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MEDISAINS
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16937309     EISSN : 26212366     DOI : -
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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Articles 256 Documents
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Effectiveness of the personal hygiene module in increasing the knowledge of pregnant women with anemia on the dangers of worm infection Saraswati, Endah; Wahida, Wahida; Nurdjaya, Malahayati
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24067

Abstract

Background: Worm infections are a common cause of anemia in pregnant women, particularly in areas with poor sanitation. While many studies have examined anemia in pregnancy, few have specifically explored the effectiveness of personal hygiene education in increasing pregnant women's knowledge of the dangers of worm infection.Purpose:  This study aimed to evaluate the effectiveness of a personal hygiene module in increasing the knowledge of pregnant women with anemia about the dangers of worm infection. Methods: This quasi-experimental study, which involved 30 pregnant women with anemia, was conducted in the coastal area of North Konawe Regency, Southeast Sulawesi Province. A purposive sampling technique was used, and data were analyzed using the paired t-test.Result: The average knowledge score before education was 29.27, significantly increasing to 52.40 after implementing the personal hygiene module (p = 0.000).Conclusions: The personal hygiene module effectively improves the knowledge of pregnant women with anemia regarding the dangers of worm infection.
The effect of consuming rosella flower-infused water on control blood pressure in pregnant women with hypertension amin, dewita rahmatul; Sugiarti, Rosi Kurnia
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24075

Abstract

Background: Hypertension during pregnancy is one of the leading causes of maternal morbidity and mortality. Rosella flower infused-water, rich in bioactive compounds such as flavonoids and polyphenols, have been shown to lower blood pressure safely. Although previous studies have highlighted the antihypertensive effects of rosella in the general population, research specifically focusing on its use in pregnant women with hypertension is still limited.Objective: This study aims to investigate the effect of rosella flower-infused water on control blood pressure reduction in pregnant women with hypertension.Method: The research design used is quasi-experimental with a pre-test and post-test approach involving 100 pregnant women with hypertension in Desa Karangraharja. The intervention group received 200 ml of rosella flower-infused water for 14 days in conjunction with nifedipine 10 mg, while the control group only received nifedipine 10 mg. The blood pressure of the control and intervention groups was measured using the Mann-Whitney Test.Results: The rosella flower-infused water effectively reduced systolic blood pressure in the intervention group by 24.92 mmHg compared to the control group by 18.78 mmHg (p=0.000). Diastolic blood pressure in the intervention group decreased by three mmHg, although this was not statistically significant compared to the control group's decrease of 3.6 mmHg (p=0.715).Conclusion: The 200 ml rosella flower-infused water for 14 consecutive days reduced systolic blood pressure in pregnant women with hypertension.
Accelerating perineal wound healing using binahong leaf extract sanitary pads Asmaidar, Asmaidar; Runjati, Runjati; Santjaka, Aris; Cicilia, Fitri
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24284

Abstract

Background: Sanitary pads are essential for postpartum mothers to accommodate lochia and prevent infection in perineal wounds. Binahong leaves (Anredera cordifolia) contain flavonoids with antiseptic, antioxidant, and analgesic properties that promote wound healing by inhibiting microbial growth and reducing inflammation. However, research on the use of sanitary pads infused with Binahong leaf extract for perineal wound healing remains limited.Objective: This study investigates the effectiveness of Binahong leaf extract sanitary pads in accelerating postpartum perineal wound healing. Methods: A quasi-experimental study with a post-test-only randomized control group design was conducted at the Poasia Health Center, Kendari City. The study included postpartum mothers meeting specific inclusion and exclusion criteria, with a total sample of 34 participants (17 intervention, 17 control). The intervention group used Binahong leaf extract sanitary pads four times daily, while the control group relied on standard dry wound care. The intervention lasted seven days, and wound healing was assessed using the REEDA scale on days three, five, and seven.Results: The findings demonstrated a significant effect of Binahong leaf extract sanitary pads on perineal wound healing. The intervention group (2.52 ± 0.87) experienced faster wound recovery than the control group (5.23 ± 1.67) (p< 0.001).Conclusion: Binahong leaf extract sanitary pads effectively accelerate perineal wound healing in postpartum mothers and may serve as an alternative wound care approach.
In vivo study of Centella asiatica leaf extract cream for Matrix Metalloproteinase-1 inhibition and collagen enhancement to prevent photoaging Purmawanti, Sri; W, Joko Wahyu; Sumarawati, Titiek
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24719

Abstract

Background: Ultraviolet B (UVB) exposure accelerates skin aging, causing wrinkles and increasing matrix metalloproteinase-1 (MMP-1) activity, which degrades collagen. Centella asiatica (CA) has well-documented anti-inflammatory and antioxidant properties that may counteract UVB-induced photoaging. However, studies on its topical formulation for MMP-1 inhibition and collagen enhancement remain limited.Purpose: This study aims to determine the effect of CA leaf extract cream on inhibiting MMP-1 and increasing collagen in skin tissue exposed to UVB rays.Methods: This experimental study used a post-test only control group design. The sample population of BALB/c mice was 24, divided into four groups: healthy control group (KN), negative control group (K-), Treatment 1 (P1): 10% CA extract cream dosage, and Treatment 2 (P2): 20% CA extract cream dosage. Skin tissue samples were measured for MMP-1 expression using immunohistochemistry (IHC) staining, and collagen density using Sirius Red staining. Data analysis on MMP-1 expression using One-way ANOVA test and collagen density using Kruskal Wallis test.Results: MMP-1 expression was highest in the K2 group (UVB exposure + cream base) and decreased in the P1 and P2 groups (10% CA cream), with the lowest expression in the K1 group (healthy control). However, One-Way ANOVA showed no significant differences among groups (p=0.053). Collagen density analysis using the Kruskal-Wallis test showed significant differences (p = 0.04), with a decrease in the K2 group and an increase in the K3 and K4 groups.Conclusion: Application of CA extract cream affects MMP-1 expression and collagen density in skin tissue exposed to UVB rays.
Sociodemographic and psychological factors associated with depression among nursing home elders Widyasari, Eka; Ariani, Tutu April; Aini, Nur; Marta, Ollyvia Freeska Dwi; Mashfufa, Erma Wahyu
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.25830

Abstract

Introduction: Depression in the elderly is shaped by sociodemographic and psychological factors. Depression generally affects older adults and is associated with a poor life, with sociodemographic and psychological factors such as social support and loneliness playing a role in the onset of depression. However, the relationship between these factors and depression in the elderly is still rarely explored.Purpose: This study aims to explore the relationship between psychological and sociodemographic factors on the level of depression in the elderly living in nursing homes, with a focus on social support, level of loneliness, and cognitive impairment.Methods: This study used a descriptive cross-sectional design and involved 72 older adults living in four East Java, Indonesia nursing homes. Data were collected through questionnaires using the Multidimensional Scale of Perceived Social Support (MSPSS), UCLA Loneliness Scale, Mini-Mental State Examination (MMSE), and Beck Depression Inventory-II (BDI-II), which were translated into Bahasa Indonesia. Multiple logistic regression was used to understand the relationship between sociodemographic and psychological factors and the level of depression in the elderly.Results: Marital status (AOR 0.177, p = 0.030) and social support (AOR 0.950, p = 0.040) are significantly associated with depression in the elderly.Conclusion: Marital status and level of social support have the potential to cause depression in the elderly living in nursing homes.
Poundfit exercise and cardiometabolic health in women: a quasi-experimental study Sucipto, Adi; Rahmadani , Irianti Fitri; Afriani, Yuni; Sari, Siska Puspita; Boru, Dhelsiana Rambu Desi; Nabila , Dinda Rambu; Puspaningtyas, Desty Ervira
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.24480

Abstract

Background: Poundfit is a rhythmic, music-driven aerobic exercise that integrates cardiovascular movement and strength-based activities. Despite its growing popularity, evidence regarding its effects on cardiometabolic parameters in healthy adults remains limited. Objective: This study aimed to evaluate the effects of a short-term Poundfit exercise program on blood pressure and blood glucose levels in healthy adult women. Methods: A quasi-experimental one-group pretest–posttest design was conducted among 22 women aged 19–50 years. Participants attended Poundfit exercise sessions twice weekly for two weeks, with each session lasting 60 minutes. Blood pressure and blood glucose levels were measured before and after the intervention. Pretest–posttest comparisons were analyzed using the Wilcoxon signed-rank test. Results: Following the two-week intervention, systolic and diastolic blood pressure showed slight reductions, while blood glucose levels showed a slight increase; however, none of these changes were statistically significant (p = 0.122 for systolic blood pressure, p = 0.933 for diastolic blood pressure, and p = 0.220 for blood glucose). Conclusion: A two-week Poundfit exercise program did not result in statistically significant changes in blood pressure or blood glucose levels in healthy adult women. These findings suggest that short-term Poundfit training may be insufficient to produce measurable cardiometabolic improvements in normotensive individuals, highlighting the need for longer or more intensive exercise interventions in future studies.
In vivo study on the effect of noni leaf extract cream (Morinda Citrifolia L) on PDGF and TNF-α levels in cut wounds Sari, Shintia Devi Arum; Mulyani, Sri Priyantini; Putra, Agung; Setiawan , Eko
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25252

Abstract

ABSTRACT Background: Skin wounds damage the structure and epithelial tissue, resulting in scar tissue formation. Prolonged wound healing or excessive body response will inhibit the normal process and produce unaesthetic scar tissue. Many plant extracts and their active components can accelerate the wound healing process, Noni leaf extract has antioxidant activity and accelerates wound healing. Objective: This study aims to determine the effect of noni leaf extract cream (Morinda Citrifolia L) on TNF-α and PDGF levels in Wistar rats with incised wounds. Method: A laboratory experimental study with a post-test only control group design. Consisting of five treatment groups, namely the healthy rat group (KS), Negative group (KN) rats with incised wounds without treatment, positive group (KP) rats with incised wounds that were smeared with povidone-iodine cream, treatment group 1 (P1) rats that were smeared with 20% noni leaf extract cream, and treatment group 2 (P2) rats that were smeared with 40% noni leaf extract cream, treatment for 3 days then examined the levels of TNF-α and PDGF skin tissue using the ELISA method. Results: The average TNF-α levels showed a significant difference between groups p of 0.000 (p <0.05) with the One way anova test, the highest average in group (KN) 220.68 pg / mL, there was a decrease in all treatment groups with the lowest TNF-α levels in group (KP) 76.59 pg / mL. The average results of TNF-α levels showed a significant difference of p 0.000 (<0.05) with the One-way ANOVA test, the group without intervention (KP) had the lowest PDGF levels while the group (P2) experienced the highest increase in PDGF levels. Conclusion: Administration of noni leaf extract cream with doses of 20% and 40% had an effect on reducing TNF-α levels and increasing PDGF levels in Wistar rats with incised wounds.
Kelakai serum reduces UVB-induced vascular endothelial growth factor and interleukin-6: in vivo study Ulfadhina, Nedya; Hussaana, Atina; Suparmi, Suparmi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25906

Abstract

Background: UVB exposure increases reactive oxygen species leading to higher expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6), which accelerate photoaging. Kelakai leaf (Stenochlaena palustris) contains flavonoids and phenolic compounds with antioxidant and anti-inflammatory potential, yet its efficacy in serum formulations has not been evaluated. Purpose: To determine the effect of kelakai leaf extract serum on VEGF and IL-6 expression in BALB/c mice exposed to subchronic UVB radiation. Method: This experimental post-test only control group study used 30 BALB/c mice assigned to five groups: healthy control (K1), UVB-exposed negative control (K2), UVB + 0.025% retinoid serum (K3), UVB + 2% kelakai serum (K4), and UVB + 4% kelakai serum (K5). UVB exposure (160 mJ/cm²) was given for 14 days followed by topical treatment. Skin tissues were examined using immunohistochemistry to assess VEGF and IL-6 expression. Data were analyzed using the Kruskal–Wallis test followed by Mann–Whitney. Results: VEGF and IL-6 expression were highest in K2 and lowest in K1. Both retinoid and kelakai serum significantly reduced expression levels (p<0.05). The 4% kelakai serum (K5) produced greater reductions than the 2% dose, approaching the effect of retinoid serum. Conclusion: Kelakai leaf extract serum at 4% effectively decreases VEGF and IL-6 expression in UVB-exposed mice, supporting its potential as a natural anti-photoaging agent.
Patterns and predictors of anaemia in haemodialysis patients: relationship with comorbidities and dialysis exposure time Handrean, I Gede Eka; Putra MN, I Made Mahadinata; Pratama Putra, I Gede Laksmana
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.26063

Abstract

Background: Anaemia is a common and serious complication in patients with chronic kidney disease (CKD) undergoing haemodialysis, contributing to increased morbidity, mortality, and reduced quality of life. Its prevalence and predictors vary across populations, and evidence from Indonesian cohorts remains limited. Objective: This study aimed to investigate the prevalence, severity, and predictors of anaemia in haemodialysis patients, with a particular focus on the influence of comorbidities and dialysis duration. Methods: A cross-sectional analytic study was conducted among 71 CKD patients undergoing regular haemodialysis at Kenak Medika Ubud Hospital between July and August 2024. Data on demographics, dialysis duration, comorbidities, and laboratory parameters (Hb, BUN, SC, MCV, MCH) were extracted from medical records. Anaemia severity was classified according to WHO and KDIGO guidelines. Statistical analysis included descriptive statistics, Chi-square tests, ANOVA, correlation analysis, and multivariate linear regression. Results: The prevalence of anaemia was 70.4%, with moderate anaemia being the most common presentation (52.1%). Patients with dialysis duration >24 months had significantly lower haemoglobin levels compared to those with shorter treatment exposure (p = 0.014). Multivariate regression analysis identified hypertension (p = 0.009) and cardiovascular disease (p = 0.013) as significant predictors of haemoglobin levels, while diabetes mellitus, BUN, SC, MCV, and MCH showed no significant associations. Conclusion: Anaemia remains highly prevalent in haemodialysis patients, with dialysis duration and cardiovascular comorbidities emerging as key predictors. These findings underscore the importance of routine anaemia monitoring, individualized treatment strategies, and integrated management of cardiovascular comorbidities to optimize outcomes in haemodialysis populations.
Sub-acute toxicity evaluation of Ziziphus spina-christi and Adenanthera pavonina leaf extracts combination in rats: an in vivo study Ngibad, Khoirul; Ayu , Patricia Gaby; Fafa , Angelica Rosia; Tria , Novitasari; Farichatul , Wachda
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27311

Abstract

Background: The safety of combined herbal extracts remains underexplored, particularly for Ziziphus spina-christi and Adenanthera pavonina, which contain bioactive compounds with potential toxic effects. Objective: To evaluate the sub-acute toxicity of combined leaf extracts on hematological, biochemical, and organ morphology parameters in Wistar rats. Method: Thirty male and female rats were randomized into five groups receiving vehicle control or extract doses of 4000, 8000, and 10,000 mg/kg BW for 21 days following OECD 407. Blood hematology, renal biomarkers, bilirubin levels, organ weight, and morphology were analyzed. Results: Mortality increased dose-dependently, reaching 20% in males and 10% in females at 10,000 mg/kg BW. Hematology and renal biomarkers showed no significant differences (p>0.05). Total bilirubin increased at the highest dose. Morphological abnormalities, including pale discoloration and dark foci, were observed in liver and kidneys at higher doses. Conclusion: The combination extract is safe up to 8000 mg/kg BW, while 10,000 mg/kg BW induces organ alterations and increased mortality.

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