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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 452 Documents
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Analysis of Biological Activities of Two Novel Metal (II) Complexes of Andrographis Paniculata Crude Extract Mary Adelaide Oladipo; Ayodele Oluwabunmi Ojo; Kayode Taiwo Ishola
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.391-397

Abstract

Many diseases in nature have led to the death of many young and old. Many bacteria have developed resistance to the available antibiotics on the market. And many drugs employed in treating many diseases such as diabetes mellitus are expensive and are not locally available. Therefore, in order to search for more effective, inexpensive, and locally available drugs, this study synthesized and investigated the biological activities of Andrographis paniculata crude extract and its Co (II) and Ni (II) complexes. The crude extract and synthesized complexes were characterized using a solubility test, Infrared, and Ultraviolet-Visible spectroscopic analysis. Their antibacterial potentials were investigated against two gram-negative bacteria (Escherichia coli,Staphylococcus aureus) and three gram-negative bacteria (Proteus, Klebsiella, Pseudomonas) while their antidiabetic activities were examined against ?-amylase and ?-glucosidase enzymes. Acarbose was employed as a standard drug. The crude extract and its metal complexes showed different degrees of solubility in the employed solvents. Infrared analysis suggested coordination of the crude extract to the metal ions through the oxygen donor atom while the formation of the complexes was affirmed through the occurrence of d-d transitions in the visible region of the metal complexes. The metal complexes were found to display more antibacterial activity than the crude extract. Co (II) and Ni (II) complexes of the crude extract were found to exhibit better activities against ?-amylase and ?-glucosidase enzymes, respectively than the crude extract and acarbose. It is concluded that the metal complexes could be considered potential antibacterial and antidiabetic agents.
Identification of Primary and Secondary Metabolites of Apis cerana Honey using FTIR-ATR Diamond Spectroscopy and Their Botanical Origin Lestari, Tiffany Hanik; Susandarini, Ratna
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.467-475

Abstract

Apis cerana Fab. is one of the popular honeybees species among beekeepers in Indonesia. This species is easy to care for and produces valuable honey products. Honey from A. cerana is abundantly available in traditional and modern markets in Indonesia. The purpose of this study was to identify the primary and secondary metabolites in the honey produced by A. cerana using FTIR-ATR Diamond spectroscopy. Twelve samples of honey from three provinces in Java Island were used in this study. In general, all honey samples contained protein, carbohydrate, water, alcohol, cellulose, alkaloid, tannin, and flavonoid. Variation on primary and secondary metabolites in honey samples was strongly affected by the botanical origin, geographical origin, and the local condition around beekeeping areas where the honeycombs were placed.
Chemical Properties of Liquid Broth Extracted from Freshwater and Marine Shrimp Shells Waste Fadhallah, Esa Ghanim; Koesoemawardani, Dyah; Indraningtyas, Lathifa
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.437-440

Abstract

Indonesia's shrimp industry is growing rapidly, but a surge in shrimp waste such as shells and heads’ shrimps are increasing as well. These waste products contain important components such as protein, minerals, and amino acids. This study aims to determine the chemical properties of liquid broth extracted from freshwater and marine shrimp shells, including ash, protein, fat, monosodium glutamate (MSG), and antioxidant. The liquid broth was extracted by boiling shrimp shells and heads in water with a ratio of 1:2 for 1 hour at 80oC. Results indicate that the type of shrimp used did not affect the broth's ash, fat, protein, MSG, or antioxidant content. Marine and freshwater shrimp liquid broths contain 0.56% and 0.28% ash, 0.10% and 0.50% fat, 2.19% and 1.97% protein, 1.5291% and 1.6274% MSG, and 2263.73 ppm and 2786.2 ppm antioxidant.
The Potential of a Sumbawa Herbal Oil-Based Oleogel as Burn Wound Dressing Yuniar, Andi Irma; Yasid, Nurul Wahidah; Nissatuljannah, Syarifah Fatimah; Rijal, Syamsu; Makmun, Armanto
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.559-562

Abstract

This study aimed to innovate the current Sumbawa oil preparation which is still in the form of liquid into an oleogel so that it is easier to apply and more practical for distribution and storage. Phytochemical analysis of Sumbawa oil showed the contents of phenols, flavonoids, and alkaloids. By adding hydroxyethyl cellulose (HEC) as a gelling agent and glycerin as a humectant, Sumbawa oil can be served in the form of an oleogel. The pH measurement of the Sumbawa oil oleogel at levels of 90%, 95%, and 100% ranged from 7.0–7.3 which is the ideal acidity level for the wound healing process. In the antimicrobial activity test with S. aureus and E. coli, the zone of inhibition ranged from 12.1–14.7 mm which is considered strong. Meanwhile, in in vitro testing of the anti-inflammatory activity using the human red blood cell membrane stabilization method, the stability level of each was obtained to be 78% for 100% Sumbawa oil, 74% for oleogel with 95% Sumbawa oil, and 73% for oleogel with 90% Sumbawa oil. The oleogel morphology observation using a scanning electron microscope showed a good gelation process at 5% and 10% HEC levels.
The Anticancer Properties of Guava Leaves (Psidium guajava L.) and Turmeric Rhizome (Curcuma longa L.) Against Breast Cancer: A Literature Study Angga Puja Asiandu; Widya Sari; Septi Widiya Sari; Alif Syahrul Abdul Majid
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.407-412

Abstract

Breast cancer, one of the most deadly diseases occurring in women, is caused by factors. In the healing process, the sufferer needs treatment, such as radiation techniques, surgery, and chemotherapy. But, these techniques have avoidable weaknesses that damage healthy cells. To date, natural sources can be utilized in medicine field. Guava (Psidium guajava L.) and turmeric (Curcuma longa L.) are two common plants obtaining compounds that inhibit the growth of cancer cells based on phytochemical properties. This study was written to review the potential both of plants as anticancer agents. Through the literature, guava leaf extract consists of flavonoids, tannins, alkaloids, saponins, terpenoids that inhibit the proliferation of cancer cells. Besides, turmeric also has tannins, alkaloids, terpenoids, flavonoids, glycosides, sterols, and curcumin. The presence of curcumin reduces histamine production which induce inflammation and decrease toxin. Because of curcumin, breast cancer cells have dehydration before apoptosis.
In Silico BCell Epitope Design of Zika Virus Vaccine Using “Zika Virus Isolate Zika Virus/H sapiensTc/Tha/2006/CVD_06020 Complete Genome” Savitri, Lisa; Juwita, Syntia Tanu; Antoro, Ester Lianawati; Wulansari, Ida Septika; Sukmawati, Datin An Nisa; Freitas, João Gregório; Ornai, Andre Mario Sequeira Alves
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.525-531

Abstract

ZIKV has been found in the cerebrospinal fluid (CSF) and brains of adults infected with viruses that manifest neurological disorders. ZIKV is a mosquito-borne single-stranded RNA virus, which belongs to the family Flaviviridae. The efforts of the scientific community have rapidly increased knowledge about this virus. However, understanding the complexities of ZIKV infection, transmission and pathogenesis remains an urgent challenge. Therefore, it is critical to study competent vectors and natural reservoirs for ZIKV, viral genetic diversity and flavivirus coinfection. Due to the great challenges to develop a ZIKV vaccine, it is still not possible to be immunized against ZIKV infection and related pathologies. The methods are nucleotide search for the Zika virus was carried out in silico, using the NCBI bioinformatics application by providing access to biomedical and genomic information. /H. sapiens-tc/THA/2006/CVD_06-020, the complete genome was then searched for FASTA, then prediction of vaccine epitope using the IEDB. The vaccine candidate peptides were analyzed for their antigenicity using VaxiJen. Proteins were classified by AllerTop to known allergenicity, then ToxinPred to predict and design toxic/non-toxic peptides. There are 30 peptide sequences are predicted to be a candidate of peptides B-cell epitope zika virus vaccine design using “zika virus isolate zika virus/H. sapiens-tc/THA/2006/CVD_06-020, complete genome”.
Nephroprotective Activities of Ethanol Root Extract and Fractions of Hippocratea africana Against Doxorubicin-Induced Kidney Toxicity Noah, Kufre U.; Udobang, John A.; Okokon, Jude E.; Anagboso, Martin O.; Ebong, Nwakaego Omonigho
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.477-484

Abstract

Hippocratea africana root used locally in the treatment of poisoning was investigated to confirm its antidotal potential in rats. The root extract (200-600 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 400 mg/kg) were evaluated for nephroprotective activity against doxorubicin-induced kidney injury in rats. Kidney function parameters, kidney oxidative stress markers and kidney histology were used to assess the kidney protective effect of the extract. The root extract and fractions (200-600 mg/kg) significantly (p<0.05-0.01) reduced the levels of creatinine, urea and electrolytes that were elevated by doxorubicin. Also, the MDA level elevated by doxorubicin was reduced by the extract and fractions co-administration, while the levels of GSH, GST, SOD, GPx, and CAT that were decreased by doxorubicin were significantly (p<0.01) elevated by the root extract/fractions. Histology of the kidney sections of extract/fractions -treated animals showed reductions in the pathological features compared to the organotoxic-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective potential. The anti-toxic effect of this plant may in part be mediated through the chemical constituents of the plant. The plant, Hippocratea africana possesses anti-toxicant properties which can be exploited in the treatment of doxorubicin related toxicities.
Alkaloids Lead to Potential Inhibition of the Acyl Carrier Protein Reductase to Attenuate Tuberculosis; an in-silico Analysis Kamran, Pernia; Ibrahim, Ahsan
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.441-450

Abstract

Tuberculosis (TB) is a contagious infection that mostly affects the lungs. Mycobacterium tuberculosis causes tuberculosis infection, leading to granulomatous lesions in affected lung tissue. It is one of the most prevalent and deadly infectious diseases among the under developed countries. This study aims to investigate the possible inhibition of the acyl carrier protein reductase for preventing tuberculosis by well-known alkaloids, thereby reducing Mycobacterium tuberculosis growth in the lungs and thereby reducing the incidence of latent and active TB. About five natural alkaloids were subjected to the molecular docking analysis, which produced favorable findings in terms of best pose and binding energies of these compounds towards the active residues of mycobacterial ACP reductase, with values ranging from -10 kcal/mol to -9.1 kcal/mol. The molecular dynamics simulation produced similar encouraging results. All of the prospective alkaloid compounds were subjected to an in-silico toxicity investigation, which determined that every compound was safe and non-toxic. Further studies may be necessary for effective formulation development employing these compounds as part of the process of drug discovery and development. The findings from this study may be helpful in the development of the novel nanoformulations using natural products for pharmacotherapy of tuberculosis infection.
Study of Physical, Chemical, and Organoleptic Properties of Functional Drink Turkey Berry (Solanum torvum swartz) with the Addition of Butterfly Pea Flower (Clitoria ternatea linn) and Emprit Ginger (Zingiber officinale var. Amarum) Anggriani, Rista; Putri, Nina Nurazizah Purnomo; Wahyudi, Vritta Amroini
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.563-575

Abstract

Turkey berry (Solanum torvum Swartz) is a wild plant often found in Indonesia and its usage is still limited. Turkey berry has a high potential as a source of antioxidants, which can be consumed as a functional drink. Ginger and butterfly pea flowers were selected as additional ingredients in composite drinks to enhance the quality of the functional drink in terms of function and sensory characteristics. This study aimed to determine the effects of variations in the concentration of turkey berry, butterfly pea flower, and ginger on the physical, chemical, and organoleptic characteristics. The design method used a Simple Randomized Block Design with four treatment combinations to be analyzed in three repetitions. Data were analyzed using Analysis of Variance (ANOVA) to determine the effects of the treatment. The results showed that turkey berry, in combination with ginger and butterfly pea flower, had a significant effect on the physicochemical and organoleptic characteristics, including pH, total phenolic content, total flavonoid content, antioxidants, color, aroma, taste, and preference.
Peptide Fractions from Pepsin-digested Moringa oleifera Seed Proteins Inhibit Hemoglobin Glycation and Carbohydrate-hydrolyzing Enzymes Oluwafemi Emmanuel Ekun
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.413-422

Abstract

The multidirectional abilities of peptide digests and fractions obtained from the hydrolysis of food-based proteins have been investigated in recent times. This study aims to evaluate the effects of pepsin-derived Moringa oleifera seed protein hydrolysates and fractions on hemoglobin glycation and the carbohydrases - ?-amylase and ?-glucosidase. Proteins were extracted from M. oleifera seeds and consequently digested using pepsin. The hydrolysates obtained were separated into fractions of <1 kD, 1-3 kD, and 3-5 kD ranges using size-exclusion chromatography and comparison with elution volumes of known standards. The activities of the hydrolysates and peptide fractions against both the non-enzymatic glycation of hemoglobin and the carbohydrases were determined in vitro. Results revealed that the hydrolysate and its peptide fractions demonstrated varying abilities against the glycation of hemoglobin, with the unfractionated hydrolysate showing better activities (78.230 0.774 % at a maximum concentration of 1.0 mg/ml) than its peptide fractions. Also, the hydrolysates and fractions demonstrated higher inhibitory effects on a-amylase (with all fractions displaying above 50% inhibition at a final concentration of 1.0 mg/mL) than against a-glucosidase. Kinetic analysis of a selected fraction showed that it inhibited ?-amylase via a mixed mechanism (Ki = 0.029 mg/mL) but displayed an uncompetitive mode for ?-glucosidase inhibition (Ki = 0.333 mg/mL). Therefore, it is inferred that M. oleifera seed proteins encode potentially therapeutic peptide sequences that could be further processed to formulate potential antidiabetic agents.

Page 18 of 46 | Total Record : 452

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