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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 349 Documents

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PENGARUH KOMBINASI EKSTRAK ETANOL DAUN SIRSAK DAN GEMFIBROZIL TERHADAP KADAR TRIGLISERIDA DAN HDL TIKUS YANG DIINDUKSI PAKAN TINGGI LEMAK Ririn Lispita Wulandari; Sri Susilowati; Sucyati Amelya
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Soursop leaves ethanol extract (SLEE) has been shown to lower blood levels of total cholesterol. However, it not yet investigated the effects on triglyceride and HDL levels. There is also no research on combining related soursop leaves with gemfibrozil. The purpose of this study is to compare the efficacy of combination therapy SLEE and gemfibrozil to SLEE or gemfibrozil single treatment on decreasing triglyceride levels and increase HDL level in rats induced by high-fat feeding. Thirty male Wistar rats were divided into six groups (normal control, hyperlipidemia control, single gemfibrozil, single SLEE, 1st combination, and 2nd combination groups). Each group treated a high-fat feed two times a day for 14 days, except for the normal control. The test material was treated one time a day for five days. Measurement levels of triglycerides and HDL used GPO-PAP reagent and Direct Enzymatic Colorimetric Test. The data was analyzed by One-Way ANOVA test followed by Tukey's test. The results showed that SLEE can decrease triglyceride’s level and increase HDL levels of male Wistar rats. The combination of SLEE and gemfibrozil also can decrease triglyceride’s level and increase HDL level. However, there are no significances different between the efficacy of combination SLEE and gemfibrozil than SLEE or gemfibrozil single treatment in decreasing triglyceride's level and increase HDL levels of male Wistar rats. Keywords: Hyperlipidemia, triglyceride, HDL, Soursop leaves ethanol extract, gemfibrozil.

EVALUASI PERESEPAN ANTIBIOTIK PASIEN INFEKSI SALURAN KEMIH DI INSTALASI RAWAT INAP RUMAH SAKIT ROEMANI SEMARANG Hening Pratiwi; Septimawanto Dwi P
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTInappropriate antibiotics prescribing in Urinary Tract Infection (UTI) can lead antibiotic’s resistance. Hospitals should have a formulary as a reference for providing medical services to the patients. This study aimed to determine the types of antibiotics that prescribed for UTI treatment and determine the level of antibiotics prescribing conformity with the Roemani Semarang hospital’s formulary (2009) and WHO guidelines 2001. This study used a non-analytical descriptive design and retrospectively. The samples were 73 patients. This study includes the pattern of antibiotic prescribing in UTI patients and conformity with 2009 hospital formulary and 2001 WHO guidelines. The results showed that antibiotics are widely used cefotaxime (cephalosporins) 14 cases (19.18%), levofloxacin (quinolones) 11 cases (15.07%), and ceftriaxone (cephalosporins) 10 cases (13.70%). The combination that widely prescribed is a cephalosporins combination with quinolones three cases (4.11%), cephalosporin combination with other cephalosporins three cases (4.11%), and the combination of a cephalosporin with an aminoglycoside two cases (2.74%). There are 68 recipes (93%) suitable with hospital formulary, and five recipes (7%) not listed on the hospital formulary Roemani 2009. The UTI antibiotic monotherapy in women, men, and children do not exist in accordance with the WHO guidelines 2001. Key words: Urinary Tract Infections, antibiotics, hospital formulary, Roemani Hospital Semarang

EKSTRAK BIJI ALPUKAT SEBAGAI PEMBUSA DETERJEN: “PEMANFAATAN POTENSI BAHAN ALAM DAN MENEKAN BIAYA PRODUKSI” Hazena Misgi Damayanti; Nabila Annisa Praditia; Reni Widaya Murti; Midar Ahmad; Naniek Widyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The use of powder detergent in Indonesia started to increase dramatically in the 1990s. Raw materials for use in the formulation detergents are active ingredients, excipients, support materials, additives, fragrance materials, and antifoam. The active ingredients of detergents, such as Sodium Lauryl Sulfonate (SLS) are utilized to increase the cleaning power. SLS known as an import detergent active ingredients and has a high price. Avocado seed is known containing several secondary metabolites such as alkaloids, triterpenoids, tannins, flavonoids, and saponins. Saponins have an important role as a producer of foam in industrial detergents, soaps, and shampoos. The purpose of this study is to determine the effectiveness of the avocado seed extract as an additive in detergents production. This research was carried out by mixing the avocado seed extract concentration of 14%; 28%; 42%; 56% and 70% with other detergent ingredients. The measurements include the analysis of physicochemical properties as require: pH level, viscosity and foam stability. Data were analyzed theoretically and statistically by One-way ANOVA. The results show that the detergent formula avocado seed extracts 28% can be used as a substitute for SLS 28%. Key words: Seed Avocado, detergents, saponin, SLS

UJI KELARUTAN UNTUK SELEKSI FASE MINYAK, SURFAKTAN DAN KOSURFAKTAN DALAM PREPARASI SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID lis Wahyuningsih; Sugiyanto Sugiyanto; Yuswanto Yuswanto; Ronny Martein
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Furosemide has a low solubility in water and leads to absorption profile this drug is highly variable after oral administration. Self-nano emulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for furosemide to improve its absorption profile. Selection of oil phase, surfactant and cosurfactant has an important role in furosemide SNEDDS. The solubility of furosemide performed in the oil phase: oleic acid, red palm oil, and olive oil. The solubility of furosemide was also measured in a surfactant: tween 80, tween 20 and cremophor RH40 and the cosurfactant: propilenglikol (PG), polyethylene glycol (PEG) 400 and glycerol. The solubility test was performed at a temperature of 37°C and furosemide levels in the oil phase, surfactant and cosurfactant were determined by a spectrophotometer. Furosemide solubility in the oil phase of oleic acid, red palm oil, and olive oil are (158, 80 and 32) mg/mL respectively. Meanwhile, furosemide solubility in surfactant tween 80, tween 20 and cremophor RH40 are (278.889; 202.527 and 237.250) mg/mL respectively. In addition, the solubility of furosemide in a cosurfactant PG, PEG 400 and glycerol are (92.0; 1374.867 and 225.044) mg/mL respectively. This study concluded that the greatest furosemide solubility in the oil phase, surfactant and cosurfactant respectively is oleic acid, tween 80 and PEG 400. These materials can be selected as a component of furosemide SNEDDS. Key words: furosemide, SNEDDS, oil phase, surfactant, cosurfactant

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN KARIKA (Carica pubescens) DENGAN METODE DPPH BESERTA IDENTIFIKASI SENYAWA ALKALOID, FENOL DAN FLAVONOID Indranila Indranila; Maria Ulfah
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Antioxidant is a compound that can inhibit free radicals. Free radicals can cause several diseases. The purpose of this study is to reveal the antioxidant activity of carica leave ethanol extract (CLEE) (Carica pubescens) and determine its active compounds. The extract produces with maceration method using ethanol 96% as a solvent. The antioxidant activities of CLEE series concentration (2.5; 5.0; 10.0; 15.0; 20.0 and 25.0) ppm and vitamin C series concentration of (0.5; 1.0; 1.5; 2.0 and 2.5) ppm as standard antioxidant were measured with DPPH method. Absorbance was observed by spectrophotometer UV-Vis. Antioxidant activities presented by IC50 value derived from probit analysis. Identification of active compounds in CLEE was performed by Thin Layer Chromatography (TLC) method. The results showed that the IC50 value for CLEE and vitamin C as an antioxidant were 30.8 ppm and 2.9 ppm respectively. Base on TLC analysis, alkaloids, a phenol compound, and flavonoids were found in CLEE. Key words: antioxidant, Carica pubescens, DPPH, TLC

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT KULIT AKAR SENGGUGU (Clerodendrum serratum) ASAL IMOGIRI, YOGYAKARTA Nasrudin Nasrudin; Mustofa Mustofa; Ratna Asmah
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Senggugu (Clerodendrum serratum) is one of the potential plants as the source of natural antioxidant. Traditionally, some Asian countries, as well as Indonesia, has been applied this plant for treatment in various diseases. The leaf and stems of Clerodendrum pholimidis and Clerodendrum viscosum that are the same genus with senggugu indicated that they are potential as an antioxidant. The Senggugu plants growing in India, China and Malaysia have been reported that the extracts of the plant are also active as an antioxidant. The objective of this work is to study antioxidant activity of ethyl acetate extracts of the senggugu root-stem collected from Imogiri, Yogyakarta. The extract was obtained through sequential maceration technique using n-hexane, ethyl acetate, and methanol solvents. The antioxidant activity of the extract was then examined by DPPH (2,2-dipphenyl-1-pycryl hydrazyl) and rutin as the standard antioxidant. The results showed that the ethyl acetate extracts of root-stem of the senggugu have antioxidant activity property with IC50 of 30.968±0.686 μg/mL and IC50 of 1.741±0.091 μg/mL for rutin as the standard antioxidant. Key words: Root-stem, Clerodendrum serratum, antioxidant

UJI AKTIVITAS ANTIOKSIDAN FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN KARIKA (Carica pubescens) DAN IDENTIFIKASI SENYAWA ALKALOID DAN FLAVONOIDNYA Annis Mu’awwanah; Maria Ulfah
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Free radicals can lead to various dangerous diseases, such as cancer. Active compounds from medicinal plants such as flavonoids and alkaloids have been shown the antioxidant effects and may serve to prevent the negative effects of free radicals. Two of these compounds have been identified in leaf extract (Carica pubescens) and can be separated from other compounds with fractionation method. The purpose of this study was to determine the antioxidant activity of n-hexane fraction of karika leaves ethanol extract (HFKLEE) with DPPH method and identify its alkaloids and flavonoids compounds. Antioxidant activity of HFKLEE series concentration (50; 100; 150; 200; 250 and 300) ppm was performed by the DPPH method. Vitamin C series concentration (0.5; 1.0; 1.5; 2.0 and 2.5) ppm was used as a standard solution. Identification of alkaloids and flavonoids compound in HFKLEE determined by the thin layer chromatography (TLC) method. The results showed that HFKLEE has antioxidant activity with IC50 values of 157.134 ppm and Vitamin C at 2.875 ppm. TLC results indicate the presence of alkaloids and flavonoids compounds in HFKLEE. Key words: Karika leaves (Carica pubescens), n-hexane fraction, antioxidant, flavonoids and alkaloids

POTENSI RIMPANG KENCUR (Kaempferia galanga L.) SEBAGAI PENCEGAH OSTEOPOROSIS DAN PENURUN KOLESTEROL MELAUI STUDI IN-VIVO DAN IN-SILICO Sri Handayani; Fera Elia; Siti Istatoah; Erika Indah; Ibrahim Arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Ethyl p-methoxycinnamate and ethyl cinnamate as a phytoestrogen in galangal root (Kaempferia galanga L.) expected to be used for replacing the Hormone Replacement Therapy on prevention osteoporosis and as anti-cholesterol in menopausal women. The purpose of this study is to explore the potential estrogenic effect of galangal root extract on prevention of osteoporosis and as an anti-cholesterol agent. In-silico test is performed to measure the molecular interactions between ethyl p-methoxycinnamate and ethyl cinnamate with estrogen receptor protein (1QKM) and in-vivo tests conducted by the ovariectomy method on female Wistar rats. Thirty female Wistar rats were divided into six treatment groups. Group I is the normal mice and the group II-VI is the ovariectomies rats. Ovariectomy surgery performed at 70 days of age rats. Group II is the baseline of ovariectomized rats. Group III rats treated with CMC-Na 0.5% (control). Group IV rats are treated with estradiol 2 μg/kg BW/day while the group V and VI rats are rats treated with galangal root ethanol extract (500 and 1.000) mg/kg BW/day. Administration of the test material was performed for 30 days. At the end of the experiment, a blood sample was taken from orbital sinus for measurement of blood lipid levels. All the rats were sacrificed for necropsy procedures. The results showed that galangal root ethanol extracts significantly decrease the cholesterol and LDL levels, and enhance the femur bone density. However, extract has not significantly effect in decrease the triglyceride and enhance the HDL levels of ovariectomized rats. There were almost the same binding energy between ethyl p-methoxycinnamate, ethyl cinnamate and 17β-estradiol on 1QKM protein with binding energy is -94.9984; -949 948 and -94.9982 respectively. Key words: Kaempferia galanga L., osteoporosis and anti-cholesterol agent, in-vivo, in-silico

PENGARUH SUHU DAN LAMA PENYIMPANAN TERHADAP KANDUNGAN VITAMIN C DALAM CABAI MERAH (Capsicum annuum. L) DAN AKTIVITAS ANTIOKSIDANNYA Aqnes Budiarti; Dyah Ayu Elisa_Kurnianingrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTVitamin C is known as an antioxidant. The vitamin C level in food can be affected by temperature and prolonged storage. Red chili (Capsicum annum L) could be decomposed due to storage. This study aims to investigate the influence of temperature and storage time to the vitamin C level in red chili and its antioxidant activity. The determination of vitamin C level used a spectrophotometric method and the antioxidant activity assay using DPPH method. Red chili was storage in 0 (zero) days, three (3) days and 7 (seven) days. Storage temperature varies at 0⁰C; 10⁰C and room temperature. Data were analyzed statistically with a linearity test and model polynomial regression (curve) with a 95% confidence level. The results showed that the duration of storage significantly influenced the vitamin C level in red chili and its antioxidant activity. Contrary to the duration of storage, the storage temperature had no effect on the vitamin C level and antioxidant activity in red chili. The vitamin C level and antioxidant activity was highest in the storage 0 (zero) days that were the vitamin C level of 0.24% w/w and antioxidant activity of 35.58%. Keywords: Temperature and prolonged storage, red chili, antioxidant activity, DPPH

AKTIVITAS ANTIBAKTERI FORMULA OPTIMUM KRIM ANTIACNE FRAKSI ETIL ASETAT EKSTRAK DAUN TEH HIJAU (Camelia sinensis L) Naniek Widyaningrum; Achmad Fudholi; Sudarsono Sudarsono; Erna P. Setyowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Green tea (Camellia sinensis L) contains EGCG, which has antibacterial activity. Stability, optimal concentration and formulation development has been observed before. This study aimed to determine the antibacterial effect stability of the ethyl acetate fractions of green tea leaves extract cream optimum formula and ethyl acetate fraction of green tea leaves extract (EAFGTLE 6%) against acne-causing bacteria, S. epidermidis. Anti-bacterial activity performed with diffusion assay method on S. epidermidis ATCC 35984 growths. The stability of anti-bacterial activity obtains during three months. The result analyzed using paired sample t-test (p: 0.95). The result showed there was no significant difference between EAFGTLE 6% inhibition ability (p=0.081) or even cream dosage optimum formula (p=0.079) during three months. It can be concluded that EAFGTLE 6% and optimum formula cream could inhibit its effectiveness during three months. Key words: Antibacterial activity, cream, ethyl acetate fraction, green tea leaves extract

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