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Global Medical and Health Communication

gmhc
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Published by Universitas Islam Bandung

ISSN : 23019123 EISSN : 24605441 DOI : https://doi.org/10.29313/gmhc

Core Subject : Health, Science,

Dentistry Health Professions Immunology & microbiology Nursing Public Health

Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.

Arjuna Subject : Kedokteran - Epidemilogi

Articles 422 Documents

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Primary Hippocampal Cell Culture and Its Application in Medical Researches Atik, Nur; Nandika, Alfya; Avriyanti, Erda; Bhatara, Tryando; Kartiwa, Raden Angga
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Studies in neuroscience can be performed in vitro and in vivo. In vivo studies will show significant results, but it is difficult to do and time-consuming. Primary hippocampal cell culture widely has used in neurobiological studies such as identifying the cellular mechanism of proteins, neuronal activity, and characteristics. The results of studies conducted on this cell culture will be very useful in discovering pathogenesis of a disease, the effect of a substance on the neuron, and neural basis of memory and learning. However, currently in Indonesia, primary hippocampal cell culture is still rare and difficult to do. The purpose of this study was to demonstrate that primary hippocampal cell culture can be done and developed in Indonesia and to review the application of it in medical researches. The study was an experimental study by obtaining neurons from animal’s hippocampus was conducted in 2015–2018 at Department of Cell Biology, Graduate School of Medicine Osaka University and Faculty of Medicine Universitas Padjadjaran. The experimental animal was mice embryo gathered 17.5-days postcoitus. Enzymatic and mechanical methods collected primary hippocampal cells. The cells counted and cultured, which later were observed to see neuron differentiation. The average number of culture cells from 3 embryonic’s hippocampus were 2.39×106. Neuron differentiation observed on the first day and more visible and numerous on the third day after plating. In conclusion, primary hippocampal cell culture using hippocampus from one hemisphere of embryonic mice brain showed a sufficient number of cells to carry out research and showed neuron differentiation. KULTUR SEL PRIMER HIPOKAMPUS DAN PENGGUNAANNYA DALAM RISET KEDOKTERANPenelitian dalam neurobiologi dapat dilakukan secara in vitro dan in vivo. Penelitian secara in vivo sangat berdampak hasilnya, namun sulit dan memakan waktu yang lama. Kultur sel primer hipokampus banyak digunakan dalam penelitian neurobiologi seperti melihat mekanisme protein seluler, serta aktivitas dan karakteristik neuron. Hasil penelitian yang dilakukan pada kultur sel ini akan sangat bermanfaat dalam menemukan proses suatu penyakit, efek suatu zat terhadap sel saraf, dan kemampuan belajar serta memori. Akan tetapi, saat ini di Indonesia kultur sel primer hipokampus masih jarang dan sulit dilakukan. Tujuan penelitian ini adalah menunjukkan bahwa kultur sel hipokampus primer dapat dilakukan dan dikembangkan di Indonesia, serta meninjau penerapannya dalam riset kedokteran. Penelitian ini merupakan studi eksperimental dengan mengoleksi neuron dari hipokampus hewan coba yang dilakukan pada tahun 2015–2018 di Department of Cell Biology, Graduate School of Medicine Osaka University dan Fakultas Kedokteran Universitas Padjadjaran. Hewan coba berupa embrio mencit hari ke-17,5 pascakoitus. Sel primer hipokampus dikoleksi untuk dihitung dan dikultur menggunakan metode enzimatik dan mekanik. Observasi neuron pada kultur dilanjutkan dengan mengamati diferensiasi neuron. Rerata jumlah sel kultur dari 3 hipokampus adalah 2,39×106. Diferensiasi neuron sudah tampak pada hari pertama dan makin jelas serta tampak pada hari ketiga pascapenanaman. Simpulan, kultur sel primer hipokampus menggunakan hipokampus dari salah satu sisi hemisfer otak menunjukkan jumlah sel yang cukup untuk melakukan suatu penelitian dan menunjukkan diferensiasi dari neuron.

Pengaruh Ekstrak Etanol Buah Mahkota Dewa {Phaleria macrocarpa (Scheff) Boerl} per Oral terhadap Kontraktilitas Uterus Mencit Model Gravida Raden Anita Indriyanti; M. Sujatno; A. W. Soekandar
Global Medical & Health Communication (GMHC) Vol 4, No 1 (2016)
Publisher : Universitas Islam Bandung

Tanaman mahkota dewa {Phaleria macrocarpa (Scheff) Boerl} adalah tanaman yang tumbuh dan dimanfaatkan sebagai obat alternatif karena memiliki kandungan zat aktif yang dapat menyembuhkan berbagai penyakit. Penggunaan mahkota dewa ini tidak boleh dikonsumsi oleh wanita hamil karena dapat meningkatkan kontraksi uterus sehingga dapat menyebabkan abortus. Tujuan penelitian membandingkan efek pemberian ekstrak buah mahkota dewa dengan oksitosin terhadap kontraktilitas uterus. Penelitian eksperimental laboratorik dilakukan di Laboratorium Faal dan Farmakologi Klinik Fakultas Kedokteran Unpad Jatinangor Bandung periode Juli–November 2005 dengan memakai 27 ekor mencit gravida galur Swiss-Webster dalam 3 kelompok. Kelompok I sebagai kontrol negatif, kelompok II diberi suntikan oksitosin 0,045 mL/mnt (0,45 mU) intravena, dan kelompok III diberi ekstrak buah mahkota dewa kadar 6,25% sebanyak 0,5 mL per oral. Tiap-tiap kelompok diukur kontraktilitas uterusnya. Hasil perhitungan diolah dengan analisis varians (ANOVA) dilanjutkan dengan Uji Duncan. Pada kelompok mahkota dewa menggambarkan kontraksi yang bersifat ritmis dengan amplitudo kecil dan nilai frekuensi kontraksi tertinggi (119x/30 menit) dan perbedaan yang sangat signifikan versus kelompok kontrol tanpa perlakuan (16x/30 menit) dan kelompok oksitosin (23x/30menit). Kekuatan kontraksi pada pemberian ekstrak etanol buah mahkota dewa lebih rendah (1,2 cm) daripada kelompok kontrol tanpa perlakuan (1,6 cm), sedangkan kelompok yang diberi oksitosin menghasilkan kekuatan kontraksi paling kuat (2,6 cm). Simpulan, pemberian ekstrak etanol buah mahkota dewa menggambarkan kontraksi yang bersifat ritmis dengan amplitudo kecil serta menghasilkan frekuensi kontraksi tertinggi dan amplitudo terendah dibanding dengan kelompok kontrol dan kelompok oksitosin intravena. THE EFFECT OF MAHKOTA DEWA {PHALERIA MACROCARPA (SCHEFF) BOERL} FRUIT ETHANOL EXTRACTS PER ORAL TO UTERINE CONTRACTION OF GRAVIDA TYPE MICEMahkota dewa {Phaleria macrocarpa (Scheff) Boerl} known as a plant that used as an alternative medicine. Because of its rich active substances, it is believed to heal many diseases. Caution for this plant is that it must not be consumed by pregnant women, because it may increase the uterine contraction and cause an abortion. The aim of strudy was to compare the effect of Phaleria macrocarpa (Scheff) Boerl fruit extracts and oxytocin to uterine contraction. The experimental study with complete randomized had been conducted to 27 pregnant Swiss-Webster mouses in Laboratorium Faal and Farmakologi Klinik Fakultas Kedokteran Unpad Jatinangor Bandung periode July–November 2005 that devided in 3 groups. Group I served as a negative control, group II was given oxytocin 0.045 mL/mnt (0.045 mU) intravenous, and group III was given mahkota dewa ethanol extract 6.25% for 0.5 mL orally. The measurement for each group’s uterine contractility consisted of the number of frequency and level of contraction strength. The result analyzed using variant analysis (ANOVA) and Duncan test. Result showed that in mahkota dewa group, a rhythmical contraction with low amplitudo with the highest point (119x/30 mnt) for contraction frequency, compared to control group(16x/30 mnt) and oxytocin group (23x/30 mnt). It showed that in group given mahkota dewa ethanol extract the level of contraction strength was lower (1.2 cm) than control group (1.6 cm). While group given oxytocin intravenously had the highest level of contraction strength (2.6 cm). In conclusion mahkota dewa ethanol extract performed a rhythmical contraction with low amplitudo and has the highest point for contraction frequency, and the lowest level of contraction strength compared to those in control group and oxytocin group.

Penurunan Kadar Gula Darah Akibat Pemberian Ekstrak Manggis (Garcinia mangostana) dan Tomat (Lycopersicum esculentum Mill) pada Tikus Diabetes Yusni Yusni; Ieva Baniasih Akbar; Rezania Rezania; Raipati Fahlevi
Global Medical & Health Communication (GMHC) Vol 5, No 1 (2017)
Publisher : Universitas Islam Bandung

Masyarakat percaya bahwa kulit manggis dan tomat dapat menurunkan kadar gula darah dan bermanfaat sebagai antidiabetes, namun hal ini perlu diuji untuk menemukan bukti ilmiahnya. Tujuan penelitian ini adalah menganalisis efek penurunan kadar gula darah akibat pemberian kombinasi ekstrak kulit manggis (Garcinia mangostana) dengan tomat (Lycopersicum esculentum Mill) pada tikus putih (Rattus norvegicus) Wistar diabetes. Penelitian ini menggunakan rancangan pretest-posttest with control group design. Ekstrak manggis dan tomat dibuat di Laboratorium Kimia, FMIPA, Universitas Syiah Kuala, Banda Aceh, sedangkan pemberian perlakuan dan pemeriksaan kadar gula darah dilakukan di Laboratorium Hewan Coba, Fakultas Kedokteran Hewan, Universitas Syiah Kuala, Banda Aceh. Waktu penelitian bulan September–November 2015. Subjek penelitian adalah tikus putih jantan galur Wistar sebanyak 30 ekor. Tikus dibagi dalam 3 kelompok secara acak dengan tiap kelompok 10 ekor: kelompok 1 (K1) adalah tikus yang tidak diinduksi aloksan dan tidak diberikan perlakuan (kontrol negatif), kelompok 2 (K2) adalah tikus yang diinduksi aloksan dan tidak diberikan perlakuan (kontrol positif), dan kelompok 3 (K3) adalah tikus yang diinduksi aloksan dan diberikan perlakuan. Perlakuan berupa pemberian ekstrak kulit manggis dan tomat 50 mg/kgBB/hari masing-masing selama 7 hari. Pemeriksaan kadar gula darah (KGD) dilakukan sebelum dan setelah pemberian perlakuan menggunakan glukometer (NESCO®). Analisis data menggunakan uji normalitas, homogenitas, dan uji ANOVA (p<0,05). Hasil penelitian menunjukkan KGD setelah perlakuan pada kelompok perlakuan mengalami penurunan secara bermakna (K1: 98,10±14,91 vs 92,50±13,97; K2: 237,10±30,31 vs 330,10±63,70; K3: 277,80±74,02 vs 105,10±15,89: p=0,00). Simpulan, pemberian kombinasi ekstrak kulit manggis dan tomat dosis 50 mg/kgBB/hari masing-masing menurunkan kadar glukosa darah tikus diabetes. Ekstrak kulit manggis dan tomat berpotensi dikembangkan sebagai obat antidiabetes.BLOOD SUGAR LEVELS REDUCTION BY MANGOSTEEN (GARCINIA MANGOSTANA) AND TOMATO (LYCOPERSICUM ESCULENTUM MILL) IN DIABETIC RATSThe people believe that the mangosteen and tomatoes can reduce blood sugar levels and useful as antidiabetic however, this statement still needs to be tested scientifically. The purpose of this study was to analyze the effect of a decrease in blood sugar levels due to the effect of the combination of mangosteen peel extract (Garcinia mangostana) and tomato (Lycopersicum esculentum Mill) in rats (Rattus norvegicus) Wistar. This type of research using a pretest-posttest control group design. The subjects were male Wistar rats with a number of subjects as many as 30 individuals. Rats were divided into 3 groups randomly with each groups of 10 rats: group 1 (K1) were rats that was not induced alloxan and not given treatment (negative control), group 2 (K2) were rats induced alloxan and given no treatment (positive control), and group 3 (K3) were rats induced alloxan and also given treatment. Provision of treatment in the form of mangosteen peel and tomato extract with each dose of 50 mg/kgBW/day and given for 7 days. Blood sampling for checking blood sugar levels is performed before and after treatment. blood sugar levels examination carried out using a glucometer (NESCO®). Analysis of data using normality, homogeneity, and ANOVA tests (p<0.05). The results showed that the blood sugar levels after administration of a combination of mangosteen peel and tomato extract in the treatment group experienced a significant reduction (K1: 98.10±14.91 vs 92.50±13.97; K2: 237.10±30.31 vs 330.10±63.70; K3: 277.80±74.02 vs 105.10±15.89: p=0.00). It can be concluded that the administration of a combination of mangosteen peel and tomato extract with each dose of 50 mg/kgBW/day can lower blood sugar levels in diabetic rats. This indicates that the mangosteen and tomatoes potential to be developed as an antidiabetic drug.

Profil Massa Lemak dan Lingkar Pinggang Dewasa Obes dan Nonobes di Cirebon Stephanus Kristianto Witono; Gaga Irawan Nugraha; Hikmat Permana; Sudigdo Adi
Global Medical & Health Communication (GMHC) Vol 6, No 1 (2018)
Publisher : Universitas Islam Bandung

Kelebihan berat badan dan kegemukan mulai menjadi masalah terhadap kesehatan pada beberapa dekade terakhir. Hal ini menjadi masalah serius terhadap kesehatan karena dapat menyebabkan sindrom metabolik yang berujung kepada kematian sehingga kegemukan perlu kita cegah sedini-dininya. Deteksi dini khususnya massa lemak dan lingkar pinggang yang menjadikan faktor prediktor sindrom metabolik perlu dilakukan untuk mencegah perjalanan penyakit obesitas. Penelitian deskriptif ini dilakukan terhadap 116 pasien (47 pasien obes dan 69 nonobes) di Klinik Pasar Balong Cirebon, 14–21 April 2016 dengan rentang usia 35–60 tahun. Pengukuran berat badan, massa lemak, dan massa bebas lemak menggunakan professional octapolar body impedance analyzer Beurer BF100, pengukuran tinggi badan menggunakan Stadiometer Seca 213 dan lingkar pinggang menggunakan body tape measure caliper Onemed. Tujuan penelitian ini adalah mengetahui persentase massa lemak dan lingkar pinggang dewasa obes dengan nonobes di Kota Cirebon sehingga dapat dijadikan acuan dalam mengatasi obesitas. Hasil massa lemak rata-rata pria dan wanita obes 30,98±4,24% dan 39,29±3,56%, serta lingkar pinggang 108,20±7,59 cm dan 93,46±8,91 cm yang berarti rata-rata dewasa obes di Cirebon mempunyai massa lemak jauh di atas klasisfikasi buruk dari American College of Sport Medicine dan lingkar pinggang jauh di atas batasan World Health Organization dan International Diabetes Federation untuk orang Asia. Hasil massa lemak rata-rata pria nonobes dalam klasifikasi rata-rata 17,81±5,21% dan wanita nonobes di bawah rata-rata 25,87±2,48%. Lingkar pinggang pria dan wanita nonobes 79,00±6,93 cm dan 74,72±5,44 cm, masih dalam klasifikasi normal. Simpulan, orang dewasa di Kota Cirebon baik obes maupun nonobes khususnya wanita mempunyai massa lemak masuk ke dalam klasifikasi buruk. Lingkar pinggang dewasa obes baik pria maupun wanita melebihi batasan World Health Organization dan International Diabetes Federation. FAT MASS AND WAIST CIRCUMFERENCE PROFILE OF ADULT OBESE AND NON-OBESE IN CIREBONOverweight and obesity are starting to become a serious health problems in the last few decades because it can cause metabolic syndrome that leads to death, so we need to prevent obesity as early as possible. We need to do early detection especially fat mass percentage and waist circumference that makes predictor factor of the occurrence of metabolic syndrome is needed to prevent or even to cut the course of obesity disease. This descriptive study was conducted on 116 patients (47 obese and 69 non-obese patients) at the Klinik Pasar Balong Cirebon, April 14–21, 2016 with age range of 35–60 years. Measurement of body weight, fat mass, fat free mass using professional octapolar body impedance analyzer Beurer BF100, while height measurement using Seca 213 Stadiometer and waist circumference using body tape measure caliper Onemed. The purpose of this research was to know fat mass and waist circumference of obese and non-obese in Cirebon, so it can be used as a reference in overcoming obesity. The mean value of fat mass men and women obese were 30.98±4.24% and 39.29±3.56%, and waist circumference 108.20±7.59 cm and 93.46±8.91 cm, which means the mean value obese adults in Cirebon have fat mass far above the bad classification of American College of Sport Medicine and waist circumference far above the boundaries of the World Health Organization and International Diabetes Federation for Asians. The mean value of non-obese fat mass percentage gain in the average classification was 17.81±5.21% and non-obese women in the classification below the average 25.87±2.48%. Non-obese male and female waist circumference 79.00±6.93 cm and 74.72±5.44 cm, still in normal classification. In conclusion, adults in Cirebon both obese and non-obese, especially women have fat mass percentage fall into bad classification. While obese adult waist circumference exceeds the limits of World Health Organization and International Diabetes Federation.

Konseling Adherence untuk Pengobatan Infeksi HIV/AIDS: Perlukah? Nirmala Kesuma
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Universitas Islam Bandung

Pengobatan antiretroviral (ARV) untuk infeksi human immunodeficiency virus/acquired immunodefisiency syndrome (HIV/AIDS) adalah pengobatan seumur hidup dengan tujuan menekan replikasi HIV dalam darah, sehingga tidak terdeteksi dengan pemeriksaan laboratorium dan pada akhirnya akan memperbaiki kualitas hidup penderita. Kegagalan terapi masih sering terjadi oleh karena ketidakpatuhan (adherence) untuk minum obat ARV. Kriteria minum ARV dengan adherence yang baik harus memenuhi ketepatan waktu minum obat, dosis obat yang benar, dan jumlah pil yang harus diminum. Pengobatan dikatakan baik apabila dalam jangka waktu sebulan semua kriteria di atas mencapai 95%. Untuk memastikan adherence minum ARV diperlukan konseling sebelum mulai minum obat. Konseling meliputi edukasi, informasi, dan dukungan emosional terhadap pasien. Sejak diberlakukannya konseling adherence di Klinik Teratai, angka kematian pasien menurun dari 13,6% pada tahun 2006 menjadi 4,3% pada tahun 2009. Simpulan, hasil penelitian di Klinik Teratai RS Dr. Hasan Sadikin Bandung menunjukkan pentingnya pasien menjalani konseling adherence sebelum memulai terapi ARV.ADHERENCE COUNSELLING FOR HIV INFECTION/AIDS TREATMENT: IS IT NECESSARY?Anti retroviral treatment (ART) for human immunodeficiency virus (HIV) infection/acquired immunodefficiency syndrome (AIDS) is a life-long treatment with the goal of the suppression of virus replication to achieve patient improved quality of life. Unfortunatelly, number of treatment failures among patient receiving ART is still high because of poor adherence. The criteria for good adherence include taking the pills in the exact time, using exact doses and number of pills. To be considered good, the level of adherence should be more than 95% during monthly treatment. Adherence counselling is an important intervention for the patient before starting ARV treatment. Counseling provides education, information and emotional support to patients. Since adherence counseling was conducted in Teratai Clinic, the number of death was significantly decreased from 13,6% in 2000 to 4,3 % in 2009. Clinical results of studies in Teratai Clinic Dr. Hasan Sadikin Hospital Bandung shows the importance of adherence counselling before starting ARV treatment.

Karakteristik Pasien dan Spesies Dermatofita Penyebab Tinea Kruris di Rumah Sakit Umum Daerah Gunung Jati Cirebon Jawa Barat Maya Wahdini; Lies Marlysa Ramli; Risa Miliawati N.H.
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Tinea kruris merupakan salah satu dermatofitosis tersering di dunia, terutama di negara berkembang dan beriklim tropis. Prevalensi dermatofitosis dan spesies penyebabnya bervariasi bergantung pada letak geografis dan berubah dari waktu ke waktu. Penelitian aspek epidemiologis dan spesies penyebab penyakit diperlukan untuk menentukan masalah kesehatan yang dihadapi, termasuk karakteristik umum, durasi penyakit, sumber penularan, lokasi penyakit pada tubuh, efloresensi, dan kultur spesies Dermatofita. Prevalensi tinea kruris di Provinsi Jawa Barat belum banyak diketahui. Tujuan penelitian ini adalah mengetahui karakteristik pasien dan spesies Dermatofita di RSUD Gunung Jati Cirebon sehingga dapat melengkapi data pola tinea kruris di Jawa Barat. Penelitian dilaksanakan di Poliklinik Kulit dan Kelamin RSUD Gunung Jati Cirebon periode Februari–April 2014. Rancangan penelitian adalah deskriptif potong lintang dengan pengambilan sampel sesuai urutan kedatangan pasien. Subjek penelitian adalah pasien tinea kruris di Poliklinik tersebut. Terhadap seluruh subjek dilakukan anamnesis, pemeriksaan fisis, dan pengambilan sampel kerokan kulit lesi untuk pemeriksaan mikroskopis langsung dan kultur jamur sehingga didapatkan 37 pasien koloni jamur positif. Pasien tinea kruris mayoritas pada wanita (24/37 pasien), usia tersering 15–44 tahun (22/37 pasien), pendidikan SD/SMP (22/37 pasien), ibu rumah tangga (9/37 pasien), gizi cukup (23/37 pasien), durasi penyakit 2 minggu–6 bulan, pertama kali terkena (30/37 pasien), disertai gatal dan berkeringat. Sumber penularan tidak diketahui (25/37 pasien), kebanyakan central clearing (19/37 pasien) dan pada lipat paha/bokong berupa makula, papula, skuama, dan hiperpigmentasi (11/37 pasien). Spesies Dermatofita penyebab tinea kruris yang paling banyak ditemukan adalah Trichophyton rubrum (28/37 pasien), diikuti dengan Trichophyton mentagrophytes (9/37 pasien). PATIENT'S CHARACTERISTIC AND DERMATOPHYTES SPECIES CAUSING TINEA CRURIS AT GUNUNG JATI GENERAL HOSPITAL CIREBON WEST JAVATinea cruris is one of the most common dermatophytosis in the world, especially in developing countries and area with warm climates. The prevalence of dermatophytosis and their etiological agents vary with geographical location and change from time to time. Study epidemiological aspects of diseases and causative agents are useful for determining the magnitude of the health problem, including general characteristics, duration of disease, source of infection, location at the body, efflorescence, and culture of Dermatophytes species. The prevalence of dermatophytosis, especially tinea cruris in West Java is unknown. The objective of this study was to know the patient's characteristic and to determine the species causing dermatophytes in Gunung Jati General Hospital Cirebon, to complete the data patterns of dermatophyte species causing tinea cruris in West Java. The study was conducted at the Dermatovenereology Clinic Gunung Jati General Hospital, Cirebon during February–April 2014. This was a descriptive cross-sectional study with consecutive sampling methods. The subjects of this study were tinea cruris patients who visited the clinic. History taking, physical examination, sampling of skin scrapings from lesion were performed in all patients. Skin scrapings was taken for direct microscopic examination and fungal cultures until 37 patients with positive fungal colonies was achieved. There were most commonly found in female (24/37 patients), age 15–44 years (22/37 patients), elementary school graduated (22/37 patients), housewives (9/37 patients), normal nutritional status (23/37 patients), duration of illness 2 weeks–6 months, first time exposured (30/37 patients), with complaints of itching and sweating. The source of the infection was unknown (25/37 patients), the most common locations was central clearing (19/37 patients) and also groin and buttocks with the most common efflorescence were macula, papules, squamma, and hyperpigmented scaly patches (11/37 patients). The most commonly isolated dermatophytes were Trichophyton rubrum (28/37 patients), followed by Trichophyton mentagrophytes (9/37 patients).

Spatial Distribution of Dengue Hemorrhagic Fever (DHF) in Urban Setting of Bandung City Titik Respati; Ardini Raksanagara; Henni Djuhaeni; Asep Sofyan
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

The proximity of urban area provides fertile ground for the exchange of bacteria, virus and other health problem. One of the diseases which have a close relationship with the environment and people interaction is dengue. At present, it still is one of the major health problems for Indonesia. One method to understand the disease is by using spatial analysis that the prevention program can be focusing on the area most affected. This study aims to analyze the spatial distribution of dengue cases in Bandung city. The method used was the mapping of dengue cases using geographic information system (GIS) with ArcView software. Data were collected from August 2015 to March 2016 in Bandung city. Results showed that dengue cases increased with fluctuated hyperendemic years especially in the year 2009, 2012, and 2013. Spreading pattern of the disease was from north of Bandung to east. The conclusion of this study dengue cases in Bandung city showed an increased trend with fluctuated hyperendemic year especially in the year 2009, 2012, and 2013. Pockets of highest reported cases were found in north to middle and east for the whole year. The spread of this disease, especially in east Bandung, showed wider affected areas in the observed year. Land usage for residential purposes without good development plan might be on factors that increase the disease transmission. DISTRIBUSI SPASIAL KASUS DEMAM BERDARAH DENGUE DI DAERAH URBAN KOTA BANDUNGKedekatan dalam wilayah urban memberikan kemudahan dalam pertukaran bakteri, virus, dan masalah kesehatan lainnya. Salah satu penyakit yang erat hubungannya dengan kedekatan pemukiman, lingkungan, dan interaksi manusia adalah demam berdarah dengue (DBD). Sampai saat ini DBD masih menjadi masalah kesehatan di Indonesia. Pencegahan suatu penyakit akan lebih mudah dilakukan apabila pemahaman mengenai penyakit tersebut sudah dapat dilakukan dengan baik. Dengan pemetaan (distribusi spasial), kasus DBD akan lebih mudah dimonitor sehingga program pencegahan dapat difokuskan pada wilayah dengan angka kejadian yang tinggi. Penelitian ini bertujuan melihat distribusi spasial kasus DBD mempergunakan geografic information system (GIS) di Kota Bandung. Metode penelitian ini adalah pemetaan kasus di wilayah tertentu dengan GIS menggunakan ArcView software menggunakan data kasus DBD dan data spasial dilaksanakan pada tahun 2015 di Kota Bandung. Hasil penelitian kasus DBD di Kota Bandung menunjukkan peningkatan dengan pola tahun hiperendemik berfluktuasi terutama pada tahun 2009, 2012, dan 2013. Pola pergerakan kasus tampak berawal dari arah utara menuju timur. Kantong wilayah dengan kasus DBD yang tinggi terkumpul di daerah utara menuju timur Kota Bandung sepanjang tahun. Simpulan penelitian ini, penyebaran kasus di wilayah Bandung menunjukkan daerah sebaran yang semakin besar dari tahun ke tahun. Pemanfaatan lahan sebagai pemukiman memiliki keterkaitan terhadap kejadian DBD.

Hubungan Tingkat Pendidikan dan Pengetahuan Ibu tentang Diare dengan Frekuensi Kejadian Diare Balita di Wilayah Kerja Puskesmas Tamansari Bandung Oktober 2013–Maret 2014 Hoirunisa Fathia; Maya Tejasari; Siti Annisa Devi Trusda
Global Medical & Health Communication (GMHC) Vol 3, No 1 (2015)
Publisher : Universitas Islam Bandung

Penyakit diare di Indonesia semakin meningkat yang dapat menyebabkan kematian terutama balita. Salah satu faktor yang memengaruhi frekuensi kejadian diare adalah pengetahuan, sikap, dan perilaku orangtua tentang diare. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pendidikan dan pengetahuan ibu tentang diare dengan frekuensi kejadian diare balita di wilayah kerja Puskesmas Tamansari Kota Bandung. Penelitian ini bersifat observasional analitik dengan rancangan desain potong lintang (cross sectional) periode April–Juni 2014. Subjek penelitian ini adalah ibu yang memiliki balita di wilayah kerja Puskesmas Tamansari. Jumlah sampel penelitian sebanyak 97 orang. Data yang dikumpulkan berupa data primer menggunakan kuesioner yang sudah divalidasi. Pengolahan data menggunakan SPSS versi 21 dan analisis statistik menggunakan uji chi-kuadrat. Hasil menunjukkan bahwa responden berpendidikan tinggi memiliki balita yang sebagian besar tidak pernah diare dan analisis statistik menunjukkan hubungan bermakna antara tingkat pendidikan dan frekuensi kejadian diare balita (p=0,001). Responden dengan pengetahuan baik sebanyak 21 dari 36 subjek memiliki balita tidak pernah diare dan analisis statistik menunjukkan hubungan bermakna antara tingkat pengetahuan ibu dan frekuensi kejadian diare balita (p=0,007). Simpulan, terdapat hubungan tingkat pendidikan ibu dan pengetahuan ibu tentang diare dengan frekuensi kejadian diare balita di wilayah kerja Puskesmas Tamansari. THE RELATIONSHIP LEVELS OF EDUCATION AND MOTHER'S KNOWLEDGE ABOUT THE FREQUENCY OF OCCURENCE OF DIARRHEA IN INFANTS OF TAMANSARI BANDUNG IN OCTOBER 2013–MARCH 2014Diarrhea disease in Indonesia is increasing, can cause death, especially in infants. One of the factors that affect the frequency of occurrence of diarrhea is knowledge, attitudes, and behaviors of parents of diarrhea. This study aims was to determine the relationship between levels of education and mother's level of knowledge about the frequency of occurrence of diarrhea in infants Puskesmas of Tamansari Bandung. This study was an observational analytic cross-sectional design in period April–June 2014. The subjects were mothers who had children in the Puskesmas of Tamansari. The number of samples were 97 people. The data collected for this study in the form of primary data using questionnaires that have been validated. Processing data using SPSS version 21 and statistical analysis using chi-square test. The results indicated that respondents with higher education category had largely toddler never had diarrhea. The results of statistical analysis showed that there was a significant relationship between the level of education and the frequency of occurrence of diarrhea infants (p=0.001). Respondents with good knowledge most had diarrhea toddler never amounted 21 of 36 subjects and the results of statistical analysis showed that there was a significant relationship between the level of knowledge of mothers with children under five diarrhea occurrence frequency (p=0.007). In conclusion, there is a relationship between the level of maternal education and the mother's level of knowledge about the frequency of occurrence of diarrhea in infants Puskesmas of Tamansari.

Profil Ekspresi mRNA Gen Murine Double Minute2, Kruppel-Like Factor4, dan c-Myc pada Fibrosarkoma Humaryanto Humaryanto; M. Nurhalim Shahib; Yoni Fuadah Syukriani; Nucki Nursjamsi Hidayat
Global Medical & Health Communication (GMHC) Vol 5, No 1 (2017)
Publisher : Universitas Islam Bandung

Fibrosarkoma hanya terjadi 1–3% dari seluruh keganasan jaringan lunak. Hingga saat ini etiologi fibrosarkoma belum diketahui dengan pasti. Beberapa faktor dapat menjadi penyebab patogenesis fibrosarkoma antara lain radiasi, terpapar zat kimia tertentu, serta infeksi human herpes virus 8 (HHV8) dan Epstein-Barr virus (EBV). Penelitian terkini menunjukkan bahwa banyak sarkoma terkait dengan mutasi genetik. Penelitian ini bertujuan melihat profil ekspresi mRNA gen Krüppel-like Factor4, Murine Double Minute2, dan c-Myc pada fibrosarkoma menggunakan teknik real time PCR kuantitatif (quantitative real time PCR, qRT-PCR). Analisis data menggunakan metode kuantititatif relatif 2-ΔΔCt. Penelitian ini menggunakan 10 sampel kasus fibrosarkoma yang ditemukan di Kota Jambi dari tahun 2011–2015. Hasil ΔCt (+SD) MDM2, KLF-4, dan c-Myc disusun dari nilai yang terkecil hingga tertinggi adalah 1,85±2,14; 2,06±3,86; 2,9±2,66 secara berurutan. Dibanding dengan level ekspresi dengan GAPDH sebagai housekeeping gene, gen MDM2 dan KLF-4 relatif menurun dua kali lipat, sedangkan gen c-Myc relatif menurun lebih dari tiga kali lipat. Simpulan, penelitian ini menunjukkan bahwa pada kasus fibrosarkoma, gen c-Myc disupresi lebih kuat dibanding dengan gen MDM2 dan KLF-4.STUDIES ON MRNA GENE EXPRESSION OF MDM2, KLF4,AND C-MYC IN FIBROSARCOMAFibrosarcoma is a rare soft tissue sarcoma, reported only 1–3% of all soft tissue sarcomas. Like any other soft-tissue sarcomas the definitive caused has not yet understood. Recognized causes include exposure to ionizing radiation, various physical and chemical factors, infection with human herpes virus (HHV8) and Epstein-Barr virus (EBV). Current research indicates many sarcomas are associated with genetic mutations. In this study, we investigated profile of mRNA gene expression KLF4, MDM2, and c-Myc of RNA in fibrosarcoma cases. The genes expression was examined using quantitative real time PCR (qRT-PCR) and we analyzed the relative gene expression using the 2-ΔΔCt method. Ten samples of fibrosarcoma cases found in Jambi city from 2011 to 2015 were used. The three targeting genes were placed in the order from lowest to highest base on their ΔCt values compared to internal control genes using GAPDH genes. The results are as follows: MDM2 1.85±2.14, KLF-4 2.06±3.86, and c-Myc 2.9±2.66 respectively. A relative quantification by normalized target gene relative to GAPDH, describes the changes in expression of three genes. The status of MDM2 and KLF-4 were relatively decreased expression by 2 fold, and the states of c-Myc were relatively decreased by more than 3 fold. This suggest that in fibrosarcoma the c-Myc gene are suppressed stonger than those MDM2 and KLF-4 genes.

Koinfeksi Sifilis Sekunder dan HIV pada Seorang Laki Suka Laki Ayu Nur Ain; Rachmatdinata Rachmatdinata; Tony S. Djajakusumah
Global Medical & Health Communication (GMHC) Vol 1, No 2 (2013)
Publisher : Universitas Islam Bandung

Dilaporkan satu kasus koinfeksi sifilis sekunder dan HIV disertai dermatitis kontak iritan pada seorang laki suka laki (LSL) berusia 24 tahun. Gambaran klinis berupa makula eritema, papula eritema, plak eritema, dan skuama tipis pada kulit kepala berambut, leher, dada, punggung, kedua lengan, dan kedua tungkai bawah. Pada kedua telapak tangan dan kaki terdapat makula eritema. Pada korpus penis dan skrotum didapatkan makula eritema, makula hiperpigmentasi, dan makula hipopigmentasi. Diagnosis sifilis sekunder ditegakkan berdasarkan gambaran klinis serta hasil pemeriksaan veneral disease research laboratory (VDRL) 1/128 dan Treponema pallidum haemagglutination assay (TPHA) 1/2.560. Penderita diterapi dengan benzatin penisilin G 2,4 juta UI intramuskular sekali seminggu selama tiga minggu. Perbaikan klinis didapatkan pada hari ke-9 dan penurunan titer VDRL sebanyak dua kali didapatkan pada satu bulan setelah pemberian terapi benzatin penisilin G yang pertama. SECONDARY SYPHILIS AND HIV COINFECTION IN A MEN WHO HAVE SEX WITH MENA case of secondary syphilis and HIV coinfection accompanied by irritant contact dermatitis in a 24-year-old men who have sex with men (MSM) was reported. The patient presented with erythematous macules, papules, plaque, and thin scales on the scalp, neck, chest, back, both arms and lower limbs. There were erythematous macules on both palms and soles, also erythematous macules, hiperpigmented macules, and hypopigmented macules on the penile shaft and scrotum. Diagnosis of secondary syphilis was established based on clinical appearances and results of veneral disease research laboratory (VDRL) 1/128 and Treponema pallidum haemagglutination assay (TPHA) 1/2,560. The patient was treated with intramuscular 2.4 million IU benzathine penicilline G once weekly for three weeks. Clinical improvement was appeared on the 9th day and twofold decrease of VDRL titer in one month after first administration of benzathine penicilline G.

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Agus Chalid

Contact Email gulid.p@gmail.com

Phone +6285220013654

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Editorial Address Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location Kota bandung, Jawa barat INDONESIA

Abstract

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Contact Name
Agus Chalid

Contact Email
gulid.p@gmail.com

Phone
+6285220013654

Journal Mail Official
gmhc.unisba@gmail.com

Editorial Address
Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location
Kota bandung,

Jawa barat

INDONESIA