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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 364 Documents
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Formulation And Antibacterial Activity Test Of Betel Leaf (Piper Betle L.) Essential Oil Mouthwash Against Streptococcus mutans Andini, Prasti; Firdaus, Anisa; Candra, Novita Diana Ayu; Salamah, Nina; Mulyaningisih, Sri
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.13872

Abstract

Dental caries is a prevalent oral health issue in Indonesia, largely caused by Streptococcus mutans. While Piper betle L. essential oil possesses known antibacterial properties, its utilization in a stable mouthwash formulation requires scientific validation. Objective: This study aimed to formulate Piper betle L. essential oil into a mouthwash emulsion and evaluate its antibacterial activity against S. mutans. Essential oil was obtained via steam distillation and formulated into mouthwashes at concentrations of 1%, 2%, and 4% (v/v) using Tween 80 as an emulsifier. Antibacterial activity was assessed using the well-diffusion method against S. mutans (0.5 McFarland standard) in independent triplicate wells (n=3). Vehicle control (without essential oil) and Povidone-Iodine 10% (positive control) were used for comparison. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (p<0.05). The formulation containing 4% essential oil exhibited the strongest antibacterial activity among the test groups, with an inhibition zone of 12.66 ± 1.76 mm, which was significantly higher than the vehicle control (9.29 ± 2.67 mm; p < 0.05). The positive control showed the highest inhibition (18.03 + 1.16 mm). Physical evaluation confirmed that all formulations remained stable during 7 days of storage at room temperature (27 ± 2°C), with no specific control of relative humidity, with pH values (6.46–6.82) and specific gravity (1.03–1.04 g/mL) within physiological limits. Piper betle L. essential oil mouthwash is physically stable and effective against S. mutans in a concentration-dependent manner, suggesting its promising potential as a natural alternative for oral hygiene maintenance
Decoding Genetic Risk: A Genome-Wide Association and Functional Analysis of Variants Linked to Liver Cancer Susceptibility: Analysis of Variants Linked to Liver Cancer Susceptibility amukti, danang prasetyaning; Daru Estiningsih; Tetie Herlina; Latifa Amalia; Ifa Aris Suminingtyas; Moch. Saiful Bachri; Ria Indah Pratami; Imam Akbar; Muhammad Ma’ruf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14048

Abstract

Liver cancer is one of the leading causes of cancer death worldwide. Genetic factors play a role in determining a person's susceptibility to this disease. Genome-Wide Association Studies (GWAS) have identified several genetic variants associated with liver cancer, but their functional mechanisms still need to be further explored. Therefore, this study aims to identify genetic variants that contribute to liver cancer, evaluate their functional effects on proteins, analyze allele frequencies across global populations, and examine gene expression in various human tissues. This study used a bioinformatics approach to identify genetic variations associated with liver cancer from the GWAS Catalog. Five selected missense variants were analyzed using SIFT and PolyPhen-2 to assess their functional impact. Allele distributions in the global population were analyzed using 1000 Genomes Project data, and gene expression was analyzed using the GTEx Portal. The analysis identified 77 candidate genes with significant associations with liver cancer, based on p-values meeting the threshold (p < 5 × 10⁻⁸). Five genes in the Missense Variant category showed a strong association with liver cancer: IFNL3, SLC30A10, PNPLA3, OSMR, and CMTR2. In the analysis using SIFT and PolyPhen-2, the rs3096380 variant (CMTR2) was deleterious, and rs738409 (PNPLA3) and rs188273166 (SLC30A10) were deleterious and probably damaging, with the potential to disrupt protein function and contribute to the pathogenesis of liver cancer. Conclusion: Genetic variations rs738409 (PNPLA3) and rs188273166 (SLC30A10) are deleterious and probably damaging, potentially disrupting protein function and contributing to liver cancer pathogenesis.
Quality of Life of COVID-19 Pfizer® Booster Vaccine Recipients Using Short Form-8 Instrument in Palu City Adisaputra, Arya Dibyo; Amelia Rumi; Khusnul Diana; Salza Syahdianti Rahmadani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14117

Abstract

The COVID-19 pandemic continues, and vaccination initiatives are still underway. Booster vaccinations are administered to enhance antibodies that decline after several months of receiving the primary vaccine doses. It is important to understand the impact of these vaccinations on recipients' quality of life. This study aims to examine the influence of demographic and clinical characteristics on the quality of life of the population in Palu City who received the Pfizer® COVID-19 booster vaccine. This research is an observational, cross-sectional study. The sampling was conducted using the consecutive sampling method, and a total of 400 individuals who met the inclusion criteria were included as the sample. This study used the Short Form-8 questionnaire to assess quality of life. Data analysis was performed using multiple linear regression. The study found that the quality of life of individuals who received the Pfizer® COVID-19 booster vaccine in Palu City was good, as evidenced by average domain scores≥50. An individual's quality of life can be assessed in terms of physical and mental aspects. Post-vaccination symptoms and a history of COVID-19 infection (p<0.05) influenced the physical aspect. Age, occupation, and a history of COVID-19 infection (p<0.05) influenced the mental aspect. The quality of life of the population in Palu City who received the Pfizer® COVID-19 booster vaccine showed a greater improvement in mental health than in physical health.
Evaluation of Knowledge Level on Self-Medication for Headache Among Students at Universitas Muhammadiyah Yogyakarta: A Descriptive Study Kurniawan Saputra, Andy; Utami, Pinasti; Yanuar Pratama, Deansyah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14140

Abstract

The extent of understanding regarding self-medication for migraines among students remains comparatively limited. Nonetheless, there has been an increasing trend in the availability of data on medications on the internet. The regular use of over-the-counter (OTC) drugs for headache management requires proactive measures to ensure safe and appropriate self-medication practices. This study seeks to determine the level of knowledge regarding self-medication for headaches among students at Universitas Muhammadiyah Yogyakarta. This study employed a descriptive design, using an observational technique and a cross-sectional methodology, with a sample of 369 students from Universitas Muhammadiyah Yogyakarta. A reliable, standardized online questionnaire was used to evaluate the subjects' knowledge. The data will be presented descriptively to illustrate the students' understanding of self-medication for headaches. The survey indicated that 87.8% of students had a "good" comprehension of self-medication for headaches, with an average score of 85.99. Nonetheless,. However, further action is required to promote safe and responsible self-medication practices among students at Universitas Muhammadiyah Yogyakarta.
Pharmaceutical Staff Behavior and Patient Satisfaction in Drug Information Services: A Cross-Sectional Study in Pekanbaru, Indonesia Aryani, Fina; Putri Ramadhani, Sari; Husnawati, Husnawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14165

Abstract

The provision of drug information by pharmaceutical staff in pharmaceutical services aims to prevent medication errors and affect patient satisfaction. Satisfaction results from a patient's assessment of health services by comparing the services received with what the patient expects. This study aims to investigate the effect of pharmaceutical staff behavior on patient satisfaction with drug information at pharmacies in Pekanbaru City. This study employs a descriptive-analytic observational/survey design with a cross-sectional approach. Data collection techniques were carried out simultaneously. The samples in this study consisted of 32 pharmaceutical staff members and 105 patients from 15 pharmacy branches. Sampling for pharmaceutical staff was conducted using the saturated sample method, while patient samples were collected using purposive sampling. A satisfaction questionnaire was prepared based on the satisfaction dimensions. Positive behavior was observed in 62% of cases, while harmful behavior was observed in 38%. The average percentage of the gap between expectations and services is 0.70. This indicates that the services provided to patients at the pharmacy exceed their perceived expectations. The Chi-Square test results yielded a p-value of 0.000, indicating a significant influence between the behavior of pharmaceutical staff and patient satisfaction in providing drug information at pharmacies in Pekanbaru City.
Adherence to Hemodialysis Therapy Among Adult Patients with Chronic Kidney Failure: A Study at Dr. Moewardi General Hospital Surakarta Novi Safitri, Melyn; Rahardjoputro, Rolando; Sardjiman
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14171

Abstract

Chronic kidney failure is a clinical syndrome caused by various chronic kidney diseases, characterized by imbalanced water, electrolyte and acid-base metabolism. Hemodialysis separates uremic substances from blood through a semipermeable membrane in an artificial kidney called a dialyzer. Adherence refers to an individual's behavior in following treatment rules, guidelines, and discipline, including medication compliance, dietary recommendations, and lifestyle changes as recommended by treatment and health advice. This study analyzes adherence levels among adult patients with chronic kidney failure undergoing hemodialysis therapy at Dr. Moewardi General Hospital, Surakarta. This analytic-observational quantitative study used cross-sectional methods with prospective purposive sampling. Data collection used closed questionnaires from February to March 2025. Results demonstrated that the majority of patients were 40-60 years old, male, with a high school education, with a hemodialysis duration of 1-5 years, and who relied on hospital-set schedules. Analysis revealed relationships between adherence and patient profiles, including age, educational level, and duration of hemodialysis
Chitosan-Based In-Situ Gels for Topical Drug Delivery: A Review of Mechanisms, Applications, and Future Prospects Alatas, Fikri; Ammarullah, Wahyu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14216

Abstract

Topical drug delivery systems are rapidly evolving to enhance therapeutic efficacy and patient compliance. Among these, in-situ gelling systems that transition from a sol to a gel state in response to physiological stimuli have emerged as a highly promising platform. This review provides a comprehensive analysis of chitosan, a natural polysaccharide, as a cornerstone polymer for the development of advanced in-situ gels. This paper, based on a systematic literature review of 63 articles published between 2015 and 2025, explores the formulation, characterization, and application of these intelligent delivery systems. Key findings highlight chitosan's exceptional properties, including biocompatibility, biodegradability, and mucoadhesion, which are crucial for effective topical therapy. The review details the primary gelation mechanisms, such as pH, temperature, and ion sensitivity that enable controlled, localized drug release. Furthermore, it summarizes extensive preclinical evidence demonstrating the versatility of chitosan-based gels in various applications, including ocular, nasal, wound healing, and even nose-to-brain drug delivery, where they significantly improve bioavailability and prolong residence time. While challenges like poor solubility and weak mechanical strength persist, innovative solutions involving polymer blending and chemical modification are effectively expanding their functional capabilities. This review concludes that chitosan-based in-situ gels represent a sophisticated and adaptable platform poised to advance next-generation, non-invasive therapeutics.
Effectiveness of Solid Antibacterial Soap Formulated with Green Mussel Shell Waste (Perna viridis) against Staphylococcus aureus Muyassar, Belvan Adzin Muyassar; Santoso, Joko; Sasmito, Ediati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14359

Abstract

Staphylococcus aureus is a major cause of skin infections and remains a public health concern due to its high prevalence and the increasing emergence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA). These conditions highlight the importance of preventive approaches using non-antibiotic topical products. This study aimed to evaluate the antibacterial effectiveness of solid soap formulated with green mussel shell powder (Perna viridis), as well as its physical quality and consumer acceptance. A true experimental posttest-only control group design was applied using five formulations: F I (2%), F II (4%), F III (6%), F IV (0%, negative control), and F V (benzalkonium chloride as positive control). Antibacterial activity was assessed using the disc diffusion method, and the data were analyzed using one-way ANOVA. The results showed a concentration-dependent antibacterial effect, with higher concentrations of green mussel shell powder producing greater inhibition against S. aureus. All formulations met physical quality standards and demonstrated good stability and homogeneity. Sensory evaluation indicated high consumer acceptance across all formulations. Overall, these findings suggest that green mussel shell powder has strong potential as a sustainable and effective antibacterial ingredient for solid soap formulations intended for preventive skin hygiene
Antioxidant Profiling and GC-MS Analysis of Active Subfractions from Jasminum sambac L. Leaf Extract Ristya Putri, Megananda; Iswandi; Harmastuti, Nuraini
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14362

Abstract

Jasmine leaves (Jasminum sambac L.) are known to contain phenolic and flavonoid compounds with antioxidant potential. This study evaluated the antioxidant activities of the ethanol extract, solvent fractions, and subfractions of jasmine leaves. It characterized the chemical profile of the most active subfraction using gas chromatography–mass spectrometry (GC–MS). Jasmine leaves were extracted by maceration using 96% ethanol and subsequently fractionated with n-hexane, ethyl acetate, and water. The ethyl acetate fraction, which exhibited the strongest antioxidant activity, was further separated by vacuum liquid chromatography to obtain subfractions. Antioxidant activity was determined using the DPPH method and expressed as IC₅₀ values. The most active subfraction was analyzed by GC–MS. The results showed that the ethyl acetate fraction had the lowest IC₅₀ among the solvent fractions, while subfraction 1 (SF1) exhibited the strongest antioxidant activity, with an IC₅₀ of 49.78 ppm, indicating strong activity. GC–MS analysis of the most active subfraction suggested the presence of antioxidant-related compound classes with tentative identification. These findings demonstrate that subfractionation enhances antioxidant activity and enriches antioxidant-related constituents in jasmine leaves, while highlighting the need for advanced analytical techniques to confirm compound identities.
Efficacy and Safety of Antihypertensive Drugs in Chronic Kidney Disease Patients at Menggala Regional General Hospital Ardhianto, Denny; Meiliana, Made Laksmi; Ismayati, Dwi; Ulandari, Syaripah; Puspita, Okta; Oktaviana, Rena
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14983

Abstract

Chronic kidney disease (CKD) is a progressive condition characterized by a gradual decline in glomerular filtration rate, often accompanied by hypertension, necessitating antihypertensive therapy. This study aimed to evaluate the effectiveness of antihypertensive drugs in achieving blood pressure targets (<140/90 mmHg or a mean arterial pressure reduction of ≥20 mmHg) and to identify the incidence of adverse effects in CKD patients at Menggala Regional General Hospital during 2024. A retrospective observational study was conducted using medical records from 199 CKD inpatients selected via purposive sampling. Data analysis employed descriptive statistics, paired t-tests for effectiveness, and chi-square tests for associations between drug types. Results indicated that combination therapy with furosemide IV, candesartan, and amlodipine was the most common (77.4%) and demonstrated effectiveness in 50.8% of cases (p=0.01). Adverse effects occurred in only 1.0% of patients, primarily peripheral edema. The findings underscore the efficacy of combination therapies involving diuretics, ARBs, and CCBs in managing hypertension in CKD, with minimal adverse events. This research provides valuable insights for optimizing antihypertensive regimens in similar settings.

Page 36 of 37 | Total Record : 364

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