated using an Electron Spin Resonance Spectroscopi in Physics Laboratory, Science and Technique Faculty - Nusa Cendana University . Based on research data analysis result, amplitude response and sensitivity of sour-sop leaves extract are obtained 9,45 Volt/kg - 10,8 Volt/kg and 9,20 x 10 -9 Gy.kg/h.Volt - 9,22 x 10 -9 Gy.kg/h.Volt respectively. Amplitude response of sour-sop leaves extract compound is linear to the absorbtion dose rate and its sensitivity is relatively constant to dose rate. Based on amplitude response and sensitivity value, sour-sop leaves extract compound is potential to use as an alternative active material in dosimeter for medical radiography purposes. Keywords : Sour-sop leaves, amplitude response, sensitivity, medical radiography
UJI AKTIVITAS ANTHELMINTIK EKSTRAK ETANOL DAUN PEPAYA PADA CACING GELANG BABI Mahatriny, Ni Nyoman; Sanggra Payani, Ni Putu; Suwanti Devi, Pande Ketut; Yulita, Santri; Astuti, Ketut Widyani; Made Oka, Ida Bagus
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Papaya leaves ethanol extract was evaluated for anthelmintic activity on pig roundworm by in vitro assay. The aim of this research is to know whether papaya leaves ethanol extract has anthelmintic activity and to determine LC100 and LT100 values of papaya leaves ethanol extract. Anthelmintic activity test was done by using 7 groups with 3 repetition. Group I soaked in CMC-Na 0,5% as control negative; group II soaked in albendazole suspense 0,6% as control positive; groups III-VII soaked in papaya leaves ethanol extract suspense (0,6%; 1,2%; 2,4%; 4,8%; and 9,6% respectively) for 40 hours. Observation was done every 2 hours to know mortality of pig roundworm. Percentage of pig roundworm mortality were analyse by Kruskal-Wallis test along with Mann-Whitney test. LC100 and LT100 value was determine using corrected probit analysis. Papaya leaves ethanol extract at dosage 1,2%; 2,4%; 4,8%; dan 9,6% has a anthelmintic activity because gives a significant value in mortality of pig roundworm if compare with control negative (p<0,05). From corrected probit analysis papaya leaves ethanol extract has LC100 in 8,301% b/v and LT100 in 28,885 hours.    Keywords:  Anthelmintic, Papaya leaves, LC100, LT100.
SINTESIS KATALITIK 2,2-DIISOPROPOKSIPROPAN DARI ISOPROPANOL UNTUK MENINGKATKAN ANGKA OKTAN BAHAN BAKAR TERBARUKAN Rianto, Agus; Islamiyah, Islamiyah; Pambudi, Khoir Eko; Al Mufih, Abdul Afif
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Research has been carried out 2,2-diisopropoksipropan catalytic synthesis of isopropanol to increase the octane number of renewable fuels. Catalytic Synthesis using Cu catalyst that falls on activated carbon (Cu / AC) for use as a process of dehydration of isopropanol to 2.2-diisopropoksipropan. This study also aims to obtain the optimum time and temperature for the dehydration of isopropanol. Preparation of carbon carried by softening coconut shell charcoal to 60-80 mesh size, then heated at a temperature of 800 ° C, washed, dried, impregnated with CuCl2 and reduced at 400 ° C with flowing hydrogen gas. The amount of metal content of Fe, Ca, and K in the carbon after the process of washing / soaking determined using Atomic Absorption Spectroscopy (AAS). Activated carbon and catalyst acidity was determined by adsorption of ammonia, isopropanol dehydration process with catalyst Cu / activated carbon (Cu / AC) carried out in an electric furnace with temperature variation: 250; 300; 350; 400; and 450 ° C and the variation in the amount of catalyst amount: 6; 8; and 10 grams, with N₂ flowed at a rate of 20 mL / min as the carrier gas, and no water vapor. Dehydration results in vapor cooled condenser and then collected for analysis by gas liquid chromatography (GC) and gas chromatography mass spectrometry (GC-MS). The results of the analysis using AAS showed that the presence of washing, soaking using 3 M HCl, the metal Fe, Ca, and K in the activated carbon is significantly reduced. The results of ammonia adsorption analysis showed that activated carbon and Cu / AC has acidity, respectively for 2.962 and 4.911 mmol / g. Catalytic activity of Cu / AC highest achieved at a temperature of 450 ° C with a catalytic amount of 10 grams of 2,2-diisopropoksipropan produce as much as 61.82%.Keywords:  Catalytic Dehydration, isopropanol, 2,2-diisopropoksipropan, Cu / activated carbon
PENGARUH CUKA SALAK TERHADAP PENURUNAN GLUKOSA DARAH DAN HISTOPATOLOGI PANKREAS TIKUS DIABETES Hamidatun, Hamidatun; Mandasari, Oty Kiki; Rosdiana, Indri; Widiyana, Septina Dwi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Diabetes mellitus is indicated by elevated levels of blood glucose and progressive changes of the structure of pancreatic islet histopathology. Salacca vinegar made from suwaru salacca is one of alternative medicine of diabetes because contain acetate acid and antioxidant. The aim of this study is to investigate the effects of salacca vinegar on blood glucose and histopathologycal of pancreas of diabetic rats. This research is based on Pre and Post Test with Control Group Design. Ratus norvegicus rats were divided into 4 groups. There were normal group, diabetes, diabetes + salacca vinegar 0,4mL and diabetes + salacca vinegar 0,7mL. The results indicated that salacca vinegar had a significant blood glucose lowering effect diabetic rats. Group of diabetes + salacca vinegar 0,4mL reduced glucose concentration of 35,06%, diabetes + salacca vinegar 0,7mL of 32,50%. Based on histopathologycal of pancreas showed that salacca vinegar recover pancreatic beta cells damaged. Conclusion is salacca vinegar had a significant blood glucose lowering effect and recover pancreatic beta cells damaged. Keywords:  Blood glucose, Diabetes Mellitus, Pancreas Histopathology, Salacca Vinegar
FOXID-EGG: PENGEMBANGAN INDUSTRI NUTRACEUTICAL BERBASIS TELUR ITIK LOKAL KAYA OMEGA-3 Andri, Faizal; Sukoco, Aji; Hilman, Taufich; Susilo, Hadi; Sibawi, Sibawi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cardiovascular disease is the number one cause of death and disability worldwide. The purpose of this experiment was to create local ducks egg enriched with omega-3 as a candidate of nutraceutical to prevent cardiovascular disease. Sixty local ducks were randomly distributed to six treatment with three levels of fish oil (0 ppm, 1500 ppm, and 3000 ppm) and two levels of tomato meal (0 ppm and 150 ppm) in a 3x2 factorial arrangement. Data of local ducks performances were analyzed using two-way Anova, data of egg yolk omega-3 fatty acid content was analyzed descriptively. There was an interaction (p<0.05) of fish oil and tomato meal supplementation on egg weight. Supplementation of 3000 ppm fish oil +150 ppm tomato meal tend to increase DHA content of egg yolk with 0,43% compare than control treatment with 0,18%. The conclusion of this research supplementation of 3000 ppm fish oil +150 ppm tomato meal could produce egg yolk of local ducks egg with 0,04% ALA and 0,43% DHA.Keywords:  cardiovascular disease, DHA, local ducks egg, fish oil, tomato meal
DOKSISIKLIN SEBAGAI INHIBITOR MMP-2 dan MMP-9 PADA DERMATITIS PAEDERUS DENGAN METODE GELATIN ZIMOGRAFI Romadhon, Brenda Desy; Kusuma, Bagus Indra; Chasya, Silvi Ahmada; Kusumaningarum, Putri Erlinda; Prasetya, Rovian Cahya
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Tomcat (Paederus sp.) venom can bring a condition called dermaconecrosis. Initially, paederin toxins was thought that come from the body of Tomcat (Paederus sp.). However, based on Piel’s research, the genes come from biosynthesis of tomcat (Paederus sp.) venom is more approach to Pseudomonas aeruginosa genes than body itself. In other fact, Pseudomonas aeruginosa can secrete enzymes metalloprotease (MMP), especially extracellular MMP-2 and MMP-9. MMP-2 and MMP-9 are gelatinase that can destroy the gelatin on human skin. There has been no previous report about the treatment of dermatitis paederus based on the mechanism of action except for the use of corticosteroids as symptomatic drugs. Because of that, researcher hypotheses that MMP-2 and MMP-9 have a role on dermatitis paederus and doxycycline can inhibit that process as MMP inhibitor and antibiotics component. The research design is quasi-experimental research, in vitro with a post-test only control group design. The research steps are Tomcat (Paederus sp.) venom extraction, doxycycline solution preparation, and electrophoresis of gelatin zymografi. The independent variables are induction of Tomcat (paederin sp.) venom and the doses of doxycycline, while the dependent variable is the density of the gel. Gel density was measured using densitometry software ImageJ and calibrated as optical density. This study describes the first time the mechanism Paederus dermatitis caused by MMP-2 and MMP-9, so that the first line of therapy that can be used is doxycycline with an effective dose of 10 mM in vitro.Keywords:  paederus dermatitis, doxycycline, gelatin zimografi, MMP
FAKTOR PENGARUH GADGET TERHADAP KECERDASAN MOTORIK SISWA SD MELALUI REGRESI LOGISTIK ORDINAL Octaviana, Fanny Ayu; Pertiwi, Tutut Januar; Purnama, Giyanti Linda; Hapsery, Alfisyahrina; Yoshinta, Andriana
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Gadget is an electronic device that has a specific function and widely used by all people, without exception for kid. Use of gadgets positively has helpful children for homework and as entertaiment. However, without realizing that overusing gadgets have a negative effect.Therefore, the research will be conducted to determine the factors affecting of using gadgets early on the development of motoric intelligence elementary students using ordinal logistic regression.  Source of data used are primary data obtained from the survey, the sampling unit are all mothers who have children in grade 1 SDN Klampis Ngasem I Surabaya. The response variable (Y) is the level of intelligence of the childs motor development (1 = poor, 2 = fair, 3 = good). The results of the analysis, can be concluded that the factors that influence the development of motor 120 students of SDN Klampis Ngasem I Surabaya is long child recognize and use of gadgets every day. Keywords:  Gadgets, Intelligence motoric skills, Logistik Ordinal Regression, Elementary Students. 
KLASIFIKASI RUMAH TANGGA MISKIN DI KABUPATEN JOMBANG DENGAN PENDEKATAN RANDOM FOREST CART Seftiana, Dian; Arleina, Oktiva Dhani; S., Giriesa Kinanti; Dewi S., Rizka Amalia; Fachrunisah, Fachrunisah
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Poverty is a major cause of a number of social problems, political, economic and particularly in developing countries. Poverty reduction is the key factor that must be done to achieve the targets in the Millennium Development Goals (MDGs) by 2015 government assistance program for the reduction of poverty that exist today have not been able to reduce the number of poor households in Jombang, whereas Jombang have a positive economic growth rate from year to year. Thus, in order to support effective and efficient government then carried out a classification based on the household assistance package that is expected by the poor households in Jombang. Poor households as the object of observation is divided into two according to their poverty status, namely Poor Households (RTM) and Chronically Poor Households (RTSM). Classification is done by using the CART approach is then combined with the method of the Random Forest to obtain a more accurate and stable classification. Classification results using Random Forest CART stated that the expected assistance package by RTSM determined by income per month, place of dispocing of fecal water, type of floor building, and source of drink water. While, the most important characteristic of RTM classification income per month, place of dispocing of fecal water, source of drink water, and large of house building. The classification result from Random Forest CART method produces a total accuracy rate of 99.50 percent for RTSM and 98.33 percent for RTM. The mapping of households in Jombang stated that cash money, cattle, and modal were the most expexted assistance package. Keywords: CART, Chronically Poor Households, Poor Households, Random Forests, Total Accuracy Rate.
YLS-THERAPY: POTENSI SUPERNATAN YOGURT LBA–ST SEBAGAI ANTIKANKER SERVIKS BERBASIS BIOMOLEKULER Permata Sari, Desie Suci; Ridho, Wildan Mochamad; Lizziyyannida, Lizziyyannida; Sholihah, Zurniatus; Putra Pratama, Satya Hanggara; Rahmani, Erita; Riawan, Wibi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cervical cancer is the third most diagnosed cancer and the fourth leading cause of cancer death in females in the world. Zebrafish have been used as experimental animals in human tumors because of similar gene expression (70%) than other experimental animals. Yogurt LBA-ST produces SCFA metabolites (acetate, lactate, and butyrate) that can provide anticarcinogenic effects. There has been a vast growth of related research focusing on proliferation and apoptosis without clear mechanism. However, Important concern need to considered in the development of tumors is protein-coding invasion, migration, and adhesion (IMA) of tumor cells. This study aims at investigating (1) Antiproliferation activities of supernatan yogurt LBA-ST (SY LBA-ST) on zebrafish embryos and HeLa cells, and (2) anti-IMA’s pathway on HeLa cells. The anti-cancer property of SY LBA-ST was evaluated by MTT assay for viability and imunositochemistry of MMP-2, Laminin5-y2, Hsp27, and TGF-β for anti-IMA mechanism. The data is collected and analyzed using One-Way ANOVA.This study could be concluded that (1) SY LBA-ST increase mortality rate and decreased the hatching rate in zebrafish embryos, LC50 ≈ 20% (v/v),  (2) supernatant, pellet, and whole yogurt shows antiproliferation activity on HeLa cells, (3) IC50 SY LBA-ST ≈ 30% (v/v) and the ED = 10% (v/v), and (4) the anti-IMA’s pathway was via decrease MMP-2, Laminin5-y2, Hsp27, and TGF-β expression (p<0.05 ± 0.005).Keywords:  lactobacillus bulgaricus-acidophilus, streptococcus thermophillus, cancer, HeLa, zebrafish

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