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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 342 Documents
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Molecular Docking and ADMET Evaluation of Fluoro-Hydroxyxanthone Derivatives as Potential Estrogen Receptor Alpha Inhibitors Puspitasari, Anita Dwi
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14236

Abstract

Fluoro-hydroxyxanthone derivatives (X1–X10) were investigated as potential inhibitors of estrogen receptor alpha (ER-α) through molecular docking and in silico ADMET profiling. The docking protocol was validated through a redocking procedure, yielding a Root Mean Square Deviation (RMSD) of 0.81 Å, which confirmed the method's reliability.  Compounds X6–X10 demonstrated favorable binding affinities ranging from −7.32 to −7.46 kcal/mol, although these values remained lower than those of the native ligand, estradiol (−10.69 kcal/mol), and tamoxifen (−9.21 kcal/mol). These compounds formed key hydrogen bond interactions with Glu353 and Arg394, similar to estradiol, suggesting a correct binding orientation within the receptor's ligand-binding domain. Structural modifications, particularly the introduction of hydroxyl and fluoro substituents, contributed to the enhanced binding energies observed in these top-performing compounds. ADMET analysis further indicated that compounds X6–X10 complied with Lipinski's Rule of Five, had acceptable oral bioavailability, metabolic stability, and the ability to cross the blood–brain barrier. However, all derivatives were predicted to exhibit mutagenic potential and hepatotoxicity, which may limit their safety profiles. In conclusion, fluoro-hydroxyxanthone derivatives, especially X6–X10, represent promising molecular scaffolds for further optimization and development as potential anti-breast cancer agents targeting ER-α
Antibacterial Activity of Ethanol Extract of Red Ginger (Zingiber officinale Roscoe) Against Proteus mirabilis Arum Rafiqah, Jovita; Nuria, Maulita Cut
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14441

Abstract

Red ginger (Zingiber officinale Roscoe) has been extensively utilized in traditional medicine and is reported to possess a wide range of biological activities. Proteus mirabilis is a pathogenic bacterium that could cause Urinary Tract Infections (UTIs). Red ginger contains flavonoid compounds, phenolics, essential oils, and tannins that may contribute to its antibacterial properties. This study aimed to evaluate the differences in antibacterial activity of the ethanol extract of red ginger at various concentrations against Proteus mirabilis and to identify its phytochemical constituents. Red ginger simplicia was macerated using 96% ethanol and the macerate was evaporated with a rotary vacuum evaporator. Extracts were made in series concentrations of 20%, 40%, 60%, and 80% w/v for the antibacterial activity test. Ampicillin was used as a positive control, while dimethylsulfoxide was used as a negative control. Antibacterial activity was assessed based on the diameter of the inhibition zones, and the data were statistically analyzed using a one-way ANOVA test, followed by a post hoc Tukey test at a 95% confidence level. The results of this study showed that there were differences (p < 0.05) in the zone of inhibition values from all series of concentrations of the ethanol extract of red ginger against Proteus mirabilis. The extract was found to contain several classes of secondary metabolites, including terpenoids, alkaloids, phenolics, flavonoids, tannins, and saponins.

Page 35 of 35 | Total Record : 342

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