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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 305 Documents
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The Antibacterial Effect of Ethanol Edamame Seeds (Glycine Max (L) Merril) Extract to E.coli Bacteria Diayu Putri Akhita; Edy Junaidi; Septa Surya Wahyudi
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.11120

Abstract

Abstract Infectious diseases can occur in all parts of the body. One of the causes infection in humans is Eschericiae coli bacteria. Eschericiae coli is a rod-shaped bacteria, a gram negative bacteria, facultative aerobics and classified family member of Enterobacteriaceae from the Gammaproteobacteria class. Along the times, E.coli bacteria have resistent to some antibiotics. So we need a new alternative. There is a antibacterial substance in the isoflavon group contained in edamame. Genistein is a main isoflavon in edamame that have antiinflammation, antibacterial, and antioxidant effects. The purpose of this study was to determine is there any antibacterial effects in ethanol edamame seeds extract to E.coli bacteria. This study used a true experimental research design in vitro with a post test only control group design. The average diameter results of the inhibition zone were analyzed using the Kruskal-Wallis method and obtained p = 0.001 which means there are significant differences in at least two groups. After that, the Mann Whitney post hoc test was conducted and a significant difference was found in the positive and negative control groups for all groups but there was no difference in the treatment group, both groups K1, K2 and K3 for all groups. Keywords : Edamame, Antibacterial, E.coli
The Effect of Azadirachta indica leaves extract on Transforming Growth Factor-β and Tumor Necrosis Factor-α in a Plasmodium berghei infected Mice model Zainabur Rahmah
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.21867

Abstract

Malaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%). This study aims to determine the effect of neem leaf extract on increasing TGF-β expression and decreasing TNF-α expression in mice infected with Plasmodium berghei. In this study there were four groups, namely Treatment 1 (in Plasmodium berghei infection without therapy). Treatment 2 (in Plasmodium berghei infection and treated with Azadirachta indica leaf extract at a dose of 0.25 mg / g BW). Treatment 3 = (in Plasmodium berghei infection and therapy with Azadirachta indica leaves at a dose of 0.5 mg / g BW). Treatment 4 = (in Plasmodium berghei infection and treated with Azadirachta indica leaves at a dose of 1 mg / g BW). TGF-β examination by elisa method and TNF-α by immunohistochemistry. Data analysis using SEM (Structural Equation Modeling) The results of treatment 1 and 2 showed a decrease in plasma TGF-β expression (t = 1.13; tcount = 1.93; ≥ttabel = 1.96) and spleen (tcount = 1.53; tcount = 1.45; ≥ttabel = 1.96) but there was an increase in spleen TNF-α expression (tcount = 1.77; tcount = 1.00; ≥ttabel = 1.96). Groups 3 and 4 showed an increase in plasma TGF-β expression (tcount = 5.13; tcount = 2.42; ≥ttable = 1.96) and spleen (tcount = 2.00; tcount = 1.97; ≥ttabel = 1.96) but there was a decrease in spleen TNF-α expression (tcount = 2.03; tcount = 2.11; ≥ttabel = 1.96). Conclusion: Azadirachta indica leaf therapy can increase TGF-β expression and decrease TNF-α expression in the spleen. Keywords: Azadirachta indica ethanol extract, transforming growth factor- β, tumor necrosis factor-α
The extract of kemangi leaves as inhibitor of biofilm from Staphylococcus aureus in vitro Putu Sri Maharani Utami; Noorhamdani Noorhamdani; Masruroh Rahayu
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.17541

Abstract

Biofilm is a mechanism of bacterial defense against antimicrobials that can cause resistance. Staphylococcus aureus is a biofilm-producing bacteria and the most often cause of skin and soft tissue infections. Therefore, efforts are needed to prevent the formation of Staphylococcus aureus biofilms. Basil leaves are herbal plants that contain eugenol and tannin compounds, which are thought to inhibit the formation of biofilms. This research is a laboratory experimental study that aims to prove the effect of basil leaves ethanol extract (Ocimum sanctum) on the establishment of Staphylococcus aureus biofilms with in vitro method and determine the minimum inhibitory biofilm concentration needed. In this study, the tube method with 7 different concentrations was used. The results of biofilm ring formation obtained and measured quantitatively using Mean Gray Value in Adobe Photoshop CS6. From the study’s results, is found that the increase in extract concentration is directly proportional to the thinning of the biofilm ring on the tube with a minimum inhibitory concentration of biofilm at a concentration of 30%. The Pearson correlation test showed a very strong and significant correlation (r = 0.898, p = 0,000), and the Oneway ANOVA comparison test known a significant difference among the mean of each group (p = 0,000). From these results it can be known that the ethanol extract Ocimum sanctum can inhibit the formation of Staphylococcus aureus biofilms in vitro.
The Effectiveness of Vitamin C Addition to Blood Glucose Levels of Hyperglycemic Mice with Glimepiride Treatment Indi Kamilia Fitri; Cholis Abrori; Dion Krismashogi Dharmawan
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.9994

Abstract

In people with diabetes mellitus (DM) there is a decrease in basal vitamin C levels which is thought to be a result of oxidative stress in the condition of hyperglycemia that it needs to increase vitamin C as an antioxidant. Hyperglycemia in DM needs to be lowered by pharmacological therapy, named glimepirid so the purpose of this study is to determine the effectiveness of vitamin C addition to the reduction of KGD hyperglycemic mice with glimepirid treatment. This study is true experimental with a sample of 25 mice 20-30 grams and divided into five groups, first the control group (K0); STZ induction group (K1); STZ induction group with glimepirid treatment (K2); STZ induction group with the treatment of vitamin C (K3); STZ induction group by treatment of a combination of glimepirid and vitamin C (K4). STZ is injected intraperitonially 150 mg / kgBB. All groups were measured for KGD 1 after induction of STZ and KGD 2 after treatment for fourteen days. The results of the STZ induction group with the treatment of a combination of glimepirid and vitamin C (K4) experienced a smaller and not significant decrease in BSL in the STZ induction group with a single glimepirid (K2) treatment. These results are thought to have an influence from interactions between drugs that cause one drug to not work optimally. The conclusion of this study is that administration of glimepirid, vitamin C, or both can reduce blood glucose levels in hyperglycemic mice with the greatest decrease occurring in the glimepirid group.
The Protection Effect Of Methanol Extract From Asam Jawa Seed On Testicular Tissue Damage Induced By Aluminium Chloride (AlCL3) Rena Normasari; Muhammad Iqbal Fauzi; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.19645

Abstract

Aluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p <0.05). Post Hoc test using Mann Whitney obtained varied p values. Post Hoc analysis between K and P1 groups, P1 and P3 groups, P1 and P4 groups showed a significant difference with p value <0.05. Based on the results of this study, methanol extract from tamarind seeds (Tamarindus indica) that was given to male wistar rats had prevented histopathological damage to the testes of rats induced by aluminum chloride (AlCl3). Keywords: aluminium, testicular cell, Tamarindus indica
Reduction of Blood Glucose Levels by Apple Vinegar in Mice Induced by Dexamethasone Mochammad Syaruz Rachmansyah; Edy Junaidi; Erfan Effendi
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.11481

Abstract

The number of people with diabetes mellitus (DM) in the world is 425 million in 2017. The use of antidiabetic drugs usually lasts long enough with high side effects. Therefore, an alternative treatment with lower side effects and the efficacy same with synthetic drugs is needed. One of alternative treatment is apple fruit which can be processed into apple vinegar. Several studies have found the hypoglycemic effect of apple cider vinegar in various dosages. The author wants to know the reduction of blood glucose levels and the effective dose of apple vinegar in reducing blood glucose levels in mice induced by dexamethasone. The type of research is true experimental laboratories with pre and post-test with control group design. This study used 28 mice. Mice were given dexamethasone for 10 days to induce hyperglycemia. After experiencing hyperglycemia, mice were divided into 7 groups consisting of negative control group, positive control group, and treatment group of 0.0625 mL apple cider vinegar, 0.125 mL, 0.25 mL, 0.5 mL, and 1 mL. The research data obtained ΔGDP in each group. Furthermore, the reduction in glucose levels is calculated. Effective dose calculation by regression analysis using percentage reduction of blood glucose levels curve. The final results showed the maximum effective dose of apple vinegar in reducing blood glucose levels is 0.341 mL with percentage reduction of blood glucose levels is 18.6%.
Potential of Cocoa Extract (Theobroma cacao) in Inhibiting Erythrocyte Damage Induced by Physalia utriculus Venom Adinningtyas Intansari; Al Munawir; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.9661

Abstract

Physalia utriculus is one of the invertebrate marine biota that is often found in Indonesia. Some symptoms of venoming due to jellyfish stings cause pain, itching, and hemolysis. In Indonesia, 13 cases of jellyfish stings were reported in 2005-2009 with three people dying in Java, Bali, and Bangka. Cocoa beans (Theobroma cacao L.) contain fat, carbohydrates, proteins, and polyphenol compounds that are useful as antioxidants. Polyphenols in the form of epicathechins, catechins, and procyanidins serve to provide protection to hemolysis. The purpose of this study was to determine the potential of ethanol extract of cacao (Theobroma cacao L.) in inhibiting the damage of erythrocyte induced by Physalia utriculus in vitro. This study used 28 samples of erythrocytes divided into seven groups, namely the normal control group, negative controls, and treatment with cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02%. Each subsequent group induced venom Physalia utriculus. The results showed that the average speed of erythrocyte lysis in the treatment group by giving cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02% respectively (seconds ± standard deviation) was 858,25 ± 94,44; 1.000,5 ± 159,93; 678,5 ± 19,71; and 1.006 ± 159,50. The mean speed of erythrocyte lysis in the negative control group was 1,025 ± 164.63 and the positive control group with the administration of N-Acetylcystein can last up to one hour after administration of venoms. Test for normality and homogeneity shows that data is normally distributed and homogeneous. One Way Annova analysis shows the significance value of p <0.05, then a post hoc analysis test was performed with the Bonferoni method to find out the differences in significance in each group. In this study it can be concluded that the administration of cocoa ethanol extract has no potential to inhibit erythrocyte damage that has been venomed by Physalia utriculus in vitro. Keywords: Physalia utriculus, cacao, erythrocyte damage
The Effect of Young Coconut Water (Cocos Nucifera L.) Consumption on VO2max in Young Adults Non-Athletes Aris Prasetyo; Dheis Aninditha Suspim
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.20185

Abstract

Abstract The availability of carbohydrates and electrolytes in the body greatly affects Volume Oxigen Maximum (VO2max) to maintain stamina and endurance. The administration of young coconut water has the effect of increasing VO2max because it contains carbohydrates and electrolytes. The administration of young coconut water 15-60 minutes before exercise has the potential to delay exhaustion and increasing performance because glucose levels are maintained and muscle glycogen stores are restored. The purpose of this study was to determine the effect of administration of young coconut water on VO2max in young adults non-athletes. This study used a quasi experimental research design with a cross over design clinical trial. A total of 30 male non-athletes aged 18-24 years who fulfill the inclusion criteria were divided into groups randomLy, the treatment group (given 300 mL of coconut water) and the control group (given 300 mL of mineral water) 60 minutes before treatment, then crossover carried out 3 days after treatment. The results showed the control group fitness index was 141.83 ± 44.69, and the fitness index of the treatment group was 176.01 ± 59.07. The sample characteristics based on VO2max showed that the treatment group had a greater VO2max by a mean of 4.84 ± 1.05 compared to the control group with a mean of 4.19 ± 0.78. The results of the Paired T-Test showed a significance value of p= 0.000 (p <0.05) indicating that there was a significant difference between the control group and the treatment group. The conclusion of this study is that giving young coconut water increases VO2max levels in young adults non-athletes. Keywords: Young coconut water, VO2max, fitness index
Subacute Stent Thrombosis: Case Series Analysis Suryono Suryono
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.19207

Abstract

Abstrak Perkembangan penanganan penyakit jantung koroner (PJK) mengalami kemajuan pesat. Pada era percutaneus coronary intervention (PCI) mortalitas dan morbiditas PJK menurun dengan penempatan stent pada area stenosis. Namun, manajemen ini masih menyisakan masalah baru berupa stent trombosis (ST) akut sekitar 0,5-2,2% dari total kasus dengan mortalitas 45%. Beberapa faktor seperti prosedur intervensi, pasien dan karakteristik lesi serta resistensi platelet menjadi pemicu kejadian ST. Kemajuan industri stent, perkembangan prosedur intervensi, dan preparasi pasien dapat menekan kejadian ST, namun resistensi antiplatelet sebagai pemicu ST pada masing-masing individu belum dapat diprediksi.
The Correlation between Occupational Stress and Job Performance of Healthcare Workers at the University of Jember Medical Center Arista Nur Isnaini; Inke Kusumastuti; Ida Srisurani Wiji Astuti
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.20401

Abstract

Healthcare professionals are prone to experiencing stress and burnout due to their responsibility to care for one’s life and mistakes in the care delivery might lead to dire consequences for the patient. Occupational stress in the healthcare service could reduce the job performance of healthcare workers. This study was therefore conducted to determine the effect of occupational stress on the performance of healthcare workers in the University of Jember Medical Center. This study employed a cross-sectional design. The research sample was 28 healthcare workers at the University of Jember Medical Center. The results of the Pearson test showed a significance value of p = 0.725, indicating no significant correlation between occupational stress and job performance of health workers at the University of Jember Medical Center. Occupational stress might be experienced by healthcare workers at University of Jember Medical Center because University of Jember Medical Center as the first level of healthcare facilities acts as a gatekeeper with significant workload and functions. However, this occupational stress didn’t affect the work performance of the healthcare workers at University of Jember Medical Center due to their excellent stress management. Future studies might benefit from utilizing other more objective stress-related measurements and recruiting larger sample size. Keywords : Occupational stress, Job Performance, Healthcare Worker

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