Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
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<![CDATA[PERBEDAAN EFEKTIVITAS ANTIBIOTIK PADA TERAPI DEMAM TIFOID DI PUSKESMAS BANCAK KABUPATEN SEMARANG TAHUN 2014 ]]>
<![CDATA[Risha Fillah Fithria]]>;
<![CDATA[Kiki Damayanti]]>;
<![CDATA[Risma Putri Fauziah]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1337
<![CDATA[ABSTRACTThere are differences on the use of antibiotics on typhoid fever’s treatment. However, there was a research concluded that there were no differences between the efficacy of antibiotics on typhoid fever's therapy that shown as fever-free time and treatment duration. The purposes of this study are to determine the various antibiotics that used on typhoid fever’s treatment and to compare the efficacy of that antibiotic at Bancak Public Health Center Semarang regency. This study was an analytically survey research, with retrospective data collection from medical records, used purposive sampling method. The research sample was all adult patients’ typhoid fever hospitalization at Bancak Public Health Center Semarang regency. Data of antibiotic’s efficacy in fever-free time and treatment duration were analyzed with Kruskal-Wallis test. The result showed that the antibiotics used on typhoid fever’s treatment at Bancak Public Health Center Semarang regency were chloramphenicol, amoxicillin, cefotaxime, ceftriaxone, and ampicillin. Ceftriaxone was an antibiotic that provided the shortest fever's free-time and duration of treatment. However, there was no statistically significant difference between efficacy of that antibiotics at Bancak Public Health Center Semarang regency (p>0.05). Key words : Antibiotics efficacy, typhoid fever’s treatment, fever’s free-time, duration of treatment, Bancak Public Health Center.]]>
<![CDATA[POTENSI FRAKSI n-HEKSAN EKSTRAK ETANOL RIMPANG LENGKUAS [Alpinia galanga (L.) Swartz.] DALAM MENINGKATKAN KUALITAS SPERMA DAN SPERMATOGENESIS ]]>
<![CDATA[Yance Anas]]>;
<![CDATA[Imam Faozi]]>;
<![CDATA[Suharjono Suharjono]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1338
<![CDATA[ABSTRACT Flavonoids and steroid's compounds have been identifying in the galangal rhizome [Alpinia galanga (L.) Swartz.]. This compound has hormonal and antioxidant effects and can improve the spermatogenesis and quality of spermatozoa. The purpose of this study is to find out the effects of the n-hexane fractions from galangal rhizome ethanol extract (HFGREE) on male Swiss mice spermatogenesis and quality of spermatozoa. This research is a laboratory experimental with randomized matched post test only controls group design. Twenty-four male Swiss mice (8-weeks old) divided among four groups: control groups (mice treated with CMC 1.0% 10 mL.kg-1.day-1), and three groups of mice treated with HFGREE (1.29; 2.58 and 5.16) mg.kg-1.day-1 for 30 days. All mice sacrificed at day 31. Furthermore, testicular tissue sections are used to calculate the score of spermatogenesis. Spermatozoa in the epididymis were used to assess the quality of spermatozoa. The results showed the HFRGEE (2.58 and 5.16) mg.kg-1.day-1 for 30 days, significantly elevate spermatogenesis score, and improve the spermatozoa count, spermatozoa motility, healthy and normal spermatozoa of male Swiss mice (p<0.05). Further studies can focus on the identification of active compounds in HFGREE that play a role in improving spermatogenesis and quality of spermatozoa. Key words: n-hexane fraction, galangal rhizome ethanol extract, spermatogenesis, quality of spermatozoa]]>
<![CDATA[ISOPROTERENOL SEBAGAI MODEL INFARK MIOKARDIAL AKUT PADA TIKUS WISTAR ]]>
<![CDATA[Wahyu Widiyaningsih]]>;
<![CDATA[Sugiyanto Sugiyanto]]>;
<![CDATA[Sitarina Widyarini]]>;
<![CDATA[Suwidjiyo Pramono]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1339
<![CDATA[ABSTRACT Decreased oxygen supply and necrosis in the heart muscle cells can lead to acute myocardial infarction. Free radical compounds can lead to oxidative stress in the heart muscle and lead to myocardial infarction. Isoproterenol is a non-selective β-adrenergic agonist can lead to acute myocardial infarction in large doses. The purpose of this study was to validate the model of acute myocardial infarction. This study using male Wistar rats aged two months as the test animal. Male Wistar rats divided into two groups: control group and treatment group. The control group treated with physiological saline and the treatment group treated with isoproterenol 85 mg/kg BW. Isoproterenol administered subcutaneously for two doses with an interval of 24 hours. After 48 hours of the isoproterenol first administration, rat heart rhythm's records with an electrocardiogram (ECG). Furthermore, the rats sacrificed and performed a necropsy. The left ventricle part in the cross section for the macroscopic observation (extensive infarction) with triphenyl tetrazolium chloride (TTC) staining, microscopic observation of infarction with hematoxylin-eosin staining (HE) and immunohistochemical (IHC) to observe the expression of caspase-3. The ECG of isoproterenol group showed elevation in the ST segment. TTC staining shows the expansion of the infarct area. The HE staining showed the typical image of myocardial infarction and the IHC staining results showed an increase in the expression of caspase-3. The results showed that isoproterenol can be use as a model myocardial infarction with parameters of infarction are ECG changes, TTC staining of infarct broad macroscopic image, a histopathological image of heart and apoptosis with the expression of caspase-3. Key words: Isoproterenol, acute myocardial infarction, cardiac histopathology]]>
<![CDATA[PENGUKURAN KUALITAS HIDUP PASIEN TUBERKULOSIS MENGGUNAKAN INSTRUMEN ST GEORGE RESPIRATORY QUESTIONNAIRE (SGRQ) DI YOGYAKARTA ]]>
<![CDATA[Hendrik Hendrik]]>;
<![CDATA[Dyah Aryani Perwitasari]]>;
<![CDATA[Ully Adhie Mulyani]]>;
<![CDATA[Jarir At Thobari]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1340
<![CDATA[ABSTRACT Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. It typically affects the lungs but can affect other sites as well. TB disease could influence the TB patients’ quality of life such as psychology of health, physical function and the leading role in society. The purpose of this research is to measure the differed TB patients’ quality of life before and during the treatment using Indonesian version of St George Respiratory Questionnaire (SGRQ) instruments that have been validated. The research used a cross-sectional design conducted prospectively in 91 new patients diagnosed as lung TB in BP4 province of Yogyakarta in November 2013 until April 2015. Patients filled out the questionnaires, and its obtained Total Score values were analyzed with Friedman's test to understand the quality of life. The results from this research showed that the quality of life of TB patient before, and during the treatment differed significantly. The Total score on the first month treatment was 43.57% and the second until the sixth months treatment was 30.40%; 25.22%; 20.50%; 18.45% and 16.51% respectively (p<0.05). The worst of quality of life was occurred in the first month treatment as the initial period before the treatment and continues to improve until the sixth-month treatment. In conclusion, the quality of life TB patients’ before and during the treatment is more increasing. Key words: Tuberculosis, SGRQ, Quality of life.]]>
<![CDATA[UJI TOKSISITAS AKUT DAN SUB KRONIS RAMUAN JAMU UNTUK FIBRO ADENOMA MAMMAE (FAM) ]]>
<![CDATA[Saryanto Saryanto]]>;
<![CDATA[Danang Ardiyanto]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1342
<![CDATA[ABSTRACT Mammary fibroadenomas (FAM) is the mammary gland benign tumor and has a high incidence rate in women aged 20-30 years. The purposes of this study are to assess the acute and subchronic toxicity of the herbs for FAM. The herb for FAM is a mixture of several simplisia (Curcuma zedoaria Rosch. rhizome; Loranthus parasiticus; Curcuma mangga Val. rhizome and Mammeria mimosa tuber) with a (10 g: 10 g: 5 g: 8 g: 7 g) ratio. Acute toxicity assay performed on the male and female Spraque-Dawley (SD) rats (aged 2-3 months with 200-250 g body weight). Forty-eight rats divided into four treatment groups (control group and three treatment groups of herbs for FAM). A decoction of herbs for FAM treated once a day orally. Toxicity clinical symptoms and lethal doses (LD50) observed for 7-14 days. Subchronic toxicity assay was also conducted in the male and female SD rats (aged 1.5-2 months with 150-200 g body weight). The three-dose series of herbs for FAM treated to the rats orally once daily for 90 days. The results of acute and subchronic toxicity assays found the quasi LD50 value of herbs for FAM is 5.000 mg/kg BW. This herb is safe for use in the medium term as an herbal medicine for FAM. Key words: FAM, acute, subchronic, toxicity assay]]>
<![CDATA[EFEK SITOTOKSIK KOMBINASI EKSTRAK METANOL DAUN KENIKIR (Cosmos caudatus, Kunth) DAN DOKSORUBISIN TERHADAP SEL KANKER PAYUDARA T47D SECARA IN-VITRO DAN IN-SILICO ]]>
<![CDATA[Fera Elia Fita]]>;
<![CDATA[Dewi Listianingsih]]>;
<![CDATA[Yunita Ayu Hapsari]]>;
<![CDATA[Raka Galih Pradana]]>;
<![CDATA[Erika Indah Safitri]]>;
<![CDATA[Ibrahim Arifin]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1343
<![CDATA[ABSTRACTDoxorubicin is chemotherapeutic agents used widely for breast cancer therapy. The use of doxorubicin may cause cardio toxicity and multi-drug resistance. In order to overcome this side effect, a combined therapy using the methanol extracts of kenikir leaves is developed. The purposes of this study are to measure the cytotoxic effect of methanol extracts of kenikir leaves and doxorubicin combination treatment against T47D breast cancer cell growth in-vitro and in-silico, as well as determining the optimal dose combination that produces the most potent cytotoxic effects. The extraction of kenikir leaves is performed with soxhletation method. The cytotoxicity assay on the T47D breast cancer cells is carried out using MTT assay. The result of this research shows that the value of IC50 methanol extracts of kenikir leaves is 778.05μg/mL. The treatment of the methanol extracts of kenikir leaves and doxorubicin combination treatment results in a strong synergy at the concentration 130 μg/mL (-41 nM); 195 μg/mL (-41 nM) and 130 μg/mL (-27.33 nM) with the value of Combination Index 0.2; 0.3 and 0.3 respectively. The result of in-silico test shows that the bond energies of aglycone flavonoid and quercetin glycoside on Bcl-2 are -63.3359 and -67.0414. Key words: Kenikir leaves extract, doxorubicin, T47D cells, molecular docking]]>
<![CDATA[UJI KLINIK MULTISENTER PENGARUH FORMULA JAMU OSTEOARTHRITIS TERHADAP RASA NYERI DIBANDING PIROXICAM ]]>
<![CDATA[Danang Ardiyanto]]>;
<![CDATA[Peristiwan R Widhi Astana]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1344
<![CDATA[ABSTRACT Herb scientification program is expected to obtain scientific evidence of the use of herb through research-based services. The purpose of this study is to reveal the efficacy of pain relief herb for osteoarthritis (OA) compared to the standard drug piroxicam. This clinical study performed through multi-center clinical trial approach involving 30 physicians who have been trained in herbs scientification trainee in February to December 2014. The study design was an open clinical trial without blinding. 123 patients with OA who met the inclusion criteria included in this study and they divided into two groups (63 subjects treat with OA herb and 60 subjects treated with piroxicam (as a control group). The OA herb consists (Curcuma xanthorrhiza roxb rhizome (15 g), Phyllanthus urinaria herbs (7 g), Curcuma domesticae rhizoma (15 g), Foeniculum vulgare Mill seeds (3 g), Orthosiphon aristatus leaves (5 g), and Acalyptha india herb (5 g)). Data collected for four weeks in both groups of patients. This clinical study concludes that the treatment of OA herb for 28 days significantly decrease the pain in patients with osteoarthritis. OA herbs can reduce the patient's VAS scores were comparable to piroxicam (p> 0.05). Key words: Osteoarthritis, pain relief herb, VAS, piroxicam]]>
<![CDATA[STUDI KLINIK EFEK SEDUHAN FORMULA JAMU HIPERTENSI TERHADAP FUNGSI GINJAL ]]>
<![CDATA[Agus Triyono]]>;
<![CDATA[Fajar Novianto]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1345
<![CDATA[ABSTRACT Clinical study on the effect of hypertension herbs steeping formula on the renal functions has been done. Hypertension herb formula consists of Apium graveolens L.; Orthosiphon spicatus (Thunb.); Centella asiatica (L.); Curcuma xantoriza; Phyllantus niruri, and Curcuma domestica. Clinical trials were conducted by open-label clinical trial and pre-post test design. Thirty human subjects who have met the inclusion and exclusion criteria were involved in this study. The study protocol was approved by the research ethics of Ethics Committee for Health Research, National Institute of Health Research and Development, Ministry of Health. Before the treatment, the subjects who had signed informed consent performed anamnesis, medical history, clinical symptoms, physical examination and laboratory tests of renal function (BUN and creatinine levels). The subjects treat with the hypertension herbs steeping formula three times a day for eight weeks, then controlled it once a week. Anamnesis on the clinical symptoms, the possibility of side effects and physical examination diagnostic on the subject performed every week. Measurement on the renal function performed every four week. Base on the anamnesis and physical examination, the clinical study concluded that there were no significant adverse effects on the subject. Paired t-test results showed that there was no significant difference on subject’s BUN and creatinine levels before and after the treatment hypertension herbs steeping formula on the 28th and 56th day (p <0.05). Clinically, the treatment of hypertension herb steeping formula for 56 days did not affect the subject’s renal function. Key words: Hypertension herbs steeping formula, renal function]]>
<![CDATA[ANALISIS KINERJA INSTALASI FARMASI RSU DAERAH X DENGAN PENDEKATAN BALANCED SCORECARD PADA PERSPEKTIF PROSES BISNIS INTERNAL ]]>
<![CDATA[Indriyati Hadi Sulistyaningrum]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1346
<![CDATA[ABSTRACT Balanced Scorecard offers the solution for comprehensive performance measurement in a public organization such as a hospital. The purpose of this study is to evaluate the department of pharmacy of RSUD X performance using a balanced scorecard approach refers to internal business perspective. The object of this study is pharmacy department of RSUD X as government district hospitals. This study is a descriptive non-experimental. Data were collected prospectively. The qualitative data obtained through questionnaires and in-depth interviews with the Chief of Pharmacy Department of RSUD X. The quantitative data are dispensing time, drug availability level and interconnection out-patient, obtained through direct observation and surveys on drugs in outpatient prescription. The result showed that the average dispensing times for compounded and non-compounded prescriptions are 21 and 15 minutes respectively. The average of drug availability level in 2012 was 98%. The general interconnection out-patients were at 99%. Therefore, it can be concluded that pharmacy department performance level of RSUD X was categorized in “sufficient criteria”, with some suggestions for improvement. Key words: Performance analysis, balanced scorecard, pharmacy department, RSUD X.]]>
<![CDATA[UJI EFEK ANALGETIK ANTIPIRETIK EKSTRAK ETANOL ALFALFA (Medicago sativa) PADA TIKUS PUTIH JANTAN GALUR WISTAR ]]>
<![CDATA[Hesti Wulan]]>;
<![CDATA[Uning Rininingsih EM.]]>;
<![CDATA[Ika Puspitaningrum]]>
<![CDATA[ Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" ]]>
Publisher : <![CDATA[Universitas Wahid Hasyim Semarang ]]>
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DOI: 10.31942/jiffk.v0i0.1347
<![CDATA[ABSTRACT Analgesic is a group of drugs to relieve pain without erasing consciousness and antipyretic is a compound that can reduce fever. This study aims to verify the effects of analgesic and antipyretic and determine the effective dose of alfalfa ethanol extract (Medicago sativa) as an analgesic-antipyretic. Twenty-five male Wistar rats were divided into five groups. Group I (negative control), rats were treated with CMC-Na 0.5%. Group II (positive control), rats were treated with paracetamol 50 mg/kg BW. Rats in group III, IV, and V were treated with a suspension of the alfalfa ethanol extract (50; 100 and 200) mg/kg BW. Pain stimuli conducted by dipping a rat's tail into 40 °C hot water for 10 seconds. Response time to a painful stimulus were measured before and 30 minutes after treatment. Fever in rats induced with 0.2 mL DPT vaccine intramuscularly. Rectal temperature was measured before treatment (initial temperature), 60 minutes after the vaccine, and 30 minutes after treatment. Data response time to the stimulus of pain and rectal temperature were statistically Analyzed with a one-way ANOVA and Scheffe test at 95% confidence level. The results showed that the alfalfa ethanol extract can improve the response time to pain stimulation and decrease the rectal temperature of fever-induced rats with a DPT vaccine. The effective dose of alfalfa ethanol extract as an analgesic-antipyretic is 200 mg/kg BW. Key words: Alfalfa ethanol extract, analgesics, antipyretics]]>
