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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 7 Documents
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Search results for , issue "Vol 10, No 3 (2023)" : 7 Documents clear
Solvent Type Effect on Preparation of Ethyl Cellulose Microparticles Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.38460

Abstract

The purpose of this study was to investigate effect of solvent type on solidification rate of ethylcellulose (EC) microparticles and particle size/distribution of emulsion droplets/hard microparticlesduring the solvent evaporation process using focused beam reflectance measurement (FBRM). ECmicroparticles were prepared by an O/W-solvent evaporation method using various solvents, includingdichloromethane, dichloromethane:methanol (1:1), ethyl acetate, and chloroform. The particle size/distribution of emulsion droplets/hard microparticles was monitored by FBRM. The morphology ofEC microparticles was characterized by scanning electron microscopy (SEM). The transformation ofemulsion droplets into solid microparticles for all solvents occured within the first 10-60 min. Thesquare weighted mean chord length of EC microparticles which were prepared using chloroform wassmallest value, but the chord counts was no the highest. The chord length distribution (CLD) measuredby FBRM showed that microparticles with a larger diameter give a wider CLD and a lower peaknumber of particles. SEM data shows that the morphology of microparticles was influenced by type ofsolvent. FBRM can be used to monitor the development of microparticle CLDs online and detect thetransformation of emulsion droplets into solid microparticles during the solvent evaporation process.The microparticle CLD and transformation processes are influenced by the type of solvent.
Development of Metformin and Glimepiride Analysis Methods Using TLC-Spectrofluorometry Adlina, Salsabila; Ibrahims, Slamet; Permana, Benny
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.33708

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder disease. DM presents in two main types 1and 2. Type 2 DM was caused by genetic and lifestyle which was the biggest contributor to DMcases. Many patients with type 2 DM treated with combination therapy using Fix Dose Combination(FDC) preparation to increase patients compliance and therapeutic effect. FDC preparations containedmetformin and glimepiride. Assay of these combination was not found in compendial. A rapid,simple, specific method analysis of metformin and glimepiride has been developed in this riset usingTLC-spectrofluorometry. Metformin and glimepiride content in tablet were determined by the TLC-spectrofluorometry using dansyl chloride as derivatization agent under alkali conditions. In the TLCmethod, metformin and glimepiride were dissolved with methanol and gives Rf values of 0.52 and0.70, respectively in system containing silika gel GF254 as stationary base and methanol:water: glacialasetic acid (6:4:0.25) as developing solvent. TLC results were scraped off and reacted using dansylchloride 0.1% then fluorescence intensity measurements were carried out at emission wavelength 483nm for metformin and 489 nm for glimepiride. Method validation is done by determining linearity,accuracy, precision, Limit Of Detection (LOD) and Limit Of Quantization (LOQ).
Production of Anti-Recombinant Human Insulin Antibody and Validation by Indirect ELISA Ambarsari, Christy; Suryadi, Herman; Yanuar, Arry
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.40641

Abstract

Human insulin potential has become an interest and is important in maintaining the success of therapyin patients with the availability of chemical-based analytical methods, however, only a few have beenusing immunoassays. This study aimed to produce IgG polyclonal antibodies from rabbits immunizedwith 1 mg/mL rhINS subcutaneously and validated by indirect ELISA. Antibody was precipitated andfractioned on a HiTrap® Protein A HP column before being quantified with a UV spectrophotometerat λ 280 nm. The characterization was conducted by Dot Blot test on a BCIP-NBT substrate, as well asSDS-PAGE and Western Blot with polyacrylamide gel concentrations of 7.5% and 17.5%. Validationwas performed using solutions containing glycerol and m-cresol as matrices spiked with rhINS. Thelinearity test in the rhINS concentration range of 80.11-200.28 μg/mL (r = 0.99) showed the linearresult. The accuracy and precision obtained an average of 99.11%±5.01 and 3.91%, while the LODand LOQ were 22.05 μg/mL and 73.51 μg/mL, respectively. Human insulin was stable at 2-8oC for 24hours (α: 0.05, ANOVA). In conclusion, in-house produced IgG polyclonal antibodies and goat anti-IgG peroxidase conjugate can be used for routine testing of human insulin.
Antidiabetic activity of matoa leaves (Pometia pinnata J.R.Forst & G. Forst) extract on hyperglycaemic alloxan-induced rats Wahyuni, Arifah Sri; Muflihah, Cita Hanif; Fadhilah, Arini; Oksaputra, Amar Khoiri; Ningrum, Nur Faizah Setya; Bakhtiar, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.33711

Abstract

Matoa (Pometia pinnata J.R.Forst & G. Forst) leaves contain polyphenols and flavonoids which areprospective for the development of the new antidiabetic agent. This research aimed to explore thepotency of matoa leaves in reducing blood glucose level and increasing plasma insulin concentrationin alloxan-induced rats. The experimental study was done in 6 treatment groups: the aquadest (normal),alloxan (Alx) 150 mg/kgBW (negative control), glibenclamide (Gli) 5 mg/kgBW (positive control),and matoa leaves extract (MLE) at the doses of 50, 100, and 200 mg/kgBW. The treatment wasadministered for 14 days orally post-induction of alloxan and fasting blood glucose (FBG) reached>200 mg/dL. Blood glucose levels were established by the GOD-PAP (Diasys) method while plasmainsulin was measured using Rat insulin ELISA kit. Hematoxyline-eosin (HE) staining on tissues wasperformed to observe the population of pancreatic beta cells. The results showed that the MLE extractat a dose of 200 mg/kgBW could decrease the FBG level to 135.25±21.14 mg/dL and increase theplasma insulin level up to 0.14%. Pancreas histopathology indicated that the number of damaged cellswere lower than negative control. In conclusion, our results affirm the promising potential of MLE asa candidate of the novel antidiabetic agent.
Cardioprotective activity of Apples Juice on Isoproterenol-Induced Myocardial Infarction in Rat Kurniati, Neng Fisheri; Nadhirah, Yuthika Raihan
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.41445

Abstract

Myocardial infarction was local necrosis of heart tissue due to reduced oxygen supply because of theocclusion of coronary arteries. Fruits could reduce the risk of developing obesity and CVDs. Severalstudies have shown that apples had a strong cardioprotective effect. This study aimed to understandthe cardioprotective activity of two variants of apples, e.g., Fuji and Malang, on isoproterenol-inducedmale Wistar rats. The cardioprotective activity test was carried out for 14 days, all testing group exceptnegative control, was induced by isoproterenol. The results of testing cardioprotective activity showedthat Fuji Apple juice and Apel Malang juice had the same capability to inhibit increasing cardiacbiomarkers value (CK and CK-MB) with the highest inhibition was 79.56% and 73.08% for FujiApples, respectively, while for Apel Malang was 69.18% and 43.04%, respectively. The result of thecardiac histopathology examination showed that both Apples could prevent cardiac tissue damage. Alljuice Apple doses had the same cardioprotective activity.
Diuretic Effect of Combination of Watercress (Nasturtium officinale) and Purslane (Portulaca oleraceae) Sutjiatmo, Afifah Bambang; Yuliartati, Ni Luh Ade; Yulianti, Maulidya; Suryani, Suryani; Vikasari, Suci Nar
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.36330

Abstract

Watercress (Nasturtium officinale) and purslane (Portulaca oleracea) are used to increase urination.This preclinical study aims to prove the diuretic effect of a combination of watercress and purslaneextracts. Simplisia of watercress and purslane herbs mixed with various combinations A (1:9), B(1:3) and C (1:1), then extracted in 50% ethanol. The animals were divided into five groups: control,furosemide 3.6 mg/kgBW, A 38 mg/kgBW, B 28 mg/kgBW, and C 10 mg/kgBW. Diuretic assay wascarried out using the modified Lipschitz method with the parameters observed were cumulative urinevolume for 6 and 24 hours, and potassium levels in 24-hour urine. The results showed the onset ofdiuretic effect of furosemide at 60 minutes, A at 150 minutes, B at 240 minutes and C at 90 minutes.Percent effectiveness of the diuretic in the furosemide was 718%, A 212%, B 231%, and C 368% whencompared to the controls. All combinations of extracts increased sodium and potassium secretion whencompared to controls, but this effect was not as strong as furosemide. All combinations of watercressand purslane herbs have a diuretic effect but weakly saluretic when compared to furosemide and thecombination that gives the best effect is combination C.
Anti-Acne Patch Formulation Silkworm Cocoon Waste with HPMC and PVP Variations Ulfa, Maria; Fatmawaty, Aisyah; Dambur, An M.R.
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.36951

Abstract

Some topical preparations for acne have been developed in the form of gels and creams. However,it is still rarely developed in the form of a patch dosage form. Waste from silkworm cocoons has theactivity of inhibiting the growth of acne-causing bacteria, can be formulated into patch preparations.This study aims to formulate anti-acne patches from silkworm cocoon waste with variations of HPMCand PVP. The formulation of the anti-acne patch from silkworm cocoon waste was made by mixingthe lyophilisate of silkworm cocoon waste with a patch base with variations of HPMC and PVP. Theformulations were divided into 3 with different concentrations of HPMC and PVP additives, namelyformulas 1 (4:1), 2 (2,3:1), and 3 (1:1), respectively, The evaluations carried out included organolepticexamination, patch thickness, weight uniformity, fold resistance, moisture absorption, drying shrinkage.The results obtained showed that the concentration of the combination of HPMC and PVP polymersin the patch preparation gave different results from all evaluations that had been carried out, includingorganoleptic evaluation, weight uniformity, fold resistance, and drying shrinkage were in accordancewith the requirements of a good patch. The optimum concentration of the combination of HPMC andPVP as a polymer in the anti-acne patch preparation from silkworm cocoons is formula 2 with a ratioof (2,3:1) as novelty in this study.

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