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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 342 Documents
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Pengaruh Informasi Kemanfaatan Penggunaan Obat Tradisional dan Suplemen Terhadap Willingness to Pay Dalam Pencegahan NCDs di Kota Yogyakarta Arisa Mardiani; Eliza Dwinta; Raden Jaka Sarwadhamana; Imram Radne Rimba Putri
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8388

Abstract

The current incidence of NCDs can not only attack the elderly but can start at a younger age. Must carry out prevention efforts as early as possible by consuming traditional medicines (OT) and supplements. Can obtain information on the benefits of the two products through packaging labels. However, many people still need to pay more attention to them, so they need to understand the proper and correct use of OT and supplements. Willingness to pay (WTP) goes hand in hand with the benefit information obtained. Because if it follows the benefits and prices, the community's WTP is expected to increase. This study aimed to determine the effect of information on the benefits of using OT and supplements on WTP in preventing NCDs in Yogyakarta with a cross-sectional study design. They conducted this research for one month in 5 sub-districts of Yogyakarta City, namely Danurejan, Gondomanan, Mantrijeron, Umbulharjo, and Wirobrajan sub-districts with 107 respondents. The sampling technique uses accidental sampling, and the research instrument is a WTP questionnaire. The results of the research on statistical tests using Kendall Tau found that the significance values were 0.225 (OT) and 0.094 (supplements) > 0.05, so it concluded that information on the benefits of using OT and supplements from packaging labels did not affect WTP in preventing NCDs in the City of Yogyakarta.
Penggunaan Terapi Inhalasi dan Kontrol Asma pada Pasien Anak: Narrative Review Windari, Nurul Irna
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.8359

Abstract

Pada tahun 2019, prevalensi asma dunia diperkirakan mencapai 262 juta dengan angka kematian mencapai 461 ribu jiwa. Anak dengan jenis kelamin laki-laki sebagai salah satu faktor yang mempengaruhi perkembangan asma. Kondisi asma dapat dikontrol agar tidak terjadi kekambuhan (eksaserbasi) dan perburukan. Luaran klinis terapi inhalasi dipengaruhi oleh ketepatan saat menggunakan terapi dan jenis terapi inhalasi. Penelitian merupakan narrative literatur review. Pencarian artikel melalui Pubmed, Google Schoolar, dan Research Gate. Kriteria inklusi yaitu jurnal berbahasa Inggris maupun Indonesia, penerbitan 10 tahun terakhir (2013-2023), original artikel dan free download. Jurnal diidentifikasi untuk memastikan relevansi jurnal terhadap topik dari penelitian ini. Diperoleh 8 jurnal terkait ketepatan penggunaan perangkat terapi inhalasi dan 9 jurnal terkait perbedaan perangkat inhalasi dan pengaruh terhadap luaran klinis. Hasil kajian literatur menunjukkan masih banyak ketidaktepatan dalam penggunaan terapi inhalasi. Pemilihan perangkat inhalasi harus mempertimbangkan kemampuan anak atau caregiver dalam menggunakan perangkat inhalasi. Perlu dilakukan edukasi untuk pasien, dikarenakan ketepatan penggunaan perangkat inhalasi merupakan faktor dominan yang mempengaruhi luaran klinis pada pasien asma anak.
Pemanfaatan Tanaman dalam Sediaan Kosmetika Sebagai Antioksidan dan Anti-Tirosinase: Narrative Review Resina Hajar; Fikri Alatas
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.10822

Abstract

Studies on the antioxidant activity of various plants growing in Indonesia have been widely conducted, however, information relating to testing its activity as an anti-tyrosinase and its formulation in cosmetic preparations is still limited. This literature review explores the use of plants with antioxidant and anti-tyrosinase activity and their development in cosmetic dosage forms. The method for searching references in national and international journals is carried out with the help of the Google Scholar and PubMed search engines published in the last 10 years (2014-2023). After screening by paying attention to inclusion and exclusion criteria, 32 journal articles were used to write this article. Antioxidant and anti-tyrosinase activities are found in almost all parts of the plant, which are generally extracted by maceration with ethanol solvent. Various methods for testing antioxidant activity in vitro are generally based on the presence of a redox reaction between a free radical reagent and an antioxidant which is analyzed spectrophotometrically, while testing anti-tyrosinase activity, is generally tested based on reducing the amount of dopachrome formed in the presence of anti-tyrosinase. The use of plants with antioxidant and anti-tyrosinase activity in cosmetic preparations has been carried out, although it is still limited to conventional preparations, such as creams and gels.
Analisis Drugs Related Problems pada Pasien Kanker Payudara di Rumah Sakit Umum Daerah KRMT Wongsonegoro Semarang Tahun 2022 Sri Susilowati; Firda Shely Septasari
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.11712

Abstract

Drugs Related Problems (DRPs) are problems related to patient treatment that can affect the effectiveness and safety of therapy. Breast cancer patients who receive chemotherapy usually consists of a combination of several drugs. Administration of a combination of chemotherapy drugs can cause DRPs. This study aims to determine the actual and potential incidence of DRPs and their causes in breast cancer patients at the KRMT Wongsonegoro Regional General Hospital, Semarang in 2022. This research was conducted observationally with a cross-sectional research design and retrospective data collection by observing medical record data of breast cancer patients. There were 30 samples that met the inclusion and exclusion criteria. The classification of DRPs refers to the Regulation of the Minister of Health of the Republic of Indonesia Number 34 of 2021 concerning Standards of Pharmaceutical Services in Clinics. DRPs were analyzed using the National Guidelines for Medical Services for Breast Cancer Management in 2018. Analysis of potential drug interactions used medscape.com. Data analysis was carried out descriptively. The results showed that the most frequently used chemotherapy regimen was cyclophosphamide + doxorubicin + fluorouracil (76.67%). All patient samples experienced actual and potential DRPs with the cause being indication without medication (46.67%), medication without indication (0%), too high a dose (90%), too low a dose (100%), side effects undesired (100%), potential drug interactions (100%) and duration of treatment (53.2%). The prevalence of DRPs in our setting was high so that it could affect therapy outcomes of patient. Therefore, it is hoped that there will be an evaluation to reduce the prevalence of DRPs, by optimizing clinical pharmacy service practices such as reviewing prescriptions, monitoring effectiveness therapy and adverse drug reaction also conducting interprofessional collaboration.
Asthma Control and Quality of Life of Asthma Patients At St General Hospital Jatmiko susilo; Soleha Kurniawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8599

Abstract

Asthma is a chronic condition characterized by chronic airway inflammation that causes various respiratory symptoms that can severely impact a patient's daily life. Suboptimal control of asthma is associated with increased costs of care and treatment and decreased quality of life (QoL). This study aims to examine asthma control status and its relationship with the QoL of asthma patients at ST. General Hospital. This cross-sectional study involved 50 asthmatics aged 18-65 who attended ST. General Hospital. Two questionnaires were used: an asthma control test (ACT) and an adult asthma quality-of-life questionnaire (Mini-AQLQ). By using SPSS, the Spearman Rank test was employed to identify associations with a 95% confidence level. Of the 50 respondents studied, asthma status was categorized as partially controlled (50%), totally controlled (14%), and uncontrolled (36%). A significantly worse QoL was observed in respondents with uncontrolled asthma, whereas a good QoL (minimal or no impairment) was observed in partially controlled respondents (p = <0.001). There was a relationship between asthma control and the respondent's QoL (rho = 0.832). Appropriate treatment will increase asthma control and improve the QoL of patients treated at ST. General Hospital. Further research is needed to evaluate risk factors, psychological effects, and behavioral screening in poorly controlled asthma patients.
Profil Pasien Sindrom Koroner Akut dan Pengobatannya Pada Rumah Sakit di Kota Tasikmalaya Sahrul Hikam; Ilham Alifiar; Yedy Purwandi Sukmawan
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8242

Abstract

Sindrom koroner akut (SKA) merupakan penyebab kematian nomor 1 di dunia dan nomor 2 di Indonesia setelah strok. Pengobatan yang tepat dapat menurunkan resiko terjadinya kematian akibat SKA. Antiplatelet, antikoagulan atau fibrinolitik merupakan obat yang digunakan untuk penatalaksanaan SKA. Akan tetapi, sampai saat ini gambaran penggunaan obat pada pasien SKA di Indonesia yang meliputi SKA-NSTEMI dan SKA-STEMI masih terbatas. Selain itu, profil dan penggunaan obat SKA di kota Tasikmalaya masih belum diketahui. Tujuan penelitian ini adalah untuk mengetahui gambaran pasien SKA dan pengobatannya. Penelitian ini merupakan penelitian observasional retrospektif terhadap data rekam medis pasien pada Januari 2020- Desember 2020. Pasien yang masuk kedalam kriteria penelitian berjumlah 78 pasien. Hasil studi menunjukkan bahwa kejadian SKA-STEMI lebih banyak dibandingkan SKA-NSTEMI (RR 4,0986, CI 95% 2.2296-7.5345, p 0,0001), dan banyak terjadi pada usia 40-60 tahun dengan jenis kelamin laki-laki. Gastroesophageal reflux disease (GERD), diabetes melitus dan hipertensi merupakan komorbid terbanyak pada pasien SKA-STEMI, sedangkan hipertensi dan dispepsia merupakan komorbid terbanyak pasien SKA-NSTEMI. Hasil uji hubungan chi square menunjukkan tidak terdapat perbedaan antara jenis SKA dengan usia, jenis kelamin dan komorbid (p>0,05). Pada profil penggunaan obat, antiplatelet meliputi aspirin dan clopidogrel digunakan pada seluruh pasien SKA, sedangkan antikoagulan fondaparinux lebih banyak digunakan dibandingkan dengan enoxaparin (55 vs 23). SKA-STEMI mendominasi dibandingkan SKA-NSTEMI dengan pengobatan yang digunakan adalah aspirin, clopidogrel, fondaparinux, atau enoxaparin, selain itu usia, jenis kelamin dan komorbid tidak berhubungan dengan jenis SKA.
Deciphering the Molecular Basis of Mutated Binding Site Bromodomain-Ligand Complexes: Insights from Molecular Dynamics Simulations and Decoded Interaction Fingerprint Analysis Riandono, Fransiscus Deddy
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.8760

Abstract

This study aims to predict structural stability changes and to identify the molecular determinants of ligand-bromodomain complex interactions that undergo mutations in the ligand binding site (LBS) using computational chemistry methods. The stability changes of the complexes were investigated using Molecular Dynamics (MD) simulations during a 25 ns production run. The identification of molecular interaction determinants was performed by decoding the interaction fingerprint, utilizing the output of trajectory data of the MD simulations, which were converted into a series of pdb files along the time step. The system preparations were done using CHARMM-GUI. The MD simulations were carried out using the GROMACS program. Protein-ligand interaction fingerprints (PLIF) were identified using the PyPLIF-HIPPOS program. This study successfully predicted the stability of both wild-type and mutated ligand-bromodomain complex structures, where the W81A mutation led to a decrease in complex stability. The key residues and non-hydrophobic interaction types responsible for the stabilities were identified as TRP81 aromatic edge-to-face, TYR139 aromatic edge-to-face, and TYR139 aromatic face-to-face.
Pengetahuan Dan Rasionalitas Penggunaan Swamedikasi Masyarakat: Kajian Pada Masyarakat Kecamatan Sekupang Batam Khairunnisa Khairunnisa
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.8517

Abstract

Self-medication is the community's independent efforts to overcome diseases and symptoms before getting medical services. Irrational drug usage is common in its implementation due to the lack of public knowledge about rational medicine. This study aimed to measure the level of knowledge and rationality in self-medication in the community. This study was descriptive research using a cross-sectional survey method. Data was collected online using validated questionnaires. The knowledge and rationality questionnaires each had 10 questions, each respondent who answered correctly was scored 2 points, while those who answered incorrectly or did not know were scored 0.  Data was collected using the snowball sampling method. Data were analyzed descriptively to assess characteristics, knowledge and rationality. The chi-square test was used to assess the relationship between characteristics with knowledge and rationality.  A total of 375 respondents took part in the study. Most respondents had a moderate or fairly good level of knowledge (40.8%) and 68.5% of respondents had used self-medication rationally. The chi-square test showed that the last education affected knowledge and rationality of using self-medication, another factor that affected knowledge was a job. Knowledge did not significantly affect self-medication rationality. Knowledge about self-medication must be improved to increase public self-medication rationality. 
Evaluasi Standar Pelayanan Minimum pada Pelayanan Resep Pasien Rawat Jalan di Instalasi Farmasi Rumah Sakit Umum Daerah dr. Gondo Suwarno Nilam Cahya Aprilia; Iswandi Iswandi; Sumaryana Sumaryana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.7653

Abstract

Pelayanan kefarmasian merupakan kegiatan yang bertujuan untuk mengidentifikasi, mencegah, dan menyelesaikan masalah terkait obat. Perlunya dilakukan evaluasi terhadap waktu tunggu pelayanan kefarmasian di instalasi farmasi adalah untuk mengetahui kelemahan yang dapat memperlambat pelayanan resep, sehingga dapat segera dilakukan perbaikan dalam rangka meningkatkan kualitas pelayanan kefarmasian.Penelitian ini bertujuan untuk mengetahui ketersediaan formularium, lama waktu tunggu pelayanan resep rawat jalan, tidak adanya kesalahan dalam pemberian obat dan kepuasan pasien di Instalasi Farmasi RSUD dr. Gondo Suwarno. Rancangan penelitian ini menggunakan analisis deskriptif observasional menggunakan pendekatan cross sectional.  Teknik sampling probabilitas sampling dengan cara simple random sampling (SRS). Berdasarkan hasil penelitian diperoleh kesimpulan bahwa ketersediaan formularium tersedia dan diperbaharui setiap 3 tahun sekali dengan evaluasi 1 tahun sekali, waktu tunggu pelayanan obat non racikan yaitu 38,07 menit ≥ 30 menit, waktu tunggu pelayanan obat racikan yaitu 41,03 menit ≤ 60 menit, tidak adanya kesalahan pemberian obat sebesar 100 % dan kepuasan pasien 78,79 % ≤ 80 %. Berdasarkan standar pelayanan minimum yang terdapat di RSUD dr. Gondo Suwarno telah memenuni standar minimal dari Departemen Kesehatan Republik Indonesia. Implikasi penelitian ini adalah mempersingkat lama waktu tunggu pelayanan resep obat dimana sumber daya manusia yang kurang terampil akan menyebabkan durasi pelayanan semakin lama.
A Literature Review On the Formulation, Characterization, and Stability of Cinnamomum burmannii Emulgel Extract as an Antioxidant and Sunscreen Rodhia Ulfa; Ferdy Firmansyah; Fenny Khairunnisa; Putri Lestari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9126

Abstract

Emulgel is a pharmaceutical formulation that integrates the characteristics of both emulsions and gels, resulting in a semisolid product. The utilization of emulgel formulations has been shown to enhance the efficacy of drug delivery by facilitating deeper skin penetration and subsequently augmenting its pharmacological activity. The antioxidant and sunscreen properties of cinnamon bark extract make it suitable for incorporation into an emulgel formulation. Variations in the concentration of extracts and gelling agents can have an impact on the physical properties, stability, and pharmacological efficacy of the emulgel. The objective of this review is to ascertain the optimal concentrations of extracts and gelling agents in emulgel formulations for enhanced efficacy. The employed methodology entails conducting a comprehensive review of scholarly articles pertaining to emulgel formulations containing cinnamon bark extract. These formulations encompass a range of concentrations of both the extract itself and gelling agents, while also possessing antioxidant and sunscreen properties. The formulation that is recommended is one that satisfies the criteria pertaining to its physical attributes, stability, and pharmacological efficacy. The emulgel formulation that best meets the specified criteria consists of a 1% concentration of cinnamon bark extract in combination with the gelling agent Viscolam MAC 5%.

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